{"id":"https://openalex.org/W4316340001","doi":"https://doi.org/10.1093/bib/bbad005","title":"Modeling and analyzing single-cell multimodal data with deep parametric inference","display_name":"Modeling and analyzing single-cell multimodal data with deep parametric inference","publication_year":2023,"publication_date":"2023-01-01","ids":{"openalex":"https://openalex.org/W4316340001","doi":"https://doi.org/10.1093/bib/bbad005","pmid":"https://pubmed.ncbi.nlm.nih.gov/36642414"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbad005","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbad005","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101873904","display_name":"Huan Hu","orcid":"https://orcid.org/0000-0002-9677-5745"},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]},{"id":"https://openalex.org/I146620803","display_name":"Wenzhou University","ror":"https://ror.org/020hxh324","country_code":"CN","type":"education","lineage":["https://openalex.org/I146620803"]},{"id":"https://openalex.org/I4210123185","display_name":"Zhejiang Lab","ror":"https://ror.org/02m2h7991","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210123185"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huan Hu","raw_affiliation_strings":["Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), and Wenzhou Institute and Wenzhou Key Laboratory of Biophysics, , Zhejiang 325001 , China","Xiamen University Department of Physics, and Fujian Provincial Key Laboratory for Soft Functional Materials Research, , Xiamen 361005 , China","Xiamen University National Institute for Data Science in Health and Medicine, and State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, , Xiamen 36100 5 China"],"affiliations":[{"raw_affiliation_string":"Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), and Wenzhou Institute and Wenzhou Key Laboratory of Biophysics, , Zhejiang 325001 , China","institution_ids":["https://openalex.org/I146620803","https://openalex.org/I4210165038","https://openalex.org/I4210123185"]},{"raw_affiliation_string":"Xiamen University Department of Physics, and Fujian Provincial Key Laboratory for Soft Functional Materials Research, , Xiamen 361005 , China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"Xiamen University National Institute for Data Science in Health and Medicine, and State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, , Xiamen 36100 5 China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050066561","display_name":"Zhen Feng","orcid":"https://orcid.org/0000-0003-1281-4522"},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I2801769982","display_name":"First Affiliated Hospital of Wenzhou Medical University","ror":"https://ror.org/03cyvdv85","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2801769982"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen Feng","raw_affiliation_strings":["Wenzhou Medical University First Affiliated Hospital of Wenzhou Medical University, , Wenzhou 325000 , China"],"affiliations":[{"raw_affiliation_string":"Wenzhou Medical University First Affiliated Hospital of Wenzhou Medical University, , Wenzhou 325000 , China","institution_ids":["https://openalex.org/I27781120","https://openalex.org/I2801769982"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024211884","display_name":"Hai Lin","orcid":"https://orcid.org/0000-0002-5435-9583"},"institutions":[{"id":"https://openalex.org/I4210123185","display_name":"Zhejiang Lab","ror":"https://ror.org/02m2h7991","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210123185"]},{"id":"https://openalex.org/I146620803","display_name":"Wenzhou University","ror":"https://ror.org/020hxh324","country_code":"CN","type":"education","lineage":["https://openalex.org/I146620803"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hai Lin","raw_affiliation_strings":["Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), and Wenzhou Institute and Wenzhou Key Laboratory of Biophysics, , Zhejiang 325001 , China"],"affiliations":[{"raw_affiliation_string":"Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), and Wenzhou Institute and Wenzhou Key Laboratory of Biophysics, , Zhejiang 325001 , China","institution_ids":["https://openalex.org/I146620803","https://openalex.org/I4210165038","https://openalex.org/I4210123185"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100745531","display_name":"Junjie Zhao","orcid":"https://orcid.org/0000-0002-0105-0531"},"institutions":[{"id":"https://openalex.org/I37987034","display_name":"Guangzhou University","ror":"https://ror.org/05ar8rn06","country_code":"CN","type":"education","lineage":["https://openalex.org/I37987034"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junjie Zhao","raw_affiliation_strings":["Guangzhou University Cyberspace Institute of Advanced Technology, , Guangzhou 510000 , China"],"affiliations":[{"raw_affiliation_string":"Guangzhou University Cyberspace Institute of Advanced Technology, , Guangzhou 510000 , China","institution_ids":["https://openalex.org/I37987034"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100610339","display_name":"Yaru Zhang","orcid":"https://orcid.org/0000-0002-6167-7248"},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210086973","display_name":"Affiliated Eye Hospital of Wenzhou Medical College","ror":"https://ror.org/000sxmx78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086973"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yaru Zhang","raw_affiliation_strings":["Wenzhou Medical University Institute of Biomedical Big Data, School of Ophthalmology & Optometry and Eye Hospital, School of Biomedical Engineering, , Wenzhou 325027 , China"],"affiliations":[{"raw_affiliation_string":"Wenzhou Medical University Institute of Biomedical Big Data, School of Ophthalmology & Optometry and Eye Hospital, School of Biomedical Engineering, , Wenzhou 325027 , China","institution_ids":["https://openalex.org/I4210086973","https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051866955","display_name":"Fei Xu","orcid":"https://orcid.org/0000-0001-7469-2933"},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Xu","raw_affiliation_strings":["Xiamen University Department of Physics, and Fujian Provincial Key Laboratory for Soft Functional Materials Research, , Xiamen 361005 , China"],"affiliations":[{"raw_affiliation_string":"Xiamen University Department of Physics, and Fujian Provincial Key Laboratory for Soft Functional Materials Research, , Xiamen 361005 , China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100745210","display_name":"Lingling Chen","orcid":"https://orcid.org/0000-0002-9040-6797"},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lingling Chen","raw_affiliation_strings":["Xiamen University Department of Physics, and Fujian Provincial Key Laboratory for Soft Functional Materials Research, , Xiamen 361005 , China"],"affiliations":[{"raw_affiliation_string":"Xiamen University Department of Physics, and Fujian Provincial Key Laboratory for Soft Functional Materials Research, , Xiamen 361005 , China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100352673","display_name":"Feng Chen","orcid":"https://orcid.org/0000-0001-7849-2023"},"institutions":[{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Feng Chen","raw_affiliation_strings":["Xiamen University Department of Physics, and Fujian Provincial Key Laboratory for Soft Functional Materials Research, , Xiamen 361005 , China"],"affiliations":[{"raw_affiliation_string":"Xiamen University Department of Physics, and Fujian Provincial Key Laboratory for Soft Functional Materials Research, , Xiamen 361005 , China","institution_ids":["https://openalex.org/I191208505"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072028287","display_name":"Yunlong Ma","orcid":"https://orcid.org/0000-0002-1299-4802"},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210086973","display_name":"Affiliated Eye Hospital of Wenzhou Medical College","ror":"https://ror.org/000sxmx78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086973"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunlong Ma","raw_affiliation_strings":["Wenzhou Medical University Institute of Biomedical Big Data, School of Ophthalmology & Optometry and Eye Hospital, School of Biomedical Engineering, , Wenzhou 325027 , China"],"affiliations":[{"raw_affiliation_string":"Wenzhou Medical University Institute of Biomedical Big Data, School of Ophthalmology & Optometry and Eye Hospital, School of Biomedical Engineering, , Wenzhou 325027 , China","institution_ids":["https://openalex.org/I4210086973","https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083159278","display_name":"Jianzhong Su","orcid":"https://orcid.org/0000-0002-1172-7411"},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210086973","display_name":"Affiliated Eye Hospital of Wenzhou Medical College","ror":"https://ror.org/000sxmx78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086973"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianzhong Su","raw_affiliation_strings":["Wenzhou Medical University Institute of Biomedical Big Data, School of Ophthalmology & Optometry and Eye Hospital, School of Biomedical Engineering, , Wenzhou 325027 , China"],"affiliations":[{"raw_affiliation_string":"Wenzhou Medical University Institute of Biomedical Big Data, School of Ophthalmology & Optometry and Eye Hospital, School of Biomedical Engineering, , Wenzhou 325027 , China","institution_ids":["https://openalex.org/I4210086973","https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052565646","display_name":"Qi Zhao","orcid":"https://orcid.org/0000-0001-9713-1864"},"institutions":[{"id":"https://openalex.org/I114117164","display_name":"University of Science and Technology Liaoning","ror":"https://ror.org/03grx7119","country_code":"CN","type":"education","lineage":["https://openalex.org/I114117164"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qi Zhao","raw_affiliation_strings":["University of Science and Technology Liaoning School of Computer Science and Software Engineering, , Anshan 114051 , China"],"affiliations":[{"raw_affiliation_string":"University of Science and Technology Liaoning School of Computer Science and Software Engineering, , Anshan 114051 , China","institution_ids":["https://openalex.org/I114117164"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5069370586","display_name":"Jianwei Shuai","orcid":"https://orcid.org/0000-0002-8712-0544"},"institutions":[{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]},{"id":"https://openalex.org/I146620803","display_name":"Wenzhou University","ror":"https://ror.org/020hxh324","country_code":"CN","type":"education","lineage":["https://openalex.org/I146620803"]},{"id":"https://openalex.org/I4210123185","display_name":"Zhejiang Lab","ror":"https://ror.org/02m2h7991","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210123185"]},{"id":"https://openalex.org/I191208505","display_name":"Xiamen University","ror":"https://ror.org/00mcjh785","country_code":"CN","type":"education","lineage":["https://openalex.org/I191208505"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jianwei Shuai","raw_affiliation_strings":["Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), and Wenzhou Institute and Wenzhou Key Laboratory of Biophysics, , Zhejiang 325001 , China","Xiamen University Department of Physics, and Fujian Provincial Key Laboratory for Soft Functional Materials Research, , Xiamen 361005 , China","Xiamen University National Institute for Data Science in Health and Medicine, and State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, , Xiamen 36100 5 China"],"affiliations":[{"raw_affiliation_string":"Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou Oujiang Laboratory (Zhejiang Lab for Regenerative Medicine, Vision and Brain Health), and Wenzhou Institute and Wenzhou Key Laboratory of Biophysics, , Zhejiang 325001 , China","institution_ids":["https://openalex.org/I146620803","https://openalex.org/I4210165038","https://openalex.org/I4210123185"]},{"raw_affiliation_string":"Xiamen University Department of Physics, and Fujian Provincial Key Laboratory for Soft Functional Materials Research, , Xiamen 361005 , China","institution_ids":["https://openalex.org/I191208505"]},{"raw_affiliation_string":"Xiamen University National Institute for Data Science in Health and Medicine, and State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, , Xiamen 36100 5 China","institution_ids":["https://openalex.org/I191208505"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5052565646","https://openalex.org/A5069370586"],"corresponding_institution_ids":["https://openalex.org/I114117164","https://openalex.org/I146620803","https://openalex.org/I191208505","https://openalex.org/I4210123185","https://openalex.org/I4210165038"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":10.4643,"has_fulltext":false,"cited_by_count":60,"citation_normalized_percentile":{"value":0.9879505,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"24","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9894000291824341,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9848999977111816,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7362828254699707},{"id":"https://openalex.org/keywords/parametric-statistics","display_name":"Parametric statistics","score":0.5551900863647461},{"id":"https://openalex.org/keywords/python","display_name":"Python (programming language)","score":0.5416442155838013},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.5346120595932007},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4328348636627197},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3737329840660095},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3235619068145752},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15352550148963928}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7362828254699707},{"id":"https://openalex.org/C117251300","wikidata":"https://www.wikidata.org/wiki/Q1849855","display_name":"Parametric statistics","level":2,"score":0.5551900863647461},{"id":"https://openalex.org/C519991488","wikidata":"https://www.wikidata.org/wiki/Q28865","display_name":"Python (programming language)","level":2,"score":0.5416442155838013},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.5346120595932007},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4328348636627197},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3737329840660095},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3235619068145752},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15352550148963928},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007963","descriptor_name":"Leukocytes, Mononuclear","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbad005","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbad005","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:36642414","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36642414","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4468160391","display_name":null,"funder_award_id":"11874310","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5586548623","display_name":null,"funder_award_id":"2021ZD0201900","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5744063626","display_name":null,"funder_award_id":"12090052","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W980174965","https://openalex.org/W1509777618","https://openalex.org/W1959608418","https://openalex.org/W1974180347","https://openalex.org/W1987971958","https://openalex.org/W2006255103","https://openalex.org/W2051224630","https://openalex.org/W2085487226","https://openalex.org/W2111836805","https://openalex.org/W2148788634","https://openalex.org/W2152692691","https://openalex.org/W2739492614","https://openalex.org/W2752426001","https://openalex.org/W2939422961","https://openalex.org/W2949177718","https://openalex.org/W2951381561","https://openalex.org/W2955045694","https://openalex.org/W2990549530","https://openalex.org/W3003223443","https://openalex.org/W3009609875","https://openalex.org/W3011812996","https://openalex.org/W3021145032","https://openalex.org/W3027051073","https://openalex.org/W3047141442","https://openalex.org/W3048598023","https://openalex.org/W3090209951","https://openalex.org/W3108728530","https://openalex.org/W3118450989","https://openalex.org/W3126377892","https://openalex.org/W3129866267","https://openalex.org/W3158727313","https://openalex.org/W3159865332","https://openalex.org/W3164692211","https://openalex.org/W3164839005","https://openalex.org/W3165868790","https://openalex.org/W3185274815","https://openalex.org/W3189657756","https://openalex.org/W3194959274","https://openalex.org/W3197149574","https://openalex.org/W4200144569","https://openalex.org/W4200250969","https://openalex.org/W4200321144","https://openalex.org/W4210607196","https://openalex.org/W4213169638","https://openalex.org/W4214581892","https://openalex.org/W4220661922","https://openalex.org/W4220668517","https://openalex.org/W4220682422","https://openalex.org/W4221079080","https://openalex.org/W4223992851","https://openalex.org/W4224219253","https://openalex.org/W4225278475","https://openalex.org/W4225548364","https://openalex.org/W4254181784","https://openalex.org/W4280515355","https://openalex.org/W4280546004","https://openalex.org/W4280629587","https://openalex.org/W4281628971","https://openalex.org/W4281695630","https://openalex.org/W4283592141","https://openalex.org/W4285076853","https://openalex.org/W4286009485","https://openalex.org/W6640963894","https://openalex.org/W6804515744","https://openalex.org/W6838409118","https://openalex.org/W6838589096","https://openalex.org/W6839938531"],"related_works":["https://openalex.org/W2341492732","https://openalex.org/W3187193180","https://openalex.org/W106542691","https://openalex.org/W1699080303","https://openalex.org/W4297799326","https://openalex.org/W3116064965","https://openalex.org/W4287027380","https://openalex.org/W3193760048","https://openalex.org/W4285822516","https://openalex.org/W2505261959"],"abstract_inverted_index":{"The":[0,164],"proliferation":[1],"of":[2,58,74,116,139,171],"single-cell":[3,33,44,151],"multimodal":[4,34,45,49,67,152],"sequencing":[5],"technologies":[6],"has":[7,93],"enabled":[8],"us":[9],"to":[10],"understand":[11],"cellular":[12],"heterogeneity":[13,73],"with":[14,83],"multiple":[15,88],"views,":[16],"providing":[17],"novel":[18],"and":[19,100,134,168],"actionable":[20],"biological":[21,159],"insights":[22,160],"into":[23,47,161],"the":[24,66,72,84,114,136],"disease-driving":[25],"mechanisms.":[26],"Here,":[27],"we":[28,126],"propose":[29,128],"a":[30,48,108,129,149],"comprehensive":[31],"end-to-end":[32],"analysis":[35,153],"framework":[36,154],"named":[37],"Deep":[38],"Parametric":[39],"Inference":[40],"(DPI).":[41],"DPI":[42,92,97,110,147,172],"transforms":[43],"data":[46],"parameter":[50,68],"space":[51,69],"by":[52],"inferring":[53],"individual":[54,79],"modal":[55],"parameters.":[56],"Analysis":[57],"cord":[59],"blood":[60,121],"mononuclear":[61,122],"cells":[62,75,123,142],"(CBMC)":[63],"reveals":[64],"that":[65,91,155],"can":[70,98,111,156],"characterize":[71],"more":[76],"comprehensively":[77],"than":[78],"modalities.":[80],"Furthermore,":[81],"comparisons":[82],"state-of-the-art":[85],"methods":[86],"on":[87],"datasets":[89,167],"show":[90],"superior":[94],"performance.":[95],"Additionally,":[96],"reference":[99],"query":[101],"cell":[102,130],"types":[103],"without":[104],"batch":[105],"effects.":[106],"As":[107],"result,":[109],"successfully":[112],"analyze":[113,135],"progression":[115],"COVID-19":[117],"disease":[118],"in":[119],"peripheral":[120],"(PBMC).":[124],"Notably,":[125],"further":[127],"state":[131],"vector":[132],"field":[133],"transformation":[137],"pattern":[138],"bone":[140],"marrow":[141],"(BMC)":[143],"states.":[144],"In":[145],"conclusion,":[146],"is":[148],"powerful":[150],"provide":[157],"new":[158],"biomedical":[162],"researchers.":[163],"python":[165],"packages,":[166],"user-friendly":[169],"manuals":[170],"are":[173],"freely":[174],"available":[175],"at":[176],"https://github.com/studentiz/dpi.":[177]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":38},{"year":2023,"cited_by_count":13}],"updated_date":"2026-03-06T13:50:29.536080","created_date":"2025-10-10T00:00:00"}
