{"id":"https://openalex.org/W4312094131","doi":"https://doi.org/10.1093/bib/bbac533","title":"SAM-DTA: a sequence-agnostic model for drug\u2013target binding affinity prediction","display_name":"SAM-DTA: a sequence-agnostic model for drug\u2013target binding affinity prediction","publication_year":2022,"publication_date":"2022-12-21","ids":{"openalex":"https://openalex.org/W4312094131","doi":"https://doi.org/10.1093/bib/bbac533","pmid":"https://pubmed.ncbi.nlm.nih.gov/36545795"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbac533","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbac533","pdf_url":"https://academic.oup.com/bib/article-pdf/24/1/bbac533/48783303/bbac533.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/24/1/bbac533/48783303/bbac533.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101417955","display_name":"Zhiqiang Hu","orcid":"https://orcid.org/0000-0003-0830-815X"},"institutions":[{"id":"https://openalex.org/I4210128910","display_name":"Group Sense (China)","ror":"https://ror.org/036wd5777","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210128910"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhiqiang Hu","raw_affiliation_strings":["SenseTime Research , Shanghai, 201103, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SenseTime Research , Shanghai, 201103, China","institution_ids":["https://openalex.org/I4210128910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100692277","display_name":"Wenfeng Liu","orcid":"https://orcid.org/0009-0004-7221-2990"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenfeng Liu","raw_affiliation_strings":["Department of Computer Science and Engineering , East China University of Science and Technology, Shanghai 200237, China","Shanghai Matwings Technology Co. , Ltd., Shanghai, 200240, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering , East China University of Science and Technology, Shanghai 200237, China","institution_ids":["https://openalex.org/I143593769"]},{"raw_affiliation_string":"Shanghai Matwings Technology Co. , Ltd., Shanghai, 200240, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101521207","display_name":"Chenbin Zhang","orcid":"https://orcid.org/0009-0005-9431-9681"},"institutions":[{"id":"https://openalex.org/I4210128910","display_name":"Group Sense (China)","ror":"https://ror.org/036wd5777","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210128910"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chenbin Zhang","raw_affiliation_strings":["SenseTime Research , Shanghai, 201103, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SenseTime Research , Shanghai, 201103, China","institution_ids":["https://openalex.org/I4210128910"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004290401","display_name":"Jiawen Huang","orcid":"https://orcid.org/0000-0002-9051-5678"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiawen Huang","raw_affiliation_strings":["Department of Computer Science and Engineering , East China University of Science and Technology, Shanghai 200237, China","Shanghai Matwings Technology Co. , Ltd., Shanghai, 200240, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering , East China University of Science and Technology, Shanghai 200237, China","institution_ids":["https://openalex.org/I143593769"]},{"raw_affiliation_string":"Shanghai Matwings Technology Co. , Ltd., Shanghai, 200240, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066553616","display_name":"Shaoting Zhang","orcid":"https://orcid.org/0000-0002-8719-448X"},"institutions":[{"id":"https://openalex.org/I4210100255","display_name":"Beijing Academy of Artificial Intelligence","ror":"https://ror.org/016a74861","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210100255"]},{"id":"https://openalex.org/I4210128910","display_name":"Group Sense (China)","ror":"https://ror.org/036wd5777","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210128910"]},{"id":"https://openalex.org/I4391012619","display_name":"Shanghai Artificial Intelligence Laboratory","ror":"https://ror.org/03wkvpx79","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391012619"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shaoting Zhang","raw_affiliation_strings":["SenseTime Research , Shanghai, 201103, China","Shanghai Artificial Intelligence Laboratory , Shanghai 200232, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SenseTime Research , Shanghai, 201103, China","institution_ids":["https://openalex.org/I4210128910"]},{"raw_affiliation_string":"Shanghai Artificial Intelligence Laboratory , Shanghai 200232, China","institution_ids":["https://openalex.org/I4210100255","https://openalex.org/I4391012619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058941949","display_name":"Huiqun Yu","orcid":"https://orcid.org/0000-0002-1899-1135"},"institutions":[{"id":"https://openalex.org/I143593769","display_name":"East China University of Science and Technology","ror":"https://ror.org/01vyrm377","country_code":"CN","type":"education","lineage":["https://openalex.org/I143593769"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huiqun Yu","raw_affiliation_strings":["Department of Computer Science and Engineering , East China University of Science and Technology, Shanghai 200237, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering , East China University of Science and Technology, Shanghai 200237, China","institution_ids":["https://openalex.org/I143593769"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014672057","display_name":"Yi Xiong","orcid":"https://orcid.org/0000-0003-2910-6725"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Xiong","raw_affiliation_strings":["School of Life Sciences and Biotechnology , Shanghai Jiao Tong University, Shanghai 200240, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Life Sciences and Biotechnology , Shanghai Jiao Tong University, Shanghai 200240, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100458874","display_name":"Hao Liu","orcid":"https://orcid.org/0000-0003-0994-6284"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Liu","raw_affiliation_strings":["Institute of Natural Sciences , Shanghai Jiao Tong University, Shanghai 200240, China","Shanghai Matwings Technology Co. , Ltd., Shanghai, 200240, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Natural Sciences , Shanghai Jiao Tong University, Shanghai 200240, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Shanghai Matwings Technology Co. , Ltd., Shanghai, 200240, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100615915","display_name":"Ke Song","orcid":"https://orcid.org/0000-0002-7866-2499"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Song Ke","raw_affiliation_strings":["Shanghai Matwings Technology Co. , Ltd., Shanghai, 200240, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Matwings Technology Co. , Ltd., Shanghai, 200240, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000680377","display_name":"Liang Hong","orcid":"https://orcid.org/0000-0003-0107-336X"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210100255","display_name":"Beijing Academy of Artificial Intelligence","ror":"https://ror.org/016a74861","country_code":"CN","type":"other","lineage":["https://openalex.org/I4210100255"]},{"id":"https://openalex.org/I4391012619","display_name":"Shanghai Artificial Intelligence Laboratory","ror":"https://ror.org/03wkvpx79","country_code":null,"type":"facility","lineage":["https://openalex.org/I4391012619"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liang Hong","raw_affiliation_strings":["Institute of Natural Sciences , Shanghai Jiao Tong University, Shanghai 200240, China","School of Life Sciences and Biotechnology , Shanghai Jiao Tong University, Shanghai 200240, China","School of Pharmacy , Shanghai Jiao Tong University, Shanghai 200240, China","School of Physics and Astronomy , Shanghai Jiao Tong University, Shanghai 200240, China","Shanghai Artificial Intelligence Laboratory , Shanghai 200232, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Natural Sciences , Shanghai Jiao Tong University, Shanghai 200240, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"School of Life Sciences and Biotechnology , Shanghai Jiao Tong University, Shanghai 200240, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"School of Pharmacy , Shanghai Jiao Tong University, Shanghai 200240, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"School of Physics and Astronomy , Shanghai Jiao Tong University, Shanghai 200240, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"Shanghai Artificial Intelligence Laboratory , Shanghai 200232, China","institution_ids":["https://openalex.org/I4210100255","https://openalex.org/I4391012619"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5100615915","https://openalex.org/A5101417955"],"corresponding_institution_ids":["https://openalex.org/I4210128910"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":1.8266,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.87400511,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":98},"biblio":{"volume":"24","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.9930999875068665,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7138350009918213},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.6875423192977905},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.5966447591781616},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.547946035861969},{"id":"https://openalex.org/keywords/drug-target","display_name":"Drug target","score":0.5289499759674072},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.5228248834609985},{"id":"https://openalex.org/keywords/training-set","display_name":"Training set","score":0.4960523545742035},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.48347288370132446},{"id":"https://openalex.org/keywords/task","display_name":"Task (project management)","score":0.45872777700424194},{"id":"https://openalex.org/keywords/protein-sequencing","display_name":"Protein sequencing","score":0.4486163854598999},{"id":"https://openalex.org/keywords/mean-squared-error","display_name":"Mean squared error","score":0.42515650391578674},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3785138428211212},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.34426623582839966},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3334464430809021},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.1971845030784607},{"id":"https://openalex.org/keywords/peptide-sequence","display_name":"Peptide sequence","score":0.18629536032676697},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.16244128346443176},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.15396136045455933},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.11662206053733826},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.08057281374931335}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7138350009918213},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.6875423192977905},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.5966447591781616},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.547946035861969},{"id":"https://openalex.org/C2989108626","wikidata":"https://www.wikidata.org/wiki/Q904407","display_name":"Drug target","level":2,"score":0.5289499759674072},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.5228248834609985},{"id":"https://openalex.org/C51632099","wikidata":"https://www.wikidata.org/wiki/Q3985153","display_name":"Training set","level":2,"score":0.4960523545742035},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.48347288370132446},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.45872777700424194},{"id":"https://openalex.org/C10010492","wikidata":"https://www.wikidata.org/wiki/Q3142557","display_name":"Protein sequencing","level":4,"score":0.4486163854598999},{"id":"https://openalex.org/C139945424","wikidata":"https://www.wikidata.org/wiki/Q1940696","display_name":"Mean squared error","level":2,"score":0.42515650391578674},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3785138428211212},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.34426623582839966},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3334464430809021},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.1971845030784607},{"id":"https://openalex.org/C167625842","wikidata":"https://www.wikidata.org/wiki/Q899763","display_name":"Peptide sequence","level":3,"score":0.18629536032676697},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.16244128346443176},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.15396136045455933},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11662206053733826},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.08057281374931335},{"id":"https://openalex.org/C187736073","wikidata":"https://www.wikidata.org/wiki/Q2920921","display_name":"Management","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbac533","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbac533","pdf_url":"https://academic.oup.com/bib/article-pdf/24/1/bbac533/48783303/bbac533.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:36545795","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36545795","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":{"id":"doi:10.1093/bib/bbac533","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbac533","pdf_url":"https://academic.oup.com/bib/article-pdf/24/1/bbac533/48783303/bbac533.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1862577985","display_name":null,"funder_award_id":"21873101","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2191216477","display_name":null,"funder_award_id":"32030063","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2914917180","display_name":null,"funder_award_id":"2019-01-07-00-02-E00076","funder_id":"https://openalex.org/F4320321881","funder_display_name":"Shanghai Municipal Education Commission"},{"id":"https://openalex.org/G6364041800","display_name":null,"funder_award_id":"11504231","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6935379057","display_name":null,"funder_award_id":"31630002","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G865850907","display_name":null,"funder_award_id":"2019-01","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321881","display_name":"Shanghai Municipal Education Commission","ror":"https://ror.org/05tewj457"},{"id":"https://openalex.org/F4320322999","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4312094131.pdf","grobid_xml":"https://content.openalex.org/works/W4312094131.grobid-xml"},"referenced_works_count":66,"referenced_works":["https://openalex.org/W1466286227","https://openalex.org/W1970577443","https://openalex.org/W2012438480","https://openalex.org/W2018796817","https://openalex.org/W2019974881","https://openalex.org/W2021348977","https://openalex.org/W2044002635","https://openalex.org/W2064675550","https://openalex.org/W2093221728","https://openalex.org/W2096541451","https://openalex.org/W2096864392","https://openalex.org/W2109991441","https://openalex.org/W2117620409","https://openalex.org/W2135957668","https://openalex.org/W2138512826","https://openalex.org/W2157331557","https://openalex.org/W2177317049","https://openalex.org/W2189911347","https://openalex.org/W2214665483","https://openalex.org/W2336040088","https://openalex.org/W2399976582","https://openalex.org/W2594183968","https://openalex.org/W2605952223","https://openalex.org/W2615136515","https://openalex.org/W2741292700","https://openalex.org/W2744129621","https://openalex.org/W2781821160","https://openalex.org/W2784213390","https://openalex.org/W2785947426","https://openalex.org/W2809216727","https://openalex.org/W2896457183","https://openalex.org/W2898364362","https://openalex.org/W2949504121","https://openalex.org/W2955251621","https://openalex.org/W2963716836","https://openalex.org/W2964113829","https://openalex.org/W3093397714","https://openalex.org/W3096561213","https://openalex.org/W3150635270","https://openalex.org/W3151148247","https://openalex.org/W3154258817","https://openalex.org/W3177828909","https://openalex.org/W3187980261","https://openalex.org/W4200139236","https://openalex.org/W4205167309","https://openalex.org/W4236965008","https://openalex.org/W4253191544","https://openalex.org/W4280521575","https://openalex.org/W4288358813","https://openalex.org/W4288419263","https://openalex.org/W4294558607","https://openalex.org/W4295312788","https://openalex.org/W4295547865","https://openalex.org/W6653123006","https://openalex.org/W6685265622","https://openalex.org/W6685350579","https://openalex.org/W6687483927","https://openalex.org/W6688357764","https://openalex.org/W6735840763","https://openalex.org/W6736091738","https://openalex.org/W6738964360","https://openalex.org/W6755207826","https://openalex.org/W6760045743","https://openalex.org/W6763912176","https://openalex.org/W6766978945","https://openalex.org/W6838191272"],"related_works":["https://openalex.org/W2553548503","https://openalex.org/W3045995536","https://openalex.org/W1967404732","https://openalex.org/W2226749982","https://openalex.org/W1989543759","https://openalex.org/W4310831746","https://openalex.org/W4308253407","https://openalex.org/W4353017618","https://openalex.org/W3206915023","https://openalex.org/W4379010217"],"abstract_inverted_index":{"Drug-target":[0],"binding":[1],"affinity":[2],"prediction":[3],"is":[4,50,66,101],"a":[5,48,64,86,93],"fundamental":[6],"task":[7],"for":[8,15,157],"drug":[9],"discovery":[10],"and":[11,31,36,95,127,153,183],"has":[12],"been":[13],"studied":[14],"decades.":[16],"Most":[17],"methods":[18],"follow":[19],"the":[20,25,28,32,70,109,118,128,140,150,154,163,166],"canonical":[21],"paradigm":[22,111],"that":[23,47,72,100,108],"processes":[24],"inputs":[26],"of":[27,98,123,130,165],"protein":[29,65],"(target)":[30],"ligand":[33],"(drug)":[34],"separately":[35],"then":[37],"combines":[38],"them":[39],"together.":[40],"In":[41],"this":[42],"study":[43],"we":[44,76],"demonstrate,":[45],"surprisingly,":[46],"model":[49,168],"able":[51],"to":[52,59,91,171],"achieve":[53],"even":[54],"superior":[55],"performance":[56],"without":[57],"access":[58],"any":[60],"protein-sequence-related":[61],"information.":[62],"Instead,":[63],"characterized":[67],"completely":[68],"by":[69],"ligands":[71,99],"it":[73],"interacts.":[74],"Specifically,":[75],"treat":[77],"different":[78],"proteins":[79,146,173],"separately,":[80],"which":[81],"are":[82,147,185],"jointly":[83],"trained":[84],"in":[85,169,177],"multi-head":[87],"manner,":[88],"so":[89],"as":[90,174,176],"learn":[92],"robust":[94],"universal":[96],"representation":[97],"generalizable":[102],"across":[103],"proteins.":[104],"Empirical":[105],"evidences":[106],"show":[107],"novel":[110],"outperforms":[112],"its":[113],"competitive":[114],"sequence-based":[115],"counterpart,":[116],"with":[117,135],"Mean":[119],"Squared":[120],"Error":[121],"(MSE)":[122],"0.4261":[124],"versus":[125,132],"0.7612":[126],"R-Square":[129],"0.7984":[131],"0.6570":[133],"compared":[134],"DeepAffinity.":[136],"We":[137],"also":[138],"investigate":[139],"transfer":[141],"learning":[142],"scenario":[143],"where":[144],"unseen":[145,172],"encountered":[148],"after":[149],"initial":[151],"training,":[152],"cross-dataset":[155],"evaluation":[156],"prospective":[158],"studies.":[159],"The":[160],"results":[161],"reveals":[162],"robustness":[164],"proposed":[167],"generalizing":[170],"well":[175],"predicting":[178],"future":[179],"data.":[180],"Source":[181],"codes":[182],"data":[184],"available":[186],"at":[187],"https://github.com/huzqatpku/SAM-DTA.":[188]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":3}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
