{"id":"https://openalex.org/W4293802793","doi":"https://doi.org/10.1093/bib/bbac349","title":"IgIDivA: immunoglobulin intraclonal diversification analysis","display_name":"IgIDivA: immunoglobulin intraclonal diversification analysis","publication_year":2022,"publication_date":"2022-08-30","ids":{"openalex":"https://openalex.org/W4293802793","doi":"https://doi.org/10.1093/bib/bbac349","pmid":"https://pubmed.ncbi.nlm.nih.gov/36044248"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbac349","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbac349","pdf_url":"https://academic.oup.com/bib/article-pdf/23/5/bbac349/45939590/bbac349.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bib/article-pdf/23/5/bbac349/45939590/bbac349.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060785850","display_name":"Laura Zaragoza\u2010Infante","orcid":"https://orcid.org/0000-0003-0207-257X"},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I2800980381","display_name":"AHEPA University Hospital","ror":"https://ror.org/01q1jaw52","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2800980381"]},{"id":"https://openalex.org/I4210134249","display_name":"Centre for Research and Technology Hellas","ror":"https://ror.org/03bndpq63","country_code":"GR","type":"facility","lineage":["https://openalex.org/I4210134249"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Laura Zaragoza-Infante","raw_affiliation_strings":["Hematology Unit, 1st Dept of Internal Medicine, Aristotle University of Thessaloniki , AHEPA Hospital, Thessaloniki","Institute of Applied Biosciences, Centre for Research and Technology Hellas , Thessaloniki, Greece"],"raw_orcid":"https://orcid.org/0000-0003-0207-257X","affiliations":[{"raw_affiliation_string":"Hematology Unit, 1st Dept of Internal Medicine, Aristotle University of Thessaloniki , AHEPA Hospital, Thessaloniki","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I2800980381"]},{"raw_affiliation_string":"Institute of Applied Biosciences, Centre for Research and Technology Hellas , Thessaloniki, Greece","institution_ids":["https://openalex.org/I4210134249"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078219412","display_name":"Valentin Junet","orcid":"https://orcid.org/0000-0002-6138-0612"},"institutions":[{"id":"https://openalex.org/I123044942","display_name":"Universitat Aut\u00f2noma de Barcelona","ror":"https://ror.org/052g8jq94","country_code":"ES","type":"education","lineage":["https://openalex.org/I123044942"]},{"id":"https://openalex.org/I4210164457","display_name":"Anaxomics (Spain)","ror":"https://ror.org/05jnac203","country_code":"ES","type":"company","lineage":["https://openalex.org/I4210164457"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Valentin Junet","raw_affiliation_strings":["Anaxomics Biotech SL , Barcelona, Spain","Institute of Biotechnology and Biomedicine, Universitat Aut\u00f2noma de Barcelona , Barcelona, Spain"],"raw_orcid":"https://orcid.org/0000-0002-6138-0612","affiliations":[{"raw_affiliation_string":"Anaxomics Biotech SL , Barcelona, Spain","institution_ids":["https://openalex.org/I4210164457"]},{"raw_affiliation_string":"Institute of Biotechnology and Biomedicine, Universitat Aut\u00f2noma de Barcelona , Barcelona, Spain","institution_ids":["https://openalex.org/I123044942"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062606774","display_name":"Nikos Pechlivanis","orcid":null},"institutions":[{"id":"https://openalex.org/I4210134249","display_name":"Centre for Research and Technology Hellas","ror":"https://ror.org/03bndpq63","country_code":"GR","type":"facility","lineage":["https://openalex.org/I4210134249"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Nikos Pechlivanis","raw_affiliation_strings":["Institute of Applied Biosciences, Centre for Research and Technology Hellas , Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Applied Biosciences, Centre for Research and Technology Hellas , Thessaloniki, Greece","institution_ids":["https://openalex.org/I4210134249"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087364126","display_name":"Styliani-Christina Fragkouli","orcid":null},"institutions":[{"id":"https://openalex.org/I4210134249","display_name":"Centre for Research and Technology Hellas","ror":"https://ror.org/03bndpq63","country_code":"GR","type":"facility","lineage":["https://openalex.org/I4210134249"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Styliani-Christina Fragkouli","raw_affiliation_strings":["Institute of Applied Biosciences, Centre for Research and Technology Hellas , Thessaloniki, Greece"],"raw_orcid":"https://orcid.org/0000-0003-4067-7123","affiliations":[{"raw_affiliation_string":"Institute of Applied Biosciences, Centre for Research and Technology Hellas , Thessaloniki, Greece","institution_ids":["https://openalex.org/I4210134249"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083743646","display_name":"Serovpe Amprachamian","orcid":null},"institutions":[{"id":"https://openalex.org/I4210134249","display_name":"Centre for Research and Technology Hellas","ror":"https://ror.org/03bndpq63","country_code":"GR","type":"facility","lineage":["https://openalex.org/I4210134249"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Serovpe Amprachamian","raw_affiliation_strings":["Institute of Applied Biosciences, Centre for Research and Technology Hellas , Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Applied Biosciences, Centre for Research and Technology Hellas , Thessaloniki, Greece","institution_ids":["https://openalex.org/I4210134249"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030925125","display_name":"Triantafyllia \u039aoletsa","orcid":"https://orcid.org/0000-0002-4435-3532"},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Triantafyllia Koletsa","raw_affiliation_strings":["Department of Pathology, School of Medicine, Aristotle University of Thessaloniki"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, School of Medicine, Aristotle University of Thessaloniki","institution_ids":["https://openalex.org/I21370196"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034892288","display_name":"Anastasia Chatzidimitriou","orcid":"https://orcid.org/0000-0002-8106-1846"},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I4210134249","display_name":"Centre for Research and Technology Hellas","ror":"https://ror.org/03bndpq63","country_code":"GR","type":"facility","lineage":["https://openalex.org/I4210134249"]}],"countries":["GR","SE"],"is_corresponding":false,"raw_author_name":"Anastasia Chatzidimitriou","raw_affiliation_strings":["Department of Molecular Medicine and Surgery, Karolinska Institute , Stockholm, Sweden","Institute of Applied Biosciences, Centre for Research and Technology Hellas , Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine and Surgery, Karolinska Institute , Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Institute of Applied Biosciences, Centre for Research and Technology Hellas , Thessaloniki, Greece","institution_ids":["https://openalex.org/I4210134249"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101853210","display_name":"Maria Papaioannou","orcid":"https://orcid.org/0000-0002-1999-9622"},"institutions":[{"id":"https://openalex.org/I21370196","display_name":"Aristotle University of Thessaloniki","ror":"https://ror.org/02j61yw88","country_code":"GR","type":"education","lineage":["https://openalex.org/I21370196"]},{"id":"https://openalex.org/I2800980381","display_name":"AHEPA University Hospital","ror":"https://ror.org/01q1jaw52","country_code":"GR","type":"healthcare","lineage":["https://openalex.org/I2800980381"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Maria Papaioannou","raw_affiliation_strings":["Hematology Unit, 1st Dept of Internal Medicine, Aristotle University of Thessaloniki , AHEPA Hospital, Thessaloniki"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hematology Unit, 1st Dept of Internal Medicine, Aristotle University of Thessaloniki , AHEPA Hospital, Thessaloniki","institution_ids":["https://openalex.org/I21370196","https://openalex.org/I2800980381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044130307","display_name":"\u039a\u03ce\u03c3\u03c4\u03b1\u03c2 \u03a3\u03c4\u03b1\u03bc\u03b1\u03c4\u03cc\u03c0\u03bf\u03c5\u03bb\u03bf\u03c2","orcid":"https://orcid.org/0000-0001-8529-640X"},"institutions":[{"id":"https://openalex.org/I28166907","display_name":"Karolinska Institutet","ror":"https://ror.org/056d84691","country_code":"SE","type":"education","lineage":["https://openalex.org/I28166907"]},{"id":"https://openalex.org/I4210134249","display_name":"Centre for Research and Technology Hellas","ror":"https://ror.org/03bndpq63","country_code":"GR","type":"facility","lineage":["https://openalex.org/I4210134249"]}],"countries":["GR","SE"],"is_corresponding":false,"raw_author_name":"Kostas Stamatopoulos","raw_affiliation_strings":["Department of Molecular Medicine and Surgery, Karolinska Institute , Stockholm, Sweden","Institute of Applied Biosciences, Centre for Research and Technology Hellas , Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Medicine and Surgery, Karolinska Institute , Stockholm, Sweden","institution_ids":["https://openalex.org/I28166907"]},{"raw_affiliation_string":"Institute of Applied Biosciences, Centre for Research and Technology Hellas , Thessaloniki, Greece","institution_ids":["https://openalex.org/I4210134249"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008694656","display_name":"Andreas Agathangelidis","orcid":"https://orcid.org/0000-0002-8467-7945"},"institutions":[{"id":"https://openalex.org/I200777214","display_name":"National and Kapodistrian University of Athens","ror":"https://ror.org/04gnjpq42","country_code":"GR","type":"education","lineage":["https://openalex.org/I200777214"]},{"id":"https://openalex.org/I4210134249","display_name":"Centre for Research and Technology Hellas","ror":"https://ror.org/03bndpq63","country_code":"GR","type":"facility","lineage":["https://openalex.org/I4210134249"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Andreas Agathangelidis","raw_affiliation_strings":["Faculty of Biology, National and Kapodistrian University of Athens , Athens, Greece","Institute of Applied Biosciences, Centre for Research and Technology Hellas , Thessaloniki, Greece"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Biology, National and Kapodistrian University of Athens , Athens, Greece","institution_ids":["https://openalex.org/I200777214"]},{"raw_affiliation_string":"Institute of Applied Biosciences, Centre for Research and Technology Hellas , Thessaloniki, Greece","institution_ids":["https://openalex.org/I4210134249"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078171708","display_name":"Fotis Psomopoulos","orcid":"https://orcid.org/0000-0002-0222-4273"},"institutions":[{"id":"https://openalex.org/I4210134249","display_name":"Centre for Research and Technology Hellas","ror":"https://ror.org/03bndpq63","country_code":"GR","type":"facility","lineage":["https://openalex.org/I4210134249"]}],"countries":["GR"],"is_corresponding":true,"raw_author_name":"Fotis Psomopoulos","raw_affiliation_strings":["Institute of Applied Biosciences, Centre for Research and Technology Hellas , Thessaloniki, Greece"],"raw_orcid":"https://orcid.org/0000-0002-0222-4273","affiliations":[{"raw_affiliation_string":"Institute of Applied Biosciences, Centre for Research and Technology Hellas , Thessaloniki, Greece","institution_ids":["https://openalex.org/I4210134249"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5078171708"],"corresponding_institution_ids":["https://openalex.org/I4210134249"],"apc_list":{"value":3885,"currency":"USD","value_usd":3885},"apc_paid":{"value":3885,"currency":"USD","value_usd":3885},"fwci":1.2295,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.799781,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"23","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11725","display_name":"Immunodeficiency and Autoimmune Disorders","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9939000010490417,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/somatic-hypermutation","display_name":"Somatic hypermutation","score":0.8161333799362183},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.760500431060791},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6241794228553772},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5029506087303162},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.44436484575271606},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4219960570335388},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.25322964787483215},{"id":"https://openalex.org/keywords/b-cell","display_name":"B cell","score":0.18600335717201233}],"concepts":[{"id":"https://openalex.org/C128526571","wikidata":"https://www.wikidata.org/wiki/Q619302","display_name":"Somatic hypermutation","level":4,"score":0.8161333799362183},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.760500431060791},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6241794228553772},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5029506087303162},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.44436484575271606},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4219960570335388},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.25322964787483215},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.18600335717201233},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005803","descriptor_name":"Genes, Immunoglobulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005803","descriptor_name":"Genes, Immunoglobulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005803","descriptor_name":"Genes, Immunoglobulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005803","descriptor_name":"Genes, Immunoglobulin","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007136","descriptor_name":"Immunoglobulins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bib/bbac349","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbac349","pdf_url":"https://academic.oup.com/bib/article-pdf/23/5/bbac349/45939590/bbac349.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:36044248","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36044248","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9487589","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9487589","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"},{"id":"pmh:oai:ddd.uab.cat:266413","is_oa":true,"landing_page_url":"https://ddd.uab.cat/record/266413","pdf_url":null,"source":{"id":"https://openalex.org/S4306400380","display_name":"Dip\u00f2sit Digital de Documents de la UAB (Universitat Aut\u00f2noma de Barcelona)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I123044942","host_organization_name":"Universitat Aut\u00f2noma de Barcelona","host_organization_lineage":["https://openalex.org/I123044942"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1093/bib/bbac349","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbac349","pdf_url":"https://academic.oup.com/bib/article-pdf/23/5/bbac349/45939590/bbac349.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Partnerships for the goals","id":"https://metadata.un.org/sdg/17","score":0.4099999964237213}],"awards":[{"id":"https://openalex.org/G6761937971","display_name":"COmbatting disorders of adaptive immunity with Systems MedICine","funder_award_id":"765158","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4293802793.pdf","grobid_xml":"https://content.openalex.org/works/W4293802793.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W185284815","https://openalex.org/W1568859377","https://openalex.org/W1599013943","https://openalex.org/W1650999727","https://openalex.org/W1852019155","https://openalex.org/W1975100378","https://openalex.org/W1997581121","https://openalex.org/W2009125186","https://openalex.org/W2010013828","https://openalex.org/W2013199443","https://openalex.org/W2027505310","https://openalex.org/W2031263707","https://openalex.org/W2041282815","https://openalex.org/W2052059548","https://openalex.org/W2054686030","https://openalex.org/W2067005655","https://openalex.org/W2068868786","https://openalex.org/W2070232733","https://openalex.org/W2076747220","https://openalex.org/W2092989766","https://openalex.org/W2098309323","https://openalex.org/W2111414304","https://openalex.org/W2112587694","https://openalex.org/W2113392525","https://openalex.org/W2114690058","https://openalex.org/W2129509656","https://openalex.org/W2138270253","https://openalex.org/W2148855679","https://openalex.org/W2154841949","https://openalex.org/W2166526425","https://openalex.org/W2170654913","https://openalex.org/W2194452929","https://openalex.org/W2274943243","https://openalex.org/W2546622097","https://openalex.org/W2750920587","https://openalex.org/W2998126222","https://openalex.org/W3003422837","https://openalex.org/W3041731967","https://openalex.org/W3084292795","https://openalex.org/W3089965518","https://openalex.org/W3090488793","https://openalex.org/W3092193830","https://openalex.org/W3110696950","https://openalex.org/W3165051101","https://openalex.org/W3208184855","https://openalex.org/W4251633039","https://openalex.org/W4252684946","https://openalex.org/W4392322140","https://openalex.org/W6660764124","https://openalex.org/W6662211799","https://openalex.org/W6678059284","https://openalex.org/W6756104473","https://openalex.org/W6772683690","https://openalex.org/W6784014067","https://openalex.org/W6795693698","https://openalex.org/W6802848915","https://openalex.org/W6862216574"],"related_works":["https://openalex.org/W2042602909","https://openalex.org/W2141204992","https://openalex.org/W2002128513","https://openalex.org/W2092874662","https://openalex.org/W2087238853","https://openalex.org/W2171277769","https://openalex.org/W2072653621","https://openalex.org/W1991523530","https://openalex.org/W2118425863","https://openalex.org/W2291114559"],"abstract_inverted_index":{"Intraclonal":[0],"diversification":[1,130],"(ID)":[2],"within":[3,159],"the":[4,29,38,47,53,71,77,88,107,115,119,127,138,145,160,164,172,189,200,221,228],"immunoglobulin":[5,128],"(IG)":[6],"genes":[7,40,167],"expressed":[8],"by":[9],"B":[10,58],"cell":[11,59],"clones":[12,60],"arises":[13],"due":[14],"to":[15,70,96],"ongoing":[16],"somatic":[17],"hypermutation":[18],"(SHM)":[19],"in":[20,37,43,61,76,103,170],"a":[21,111,134],"context":[22],"of":[23,33,35,46,57,73,79,93,99,118,144,163,192,202,209,218,223],"continuous":[24],"interactions":[25],"with":[26,196],"antigen(s).":[27],"Defining":[28],"nature":[30],"and":[31,55,63,91,141,154,168,184],"order":[32],"appearance":[34],"SHMs":[36,94,156],"IG":[39,80,166],"can":[41],"assist":[42],"improved":[44],"understanding":[45],"ID":[48,120,146,193,203,219],"process,":[49],"shedding":[50],"light":[51],"into":[52],"ontogeny":[54],"evolution":[56],"health":[62],"disease.":[64],"Such":[65],"endeavor":[66],"is":[67,243],"empowered":[68],"thanks":[69],"introduction":[72],"high-throughput":[74,149],"sequencing":[75,150],"study":[78],"gene":[81],"repertoires.":[82],"However,":[83],"few":[84],"existing":[85],"tools":[86],"allow":[87],"identification,":[89],"quantification":[90],"characterization":[92],"related":[95],"ID,":[97],"all":[98],"which":[100],"have":[101],"limitations":[102],"their":[104],"analysis,":[105],"highlighting":[106],"need":[108],"for":[109,114,137,188,199,206],"developing":[110],"purpose-built":[112,224],"tool":[113],"comprehensive":[116],"analysis":[117,131,143,198],"process.":[121],"In":[122],"this":[123],"work,":[124],"we":[125],"present":[126],"intraclonal":[129],"(IgIDivA)":[132],"tool,":[133],"novel":[135],"methodology":[136],"in-depth":[139],"qualitative":[140],"quantitative":[142],"process":[147],"from":[148],"data.":[151],"IgIDivA":[152,213,231,242],"identifies":[153],"characterizes":[155],"that":[157],"occur":[158],"variable":[161],"domain":[162],"rearranged":[165],"studies":[169],"detail":[171],"connections":[173],"between":[174],"identified":[175],"SHMs,":[176],"establishing":[177],"mutational":[178],"pathways.":[179],"Moreover,":[180],"it":[181],"combines":[182],"established":[183],"new":[185],"graph-based":[186],"metrics":[187],"objective":[190],"determination":[191],"level,":[194],"combined":[195],"statistical":[197],"comparison":[201],"level":[204],"features":[205],"different":[207],"groups":[208],"samples.":[210],"Of":[211],"importance,":[212],"also":[214,234],"provides":[215],"detailed":[216],"visualizations":[217],"through":[220],"generation":[222],"graph":[225],"networks.":[226],"Beyond":[227],"method":[229],"design,":[230],"has":[232],"been":[233],"implemented":[235],"as":[236],"an":[237],"R":[238],"Shiny":[239],"web":[240],"application.":[241],"freely":[244],"available":[245],"at":[246],"https://bio.tools/igidiva.":[247]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}