{"id":"https://openalex.org/W4293023608","doi":"https://doi.org/10.1093/bib/bbac324","title":"CellDrift: inferring perturbation responses in temporally sampled single-cell data","display_name":"CellDrift: inferring perturbation responses in temporally sampled single-cell data","publication_year":2022,"publication_date":"2022-08-23","ids":{"openalex":"https://openalex.org/W4293023608","doi":"https://doi.org/10.1093/bib/bbac324","pmid":"https://pubmed.ncbi.nlm.nih.gov/35998893"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbac324","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbac324","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1093/bib/bbac324","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061566377","display_name":"Kang Jin","orcid":"https://orcid.org/0000-0001-5638-040X"},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kang Jin","raw_affiliation_strings":["Department of Biomedical Informatics, University of Cincinnati , Cincinnati, OH 45229, USA","Division of Biomedical Informatics, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, OH 45229, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, University of Cincinnati , Cincinnati, OH 45229, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Division of Biomedical Informatics, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, OH 45229, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052996639","display_name":"Daniel Schnell","orcid":null},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Schnell","raw_affiliation_strings":["Division of Biomedical Informatics, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, OH 45229, USA"],"affiliations":[{"raw_affiliation_string":"Division of Biomedical Informatics, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, OH 45229, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101603719","display_name":"Guangyuan Li","orcid":"https://orcid.org/0000-0002-0628-2454"},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Guangyuan Li","raw_affiliation_strings":["Department of Biomedical Informatics, University of Cincinnati , Cincinnati, OH 45229, USA","Division of Biomedical Informatics, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, OH 45229, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, University of Cincinnati , Cincinnati, OH 45229, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Division of Biomedical Informatics, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, OH 45229, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058320928","display_name":"Nathan Salomonis","orcid":"https://orcid.org/0000-0001-9689-2469"},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nathan Salomonis","raw_affiliation_strings":["Department of Biomedical Informatics, University of Cincinnati , Cincinnati, OH 45229, USA","Department of Pediatrics, University of Cincinnati School of Medicine , Cincinnati, OH 45256, USA","Division of Biomedical Informatics, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, OH 45229, USA","Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, OH 45256, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, University of Cincinnati , Cincinnati, OH 45229, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Pediatrics, University of Cincinnati School of Medicine , Cincinnati, OH 45256, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Division of Biomedical Informatics, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, OH 45229, USA","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, OH 45256, USA","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017246903","display_name":"V. B. Surya Prasath","orcid":"https://orcid.org/0000-0001-7163-7453"},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"V B Surya Prasath","raw_affiliation_strings":["Department of Biomedical Informatics, University of Cincinnati , Cincinnati, OH 45229, USA","Department of Electrical Engineering and Computer Science, University of Cincinnati , OH 45256, USA","Division of Biomedical Informatics, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, OH 45229, USA","Department of Electrical Engineering and Computer Science, University of Cincinnati, OH 45256, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, University of Cincinnati , Cincinnati, OH 45229, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, University of Cincinnati , OH 45256, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Division of Biomedical Informatics, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, OH 45229, USA","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, University of Cincinnati, OH 45256, USA","institution_ids":["https://openalex.org/I63135867"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041421005","display_name":"Rhonda D. Szczesniak","orcid":"https://orcid.org/0000-0003-0705-715X"},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rhonda Szczesniak","raw_affiliation_strings":["Division of Biostatistics and Epidemiology, Cincinnati Children\u2019s Hospital Medical Center , OH 45229, USA"],"affiliations":[{"raw_affiliation_string":"Division of Biostatistics and Epidemiology, Cincinnati Children\u2019s Hospital Medical Center , OH 45229, USA","institution_ids":["https://openalex.org/I1285204247"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064856328","display_name":"Bruce J. Aronow","orcid":"https://orcid.org/0000-0001-5109-6514"},"institutions":[{"id":"https://openalex.org/I1285204247","display_name":"Cincinnati Children's Hospital Medical Center","ror":"https://ror.org/01hcyya48","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1285204247"]},{"id":"https://openalex.org/I63135867","display_name":"University of Cincinnati","ror":"https://ror.org/01e3m7079","country_code":"US","type":"education","lineage":["https://openalex.org/I63135867"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bruce J Aronow","raw_affiliation_strings":["Department of Biomedical Informatics, University of Cincinnati , Cincinnati, OH 45229, USA","Department of Electrical Engineering and Computer Science, University of Cincinnati , OH 45256, USA","Department of Pediatrics, University of Cincinnati School of Medicine , Cincinnati, OH 45256, USA","Division of Biomedical Informatics, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, OH 45229, USA","Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, OH 45256, USA","Department of Electrical Engineering and Computer Science, University of Cincinnati, OH 45256, USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Informatics, University of Cincinnati , Cincinnati, OH 45229, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, University of Cincinnati , OH 45256, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Pediatrics, University of Cincinnati School of Medicine , Cincinnati, OH 45256, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Division of Biomedical Informatics, Cincinnati Children\u2019s Hospital Medical Center , Cincinnati, OH 45229, USA","institution_ids":["https://openalex.org/I1285204247"]},{"raw_affiliation_string":"Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati, OH 45256, USA","institution_ids":["https://openalex.org/I63135867"]},{"raw_affiliation_string":"Department of Electrical Engineering and Computer Science, University of Cincinnati, OH 45256, USA","institution_ids":["https://openalex.org/I63135867"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5064856328"],"corresponding_institution_ids":["https://openalex.org/I1285204247","https://openalex.org/I63135867"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":0.8665,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.71292921,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"23","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9900000095367432,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9764999747276306,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/leverage","display_name":"Leverage (statistics)","score":0.7570598125457764},{"id":"https://openalex.org/keywords/perturbation","display_name":"Perturbation (astronomy)","score":0.6393600702285767},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5334603786468506},{"id":"https://openalex.org/keywords/missing-data","display_name":"Missing data","score":0.4369277358055115},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.42319613695144653},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3554706871509552},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.26818060874938965},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.2074076533317566},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.09634667634963989}],"concepts":[{"id":"https://openalex.org/C153083717","wikidata":"https://www.wikidata.org/wiki/Q6535263","display_name":"Leverage (statistics)","level":2,"score":0.7570598125457764},{"id":"https://openalex.org/C177918212","wikidata":"https://www.wikidata.org/wiki/Q803623","display_name":"Perturbation (astronomy)","level":2,"score":0.6393600702285767},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5334603786468506},{"id":"https://openalex.org/C9357733","wikidata":"https://www.wikidata.org/wiki/Q6878417","display_name":"Missing data","level":2,"score":0.4369277358055115},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42319613695144653},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3554706871509552},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.26818060874938965},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.2074076533317566},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09634667634963989},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbac324","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbac324","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:35998893","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35998893","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:9487655","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9487655","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbac324","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbac324","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2567639249","display_name":null,"funder_award_id":"HL148865","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W16794263","https://openalex.org/W1990881776","https://openalex.org/W2000526324","https://openalex.org/W2031534975","https://openalex.org/W2091083714","https://openalex.org/W2190545194","https://openalex.org/W2798816298","https://openalex.org/W2904478560","https://openalex.org/W2953064750","https://openalex.org/W2963123914","https://openalex.org/W2965552103","https://openalex.org/W2997280954","https://openalex.org/W3006033724","https://openalex.org/W3012822000","https://openalex.org/W3015321334","https://openalex.org/W3025989739","https://openalex.org/W3040531409","https://openalex.org/W3040876684","https://openalex.org/W3047168254","https://openalex.org/W3047549677","https://openalex.org/W3048745453","https://openalex.org/W3088414753","https://openalex.org/W3101695926","https://openalex.org/W3108714922","https://openalex.org/W3108941787","https://openalex.org/W3110852430","https://openalex.org/W3113769443","https://openalex.org/W3126460810","https://openalex.org/W3128961456","https://openalex.org/W3153727370","https://openalex.org/W3157384750","https://openalex.org/W3170265427","https://openalex.org/W3174093303","https://openalex.org/W3202649987","https://openalex.org/W3216931901","https://openalex.org/W4210782186","https://openalex.org/W4220979272","https://openalex.org/W4226183288","https://openalex.org/W4302768905","https://openalex.org/W4375955255","https://openalex.org/W4399573750","https://openalex.org/W6773045071"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2082860237","https://openalex.org/W2119695867","https://openalex.org/W2130076355","https://openalex.org/W1990804418","https://openalex.org/W1993764875","https://openalex.org/W2046158694","https://openalex.org/W2788277189","https://openalex.org/W2013243191","https://openalex.org/W1971568933"],"abstract_inverted_index":{"Cells":[0],"and":[1,24,99,118,122,137],"tissues":[2],"respond":[3],"to":[4,22,79,83,102,110,126],"perturbations":[5,29],"in":[6,14,77,91],"multiple":[7,111],"ways":[8],"that":[9,65],"can":[10],"be":[11],"sensitively":[12],"reflected":[13],"the":[15,26,36,45,92,100],"alterations":[16],"of":[17,28,39,47,68,73,94],"gene":[18,41,129],"expression.":[19],"Current":[20],"approaches":[21],"finding":[23],"quantifying":[25],"effects":[27],"on":[30],"cell-level":[31],"responses":[32],"over":[33],"time":[34,105],"disregard":[35],"temporal":[37,71],"consistency":[38],"identifiable":[40],"programs.":[42],"To":[43],"leverage":[44],"occurrence":[46],"these":[48],"patterns":[49,72,98],"for":[50],"perturbation":[51,97],"analyses,":[52],"we":[53],"developed":[54],"CellDrift":[55,87,109],"(https://github.com/KANG-BIOINFO/CellDrift),":[56],"a":[57],"generalized":[58],"linear":[59],"model-based":[60],"functional":[61],"data":[62],"analysis":[63],"method":[64],"is":[66],"capable":[67],"identifying":[69],"covarying":[70],"various":[74],"cell":[75],"types":[76],"response":[78],"perturbations.":[80],"As":[81],"compared":[82],"several":[84],"other":[85],"approaches,":[86],"demonstrated":[88,123],"superior":[89],"performance":[90],"identification":[93],"temporally":[95],"varied":[96],"ability":[101,125],"impute":[103],"missing":[104],"points.":[106],"We":[107],"applied":[108],"longitudinal":[112],"datasets,":[113],"including":[114],"COVID-19":[115],"disease":[116],"progression":[117],"gastrointestinal":[119],"tract":[120],"development,":[121],"its":[124],"identify":[127],"specific":[128],"programs":[130],"associated":[131],"with":[132],"sequential":[133],"biological":[134],"processes,":[135],"trajectories":[136],"outcomes.":[138]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}