{"id":"https://openalex.org/W4284970964","doi":"https://doi.org/10.1093/bib/bbac278","title":"Evaluating methylation of human ribosomal DNA at each CpG site reveals its utility for cancer detection using cell-free DNA","display_name":"Evaluating methylation of human ribosomal DNA at each CpG site reveals its utility for cancer detection using cell-free DNA","publication_year":2022,"publication_date":"2022-07-09","ids":{"openalex":"https://openalex.org/W4284970964","doi":"https://doi.org/10.1093/bib/bbac278","pmid":"https://pubmed.ncbi.nlm.nih.gov/35804466"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbac278","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbac278","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101527018","display_name":"Xianglin Zhang","orcid":"https://orcid.org/0000-0002-8585-1917"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xianglin Zhang","raw_affiliation_strings":["Ministry of Education Key Laboratory of Bioinformatics; Center for Synthetic and Systems Biology; Beijing National Research Center for Information Science and Technology; Department of Automation, Tsinghua University , Beijing 100084, China"],"affiliations":[{"raw_affiliation_string":"Ministry of Education Key Laboratory of Bioinformatics; Center for Synthetic and Systems Biology; Beijing National Research Center for Information Science and Technology; Department of Automation, Tsinghua University , Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029698735","display_name":"Xiaodong Jia","orcid":"https://orcid.org/0000-0002-2145-6272"},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaodong Jia","raw_affiliation_strings":["Senior Department of Oncology, Fifth Medical Center of PLA General Hospital , Beijing 100039, China"],"affiliations":[{"raw_affiliation_string":"Senior Department of Oncology, Fifth Medical Center of PLA General Hospital , Beijing 100039, China","institution_ids":["https://openalex.org/I2802939634"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075289664","display_name":"Bixi Zhong","orcid":null},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bixi Zhong","raw_affiliation_strings":["Ministry of Education Key Laboratory of Bioinformatics; Center for Synthetic and Systems Biology; Beijing National Research Center for Information Science and Technology; Department of Automation, Tsinghua University , Beijing 100084, China"],"affiliations":[{"raw_affiliation_string":"Ministry of Education Key Laboratory of Bioinformatics; Center for Synthetic and Systems Biology; Beijing National Research Center for Information Science and Technology; Department of Automation, Tsinghua University , Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100634707","display_name":"Lei Wei","orcid":"https://orcid.org/0000-0002-1546-6458"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Wei","raw_affiliation_strings":["Ministry of Education Key Laboratory of Bioinformatics; Center for Synthetic and Systems Biology; Beijing National Research Center for Information Science and Technology; Department of Automation, Tsinghua University , Beijing 100084, China"],"affiliations":[{"raw_affiliation_string":"Ministry of Education Key Laboratory of Bioinformatics; Center for Synthetic and Systems Biology; Beijing National Research Center for Information Science and Technology; Department of Automation, Tsinghua University , Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100325933","display_name":"Jiaqi Li","orcid":"https://orcid.org/0000-0001-9038-9010"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiaqi Li","raw_affiliation_strings":["Ministry of Education Key Laboratory of Bioinformatics; Center for Synthetic and Systems Biology; Beijing National Research Center for Information Science and Technology; Department of Automation, Tsinghua University , Beijing 100084, China"],"affiliations":[{"raw_affiliation_string":"Ministry of Education Key Laboratory of Bioinformatics; Center for Synthetic and Systems Biology; Beijing National Research Center for Information Science and Technology; Department of Automation, Tsinghua University , Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100761365","display_name":"Wei Zhang","orcid":"https://orcid.org/0000-0003-4264-5758"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wei Zhang","raw_affiliation_strings":["Ministry of Education Key Laboratory of Bioinformatics; Center for Synthetic and Systems Biology; Beijing National Research Center for Information Science and Technology; Department of Automation, Tsinghua University , Beijing 100084, China"],"affiliations":[{"raw_affiliation_string":"Ministry of Education Key Laboratory of Bioinformatics; Center for Synthetic and Systems Biology; Beijing National Research Center for Information Science and Technology; Department of Automation, Tsinghua University , Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038892722","display_name":"Huan Fang","orcid":"https://orcid.org/0000-0003-0317-5394"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huan Fang","raw_affiliation_strings":["Ministry of Education Key Laboratory of Bioinformatics; Center for Synthetic and Systems Biology; Beijing National Research Center for Information Science and Technology; Department of Automation, Tsinghua University , Beijing 100084, China"],"affiliations":[{"raw_affiliation_string":"Ministry of Education Key Laboratory of Bioinformatics; Center for Synthetic and Systems Biology; Beijing National Research Center for Information Science and Technology; Department of Automation, Tsinghua University , Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033512723","display_name":"Yanda Li","orcid":"https://orcid.org/0000-0002-9439-202X"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanda Li","raw_affiliation_strings":["Ministry of Education Key Laboratory of Bioinformatics; Center for Synthetic and Systems Biology; Beijing National Research Center for Information Science and Technology; Department of Automation, Tsinghua University , Beijing 100084, China"],"affiliations":[{"raw_affiliation_string":"Ministry of Education Key Laboratory of Bioinformatics; Center for Synthetic and Systems Biology; Beijing National Research Center for Information Science and Technology; Department of Automation, Tsinghua University , Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064260340","display_name":"Yinying Lu","orcid":"https://orcid.org/0009-0009-6145-1976"},"institutions":[{"id":"https://openalex.org/I2802939634","display_name":"Chinese PLA General Hospital","ror":"https://ror.org/04gw3ra78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2802939634"]},{"id":"https://openalex.org/I180726961","display_name":"Shenzhen University","ror":"https://ror.org/01vy4gh70","country_code":"CN","type":"education","lineage":["https://openalex.org/I180726961"]},{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yinying Lu","raw_affiliation_strings":["Center for Synthetic and Systems Biology, Tsinghua University , Beijing, 100084, China","Comprehensive Liver Cancer Center, Fifth Medical Center of PLA General Hospital , Beijing 100039, China","Guangdong Key Laboratory of Epigenetics, College of Life Sciences and Oceanography, Shenzhen University , Shenzhen, Guangdong, 518055, China"],"affiliations":[{"raw_affiliation_string":"Center for Synthetic and Systems Biology, Tsinghua University , Beijing, 100084, China","institution_ids":["https://openalex.org/I99065089"]},{"raw_affiliation_string":"Comprehensive Liver Cancer Center, Fifth Medical Center of PLA General Hospital , Beijing 100039, China","institution_ids":["https://openalex.org/I2802939634"]},{"raw_affiliation_string":"Guangdong Key Laboratory of Epigenetics, College of Life Sciences and Oceanography, Shenzhen University , Shenzhen, Guangdong, 518055, China","institution_ids":["https://openalex.org/I180726961"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008093795","display_name":"Xiaowo Wang","orcid":"https://orcid.org/0000-0003-2965-8036"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaowo Wang","raw_affiliation_strings":["Ministry of Education Key Laboratory of Bioinformatics; Center for Synthetic and Systems Biology; Beijing National Research Center for Information Science and Technology; Department of Automation, Tsinghua University , Beijing 100084, China"],"affiliations":[{"raw_affiliation_string":"Ministry of Education Key Laboratory of Bioinformatics; Center for Synthetic and Systems Biology; Beijing National Research Center for Information Science and Technology; Department of Automation, Tsinghua University , Beijing 100084, China","institution_ids":["https://openalex.org/I99065089"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5101527018"],"corresponding_institution_ids":["https://openalex.org/I99065089"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":0.5147,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.61011312,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":97},"biblio":{"volume":"23","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7946652173995972},{"id":"https://openalex.org/keywords/cpg-site","display_name":"CpG site","score":0.7937992811203003},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7122251391410828},{"id":"https://openalex.org/keywords/methylation","display_name":"Methylation","score":0.6940216422080994},{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.617756724357605},{"id":"https://openalex.org/keywords/differentially-methylated-regions","display_name":"Differentially methylated regions","score":0.5300179719924927},{"id":"https://openalex.org/keywords/ribosomal-dna","display_name":"Ribosomal DNA","score":0.5109809637069702},{"id":"https://openalex.org/keywords/illumina-methylation-assay","display_name":"Illumina Methylation Assay","score":0.4768701195716858},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.4644218981266022},{"id":"https://openalex.org/keywords/dna","display_name":"DNA","score":0.43936794996261597},{"id":"https://openalex.org/keywords/ribosomal-rna","display_name":"Ribosomal RNA","score":0.41798195242881775},{"id":"https://openalex.org/keywords/molecular-biology","display_name":"Molecular biology","score":0.4047199785709381},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3922409117221832},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2812332510948181},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.11917105317115784}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.7946652173995972},{"id":"https://openalex.org/C140173407","wikidata":"https://www.wikidata.org/wiki/Q1138358","display_name":"CpG site","level":5,"score":0.7937992811203003},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7122251391410828},{"id":"https://openalex.org/C33288867","wikidata":"https://www.wikidata.org/wiki/Q518328","display_name":"Methylation","level":3,"score":0.6940216422080994},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.617756724357605},{"id":"https://openalex.org/C154253233","wikidata":"https://www.wikidata.org/wiki/Q14862240","display_name":"Differentially methylated regions","level":5,"score":0.5300179719924927},{"id":"https://openalex.org/C207812311","wikidata":"https://www.wikidata.org/wiki/Q426560","display_name":"Ribosomal DNA","level":4,"score":0.5109809637069702},{"id":"https://openalex.org/C136953436","wikidata":"https://www.wikidata.org/wiki/Q6000286","display_name":"Illumina Methylation Assay","level":5,"score":0.4768701195716858},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4644218981266022},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.43936794996261597},{"id":"https://openalex.org/C67905577","wikidata":"https://www.wikidata.org/wiki/Q215980","display_name":"Ribosomal RNA","level":3,"score":0.41798195242881775},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4047199785709381},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3922409117221832},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2812332510948181},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.11917105317115784},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000073888","descriptor_name":"Cell-Free Nucleic Acids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000073888","descriptor_name":"Cell-Free Nucleic Acids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000073888","descriptor_name":"Cell-Free Nucleic Acids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004275","descriptor_name":"DNA, Ribosomal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004275","descriptor_name":"DNA, Ribosomal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004275","descriptor_name":"DNA, Ribosomal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006528","descriptor_name":"Carcinoma, Hepatocellular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008113","descriptor_name":"Liver Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018899","descriptor_name":"CpG Islands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbac278","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbac278","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:35804466","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35804466","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8199999928474426}],"awards":[{"id":"https://openalex.org/G1993709224","display_name":null,"funder_award_id":"81902495","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G207605852","display_name":null,"funder_award_id":"2020YFA0906900","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G5414400793","display_name":null,"funder_award_id":"KCXFZ202002011006448","funder_id":"https://openalex.org/F4320326705","funder_display_name":"Science, Technology and Innovation Commission of Shenzhen Municipality"},{"id":"https://openalex.org/G5808002254","display_name":null,"funder_award_id":"61773230","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5814160623","display_name":null,"funder_award_id":"61721003","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G993511582","display_name":null,"funder_award_id":"62050152","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320326705","display_name":"Science, Technology and Innovation Commission of Shenzhen Municipality","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W608914385","https://openalex.org/W1603913946","https://openalex.org/W1981197560","https://openalex.org/W2036897871","https://openalex.org/W2043376848","https://openalex.org/W2089470652","https://openalex.org/W2090037139","https://openalex.org/W2114591008","https://openalex.org/W2115182128","https://openalex.org/W2118382560","https://openalex.org/W2125234802","https://openalex.org/W2131374955","https://openalex.org/W2135811171","https://openalex.org/W2141836580","https://openalex.org/W2294649300","https://openalex.org/W2318191838","https://openalex.org/W2416688624","https://openalex.org/W2476271072","https://openalex.org/W2490712594","https://openalex.org/W2507026380","https://openalex.org/W2529931326","https://openalex.org/W2593934358","https://openalex.org/W2611430368","https://openalex.org/W2625191040","https://openalex.org/W2767826728","https://openalex.org/W2773619385","https://openalex.org/W2803553976","https://openalex.org/W2883148540","https://openalex.org/W2914381026","https://openalex.org/W2914700206","https://openalex.org/W2944380677","https://openalex.org/W2951877741","https://openalex.org/W2963389481","https://openalex.org/W2964558489","https://openalex.org/W2966070481","https://openalex.org/W3039020475","https://openalex.org/W3043231606","https://openalex.org/W3044496248","https://openalex.org/W3126684308","https://openalex.org/W3194020783","https://openalex.org/W3201433213","https://openalex.org/W4213142639","https://openalex.org/W4220999759","https://openalex.org/W6790061650"],"related_works":["https://openalex.org/W2296881971","https://openalex.org/W2477521417","https://openalex.org/W2011988545","https://openalex.org/W2041013779","https://openalex.org/W3171749255","https://openalex.org/W2029341502","https://openalex.org/W1998914928","https://openalex.org/W4284970964","https://openalex.org/W2535322499","https://openalex.org/W2074713956"],"abstract_inverted_index":{"Ribosomal":[0],"deoxyribonucleic":[1],"acid":[2],"(DNA)":[3],"(rDNA)":[4],"repeats":[5],"are":[6],"tandemly":[7],"located":[8],"on":[9,82,154],"five":[10],"acrocentric":[11],"chromosomes":[12],"with":[13],"up":[14],"to":[15,49,62,95,102],"hundreds":[16],"of":[17,199,207],"copies":[18],"in":[19,122,128,137],"the":[20,25,50,98,115,162,204],"human":[21],"genome.":[22],"DNA":[23,140],"methylation,":[24],"most":[26,34],"well-studied":[27],"epigenetic":[28],"mechanism,":[29],"has":[30],"been":[31],"characterized":[32],"for":[33,147],"genomic":[35],"regions":[36],"across":[37,71,112],"various":[38,72],"biological":[39],"contexts.":[40],"However,":[41],"rDNA":[42,64,83,134,200,208],"methylation":[43,65,110,120,135,209],"patterns":[44,66],"remain":[45],"largely":[46],"unexplored":[47],"due":[48],"repetitive":[51],"structure.":[52],"In":[53],"this":[54],"study,":[55],"we":[56],"designed":[57],"a":[58,145],"specific":[59],"mapping":[60],"strategy":[61],"investigate":[63],"at":[67,187],"each":[68],"CpG":[69,80],"site":[70],"physiological":[73],"and":[74,177,202],"pathological":[75],"processes.":[76],"We":[77,130],"found":[78],"that":[79,133],"sites":[81],"could":[84,141],"be":[85,142],"categorized":[86],"into":[87],"two":[88],"types.":[89],"One":[90],"is":[91,100],"within":[92],"or":[93],"adjacent":[94],"transcribed":[96,103],"regions;":[97],"other":[99],"distal":[101],"regions.":[104],"The":[105],"former":[106],"shows":[107,117,151],"highly":[108],"variable":[109],"levels":[111,121],"samples,":[113],"while":[114],"latter":[116],"stable":[118],"high":[119],"normal":[123],"tissues":[124],"but":[125],"severe":[126],"hypomethylation":[127],"tumors.":[129],"further":[131],"showed":[132],"profiles":[136],"plasma":[138],"cell-free":[139],"used":[143],"as":[144,211],"biomarker":[146],"cancer":[148,159,168],"detection.":[149],"It":[150],"good":[152],"performances":[153],"public":[155],"datasets,":[156],"including":[157],"colorectal":[158],"[area":[160],"under":[161],"curve":[163],"(AUC)":[164],"=":[165,170,175,184],"0.85],":[166],"lung":[167],"(AUC":[169,174,183],"0.84),":[171],"hepatocellular":[172,180],"carcinoma":[173,181],"0.91)":[176],"in-house":[178],"generated":[179],"dataset":[182],"0.96)":[185],"even":[186],"low":[188],"genome":[189],"coverage":[190],"(<1\u00d7).":[191],"Taken":[192],"together,":[193],"these":[194],"findings":[195],"broaden":[196],"our":[197],"understanding":[198],"regulation":[201],"suggest":[203],"potential":[205],"utility":[206],"features":[210],"disease":[212],"biomarkers.":[213]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}