{"id":"https://openalex.org/W4285041843","doi":"https://doi.org/10.1093/bib/bbac272","title":"AttentionSiteDTI: an interpretable graph-based model for drug-target interaction prediction using NLP sentence-level relation classification","display_name":"AttentionSiteDTI: an interpretable graph-based model for drug-target interaction prediction using NLP sentence-level relation classification","publication_year":2022,"publication_date":"2022-07-11","ids":{"openalex":"https://openalex.org/W4285041843","doi":"https://doi.org/10.1093/bib/bbac272","pmid":"https://pubmed.ncbi.nlm.nih.gov/35817396"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbac272","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbac272","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9294423","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5043368211","display_name":"Mehdi Yazdani-Jahromi","orcid":"https://orcid.org/0000-0001-6658-6591"},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mehdi Yazdani-Jahromi","raw_affiliation_strings":["Industrial Engineering and Management Systems, University of Central Florida , Street, 32816, 4000 Central Florida Blvd. Orlando, USA"],"affiliations":[{"raw_affiliation_string":"Industrial Engineering and Management Systems, University of Central Florida , Street, 32816, 4000 Central Florida Blvd. Orlando, USA","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054474613","display_name":"Niloofar Yousefi","orcid":"https://orcid.org/0009-0005-0071-733X"},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Niloofar Yousefi","raw_affiliation_strings":["Industrial Engineering and Management Systems, University of Central Florida , Street, 32816, 4000 Central Florida Blvd. Orlando, USA"],"affiliations":[{"raw_affiliation_string":"Industrial Engineering and Management Systems, University of Central Florida , Street, 32816, 4000 Central Florida Blvd. Orlando, USA","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024754640","display_name":"Aida Tayebi","orcid":null},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aida Tayebi","raw_affiliation_strings":["Industrial Engineering and Management Systems, University of Central Florida , Street, 32816, 4000 Central Florida Blvd. Orlando, USA"],"affiliations":[{"raw_affiliation_string":"Industrial Engineering and Management Systems, University of Central Florida , Street, 32816, 4000 Central Florida Blvd. Orlando, USA","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075351963","display_name":"Elayaraja Kolanthai","orcid":"https://orcid.org/0000-0003-2615-6866"},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]},{"id":"https://openalex.org/I4210160220","display_name":"Central Florida Neurosurgery Institute","ror":"https://ror.org/052vdf235","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160220"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elayaraja Kolanthai","raw_affiliation_strings":["College of Medicine , Bionix Cluster, , 4000 Central Florida Blvd. Orlando, 32816, Florida, USA","University of Central Florida , Bionix Cluster, , 4000 Central Florida Blvd. Orlando, 32816, Florida, USA","College of Medicine, Bionix Cluster, University of Central Florida, 4000 Central Florida Blvd. Orlando, 32816, Florida, USA"],"affiliations":[{"raw_affiliation_string":"College of Medicine , Bionix Cluster, , 4000 Central Florida Blvd. Orlando, 32816, Florida, USA","institution_ids":["https://openalex.org/I106165777","https://openalex.org/I4210160220"]},{"raw_affiliation_string":"University of Central Florida , Bionix Cluster, , 4000 Central Florida Blvd. Orlando, 32816, Florida, USA","institution_ids":["https://openalex.org/I106165777"]},{"raw_affiliation_string":"College of Medicine, Bionix Cluster, University of Central Florida, 4000 Central Florida Blvd. Orlando, 32816, Florida, USA","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013241705","display_name":"Craig J. Neal","orcid":"https://orcid.org/0000-0001-7288-4229"},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]},{"id":"https://openalex.org/I4210160220","display_name":"Central Florida Neurosurgery Institute","ror":"https://ror.org/052vdf235","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160220"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig J Neal","raw_affiliation_strings":["College of Medicine , Bionix Cluster, , 4000 Central Florida Blvd. Orlando, 32816, Florida, USA","University of Central Florida , Bionix Cluster, , 4000 Central Florida Blvd. Orlando, 32816, Florida, USA","College of Medicine, Bionix Cluster, University of Central Florida, 4000 Central Florida Blvd. Orlando, 32816, Florida, USA"],"affiliations":[{"raw_affiliation_string":"College of Medicine , Bionix Cluster, , 4000 Central Florida Blvd. Orlando, 32816, Florida, USA","institution_ids":["https://openalex.org/I106165777","https://openalex.org/I4210160220"]},{"raw_affiliation_string":"University of Central Florida , Bionix Cluster, , 4000 Central Florida Blvd. Orlando, 32816, Florida, USA","institution_ids":["https://openalex.org/I106165777"]},{"raw_affiliation_string":"College of Medicine, Bionix Cluster, University of Central Florida, 4000 Central Florida Blvd. Orlando, 32816, Florida, USA","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026168431","display_name":"Sudipta Seal","orcid":"https://orcid.org/0000-0002-0963-3344"},"institutions":[{"id":"https://openalex.org/I4210160220","display_name":"Central Florida Neurosurgery Institute","ror":"https://ror.org/052vdf235","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210160220"]},{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]},{"id":"https://openalex.org/I4210145537","display_name":"Materials Processing (United States)","ror":"https://ror.org/05j00pb84","country_code":"US","type":"company","lineage":["https://openalex.org/I4210145537"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sudipta Seal","raw_affiliation_strings":["Advanced Materials Processing and Analysis Center , Dept. of Materials Science and Engineering, , 4000 Central Florida Blvd. Orlando, 32816, Florida, USA","College of Medicine , Bionix Cluster, , 4000 Central Florida Blvd. Orlando, 32816, Florida, USA","University of Central Florida , Bionix Cluster, , 4000 Central Florida Blvd. Orlando, 32816, Florida, USA","University of Central Florida , Dept. of Materials Science and Engineering, , 4000 Central Florida Blvd. Orlando, 32816, Florida, USA","Advanced Materials Processing and Analysis Center, Dept. of Materials Science and Engineering, University of Central Florida, 4000 Central Florida Blvd. Orlando, 32816, Florida, USA","College of Medicine, Bionix Cluster, University of Central Florida, 4000 Central Florida Blvd. Orlando, 32816, Florida, USA"],"affiliations":[{"raw_affiliation_string":"Advanced Materials Processing and Analysis Center , Dept. of Materials Science and Engineering, , 4000 Central Florida Blvd. Orlando, 32816, Florida, USA","institution_ids":[]},{"raw_affiliation_string":"College of Medicine , Bionix Cluster, , 4000 Central Florida Blvd. Orlando, 32816, Florida, USA","institution_ids":["https://openalex.org/I106165777","https://openalex.org/I4210160220"]},{"raw_affiliation_string":"University of Central Florida , Bionix Cluster, , 4000 Central Florida Blvd. Orlando, 32816, Florida, USA","institution_ids":["https://openalex.org/I106165777"]},{"raw_affiliation_string":"University of Central Florida , Dept. of Materials Science and Engineering, , 4000 Central Florida Blvd. Orlando, 32816, Florida, USA","institution_ids":["https://openalex.org/I106165777"]},{"raw_affiliation_string":"Advanced Materials Processing and Analysis Center, Dept. of Materials Science and Engineering, University of Central Florida, 4000 Central Florida Blvd. Orlando, 32816, Florida, USA","institution_ids":["https://openalex.org/I4210145537","https://openalex.org/I106165777"]},{"raw_affiliation_string":"College of Medicine, Bionix Cluster, University of Central Florida, 4000 Central Florida Blvd. Orlando, 32816, Florida, USA","institution_ids":["https://openalex.org/I106165777"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062903281","display_name":"\u00d6zlem \u00d6zmen Garibay","orcid":"https://orcid.org/0000-0001-9215-694X"},"institutions":[{"id":"https://openalex.org/I106165777","display_name":"University of Central Florida","ror":"https://ror.org/036nfer12","country_code":"US","type":"education","lineage":["https://openalex.org/I106165777"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ozlem Ozmen Garibay","raw_affiliation_strings":["Industrial Engineering and Management Systems, University of Central Florida , Street, 32816, 4000 Central Florida Blvd. Orlando, USA"],"affiliations":[{"raw_affiliation_string":"Industrial Engineering and Management Systems, University of Central Florida , Street, 32816, 4000 Central Florida Blvd. Orlando, USA","institution_ids":["https://openalex.org/I106165777"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5062903281"],"corresponding_institution_ids":["https://openalex.org/I106165777"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":15.5344,"has_fulltext":false,"cited_by_count":107,"citation_normalized_percentile":{"value":0.99395858,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"23","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9872000217437744,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11948","display_name":"Machine Learning in Materials Science","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.8175637722015381},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.724311113357544},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6862304210662842},{"id":"https://openalex.org/keywords/generalizability-theory","display_name":"Generalizability theory","score":0.6654651165008545},{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.6628403663635254},{"id":"https://openalex.org/keywords/sentence","display_name":"Sentence","score":0.6194038391113281},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.5541822910308838},{"id":"https://openalex.org/keywords/drug-target","display_name":"Drug target","score":0.5511448383331299},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4904784858226776},{"id":"https://openalex.org/keywords/benchmark","display_name":"Benchmark (surveying)","score":0.47092002630233765},{"id":"https://openalex.org/keywords/natural-language-processing","display_name":"Natural language processing","score":0.42038416862487793},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.2621415853500366},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.13358518481254578},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.11643600463867188},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.08771216869354248}],"concepts":[{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.8175637722015381},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.724311113357544},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6862304210662842},{"id":"https://openalex.org/C27158222","wikidata":"https://www.wikidata.org/wiki/Q5532422","display_name":"Generalizability theory","level":2,"score":0.6654651165008545},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.6628403663635254},{"id":"https://openalex.org/C2777530160","wikidata":"https://www.wikidata.org/wiki/Q41796","display_name":"Sentence","level":2,"score":0.6194038391113281},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.5541822910308838},{"id":"https://openalex.org/C2989108626","wikidata":"https://www.wikidata.org/wiki/Q904407","display_name":"Drug target","level":2,"score":0.5511448383331299},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4904784858226776},{"id":"https://openalex.org/C185798385","wikidata":"https://www.wikidata.org/wiki/Q1161707","display_name":"Benchmark (surveying)","level":2,"score":0.47092002630233765},{"id":"https://openalex.org/C204321447","wikidata":"https://www.wikidata.org/wiki/Q30642","display_name":"Natural language processing","level":1,"score":0.42038416862487793},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.2621415853500366},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.13358518481254578},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.11643600463867188},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.08771216869354248},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C13280743","wikidata":"https://www.wikidata.org/wiki/Q131089","display_name":"Geodesy","level":1,"score":0.0},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0},{"id":"https://openalex.org/C205649164","wikidata":"https://www.wikidata.org/wiki/Q1071","display_name":"Geography","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000076722","descriptor_name":"Drug Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000076722","descriptor_name":"Drug Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000076722","descriptor_name":"Drug Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009323","descriptor_name":"Natural Language Processing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009323","descriptor_name":"Natural Language Processing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009323","descriptor_name":"Natural Language Processing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbac272","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbac272","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:35817396","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35817396","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:9294423","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9294423","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9294423","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9294423","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"},"sustainable_development_goals":[{"score":0.5899999737739563,"display_name":"Quality Education","id":"https://metadata.un.org/sdg/4"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1968319881","https://openalex.org/W1993285168","https://openalex.org/W2001855472","https://openalex.org/W2028629022","https://openalex.org/W2065807927","https://openalex.org/W2109991441","https://openalex.org/W2127372263","https://openalex.org/W2132629607","https://openalex.org/W2134967712","https://openalex.org/W2134972446","https://openalex.org/W2148145769","https://openalex.org/W2148512505","https://openalex.org/W2204695023","https://openalex.org/W2214665483","https://openalex.org/W2551706664","https://openalex.org/W2566823781","https://openalex.org/W2583907533","https://openalex.org/W2592742128","https://openalex.org/W2605952223","https://openalex.org/W2765323781","https://openalex.org/W2781821160","https://openalex.org/W2807792492","https://openalex.org/W2809216727","https://openalex.org/W2860192827","https://openalex.org/W2907262778","https://openalex.org/W2950898568","https://openalex.org/W2963722686","https://openalex.org/W2964015378","https://openalex.org/W2969996838","https://openalex.org/W2978484973","https://openalex.org/W2989848927","https://openalex.org/W3005769002","https://openalex.org/W3011478582","https://openalex.org/W3028589594","https://openalex.org/W3032123378","https://openalex.org/W3088849005","https://openalex.org/W3096561213","https://openalex.org/W3104705366","https://openalex.org/W3140330522","https://openalex.org/W4220788456","https://openalex.org/W4295547865","https://openalex.org/W4297733535","https://openalex.org/W4385245566","https://openalex.org/W6688357764","https://openalex.org/W6690815549","https://openalex.org/W6726873649","https://openalex.org/W6735840763","https://openalex.org/W6736091738","https://openalex.org/W6739901393","https://openalex.org/W6745316256","https://openalex.org/W6752083957","https://openalex.org/W6791141202"],"related_works":["https://openalex.org/W4378220270","https://openalex.org/W4319455836","https://openalex.org/W2558461040","https://openalex.org/W2474546929","https://openalex.org/W4206326513","https://openalex.org/W3004450058","https://openalex.org/W2809645723","https://openalex.org/W3209981042","https://openalex.org/W3199439588","https://openalex.org/W4376870972"],"abstract_inverted_index":{"In":[0],"this":[1],"study,":[2],"we":[3,121,135],"introduce":[4],"an":[5,182],"interpretable":[6],"graph-based":[7],"deep":[8],"learning":[9],"prediction":[10],"model,":[11],"AttentionSiteDTI,":[12],"which":[13],"utilizes":[14],"protein":[15,64,75],"binding":[16,76,140,154],"sites":[17,77],"along":[18],"with":[19,56,95],"a":[20,54,147],"self-attention":[21],"mechanism":[22],"to":[23],"address":[24],"the":[25,41,48,74,80,83,96,125,139,153,160,166,176],"problem":[26],"of":[27,43,128,178],"drug-target":[28,49,84,173],"interaction":[29],"prediction.":[30],"Our":[31],"proposed":[32,130],"model":[33,106],"is":[34,51],"inspired":[35],"by":[36,72],"sentence":[37,55],"classification":[38],"models":[39],"in":[40,159,186],"field":[42],"Natural":[44],"Language":[45],"Processing,":[46],"where":[47],"complex":[50],"treated":[52],"as":[53,181],"relational":[57],"meaning":[58],"between":[59,142,165],"its":[60],"biochemical":[61],"entities":[62],"a.k.a.":[63],"pockets":[65],"and":[66,146,169],"drug":[67,187],"molecule.":[68],"AttentionSiteDTI":[69],"enables":[70],"interpretability":[71],"identifying":[73],"that":[78],"contribute":[79],"most":[81],"toward":[82],"interaction.":[85],"Results":[86],"on":[87,112],"three":[88],"benchmark":[89],"datasets":[90],"show":[91],"improved":[92],"performance":[93],"compared":[94],"current":[97],"state-of-the-art":[98],"models.":[99],"More":[100],"significantly,":[101],"unlike":[102],"previous":[103],"studies,":[104],"our":[105,129,179],"shows":[107],"superior":[108],"performance,":[109],"when":[110],"tested":[111],"new":[113],"proteins":[114],"(i.e.":[115],"high":[116,163],"generalizability).":[117],"Through":[118],"multidisciplinary":[119],"collaboration,":[120],"further":[122],"experimentally":[123,151,170],"evaluate":[124],"practical":[126],"potential":[127,177],"approach.":[131],"To":[132],"achieve":[133],"this,":[134],"first":[136],"computationally":[137,167],"predict":[138],"interactions":[141,155,174],"some":[143],"candidate":[144],"compounds":[145],"target":[148],"protein,":[149],"then":[150],"validate":[152],"for":[156],"these":[157],"pairs":[158],"laboratory.":[161],"The":[162],"agreement":[164],"predicted":[168],"observed":[171],"(measured)":[172],"illustrates":[175],"method":[180],"effective":[183],"pre-screening":[184],"tool":[185],"repurposing":[188],"applications.":[189]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":38},{"year":2024,"cited_by_count":32},{"year":2023,"cited_by_count":28},{"year":2022,"cited_by_count":3}],"updated_date":"2026-04-02T15:55:50.835912","created_date":"2025-10-10T00:00:00"}