{"id":"https://openalex.org/W4283012806","doi":"https://doi.org/10.1093/bib/bbac223","title":"DURIAN: an integrative deconvolution and imputation method for robust signaling analysis of single-cell transcriptomics data","display_name":"DURIAN: an integrative deconvolution and imputation method for robust signaling analysis of single-cell transcriptomics data","publication_year":2022,"publication_date":"2022-06-16","ids":{"openalex":"https://openalex.org/W4283012806","doi":"https://doi.org/10.1093/bib/bbac223","pmid":"https://pubmed.ncbi.nlm.nih.gov/35709795"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbac223","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbac223","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9294432","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051160791","display_name":"Matthew Karikomi","orcid":"https://orcid.org/0000-0002-5149-9695"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]},{"id":"https://openalex.org/I530967","display_name":"Toronto Metropolitan University","ror":"https://ror.org/05g13zd79","country_code":"CA","type":"education","lineage":["https://openalex.org/I530967"]}],"countries":["CA","US"],"is_corresponding":true,"raw_author_name":"Matthew Karikomi","raw_affiliation_strings":["Department of Mathematics","Professor of Mathematics and Developmental & Cell Biology, University of California, Irvine, USA","MCSB program at University of California, Irvine, USA","Mathematics Department, University of California, Irvine, USA","Rowland Hall, University of California Irvine, Irvine CA 92697, USA","540F Rowland Hall, University of California Irvine, Irvine CA 92697, USA"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics","institution_ids":["https://openalex.org/I530967"]},{"raw_affiliation_string":"Professor of Mathematics and Developmental & Cell Biology, University of California, Irvine, USA","institution_ids":[]},{"raw_affiliation_string":"MCSB program at University of California, Irvine, USA","institution_ids":[]},{"raw_affiliation_string":"Mathematics Department, University of California, Irvine, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Rowland Hall, University of California Irvine, Irvine CA 92697, USA","institution_ids":[]},{"raw_affiliation_string":"540F Rowland Hall, University of California Irvine, Irvine CA 92697, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072894189","display_name":"Peijie Zhou","orcid":"https://orcid.org/0000-0002-4585-2923"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peijie Zhou","raw_affiliation_strings":["Department of Cell and Developmental Biology","540F Rowland Hall, University of California Irvine, Irvine CA 92697, USA","MCSB program at University of California, Irvine, USA","Rowland Hall, University of California Irvine, Irvine CA 92697, USA","Professor of Mathematics and Developmental & Cell Biology, University of California, Irvine, USA","Mathematics Department, University of California, Irvine, USA"],"affiliations":[{"raw_affiliation_string":"Department of Cell and Developmental Biology","institution_ids":[]},{"raw_affiliation_string":"540F Rowland Hall, University of California Irvine, Irvine CA 92697, USA","institution_ids":[]},{"raw_affiliation_string":"MCSB program at University of California, Irvine, USA","institution_ids":[]},{"raw_affiliation_string":"Rowland Hall, University of California Irvine, Irvine CA 92697, USA","institution_ids":[]},{"raw_affiliation_string":"Professor of Mathematics and Developmental & Cell Biology, University of California, Irvine, USA","institution_ids":[]},{"raw_affiliation_string":"Mathematics Department, University of California, Irvine, USA","institution_ids":["https://openalex.org/I204250578"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076311980","display_name":"Qing Nie","orcid":"https://orcid.org/0000-0002-8804-3368"},"institutions":[{"id":"https://openalex.org/I204250578","display_name":"University of California, Irvine","ror":"https://ror.org/04gyf1771","country_code":"US","type":"education","lineage":["https://openalex.org/I204250578"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qing Nie","raw_affiliation_strings":["NSF-Simons Center for Multiscale Cell Fate Research, University of California , Irvine","Rowland Hall, University of California Irvine, Irvine CA 92697, USA","Professor of Mathematics and Developmental & Cell Biology, University of California, Irvine, USA","MCSB program at University of California, Irvine, USA","Mathematics Department, University of California, Irvine, USA","540F Rowland Hall, University of California Irvine, Irvine CA 92697, USA"],"affiliations":[{"raw_affiliation_string":"NSF-Simons Center for Multiscale Cell Fate Research, University of California , Irvine","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"Rowland Hall, University of California Irvine, Irvine CA 92697, USA","institution_ids":[]},{"raw_affiliation_string":"Professor of Mathematics and Developmental & Cell Biology, University of California, Irvine, USA","institution_ids":[]},{"raw_affiliation_string":"MCSB program at University of California, Irvine, USA","institution_ids":[]},{"raw_affiliation_string":"Mathematics Department, University of California, Irvine, USA","institution_ids":["https://openalex.org/I204250578"]},{"raw_affiliation_string":"540F Rowland Hall, University of California Irvine, Irvine CA 92697, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5051160791"],"corresponding_institution_ids":["https://openalex.org/I204250578","https://openalex.org/I530967"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":0.6076,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.63965441,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"23","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9783999919891357,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/imputation","display_name":"Imputation (statistics)","score":0.6818258762359619},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6497368216514587},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.5994327068328857},{"id":"https://openalex.org/keywords/deconvolution","display_name":"Deconvolution","score":0.5352993607521057},{"id":"https://openalex.org/keywords/benchmarking","display_name":"Benchmarking","score":0.5270100831985474},{"id":"https://openalex.org/keywords/curse-of-dimensionality","display_name":"Curse of dimensionality","score":0.5136181712150574},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.5113903880119324},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.49710848927497864},{"id":"https://openalex.org/keywords/dimensionality-reduction","display_name":"Dimensionality reduction","score":0.46073171496391296},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4505942761898041},{"id":"https://openalex.org/keywords/embedding","display_name":"Embedding","score":0.43234890699386597},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3232734799385071},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.2729933261871338},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.2718631327152252},{"id":"https://openalex.org/keywords/missing-data","display_name":"Missing data","score":0.25594907999038696},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.23579731583595276},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.22973716259002686},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10678562521934509}],"concepts":[{"id":"https://openalex.org/C58041806","wikidata":"https://www.wikidata.org/wiki/Q1660484","display_name":"Imputation (statistics)","level":3,"score":0.6818258762359619},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6497368216514587},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.5994327068328857},{"id":"https://openalex.org/C174576160","wikidata":"https://www.wikidata.org/wiki/Q1183700","display_name":"Deconvolution","level":2,"score":0.5352993607521057},{"id":"https://openalex.org/C86251818","wikidata":"https://www.wikidata.org/wiki/Q816754","display_name":"Benchmarking","level":2,"score":0.5270100831985474},{"id":"https://openalex.org/C111030470","wikidata":"https://www.wikidata.org/wiki/Q1430460","display_name":"Curse of dimensionality","level":2,"score":0.5136181712150574},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.5113903880119324},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.49710848927497864},{"id":"https://openalex.org/C70518039","wikidata":"https://www.wikidata.org/wiki/Q16000077","display_name":"Dimensionality reduction","level":2,"score":0.46073171496391296},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4505942761898041},{"id":"https://openalex.org/C41608201","wikidata":"https://www.wikidata.org/wiki/Q980509","display_name":"Embedding","level":2,"score":0.43234890699386597},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3232734799385071},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.2729933261871338},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.2718631327152252},{"id":"https://openalex.org/C9357733","wikidata":"https://www.wikidata.org/wiki/Q6878417","display_name":"Missing data","level":2,"score":0.25594907999038696},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23579731583595276},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22973716259002686},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10678562521934509},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.0},{"id":"https://openalex.org/C162853370","wikidata":"https://www.wikidata.org/wiki/Q39809","display_name":"Marketing","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D035161","descriptor_name":"Bombacaceae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D035161","descriptor_name":"Bombacaceae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D035161","descriptor_name":"Bombacaceae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1093/bib/bbac223","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbac223","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:35709795","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35709795","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:ark:/13030/qt9pr012gv","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:escholarship.org:ark:/13030/qt9pr012gv","is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/9pr012gv","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Briefings in Bioinformatics, vol 23, iss 4","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9294432","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9294432","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9294432","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9294432","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1860401443","display_name":null,"funder_award_id":"MCB2028424","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G2111670686","display_name":null,"funder_award_id":"R01DE030565","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2318624699","display_name":null,"funder_award_id":"594598","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3205510348","display_name":null,"funder_award_id":"DMS1763272","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G4882129881","display_name":"MODULUS:RoL: Uncovering Roles of Cell Fate Decisions in Migrating Neural Crest Cells","funder_award_id":"2028424","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6840471226","display_name":null,"funder_award_id":"1763272","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G7313616998","display_name":null,"funder_award_id":"AR073159","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7371839055","display_name":null,"funder_award_id":"MCB2028424","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G848032724","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8673606761","display_name":null,"funder_award_id":"DMS1763272","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G92511650","display_name":null,"funder_award_id":"U01AR073159","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G986754019","display_name":null,"funder_award_id":"594598","funder_id":"https://openalex.org/F4320306164","funder_display_name":"Simons Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306164","display_name":"Simons Foundation","ror":"https://ror.org/01cmst727"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W1967327758","https://openalex.org/W1984883254","https://openalex.org/W1985987855","https://openalex.org/W2033642329","https://openalex.org/W2048252195","https://openalex.org/W2084385289","https://openalex.org/W2103972604","https://openalex.org/W2114104545","https://openalex.org/W2118077148","https://openalex.org/W2147730364","https://openalex.org/W2152692691","https://openalex.org/W2161643019","https://openalex.org/W2343956310","https://openalex.org/W2500090022","https://openalex.org/W2523620612","https://openalex.org/W2555892463","https://openalex.org/W2606066853","https://openalex.org/W2751468300","https://openalex.org/W2766437506","https://openalex.org/W2782251123","https://openalex.org/W2786672974","https://openalex.org/W2788908087","https://openalex.org/W2791058611","https://openalex.org/W2792693509","https://openalex.org/W2794891507","https://openalex.org/W2800392236","https://openalex.org/W2810495826","https://openalex.org/W2900411771","https://openalex.org/W2900510132","https://openalex.org/W2901677030","https://openalex.org/W2908317534","https://openalex.org/W2927507212","https://openalex.org/W2942862519","https://openalex.org/W2944189019","https://openalex.org/W2949067670","https://openalex.org/W2949148097","https://openalex.org/W2949237386","https://openalex.org/W2949471597","https://openalex.org/W2950372712","https://openalex.org/W2951217100","https://openalex.org/W2952240309","https://openalex.org/W2952303649","https://openalex.org/W2993244493","https://openalex.org/W2993894543","https://openalex.org/W2997280954","https://openalex.org/W3000010184","https://openalex.org/W3004833389","https://openalex.org/W3005127469","https://openalex.org/W3005233576","https://openalex.org/W3009609875","https://openalex.org/W3019556496","https://openalex.org/W3047141442","https://openalex.org/W3091601777","https://openalex.org/W3096486123","https://openalex.org/W3099404564","https://openalex.org/W3099810371","https://openalex.org/W3120767723","https://openalex.org/W3132661792","https://openalex.org/W3136741255","https://openalex.org/W3151543485","https://openalex.org/W3155546248","https://openalex.org/W3186021169","https://openalex.org/W3201535265","https://openalex.org/W3202248730","https://openalex.org/W4225981439","https://openalex.org/W4399639731","https://openalex.org/W6747751170","https://openalex.org/W6748816842","https://openalex.org/W6752411321","https://openalex.org/W6764340080"],"related_works":["https://openalex.org/W2726362583","https://openalex.org/W4297754234","https://openalex.org/W2167733911","https://openalex.org/W2989986177","https://openalex.org/W2087197267","https://openalex.org/W2535469297","https://openalex.org/W3211149772","https://openalex.org/W3169066860","https://openalex.org/W2073833922","https://openalex.org/W2040963032"],"abstract_inverted_index":{"Single-cell":[0],"RNA":[1],"sequencing":[2],"trades":[3],"read-depth":[4],"for":[5,34],"dimensionality,":[6],"often":[7],"leading":[8],"to":[9],"loss":[10],"of":[11,36,53,66,75,85],"critical":[12],"signaling":[13,77,105],"gene":[14,37],"information":[15],"that":[16,64],"is":[17],"typically":[18],"present":[19],"in":[20,39,100],"bulk":[21,92],"data":[22,60,93,110],"sets.":[23,61,111],"We":[24,62],"introduce":[25],"DURIAN":[26,54,67],"(Deconvolution":[27],"and":[28,50,58,73,103],"mUltitask-Regression-based":[29],"ImputAtioN),":[30],"an":[31],"integrative":[32],"method":[33,96],"recovery":[35,74],"expression":[38],"single-cell":[40,69,90,108],"data.":[41],"Through":[42],"systematic":[43],"benchmarking,":[44],"we":[45],"demonstrate":[46],"the":[47],"accuracy,":[48],"robustness":[49],"empirical":[51],"convergence":[52],"using":[55,89,107],"both":[56],"synthetic":[57],"published":[59],"show":[63],"use":[65],"improves":[68],"clustering,":[70],"low-dimensional":[71],"embedding,":[72],"intercellular":[76],"networks.":[78],"Our":[79],"study":[80],"resolves":[81],"several":[82],"inconsistent":[83],"results":[84],"cell-cell":[86],"communication":[87],"analysis":[88,106],"or":[91],"independently.":[94],"The":[95],"has":[97],"broad":[98],"application":[99],"biomarker":[101],"discovery":[102],"cell":[104],"transcriptomics":[109]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}