{"id":"https://openalex.org/W4282924213","doi":"https://doi.org/10.1093/bib/bbac152","title":"Differential performance of RoseTTAFold in antibody modeling","display_name":"Differential performance of RoseTTAFold in antibody modeling","publication_year":2022,"publication_date":"2022-05-02","ids":{"openalex":"https://openalex.org/W4282924213","doi":"https://doi.org/10.1093/bib/bbac152","pmid":"https://pubmed.ncbi.nlm.nih.gov/35598325"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbac152","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbac152","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9487640","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065118063","display_name":"Tianjian Liang","orcid":null},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I2799424032","display_name":"Discovery Institute","ror":"https://ror.org/05t8s3y29","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2799424032"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tianjian Liang","raw_affiliation_strings":["Department of Pharmaceutical Sciences , Computational Chemical Genomics Screening Center, and Pharmacometrics & System Pharmacology PharmacoAnalytics, School of Pharmacy; National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261 , USA","National Center of Excellence for Computational Drug Abuse Research","Drug Discovery Institute","Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences , Computational Chemical Genomics Screening Center, and Pharmacometrics & System Pharmacology PharmacoAnalytics, School of Pharmacy; National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261 , USA","institution_ids":["https://openalex.org/I2799424032","https://openalex.org/I170201317"]},{"raw_affiliation_string":"National Center of Excellence for Computational Drug Abuse Research","institution_ids":[]},{"raw_affiliation_string":"Drug Discovery Institute","institution_ids":["https://openalex.org/I2799424032"]},{"raw_affiliation_string":"Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100612949","display_name":"Chen Jiang","orcid":"https://orcid.org/0000-0001-8336-6814"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I2799424032","display_name":"Discovery Institute","ror":"https://ror.org/05t8s3y29","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2799424032"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chen Jiang","raw_affiliation_strings":["Department of Pharmaceutical Sciences , Computational Chemical Genomics Screening Center, and Pharmacometrics & System Pharmacology PharmacoAnalytics, School of Pharmacy; National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261 , USA","Drug Discovery Institute","Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA","National Center of Excellence for Computational Drug Abuse Research"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences , Computational Chemical Genomics Screening Center, and Pharmacometrics & System Pharmacology PharmacoAnalytics, School of Pharmacy; National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261 , USA","institution_ids":["https://openalex.org/I2799424032","https://openalex.org/I170201317"]},{"raw_affiliation_string":"Drug Discovery Institute","institution_ids":["https://openalex.org/I2799424032"]},{"raw_affiliation_string":"Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"National Center of Excellence for Computational Drug Abuse Research","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067607368","display_name":"Jiayi Yuan","orcid":"https://orcid.org/0009-0007-0121-4990"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I2799424032","display_name":"Discovery Institute","ror":"https://ror.org/05t8s3y29","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2799424032"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jiayi Yuan","raw_affiliation_strings":["Department of Pharmaceutical Sciences , Computational Chemical Genomics Screening Center, and Pharmacometrics & System Pharmacology PharmacoAnalytics, School of Pharmacy; National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261 , USA","National Center of Excellence for Computational Drug Abuse Research","Drug Discovery Institute","Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences , Computational Chemical Genomics Screening Center, and Pharmacometrics & System Pharmacology PharmacoAnalytics, School of Pharmacy; National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261 , USA","institution_ids":["https://openalex.org/I2799424032","https://openalex.org/I170201317"]},{"raw_affiliation_string":"National Center of Excellence for Computational Drug Abuse Research","institution_ids":[]},{"raw_affiliation_string":"Drug Discovery Institute","institution_ids":["https://openalex.org/I2799424032"]},{"raw_affiliation_string":"Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007622097","display_name":"Rofina Yasmin Othman","orcid":"https://orcid.org/0000-0003-4932-9889"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I2799424032","display_name":"Discovery Institute","ror":"https://ror.org/05t8s3y29","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2799424032"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yasmin Othman","raw_affiliation_strings":["Department of Pharmaceutical Sciences , Computational Chemical Genomics Screening Center, and Pharmacometrics & System Pharmacology PharmacoAnalytics, School of Pharmacy; National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261 , USA","Drug Discovery Institute","National Center of Excellence for Computational Drug Abuse Research","Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences , Computational Chemical Genomics Screening Center, and Pharmacometrics & System Pharmacology PharmacoAnalytics, School of Pharmacy; National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261 , USA","institution_ids":["https://openalex.org/I2799424032","https://openalex.org/I170201317"]},{"raw_affiliation_string":"Drug Discovery Institute","institution_ids":["https://openalex.org/I2799424032"]},{"raw_affiliation_string":"National Center of Excellence for Computational Drug Abuse Research","institution_ids":[]},{"raw_affiliation_string":"Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA","institution_ids":["https://openalex.org/I170201317"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028011485","display_name":"Xiang\u2010Qun Xie","orcid":"https://orcid.org/0000-0002-6881-6175"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I2799424032","display_name":"Discovery Institute","ror":"https://ror.org/05t8s3y29","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2799424032"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xiang-Qun Xie","raw_affiliation_strings":["Department of Pharmaceutical Sciences , Computational Chemical Genomics Screening Center, and Pharmacometrics & System Pharmacology PharmacoAnalytics, School of Pharmacy; National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261 , USA","National Center of Excellence for Computational Drug Abuse Research","Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA","Drug Discovery Institute"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences , Computational Chemical Genomics Screening Center, and Pharmacometrics & System Pharmacology PharmacoAnalytics, School of Pharmacy; National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261 , USA","institution_ids":["https://openalex.org/I2799424032","https://openalex.org/I170201317"]},{"raw_affiliation_string":"National Center of Excellence for Computational Drug Abuse Research","institution_ids":[]},{"raw_affiliation_string":"Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Drug Discovery Institute","institution_ids":["https://openalex.org/I2799424032"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076924374","display_name":"Zhiwei Feng","orcid":"https://orcid.org/0000-0001-6533-8932"},"institutions":[{"id":"https://openalex.org/I170201317","display_name":"University of Pittsburgh","ror":"https://ror.org/01an3r305","country_code":"US","type":"education","lineage":["https://openalex.org/I170201317"]},{"id":"https://openalex.org/I2799424032","display_name":"Discovery Institute","ror":"https://ror.org/05t8s3y29","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2799424032"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhiwei Feng","raw_affiliation_strings":["Department of Pharmaceutical Sciences , Computational Chemical Genomics Screening Center, and Pharmacometrics & System Pharmacology PharmacoAnalytics, School of Pharmacy; National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261 , USA","National Center of Excellence for Computational Drug Abuse Research","Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA","Drug Discovery Institute"],"raw_orcid":"https://orcid.org/0000-0001-6533-8932","affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences , Computational Chemical Genomics Screening Center, and Pharmacometrics & System Pharmacology PharmacoAnalytics, School of Pharmacy; National Center of Excellence for Computational Drug Abuse Research; Drug Discovery Institute; Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261 , USA","institution_ids":["https://openalex.org/I2799424032","https://openalex.org/I170201317"]},{"raw_affiliation_string":"National Center of Excellence for Computational Drug Abuse Research","institution_ids":[]},{"raw_affiliation_string":"Departments of Computational Biology and Structural Biology, School of Medicine, University of Pittsburgh, Pittsburgh, PA 15261, USA","institution_ids":["https://openalex.org/I170201317"]},{"raw_affiliation_string":"Drug Discovery Institute","institution_ids":["https://openalex.org/I2799424032"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5028011485","https://openalex.org/A5076924374"],"corresponding_institution_ids":["https://openalex.org/I170201317","https://openalex.org/I2799424032"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":5.4864,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.96543466,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"23","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7392529845237732},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.5454363226890564},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.46594178676605225},{"id":"https://openalex.org/keywords/core","display_name":"Core (optical fiber)","score":0.4407123029232025},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.3523895740509033},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.3445313274860382},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3307586908340454}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7392529845237732},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.5454363226890564},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.46594178676605225},{"id":"https://openalex.org/C2164484","wikidata":"https://www.wikidata.org/wiki/Q5170150","display_name":"Core (optical fiber)","level":2,"score":0.4407123029232025},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3523895740509033},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.3445313274860382},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3307586908340454},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D022801","descriptor_name":"Complementarity Determining Regions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022801","descriptor_name":"Complementarity Determining Regions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D022801","descriptor_name":"Complementarity Determining Regions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbac152","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbac152","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:35598325","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35598325","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:9487640","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9487640","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:9487640","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9487640","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2408914377","display_name":null,"funder_award_id":"P30 DA035778A1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G3588330604","display_name":null,"funder_award_id":"R01DA052329","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":30,"referenced_works":["https://openalex.org/W1724277458","https://openalex.org/W1913949000","https://openalex.org/W1982679430","https://openalex.org/W2006197769","https://openalex.org/W2012966511","https://openalex.org/W2025965594","https://openalex.org/W2051210555","https://openalex.org/W2071200955","https://openalex.org/W2105321472","https://openalex.org/W2110505462","https://openalex.org/W2132629607","https://openalex.org/W2137986227","https://openalex.org/W2162210398","https://openalex.org/W2162561057","https://openalex.org/W2167980959","https://openalex.org/W2474661075","https://openalex.org/W2483554280","https://openalex.org/W2804822363","https://openalex.org/W2972411752","https://openalex.org/W2999958881","https://openalex.org/W3092754129","https://openalex.org/W3128461460","https://openalex.org/W3138783506","https://openalex.org/W3177828909","https://openalex.org/W3186179742","https://openalex.org/W3198923619","https://openalex.org/W3199180046","https://openalex.org/W3207520855","https://openalex.org/W4206310348","https://openalex.org/W4211196614"],"related_works":["https://openalex.org/W2051487156","https://openalex.org/W2073681303","https://openalex.org/W2544423928","https://openalex.org/W2053286651","https://openalex.org/W2181743346","https://openalex.org/W2187401768","https://openalex.org/W4288089942","https://openalex.org/W2095530470","https://openalex.org/W2081981665","https://openalex.org/W1543591978"],"abstract_inverted_index":{"Antibodies":[0],"are":[1,55],"essential":[2],"to":[3,98,141,206,223],"life,":[4],"and":[5,95,168,203,213],"knowing":[6],"their":[7,100],"structures":[8,50,72,163,177],"can":[9],"facilitate":[10],"the":[11,31,48,70,77,86,92,106,149,162,188,211,217,225],"understanding":[12],"of":[13,33,73,81,88,113,178,216,227],"antibody-antigen":[14],"recognition":[15],"mechanisms.":[16],"Precise":[17],"antibody":[18,78,229],"structure":[19],"prediction":[20],"has":[21,64],"been":[22],"a":[23,27,60,116,152],"core":[24],"challenge":[25],"for":[26,52,197],"prolonged":[28],"period,":[29],"especially":[30,46,148],"accuracy":[32,182,196,226],"H3":[34,199],"loop":[35,200],"prediction.":[36],"Despite":[37],"recent":[38],"progress,":[39],"existing":[40],"methods":[41,54],"cannot":[42],"achieve":[43,138],"atomic":[44],"accuracy,":[45],"when":[47],"homologous":[49],"required":[51],"these":[53],"not":[56,184],"available.":[57],"Recently,":[58],"RoseTTAFold,":[59,82,166,219],"deep":[61],"learning-based":[62],"algorithm,":[63],"shown":[65],"remarkable":[66],"breakthroughs":[67],"in":[68,115,119,143],"predicting":[69],"3D":[71,101,176],"proteins.":[74],"To":[75],"assess":[76],"modeling":[79,144,198],"ability":[80],"we":[83,121,159,209],"first":[84],"retrieved":[85],"sequences":[87],"30":[89],"antibodies":[90],"as":[91,185,187],"test":[93],"set":[94],"used":[96],"RoseTTAFold":[97,110,136,172,193],"model":[99],"structures.":[102],"We":[103],"then":[104],"compared":[105,161],"models":[107],"constructed":[108],"by":[109,165],"with":[111,151],"those":[112],"SWISS-MODEL":[114,142,167],"different":[117,130],"way,":[118],"which":[120,220],"stratified":[122],"Global":[123],"Model":[124],"Quality":[125],"Estimate":[126],"(GMQE)":[127],"into":[128],"three":[129],"ranges.":[131],"The":[132],"results":[133,139],"indicated":[134],"that":[135],"could":[137,173],"similar":[140],"most":[145],"CDR":[146],"loops,":[147],"templates":[150],"GMQE":[153],"score":[154],"under":[155],"0.8.":[156],"In":[157,170],"addition,":[158],"also":[160],"modeled":[164],"ABodyBuilder.":[169],"brief,":[171],"accurately":[174],"predict":[175],"antibodies,":[179],"but":[180],"its":[181],"was":[183,204],"good":[186],"other":[189],"two":[190],"methods.":[191],"However,":[192],"exhibited":[194],"better":[195],"than":[201],"ABodyBuilder":[202],"comparable":[205],"SWISS-MODEL.":[207],"Finally,":[208],"discussed":[210],"limitations":[212],"potential":[214],"improvements":[215],"current":[218],"may":[221],"help":[222],"further":[224],"RoseTTAFold's":[228],"modeling.":[230]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}