{"id":"https://openalex.org/W4224325634","doi":"https://doi.org/10.1093/bib/bbac137","title":"Feature aggregation graph convolutional network based on imaging genetic data for diagnosis and pathogeny identification of Alzheimer\u2019s disease","display_name":"Feature aggregation graph convolutional network based on imaging genetic data for diagnosis and pathogeny identification of Alzheimer\u2019s disease","publication_year":2022,"publication_date":"2022-04-14","ids":{"openalex":"https://openalex.org/W4224325634","doi":"https://doi.org/10.1093/bib/bbac137","pmid":"https://pubmed.ncbi.nlm.nih.gov/35453149"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbac137","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbac137","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5048824835","display_name":"Xia-an Bi","orcid":"https://orcid.org/0000-0002-2715-3360"},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xia-an Bi","raw_affiliation_strings":["Hunan Provincial Key Laboratory of Intelligent Computing and Language Information Processing, and the College of Information Science and Engineering in Hunan Normal University, P.R. China"],"raw_orcid":"https://orcid.org/0000-0002-2715-3360","affiliations":[{"raw_affiliation_string":"Hunan Provincial Key Laboratory of Intelligent Computing and Language Information Processing, and the College of Information Science and Engineering in Hunan Normal University, P.R. China","institution_ids":["https://openalex.org/I173759888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016469915","display_name":"Wenyan Zhou","orcid":null},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]},{"id":"https://openalex.org/I3130607311","display_name":"Changsha Normal University","ror":"https://ror.org/02sqk3z62","country_code":"CN","type":"education","lineage":["https://openalex.org/I3130607311"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenyan Zhou","raw_affiliation_strings":["College of Information Science and Engineering, Hunan Normal University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information Science and Engineering, Hunan Normal University, Changsha, China","institution_ids":["https://openalex.org/I3130607311","https://openalex.org/I173759888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074197949","display_name":"Sheng Luo","orcid":"https://orcid.org/0000-0003-4214-5809"},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]},{"id":"https://openalex.org/I3130607311","display_name":"Changsha Normal University","ror":"https://ror.org/02sqk3z62","country_code":"CN","type":"education","lineage":["https://openalex.org/I3130607311"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sheng Luo","raw_affiliation_strings":["College of Information Science and Engineering, Hunan Normal University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information Science and Engineering, Hunan Normal University, Changsha, China","institution_ids":["https://openalex.org/I3130607311","https://openalex.org/I173759888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066783567","display_name":"Yuhua Mao","orcid":null},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]},{"id":"https://openalex.org/I3130607311","display_name":"Changsha Normal University","ror":"https://ror.org/02sqk3z62","country_code":"CN","type":"education","lineage":["https://openalex.org/I3130607311"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuhua Mao","raw_affiliation_strings":["College of Information Science and Engineering, Hunan Normal University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information Science and Engineering, Hunan Normal University, Changsha, China","institution_ids":["https://openalex.org/I3130607311","https://openalex.org/I173759888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101909547","display_name":"Xi Hu","orcid":"https://orcid.org/0000-0002-8794-5386"},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]},{"id":"https://openalex.org/I3130607311","display_name":"Changsha Normal University","ror":"https://ror.org/02sqk3z62","country_code":"CN","type":"education","lineage":["https://openalex.org/I3130607311"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Hu","raw_affiliation_strings":["College of Information Science and Engineering, Hunan Normal University, Changsha, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Information Science and Engineering, Hunan Normal University, Changsha, China","institution_ids":["https://openalex.org/I3130607311","https://openalex.org/I173759888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104110400","display_name":"Bin Zeng","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Bin Zeng","raw_affiliation_strings":["Hunan Youdao Information Technology Co., Ltd, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hunan Youdao Information Technology Co., Ltd, P.R. China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068761975","display_name":"Luyun Xu","orcid":"https://orcid.org/0000-0002-9889-7914"},"institutions":[{"id":"https://openalex.org/I173759888","display_name":"Hunan Normal University","ror":"https://ror.org/053w1zy07","country_code":"CN","type":"education","lineage":["https://openalex.org/I173759888"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Luyun Xu","raw_affiliation_strings":["College of Business in Hunan Normal University, P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Business in Hunan Normal University, P.R. China","institution_ids":["https://openalex.org/I173759888"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5048824835","https://openalex.org/A5068761975","https://openalex.org/A5104110400"],"corresponding_institution_ids":["https://openalex.org/I173759888"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":1.9963,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.86873417,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"23","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9882000088691711,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7106528282165527},{"id":"https://openalex.org/keywords/adjacency-matrix","display_name":"Adjacency matrix","score":0.6181750893592834},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.5684791803359985},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5610165596008301},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.5230773091316223},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.4932986795902252},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.48868563771247864},{"id":"https://openalex.org/keywords/correlation","display_name":"Correlation","score":0.4708910584449768},{"id":"https://openalex.org/keywords/node","display_name":"Node (physics)","score":0.46125730872154236},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.18221810460090637},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.09712722897529602}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7106528282165527},{"id":"https://openalex.org/C180356752","wikidata":"https://www.wikidata.org/wiki/Q727035","display_name":"Adjacency matrix","level":3,"score":0.6181750893592834},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.5684791803359985},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5610165596008301},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.5230773091316223},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.4932986795902252},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.48868563771247864},{"id":"https://openalex.org/C117220453","wikidata":"https://www.wikidata.org/wiki/Q5172842","display_name":"Correlation","level":2,"score":0.4708910584449768},{"id":"https://openalex.org/C62611344","wikidata":"https://www.wikidata.org/wiki/Q1062658","display_name":"Node (physics)","level":2,"score":0.46125730872154236},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.18221810460090637},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.09712722897529602},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C66938386","wikidata":"https://www.wikidata.org/wiki/Q633538","display_name":"Structural engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D003952","descriptor_name":"Diagnostic Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003952","descriptor_name":"Diagnostic Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003952","descriptor_name":"Diagnostic Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbac137","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbac137","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:35453149","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35453149","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1724174098","display_name":null,"funder_award_id":"2018TP1018","funder_id":"https://openalex.org/F4320330206","funder_display_name":"Science and Technology Program of Hunan Province"},{"id":"https://openalex.org/G4131278076","display_name":null,"funder_award_id":"2020YFB2104400","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G5456525320","display_name":null,"funder_award_id":"DSIE202101","funder_id":"https://openalex.org/F4320327296","funder_display_name":"Ministry of Education \u2013 Kingdom of Saudi Arabi"},{"id":"https://openalex.org/G6502659134","display_name":null,"funder_award_id":"62072173","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7326657094","display_name":null,"funder_award_id":"2020JJ4432","funder_id":"https://openalex.org/F4320322866","funder_display_name":"Natural Science Foundation of Hainan Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322866","display_name":"Natural Science Foundation of Hainan Province","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320327296","display_name":"Ministry of Education \u2013 Kingdom of Saudi Arabi","ror":null},{"id":"https://openalex.org/F4320330206","display_name":"Science and Technology Program of Hunan Province","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":43,"referenced_works":["https://openalex.org/W2174832892","https://openalex.org/W2302574298","https://openalex.org/W2500004684","https://openalex.org/W2592238465","https://openalex.org/W2607528709","https://openalex.org/W2726010443","https://openalex.org/W2740893736","https://openalex.org/W2761181345","https://openalex.org/W2769257896","https://openalex.org/W2771127066","https://openalex.org/W2793357333","https://openalex.org/W2891516347","https://openalex.org/W2903278034","https://openalex.org/W2903507433","https://openalex.org/W2908040982","https://openalex.org/W2909568441","https://openalex.org/W2933339796","https://openalex.org/W2977419935","https://openalex.org/W2981772245","https://openalex.org/W2982638646","https://openalex.org/W2985331920","https://openalex.org/W2988333851","https://openalex.org/W2989237197","https://openalex.org/W2991909137","https://openalex.org/W3000666672","https://openalex.org/W3002127012","https://openalex.org/W3005732541","https://openalex.org/W3006561196","https://openalex.org/W3007878073","https://openalex.org/W3011237672","https://openalex.org/W3021014884","https://openalex.org/W3021433360","https://openalex.org/W3033333221","https://openalex.org/W3036591144","https://openalex.org/W3036900661","https://openalex.org/W3082072206","https://openalex.org/W3093304720","https://openalex.org/W3111341622","https://openalex.org/W3112328469","https://openalex.org/W3122159847","https://openalex.org/W3157129463","https://openalex.org/W3165470999","https://openalex.org/W3181989651"],"related_works":["https://openalex.org/W4293226380","https://openalex.org/W4313906399","https://openalex.org/W4321487865","https://openalex.org/W2811106690","https://openalex.org/W4239306820","https://openalex.org/W2947043951","https://openalex.org/W2049983311","https://openalex.org/W2219512485","https://openalex.org/W4293665714","https://openalex.org/W1977633309"],"abstract_inverted_index":{"The":[0],"roles":[1],"of":[2,12,26,31,47,117,168],"brain":[3,55,65,133,156],"regions":[4,56,134,157],"activities":[5],"and":[6,28,57,80,108,129,135,150,153,158,162],"gene":[7],"expressions":[8],"in":[9,63],"the":[10,24,44,52,82,87,94,97,131,140,144,166],"development":[11,45],"Alzheimer's":[13],"disease":[14],"(AD)":[15],"remain":[16],"unclear.":[17],"Existing":[18],"imaging":[19],"genetic":[20],"studies":[21],"usually":[22],"has":[23],"problem":[25],"inefficiency":[27],"inadequate":[29],"fusion":[30],"data.":[32],"This":[33],"study":[34],"proposes":[35],"a":[36,64,71,101,122],"novel":[37],"deep":[38],"learning":[39],"method":[40],"to":[41,78,113,127,139],"efficiently":[42],"capture":[43],"pattern":[46],"AD.":[48],"First,":[49],"we":[50,69,92,120],"model":[51],"interaction":[53],"between":[54],"genes":[58],"as":[59],"node-to-node":[60],"feature":[61,72],"aggregation":[62,73],"region-gene":[66],"network.":[67],"Second,":[68],"propose":[70],"graph":[74,89,125],"convolutional":[75,90],"network":[76],"(FAGCN)":[77],"transmit":[79],"update":[81],"node":[83],"feature.":[84],"Compared":[85],"with":[86,100],"trivial":[88],"procedure,":[91],"replace":[93],"input":[95],"from":[96],"adjacency":[98],"matrix":[99,103],"weight":[102],"based":[104],"on":[105],"correlation":[106],"analysis":[107],"consider":[109],"common":[110],"neighbor":[111],"similarity":[112],"discover":[114],"broader":[115],"associations":[116],"nodes.":[118],"Finally,":[119],"use":[121],"full-gradient":[123],"saliency":[124],"mechanism":[126],"score":[128],"extract":[130],"pathogenetic":[132],"risk":[136],"genes.":[137],"According":[138],"results,":[141],"FAGCN":[142],"achieved":[143],"best":[145],"performance":[146],"among":[147],"both":[148],"traditional":[149],"cutting-edge":[151],"methods":[152],"extracted":[154],"AD-related":[155],"genes,":[159],"providing":[160],"theoretical":[161],"methodological":[163],"support":[164],"for":[165],"research":[167],"related":[169],"diseases.":[170]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}