{"id":"https://openalex.org/W4213072567","doi":"https://doi.org/10.1093/bib/bbac064","title":"Revealing the contribution of somatic gene mutations to shaping tumor immune microenvironment","display_name":"Revealing the contribution of somatic gene mutations to shaping tumor immune microenvironment","publication_year":2022,"publication_date":"2022-02-15","ids":{"openalex":"https://openalex.org/W4213072567","doi":"https://doi.org/10.1093/bib/bbac064","pmid":"https://pubmed.ncbi.nlm.nih.gov/35229870"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbac064","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbac064","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077066907","display_name":"Liwen Xu","orcid":"https://orcid.org/0000-0001-7986-5928"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liwen Xu","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113920071","display_name":"Shiwei Zhu","orcid":null},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shiwei Zhu","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091564301","display_name":"Yujia Lan","orcid":"https://orcid.org/0000-0002-8107-9181"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yujia Lan","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China"],"raw_orcid":"https://orcid.org/0000-0002-8107-9181","affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056443419","display_name":"Min Yan","orcid":"https://orcid.org/0000-0002-3911-748X"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Yan","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112844894","display_name":"Z. X. Jiang","orcid":null},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zedong Jiang","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101878654","display_name":"Jiali Zhu","orcid":"https://orcid.org/0000-0003-1541-3193"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiali Zhu","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032010689","display_name":"Gaoming Liao","orcid":null},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Gaoming Liao","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003264203","display_name":"Yanyan Ping","orcid":"https://orcid.org/0000-0002-1810-1200"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanyan Ping","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China"],"raw_orcid":"https://orcid.org/0000-0002-1810-1200","affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113033420","display_name":"Jinyuan Xu","orcid":null},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jinyuan Xu","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101665428","display_name":"Bo Pang","orcid":"https://orcid.org/0000-0002-0323-5484"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bo Pang","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013653265","display_name":"Yunpeng Zhang","orcid":"https://orcid.org/0000-0002-3709-3656"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yunpeng Zhang","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China","Key Laboratory of High Throughput Omics Big Data for Cold Region\u2019s Major Diseases in Heilongjiang Province, Harbin, Heilongjiang 150081, China","Key Laboratory of High Throughput Omics Big Data for Cold Region's Major Diseases in Heilongjiang Province, Harbin, Heilongjiang 150081, China"],"raw_orcid":"https://orcid.org/0000-0002-3709-3656","affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Key Laboratory of High Throughput Omics Big Data for Cold Region\u2019s Major Diseases in Heilongjiang Province, Harbin, Heilongjiang 150081, China","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of High Throughput Omics Big Data for Cold Region's Major Diseases in Heilongjiang Province, Harbin, Heilongjiang 150081, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003301022","display_name":"Yun Xiao","orcid":"https://orcid.org/0000-0003-0785-3957"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yun Xiao","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China","Key Laboratory of High Throughput Omics Big Data for Cold Region\u2019s Major Diseases in Heilongjiang Province, Harbin, Heilongjiang 150081, China","Key Laboratory of High Throughput Omics Big Data for Cold Region's Major Diseases in Heilongjiang Province, Harbin, Heilongjiang 150081, China"],"raw_orcid":"https://orcid.org/0000-0003-0785-3957","affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Key Laboratory of High Throughput Omics Big Data for Cold Region\u2019s Major Diseases in Heilongjiang Province, Harbin, Heilongjiang 150081, China","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of High Throughput Omics Big Data for Cold Region's Major Diseases in Heilongjiang Province, Harbin, Heilongjiang 150081, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100445596","display_name":"Xia Li","orcid":"https://orcid.org/0000-0002-9794-2648"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xia Li","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China","Key Laboratory of High Throughput Omics Big Data for Cold Region\u2019s Major Diseases in Heilongjiang Province, Harbin, Heilongjiang 150081, China","Key Laboratory of High Throughput Omics Big Data for Cold Region's Major Diseases in Heilongjiang Province, Harbin, Heilongjiang 150081, China"],"raw_orcid":"https://orcid.org/0000-0002-9794-2648","affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, Heilongjiang 150081, China","institution_ids":["https://openalex.org/I156144747"]},{"raw_affiliation_string":"Key Laboratory of High Throughput Omics Big Data for Cold Region\u2019s Major Diseases in Heilongjiang Province, Harbin, Heilongjiang 150081, China","institution_ids":[]},{"raw_affiliation_string":"Key Laboratory of High Throughput Omics Big Data for Cold Region's Major Diseases in Heilongjiang Province, Harbin, Heilongjiang 150081, China","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5003301022","https://openalex.org/A5013653265","https://openalex.org/A5100445596"],"corresponding_institution_ids":["https://openalex.org/I156144747"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":0.9488,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.71319642,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"23","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.7519305944442749},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.666964054107666},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"Tumor microenvironment","score":0.6546914577484131},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"Immunotherapy","score":0.6506838202476501},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"Cancer immunotherapy","score":0.49610623717308044},{"id":"https://openalex.org/keywords/cd8","display_name":"CD8","score":0.4881344735622406},{"id":"https://openalex.org/keywords/somatic-cell","display_name":"Somatic cell","score":0.4814457297325134},{"id":"https://openalex.org/keywords/immunophenotyping","display_name":"Immunophenotyping","score":0.42149507999420166},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.40777117013931274},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.37691089510917664},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.324552059173584},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.30454298853874207},{"id":"https://openalex.org/keywords/antigen","display_name":"Antigen","score":0.0942162275314331}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7519305944442749},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.666964054107666},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.6546914577484131},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6506838202476501},{"id":"https://openalex.org/C2780674031","wikidata":"https://www.wikidata.org/wiki/Q2012719","display_name":"Cancer immunotherapy","level":4,"score":0.49610623717308044},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4881344735622406},{"id":"https://openalex.org/C134305767","wikidata":"https://www.wikidata.org/wiki/Q725508","display_name":"Somatic cell","level":3,"score":0.4814457297325134},{"id":"https://openalex.org/C196166836","wikidata":"https://www.wikidata.org/wiki/Q902926","display_name":"Immunophenotyping","level":3,"score":0.42149507999420166},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40777117013931274},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37691089510917664},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.324552059173584},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.30454298853874207},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.0942162275314331}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007167","descriptor_name":"Immunotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018414","descriptor_name":"CD8-Positive T-Lymphocytes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbac064","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbac064","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:35229870","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35229870","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.6600000262260437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1916424752","display_name":null,"funder_award_id":"UNPYSCT-2017059","funder_id":"https://openalex.org/F4320327728","funder_display_name":"University Nursing Program for Young Scholar with Creative Talents in Heilongjiang Province"},{"id":"https://openalex.org/G301173526","display_name":null,"funder_award_id":"31871336","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3119901894","display_name":null,"funder_award_id":"LBH-Q18099","funder_id":"https://openalex.org/F4320326178","funder_display_name":"Heilongjiang Provincial Postdoctoral Science Foundation"},{"id":"https://openalex.org/G5193609024","display_name":"\u91cd\u5927\u75be\u75c5\u57fa\u56e0\u7ec4\u4e0e\u8868\u89c2\u7ec4\u6539\u53d8\u9a71\u52a8\u7684\u975e\u7f16\u7801RNA(miRNA/lncRNA)\u8c03\u63a7\u673a\u5236\u53ca\u5176\u529f\u80fd\u7814\u7a76","funder_award_id":"61873075","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5253273320","display_name":null,"funder_award_id":"32070673","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7819028244","display_name":null,"funder_award_id":"2018YFC2000100","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320326178","display_name":"Heilongjiang Provincial Postdoctoral Science Foundation","ror":null},{"id":"https://openalex.org/F4320327728","display_name":"University Nursing Program for Young Scholar with Creative Talents in Heilongjiang Province","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":73,"referenced_works":["https://openalex.org/W1498673086","https://openalex.org/W1750541350","https://openalex.org/W1910950086","https://openalex.org/W1985987855","https://openalex.org/W1994993231","https://openalex.org/W1998683957","https://openalex.org/W2024384252","https://openalex.org/W2028433016","https://openalex.org/W2055874017","https://openalex.org/W2061030201","https://openalex.org/W2068833065","https://openalex.org/W2102212449","https://openalex.org/W2102767758","https://openalex.org/W2103017472","https://openalex.org/W2123879591","https://openalex.org/W2123918574","https://openalex.org/W2130410032","https://openalex.org/W2130430382","https://openalex.org/W2138039462","https://openalex.org/W2146810078","https://openalex.org/W2162218188","https://openalex.org/W2184331293","https://openalex.org/W2201379305","https://openalex.org/W2232693424","https://openalex.org/W2256481109","https://openalex.org/W2273119405","https://openalex.org/W2275337389","https://openalex.org/W2338576144","https://openalex.org/W2398131194","https://openalex.org/W2419558864","https://openalex.org/W2465860350","https://openalex.org/W2469758901","https://openalex.org/W2518194013","https://openalex.org/W2544109448","https://openalex.org/W2559261911","https://openalex.org/W2599766640","https://openalex.org/W2606235134","https://openalex.org/W2622499649","https://openalex.org/W2782949806","https://openalex.org/W2790362775","https://openalex.org/W2796408191","https://openalex.org/W2804812017","https://openalex.org/W2884910323","https://openalex.org/W2886498337","https://openalex.org/W2888172308","https://openalex.org/W2891349395","https://openalex.org/W2894573839","https://openalex.org/W2899828884","https://openalex.org/W2909312563","https://openalex.org/W2915993617","https://openalex.org/W2923548794","https://openalex.org/W2949273159","https://openalex.org/W2957861560","https://openalex.org/W2999414916","https://openalex.org/W2999626196","https://openalex.org/W3004318979","https://openalex.org/W3005186000","https://openalex.org/W3007280090","https://openalex.org/W3007391700","https://openalex.org/W3023967107","https://openalex.org/W3037705365","https://openalex.org/W3041438702","https://openalex.org/W3047463220","https://openalex.org/W3078555423","https://openalex.org/W3095726304","https://openalex.org/W3097333495","https://openalex.org/W3110799778","https://openalex.org/W3207277076","https://openalex.org/W4200468913","https://openalex.org/W4294216483","https://openalex.org/W6746306740","https://openalex.org/W6759160571","https://openalex.org/W6780475837"],"related_works":["https://openalex.org/W2351421699","https://openalex.org/W2352602170","https://openalex.org/W2416775870","https://openalex.org/W2412817844","https://openalex.org/W2999918831","https://openalex.org/W947015185","https://openalex.org/W2625303092","https://openalex.org/W2902626376","https://openalex.org/W3095731313","https://openalex.org/W3129646946"],"abstract_inverted_index":{"Interaction":[0],"between":[1,57],"tumor":[2,40,63,200,245],"cells":[3,6,64,189,219],"and":[4,43,60,69,124,176],"immune":[5,41,67,150,184,187,201,246],"determined":[7],"highly":[8],"heterogeneous":[9],"microenvironments":[10],"across":[11,153],"patients,":[12],"leading":[13],"to":[14,29,35,51,115,137,197,233],"substantial":[15],"variation":[16],"in":[17,110,127,242],"clinical":[18,73,222],"benefits":[19],"from":[20,156],"immunotherapy.":[21,225],"Somatic":[22],"gene":[23,58,96,122,143,164,192,210,240],"mutations":[24,59,144,165,193,211,241],"were":[25],"found":[26],"not":[27],"only":[28],"elicit":[30],"adaptive":[31],"immunity":[32],"but":[33],"also":[34,178],"influence":[36,140],"the":[37,66,72,104,118,139,146,206,221,236,244],"composition":[38],"of":[39,46,55,75,89,141,148,168,209,224,238],"microenvironment":[42,68],"various":[44],"processes":[45],"antitumor":[47],"immunity.":[48],"However,":[49],"due":[50],"an":[52],"incomplete":[53],"view":[54],"associations":[56],"immunophenotypes,":[61],"how":[62],"shape":[65],"further":[70,130],"determine":[71],"benefit":[74,223],"immunotherapy":[76],"is":[77],"still":[78],"unclear.":[79],"To":[80],"address":[81],"this,":[82],"we":[83,204,228],"proposed":[84],"a":[85,230],"computational":[86,231],"approach,":[87],"inference":[88],"mutation":[90],"effect":[91],"on":[92,145,182],"immunophenotype":[93],"by":[94],"integrated":[95],"set":[97],"enrichment":[98],"analysis":[99],"(MEIGSEA),":[100],"for":[101,108,220],"tracing":[102],"back":[103],"genomic":[105],"factor":[106],"responsible":[107],"differences":[109],"immunophenotypes.":[111],"MEIGSEA":[112,136],"was":[113],"demonstrated":[114],"accurately":[116],"identify":[117],"previous":[119],"confirmed":[120],"immune-associated":[121],"mutations,":[123],"systematic":[125],"evaluation":[126],"simulation":[128],"data":[129],"supported":[131],"its":[132],"performance.":[133],"We":[134],"used":[135],"investigate":[138],"driver":[142],"infiltration":[147,167],"22":[149],"cell":[151],"types":[152],"19":[154],"cancers":[155],"The":[157,161],"Cancer":[158],"Genome":[159],"Atlas.":[160],"top":[162],"associated":[163,215],"with":[166,216],"CD8":[169,217],"T":[170,218],"cells,":[171],"such":[172],"as":[173],"CASP8,":[174],"KRAS":[175],"EGFR,":[177],"showed":[179],"extensive":[180],"impact":[181],"other":[183],"components;":[185],"meanwhile,":[186],"effector":[188],"shared":[190],"critical":[191],"that":[194,212],"collaboratively":[195],"contribute":[196],"shaping":[198,243],"distinct":[199],"microenvironment.":[202,247],"Furthermore,":[203],"highlighted":[205],"predictive":[207],"capacity":[208],"are":[213],"positively":[214],"Taken":[226],"together,":[227],"present":[229],"framework":[232],"help":[234],"illustrate":[235],"potential":[237],"somatic":[239]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
