{"id":"https://openalex.org/W35183062","doi":"https://doi.org/10.1093/bib/bbac028","title":"GARDENING ON THE ROCK","display_name":"GARDENING ON THE ROCK","publication_year":2005,"publication_date":"2005-01-01","ids":{"openalex":"https://openalex.org/W35183062","doi":"https://doi.org/10.1093/bib/bbac028","mag":"35183062"},"language":"en","primary_location":{"id":"mag:35183062","is_oa":false,"landing_page_url":"https://dialnet.unirioja.es/servlet/articulo?codigo=1260795","pdf_url":null,"source":{"id":"https://openalex.org/S67834151","display_name":"Landscape architecture","issn_l":"0023-8031","issn":["0023-8031"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/P4323284062","host_organization_name":"American Society of Landscape Architecture","host_organization_lineage":["https://openalex.org/P4323284062"],"host_organization_lineage_names":["American Society of Landscape Architecture"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Landscape architecture","raw_type":null},"type":"article","indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5066114466","display_name":"Judith B. Tankard","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Judith B. Tankard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5066114466"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00571383,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"95","issue":"9","first_page":"54","last_page":"59"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9182999730110168,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9182999730110168,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9182999730110168,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.049800001084804535,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/geology","display_name":"Geology","score":0.4553414583206177},{"id":"https://openalex.org/keywords/geotechnical-engineering","display_name":"Geotechnical engineering","score":0.3224330544471741}],"concepts":[{"id":"https://openalex.org/C127313418","wikidata":"https://www.wikidata.org/wiki/Q1069","display_name":"Geology","level":0,"score":0.4553414583206177},{"id":"https://openalex.org/C187320778","wikidata":"https://www.wikidata.org/wiki/Q1349130","display_name":"Geotechnical engineering","level":1,"score":0.3224330544471741}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:35183062","is_oa":false,"landing_page_url":"https://dialnet.unirioja.es/servlet/articulo?codigo=1260795","pdf_url":null,"source":{"id":"https://openalex.org/S67834151","display_name":"Landscape architecture","issn_l":"0023-8031","issn":["0023-8031"],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/P4323284062","host_organization_name":"American Society of Landscape Architecture","host_organization_lineage":["https://openalex.org/P4323284062"],"host_organization_lineage_names":["American Society of Landscape Architecture"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Landscape architecture","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2419460583","display_name":null,"funder_award_id":"P01 AI097092","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G3691744231","display_name":null,"funder_award_id":"U19 AI109946","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5148233484","display_name":null,"funder_award_id":"HHSN272201400005C","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G5322754015","display_name":null,"funder_award_id":"U19AI109946","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6833642267","display_name":null,"funder_award_id":"U19 AI057266","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8405245891","display_name":null,"funder_award_id":"U19AI057266","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8951126497","display_name":null,"funder_award_id":"T32 AI007090","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8951389704","display_name":null,"funder_award_id":"U19 AI082724","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2993716782","https://openalex.org/W51381450","https://openalex.org/W52263389","https://openalex.org/W2992025357","https://openalex.org/W1534790756","https://openalex.org/W2576096090","https://openalex.org/W244104242","https://openalex.org/W98006682","https://openalex.org/W73779342","https://openalex.org/W2276494177","https://openalex.org/W2585660636","https://openalex.org/W1539630107","https://openalex.org/W191002009","https://openalex.org/W60866251","https://openalex.org/W81876382","https://openalex.org/W2994522687","https://openalex.org/W1013676000","https://openalex.org/W2897399283","https://openalex.org/W2918270963","https://openalex.org/W74683584"],"abstract_inverted_index":{"Artificial":[0],"mutagenesis":[1],"and":[2,12,30,36,51,66,79,89,103,108,113,128,140,147,168,205,208],"protein":[3,31,55,82,170],"engineering":[4],"have":[5],"laid":[6],"the":[7,157],"foundation":[8],"for":[9,16,77,123,200,213],"antigenic":[10],"characterization":[11],"universal":[13],"vaccine":[14],"design":[15,65,114,122],"influenza":[17,53,85,202,216],"viruses.":[18,193],"However,":[19],"many":[20],"methods":[21],"used":[22],"in":[23,38,43],"this":[24,70],"process":[25],"require":[26],"manual":[27],"sequence":[28],"editing":[29],"expression,":[32],"limiting":[33],"their":[34],"efficiency":[35],"utility":[37],"high-throughput":[39],"applications.":[40],"More":[41],"streamlined":[42],"silico":[44],"tools":[45],"allowing":[46],"researchers":[47],"to":[48,62],"properly":[49],"analyze":[50],"visualize":[52,105],"viral":[54,101],"sequences":[56,83,102],"with":[57],"accurate":[58],"nomenclature":[59],"are":[60,145],"necessary":[61],"improve":[63],"antigen":[64,106,174,217],"productivity.":[67],"To":[68],"address":[69],"need,":[71],"we":[72,176],"developed":[73],"Librator,":[74],"a":[75,197],"system":[76],"analyzing":[78,201],"designing":[80],"custom":[81,115],"of":[84,126,136,165,187],"virus":[86,203],"hemagglutinin":[87],"(HA)":[88],"neuraminidase":[90],"(NA)":[91],"glycoproteins.":[92],"Within":[93],"Librator's":[94],"graphical":[95],"interface,":[96],"users":[97],"can":[98,180],"easily":[99],"interrogate":[100],"phylogenies,":[104],"structures":[107],"conservation,":[109],"mutate":[110],"target":[111],"residues":[112],"antigens.":[116],"Librator":[117,195],"also":[118],"provides":[119,209],"optimized":[120],"fragment":[121],"Gibson":[124],"Assembly":[125],"HA":[127,139,185,204],"NA":[129,141,206],"expression":[130],"constructs":[131],"based":[132],"on":[133],"peptide":[134],"conservation":[135],"all":[137],"historical":[138],"sequences,":[142],"ensuring":[143],"fragments":[144],"reusable":[146],"compatible":[148],"across":[149],"related":[150],"subtypes,":[151],"thereby":[152],"promoting":[153],"reagent":[154],"savings.":[155],"Finally,":[156],"program":[158],"facilitates":[159],"single-cell":[160],"immune":[161],"profiling,":[162],"epitope":[163],"mapping":[164],"monoclonal":[166],"antibodies":[167],"mosaic":[169],"design.":[171],"Using":[172],"Librator-based":[173],"construction,":[175],"demonstrate":[177],"that":[178],"antigenicity":[179],"be":[181],"readily":[182],"transferred":[183],"between":[184],"molecules":[186],"H3,":[188],"but":[189],"not":[190],"H1,":[191],"lineage":[192],"Altogether,":[194],"is":[196],"valuable":[198],"tool":[199],"proteins":[207],"an":[210],"efficient":[211],"resource":[212],"optimizing":[214],"recombinant":[215],"synthesis.":[218]},"counts_by_year":[],"updated_date":"2025-07-23T07:28:25.932669","created_date":"2016-06-24T00:00:00"}