{"id":"https://openalex.org/W4213030121","doi":"https://doi.org/10.1093/bib/bbac028","title":"Librator: a platform for the optimized analysis, design, and expression of mutable influenza viral antigens","display_name":"Librator: a platform for the optimized analysis, design, and expression of mutable influenza viral antigens","publication_year":2022,"publication_date":"2022-02-15","ids":{"openalex":"https://openalex.org/W4213030121","doi":"https://doi.org/10.1093/bib/bbac028"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbac028","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbac028","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8921739","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100440363","display_name":"Lei Li","orcid":"https://orcid.org/0000-0002-8828-5199"},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lei Li","raw_affiliation_strings":["Gale and Ira Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, 10065, USA","Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA"],"affiliations":[{"raw_affiliation_string":"Gale and Ira Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046103584","display_name":"Siriruk Changrob","orcid":"https://orcid.org/0000-0002-1826-4333"},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Siriruk Changrob","raw_affiliation_strings":["Gale and Ira Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, 10065, USA","Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA"],"affiliations":[{"raw_affiliation_string":"Gale and Ira Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089384452","display_name":"Yanbin Fu","orcid":"https://orcid.org/0000-0002-3424-4420"},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yanbin Fu","raw_affiliation_strings":["Gale and Ira Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, 10065, USA","Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA"],"affiliations":[{"raw_affiliation_string":"Gale and Ira Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041052956","display_name":"Olivia Stovicek","orcid":"https://orcid.org/0000-0001-6413-855X"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Olivia Stovicek","raw_affiliation_strings":["Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA"],"affiliations":[{"raw_affiliation_string":"Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042816843","display_name":"Jenna J. Guthmiller","orcid":"https://orcid.org/0000-0001-7566-3536"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jenna J Guthmiller","raw_affiliation_strings":["Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA"],"affiliations":[{"raw_affiliation_string":"Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036645935","display_name":"Joshua J.C. McGrath","orcid":"https://orcid.org/0000-0002-9267-5501"},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua J C McGrath","raw_affiliation_strings":["Gale and Ira Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, 10065, USA"],"affiliations":[{"raw_affiliation_string":"Gale and Ira Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001413194","display_name":"Haley L. Dugan","orcid":"https://orcid.org/0000-0003-2238-0094"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haley L Dugan","raw_affiliation_strings":["Committee on Immunology, University of Chicago, Chicago, IL 60637, USA"],"affiliations":[{"raw_affiliation_string":"Committee on Immunology, University of Chicago, Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044605162","display_name":"Christopher T. Stamper","orcid":"https://orcid.org/0000-0002-5568-8880"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher T Stamper","raw_affiliation_strings":["Committee on Immunology, University of Chicago, Chicago, IL 60637, USA"],"affiliations":[{"raw_affiliation_string":"Committee on Immunology, University of Chicago, Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101192598","display_name":"Nai\u2010Ying Zheng","orcid":null},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nai-Ying Zheng","raw_affiliation_strings":["Gale and Ira Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, 10065, USA","Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA"],"affiliations":[{"raw_affiliation_string":"Gale and Ira Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100712734","display_name":"Min Huang","orcid":null},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Min Huang","raw_affiliation_strings":["Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA"],"affiliations":[{"raw_affiliation_string":"Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011041006","display_name":"Patrick C. Wilson","orcid":"https://orcid.org/0000-0002-3537-1245"},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]},{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I4387153466","display_name":"Weill Cornell Medicine","ror":"https://ror.org/02r109517","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Patrick C Wilson","raw_affiliation_strings":["Committee on Immunology, University of Chicago, Chicago, IL 60637, USA","Gale and Ira Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, 10065, USA","Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA"],"affiliations":[{"raw_affiliation_string":"Committee on Immunology, University of Chicago, Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Gale and Ira Drukier Institute for Children's Health, Weill Cornell Medicine, New York, NY, 10065, USA","institution_ids":["https://openalex.org/I205783295","https://openalex.org/I4387153466"]},{"raw_affiliation_string":"Section of Rheumatology, Department of Medicine, University of Chicago, Chicago, IL 60637, USA","institution_ids":["https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5011041006"],"corresponding_institution_ids":["https://openalex.org/I205783295","https://openalex.org/I40347166","https://openalex.org/I4387153466"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":0.6233,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.66294272,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"23","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10167","display_name":"Influenza Virus Research Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11243","display_name":"Respiratory viral infections research","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5911966562271118},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5471746325492859},{"id":"https://openalex.org/keywords/antigen","display_name":"Antigen","score":0.5379403829574585},{"id":"https://openalex.org/keywords/epitope","display_name":"Epitope","score":0.534127950668335},{"id":"https://openalex.org/keywords/antigenicity","display_name":"Antigenicity","score":0.4555450975894928},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.4495944082736969},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.44659700989723206},{"id":"https://openalex.org/keywords/influenza-a-virus","display_name":"Influenza A virus","score":0.423597514629364},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.39215224981307983},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.34424838423728943},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.20183086395263672},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1828567385673523}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5911966562271118},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5471746325492859},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.5379403829574585},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.534127950668335},{"id":"https://openalex.org/C2779026604","wikidata":"https://www.wikidata.org/wiki/Q4774742","display_name":"Antigenicity","level":3,"score":0.4555450975894928},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4495944082736969},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.44659700989723206},{"id":"https://openalex.org/C2777546802","wikidata":"https://www.wikidata.org/wiki/Q834390","display_name":"Influenza A virus","level":3,"score":0.423597514629364},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.39215224981307983},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.34424838423728943},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20183086395263672},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1828567385673523}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbac028","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbac028","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8921739","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8921739","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8921739","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8921739","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G5322754015","display_name":null,"funder_award_id":"U19AI109946","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8405245891","display_name":null,"funder_award_id":"U19AI057266","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8906968873","display_name":null,"funder_award_id":"U19AI082724","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W173039077","https://openalex.org/W1483247593","https://openalex.org/W1971439989","https://openalex.org/W1985704471","https://openalex.org/W1988533731","https://openalex.org/W1989423333","https://openalex.org/W2005238188","https://openalex.org/W2011840149","https://openalex.org/W2022615852","https://openalex.org/W2027869475","https://openalex.org/W2040440325","https://openalex.org/W2041654633","https://openalex.org/W2048555622","https://openalex.org/W2071644795","https://openalex.org/W2080029891","https://openalex.org/W2123156966","https://openalex.org/W2127322768","https://openalex.org/W2128442209","https://openalex.org/W2130479394","https://openalex.org/W2132629607","https://openalex.org/W2132926880","https://openalex.org/W2133739308","https://openalex.org/W2141052558","https://openalex.org/W2152207030","https://openalex.org/W2158266834","https://openalex.org/W2158886341","https://openalex.org/W2165837267","https://openalex.org/W2327300044","https://openalex.org/W2339357145","https://openalex.org/W2395836201","https://openalex.org/W2795900571","https://openalex.org/W2802700163","https://openalex.org/W2866458126","https://openalex.org/W2890790004","https://openalex.org/W2891958673","https://openalex.org/W2904649548","https://openalex.org/W2913568910","https://openalex.org/W2930636010","https://openalex.org/W2969257524","https://openalex.org/W2971999614","https://openalex.org/W2990052415","https://openalex.org/W2990179039","https://openalex.org/W2990751786","https://openalex.org/W3026217928","https://openalex.org/W3043253729","https://openalex.org/W3112468504","https://openalex.org/W3157116442","https://openalex.org/W3164478716","https://openalex.org/W3165268635","https://openalex.org/W4200403158","https://openalex.org/W4249055169","https://openalex.org/W4251751280","https://openalex.org/W6629003624","https://openalex.org/W6629320136"],"related_works":["https://openalex.org/W786416207","https://openalex.org/W2367852944","https://openalex.org/W2115812853","https://openalex.org/W2004255297","https://openalex.org/W2008472229","https://openalex.org/W2435839362","https://openalex.org/W1979044599","https://openalex.org/W2078727461","https://openalex.org/W2396550544","https://openalex.org/W2072925709"],"abstract_inverted_index":{"Abstract":[0],"Artificial":[1],"mutagenesis":[2],"and":[3,13,31,37,52,67,80,90,104,109,114,129,141,148,169,206,209],"protein":[4,32,56,83,171],"engineering":[5],"have":[6],"laid":[7],"the":[8,158],"foundation":[9],"for":[10,17,78,124,201,214],"antigenic":[11],"characterization":[12],"universal":[14],"vaccine":[15],"design":[16,66,115,123],"influenza":[18,54,86,203,217],"viruses.":[19,194],"However,":[20],"many":[21],"methods":[22],"used":[23],"in":[24,39,44],"this":[25,71],"process":[26],"require":[27],"manual":[28],"sequence":[29],"editing":[30],"expression,":[33],"limiting":[34],"their":[35],"efficiency":[36],"utility":[38],"high-throughput":[40],"applications.":[41],"More":[42],"streamlined":[43],"silico":[45],"tools":[46],"allowing":[47],"researchers":[48],"to":[49,63],"properly":[50],"analyze":[51],"visualize":[53,106],"viral":[55,102],"sequences":[57,84,103],"with":[58],"accurate":[59],"nomenclature":[60],"are":[61,146],"necessary":[62],"improve":[64],"antigen":[65,107,175,218],"productivity.":[68],"To":[69],"address":[70],"need,":[72],"we":[73,177],"developed":[74],"Librator,":[75],"a":[76,198],"system":[77],"analyzing":[79,202],"designing":[81],"custom":[82,116],"of":[85,127,137,166,188],"virus":[87,204],"hemagglutinin":[88],"(HA)":[89],"neuraminidase":[91],"(NA)":[92],"glycoproteins.":[93],"Within":[94],"Librator\u2019s":[95],"graphical":[96],"interface,":[97],"users":[98],"can":[99,181],"easily":[100],"interrogate":[101],"phylogenies,":[105],"structures":[108],"conservation,":[110],"mutate":[111],"target":[112],"residues":[113],"antigens.":[117],"Librator":[118,196],"also":[119],"provides":[120,210],"optimized":[121],"fragment":[122],"Gibson":[125],"Assembly":[126],"HA":[128,140,186,205],"NA":[130,142,207],"expression":[131],"constructs":[132],"based":[133],"on":[134],"peptide":[135],"conservation":[136],"all":[138],"historical":[139],"sequences,":[143],"ensuring":[144],"fragments":[145],"reusable":[147],"compatible":[149],"across":[150],"related":[151],"subtypes,":[152],"thereby":[153],"promoting":[154],"reagent":[155],"savings.":[156],"Finally,":[157],"program":[159],"facilitates":[160],"single-cell":[161],"immune":[162],"profiling,":[163],"epitope":[164],"mapping":[165],"monoclonal":[167],"antibodies":[168],"mosaic":[170],"design.":[172],"Using":[173],"Librator-based":[174],"construction,":[176],"demonstrate":[178],"that":[179],"antigenicity":[180],"be":[182],"readily":[183],"transferred":[184],"between":[185],"molecules":[187],"H3,":[189],"but":[190],"not":[191],"H1,":[192],"lineage":[193],"Altogether,":[195],"is":[197],"valuable":[199],"tool":[200],"proteins":[208],"an":[211],"efficient":[212],"resource":[213],"optimizing":[215],"recombinant":[216],"synthesis.":[219]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2022-02-24T00:00:00"}
