{"id":"https://openalex.org/W4206023053","doi":"https://doi.org/10.1093/bib/bbab588","title":"scHFC: a hybrid fuzzy clustering method for single-cell RNA-seq data optimized by natural computation","display_name":"scHFC: a hybrid fuzzy clustering method for single-cell RNA-seq data optimized by natural computation","publication_year":2021,"publication_date":"2021-12-23","ids":{"openalex":"https://openalex.org/W4206023053","doi":"https://doi.org/10.1093/bib/bbab588","pmid":"https://pubmed.ncbi.nlm.nih.gov/35136924"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbab588","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbab588","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084369069","display_name":"Jing Wang","orcid":"https://orcid.org/0000-0002-1345-1092"},"institutions":[{"id":"https://openalex.org/I143868143","display_name":"Anhui University","ror":"https://ror.org/05th6yx34","country_code":"CN","type":"education","lineage":["https://openalex.org/I143868143"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Wang","raw_affiliation_strings":["Key Lab of Intelligent Computing and Signal Processing of Ministry of Education, School of Computer Science and Technology, Anhui University, Hefei, China"],"raw_orcid":"https://orcid.org/0000-0002-1345-1092","affiliations":[{"raw_affiliation_string":"Key Lab of Intelligent Computing and Signal Processing of Ministry of Education, School of Computer Science and Technology, Anhui University, Hefei, China","institution_ids":["https://openalex.org/I143868143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065943710","display_name":"Junfeng Xia","orcid":"https://orcid.org/0000-0003-3024-1705"},"institutions":[{"id":"https://openalex.org/I143868143","display_name":"Anhui University","ror":"https://ror.org/05th6yx34","country_code":"CN","type":"education","lineage":["https://openalex.org/I143868143"]},{"id":"https://openalex.org/I2802624667","display_name":"Hefei Institutes of Physical Science","ror":"https://ror.org/046n57345","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2802624667"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junfeng Xia","raw_affiliation_strings":["Institutes of Physical Science and Information Technology, Anhui University, Hefei, China"],"raw_orcid":"https://orcid.org/0000-0003-3024-1705","affiliations":[{"raw_affiliation_string":"Institutes of Physical Science and Information Technology, Anhui University, Hefei, China","institution_ids":["https://openalex.org/I143868143","https://openalex.org/I2802624667"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055373332","display_name":"Dayu Tan","orcid":"https://orcid.org/0000-0002-3960-8852"},"institutions":[{"id":"https://openalex.org/I143868143","display_name":"Anhui University","ror":"https://ror.org/05th6yx34","country_code":"CN","type":"education","lineage":["https://openalex.org/I143868143"]},{"id":"https://openalex.org/I2802624667","display_name":"Hefei Institutes of Physical Science","ror":"https://ror.org/046n57345","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I2802624667"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dayu Tan","raw_affiliation_strings":["Institutes of Physical Science and Information Technology, Anhui University, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institutes of Physical Science and Information Technology, Anhui University, Hefei, China","institution_ids":["https://openalex.org/I143868143","https://openalex.org/I2802624667"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081649203","display_name":"Rongxin Lin","orcid":null},"institutions":[{"id":"https://openalex.org/I143868143","display_name":"Anhui University","ror":"https://ror.org/05th6yx34","country_code":"CN","type":"education","lineage":["https://openalex.org/I143868143"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rongxin Lin","raw_affiliation_strings":["Key Lab of Intelligent Computing and Signal Processing of Ministry of Education, School of Computer Science and Technology, Anhui University, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Lab of Intelligent Computing and Signal Processing of Ministry of Education, School of Computer Science and Technology, Anhui University, Hefei, China","institution_ids":["https://openalex.org/I143868143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071754273","display_name":"Yansen Su","orcid":"https://orcid.org/0000-0002-3855-7133"},"institutions":[{"id":"https://openalex.org/I143868143","display_name":"Anhui University","ror":"https://ror.org/05th6yx34","country_code":"CN","type":"education","lineage":["https://openalex.org/I143868143"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yansen Su","raw_affiliation_strings":["Key Lab of Intelligent Computing and Signal Processing of Ministry of Education, School of Artificial Intelligence, Anhui University, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Lab of Intelligent Computing and Signal Processing of Ministry of Education, School of Artificial Intelligence, Anhui University, Hefei, China","institution_ids":["https://openalex.org/I143868143"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5064185915","display_name":"Chun-Hou Zheng","orcid":"https://orcid.org/0000-0002-2695-1926"},"institutions":[{"id":"https://openalex.org/I143868143","display_name":"Anhui University","ror":"https://ror.org/05th6yx34","country_code":"CN","type":"education","lineage":["https://openalex.org/I143868143"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chun-Hou Zheng","raw_affiliation_strings":["Key Lab of Intelligent Computing and Signal Processing of Ministry of Education, School of Artificial Intelligence, Anhui University, Hefei, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Lab of Intelligent Computing and Signal Processing of Ministry of Education, School of Artificial Intelligence, Anhui University, Hefei, China","institution_ids":["https://openalex.org/I143868143"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5064185915","https://openalex.org/A5071754273"],"corresponding_institution_ids":["https://openalex.org/I143868143"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":0.7404,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.69079984,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"23","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9925000071525574,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9488999843597412,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.8453920483589172},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6944751143455505},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.6421006917953491},{"id":"https://openalex.org/keywords/fuzzy-clustering","display_name":"Fuzzy clustering","score":0.5550103783607483},{"id":"https://openalex.org/keywords/curse-of-dimensionality","display_name":"Curse of dimensionality","score":0.4547823965549469},{"id":"https://openalex.org/keywords/fuzzy-logic","display_name":"Fuzzy logic","score":0.4455823004245758},{"id":"https://openalex.org/keywords/principal-component-analysis","display_name":"Principal component analysis","score":0.43285316228866577},{"id":"https://openalex.org/keywords/computation","display_name":"Computation","score":0.43279343843460083},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.36703142523765564},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.3365229070186615},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.28191500902175903}],"concepts":[{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.8453920483589172},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6944751143455505},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.6421006917953491},{"id":"https://openalex.org/C17212007","wikidata":"https://www.wikidata.org/wiki/Q5511111","display_name":"Fuzzy clustering","level":3,"score":0.5550103783607483},{"id":"https://openalex.org/C111030470","wikidata":"https://www.wikidata.org/wiki/Q1430460","display_name":"Curse of dimensionality","level":2,"score":0.4547823965549469},{"id":"https://openalex.org/C58166","wikidata":"https://www.wikidata.org/wiki/Q224821","display_name":"Fuzzy logic","level":2,"score":0.4455823004245758},{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.43285316228866577},{"id":"https://openalex.org/C45374587","wikidata":"https://www.wikidata.org/wiki/Q12525525","display_name":"Computation","level":2,"score":0.43279343843460083},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.36703142523765564},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.3365229070186615},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.28191500902175903}],"mesh":[{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbab588","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbab588","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:35136924","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35136924","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G247010507","display_name":null,"funder_award_id":"61873001","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3925882961","display_name":"\u81f4\u75c5\u540c\u4e49\u7a81\u53d8\u7684\u751f\u7269\u4fe1\u606f\u5b66\u7814\u7a76","funder_award_id":"62072003","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5006237592","display_name":null,"funder_award_id":"U19A2064","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1813068103","https://openalex.org/W1974364887","https://openalex.org/W1977556410","https://openalex.org/W1979283544","https://openalex.org/W1990368529","https://openalex.org/W1996747841","https://openalex.org/W1997035197","https://openalex.org/W2010653277","https://openalex.org/W2025242337","https://openalex.org/W2029906715","https://openalex.org/W2038533573","https://openalex.org/W2050040190","https://openalex.org/W2053297118","https://openalex.org/W2069089843","https://openalex.org/W2075188625","https://openalex.org/W2085667878","https://openalex.org/W2089468765","https://openalex.org/W2094510831","https://openalex.org/W2101234009","https://openalex.org/W2107680358","https://openalex.org/W2109890799","https://openalex.org/W2110768394","https://openalex.org/W2111607395","https://openalex.org/W2113076747","https://openalex.org/W2162833336","https://openalex.org/W2170864621","https://openalex.org/W2187089797","https://openalex.org/W2189625117","https://openalex.org/W2306630387","https://openalex.org/W2307567449","https://openalex.org/W2473258837","https://openalex.org/W2598326928","https://openalex.org/W2606771561","https://openalex.org/W2799414330","https://openalex.org/W2936414047","https://openalex.org/W2937917790","https://openalex.org/W2951217100","https://openalex.org/W2951381561","https://openalex.org/W2997470228","https://openalex.org/W3000911580","https://openalex.org/W3003285681","https://openalex.org/W3003444384","https://openalex.org/W3013022968","https://openalex.org/W3022825011","https://openalex.org/W3031468808","https://openalex.org/W3048323270","https://openalex.org/W3048538154","https://openalex.org/W3105146463","https://openalex.org/W3113251307","https://openalex.org/W3196939060","https://openalex.org/W4235169531","https://openalex.org/W6644682428","https://openalex.org/W6675354045","https://openalex.org/W6684050148","https://openalex.org/W6686980507"],"related_works":["https://openalex.org/W2945382830","https://openalex.org/W4224807364","https://openalex.org/W2596632494","https://openalex.org/W2535986621","https://openalex.org/W1980197432","https://openalex.org/W2382432689","https://openalex.org/W4312412183","https://openalex.org/W3192757256","https://openalex.org/W4292434959","https://openalex.org/W1973826313"],"abstract_inverted_index":{"Rapid":[0],"development":[1],"of":[2,32,47,63,69,111,188,210,216,221,244],"single-cell":[3],"RNA":[4],"sequencing":[5],"(scRNA-seq)":[6],"technology":[7],"has":[8],"allowed":[9],"researchers":[10,27],"to":[11,28,56,67,107,131,135,155,230],"explore":[12],"biological":[13],"phenomena":[14],"at":[15,252],"the":[16,30,45,61,77,109,133,142,150,157,176,189,207],"cellular":[17],"scale.":[18],"Clustering":[19],"is":[20,80,105,116,129,147,192,226,250],"a":[21,81,137,164],"crucial":[22],"and":[23,44,96,126,146,198,219,236],"helpful":[24],"step":[25],"for":[26,152,233,241],"study":[29],"heterogeneity":[31],"cell.":[33],"Although":[34],"many":[35],"clustering":[36,64,84,144,159,183,217],"methods":[37],"have":[38],"been":[39],"proposed,":[40],"massive":[41],"dropout":[42],"events":[43],"curse":[46],"dimensionality":[48],"in":[49,214],"scRNA-seq":[50,112,196,234,245],"data":[51,113,134],"make":[52],"it":[53,115,237],"still":[54],"difficult":[55],"analysis":[57,103,243],"because":[58],"they":[59],"reduce":[60,108],"accuracy":[62,218],"methods,":[65],"leading":[66],"misidentification":[68],"cell":[70],"types.":[71],"In":[72,223],"this":[73],"work,":[74],"we":[75],"propose":[76],"scHFC,":[78],"which":[79,140,173],"hybrid":[82],"fuzzy":[83],"method":[85,168,191,213,229],"optimized":[86,121],"by":[87,122,180],"natural":[88],"computation":[89],"based":[90],"on":[91,194],"Fuzzy":[92],"C":[93],"Mean":[94],"(FCM)":[95],"Gath-Geva":[97],"(GG)":[98],"algorithms.":[99],"Specifically,":[100],"principal":[101],"component":[102],"algorithm":[104,120,125,128,154],"utilized":[106],"dimensions":[110],"after":[114],"preprocessed.":[117],"Then,":[118],"FCM":[119],"simulated":[123],"annealing":[124],"genetic":[127],"applied":[130],"cluster":[132,165,177,231],"output":[136],"membership":[138],"matrix,":[139],"represents":[141],"initial":[143],"result":[145],"taken":[148],"as":[149],"input":[151],"GG":[153],"get":[156],"final":[158],"results.":[160],"We":[161],"also":[162],"develop":[163],"number":[166],"estimation":[167],"called":[169],"multi-index":[170],"comprehensive":[171],"estimation,":[172],"can":[174],"estimate":[175],"numbers":[178],"well":[179],"combining":[181],"four":[182],"effectiveness":[184],"indexes.":[185],"The":[186,247],"performance":[187,209],"scHFC":[190,212,225],"evaluated":[193],"17":[195],"datasets,":[197],"compared":[199],"with":[200],"six":[201],"state-of-the-art":[202],"methods.":[203],"Experimental":[204],"results":[205],"validate":[206],"better":[208],"our":[211],"terms":[215],"stability":[220],"algorithm.":[222],"short,":[224],"an":[227],"effective":[228],"cells":[232],"data,":[235],"presents":[238],"great":[239],"potential":[240],"downstream":[242],"data.":[246],"source":[248],"code":[249],"available":[251],"https://github.com/WJ319/scHFC.":[253]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1}],"updated_date":"2026-07-25T09:21:30.201066","created_date":"2025-10-10T00:00:00"}