{"id":"https://openalex.org/W4206718607","doi":"https://doi.org/10.1093/bib/bbab587","title":"PRODeepSyn: predicting anticancer synergistic drug combinations by embedding cell lines with protein\u2013protein interaction network","display_name":"PRODeepSyn: predicting anticancer synergistic drug combinations by embedding cell lines with protein\u2013protein interaction network","publication_year":2021,"publication_date":"2021-12-23","ids":{"openalex":"https://openalex.org/W4206718607","doi":"https://doi.org/10.1093/bib/bbab587","pmid":"https://pubmed.ncbi.nlm.nih.gov/35043159"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbab587","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbab587","pdf_url":"https://academic.oup.com/bib/article-pdf/23/2/bbab587/42806034/bbab587.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/23/2/bbab587/42806034/bbab587.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100454350","display_name":"Xiaowen Wang","orcid":"https://orcid.org/0000-0003-1880-7921"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaowen Wang","raw_affiliation_strings":["School of Software Engineering, Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Software Engineering, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030414508","display_name":"Hongming Zhu","orcid":"https://orcid.org/0000-0001-5795-5279"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongming Zhu","raw_affiliation_strings":["School of Software Engineering, Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Software Engineering, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103201665","display_name":"Yizhi Jiang","orcid":"https://orcid.org/0000-0002-9409-521X"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yizhi Jiang","raw_affiliation_strings":["School of Software Engineering, Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Software Engineering, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002713351","display_name":"Yulong Li","orcid":"https://orcid.org/0000-0002-3068-2554"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yulong Li","raw_affiliation_strings":["School of Software Engineering, Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Software Engineering, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068465714","display_name":"Chen Tang","orcid":"https://orcid.org/0000-0003-1188-4393"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chen Tang","raw_affiliation_strings":["School of Software Engineering, Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Software Engineering, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104506623","display_name":"Xiaohan Chen","orcid":"https://orcid.org/0000-0003-0619-6019"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaohan Chen","raw_affiliation_strings":["School of Software Engineering, Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Software Engineering, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101558493","display_name":"Yunjie Li","orcid":"https://orcid.org/0000-0002-3385-0576"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yunjie Li","raw_affiliation_strings":["School of Software Engineering, Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Software Engineering, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100453144","display_name":"Qi Liu","orcid":"https://orcid.org/0000-0001-5378-6404"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210128175","display_name":"Shanghai East Hospital","ror":"https://ror.org/038xmzj21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128175"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qi Liu","raw_affiliation_strings":["School of Software Engineering, Tongji University, Shanghai, China","Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Software Engineering, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]},{"raw_affiliation_string":"Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I4210128175"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5026465152","display_name":"Qin Liu","orcid":"https://orcid.org/0000-0002-9352-1694"},"institutions":[{"id":"https://openalex.org/I116953780","display_name":"Tongji University","ror":"https://ror.org/03rc6as71","country_code":"CN","type":"education","lineage":["https://openalex.org/I116953780"]},{"id":"https://openalex.org/I4210128175","display_name":"Shanghai East Hospital","ror":"https://ror.org/038xmzj21","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128175"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qin Liu","raw_affiliation_strings":["School of Software Engineering, Tongji University, Shanghai, China","Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Software Engineering, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I116953780"]},{"raw_affiliation_string":"Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine, Shanghai East Hospital, Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai, China","institution_ids":["https://openalex.org/I4210128175"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026465152","https://openalex.org/A5100453144"],"corresponding_institution_ids":["https://openalex.org/I116953780","https://openalex.org/I4210128175"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":7.0934,"has_fulltext":false,"cited_by_count":87,"citation_normalized_percentile":{"value":0.97567848,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"23","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6590366363525391},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.6261467337608337},{"id":"https://openalex.org/keywords/normalization","display_name":"Normalization (sociology)","score":0.5946110486984253},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.5827342867851257},{"id":"https://openalex.org/keywords/matthews-correlation-coefficient","display_name":"Matthews correlation coefficient","score":0.573227047920227},{"id":"https://openalex.org/keywords/convolutional-neural-network","display_name":"Convolutional neural network","score":0.5014941692352295},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.49170905351638794},{"id":"https://openalex.org/keywords/interaction-network","display_name":"Interaction network","score":0.45928099751472473},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.42741072177886963},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.14806079864501953},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.14003220200538635}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6590366363525391},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.6261467337608337},{"id":"https://openalex.org/C136886441","wikidata":"https://www.wikidata.org/wiki/Q926129","display_name":"Normalization (sociology)","level":2,"score":0.5946110486984253},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.5827342867851257},{"id":"https://openalex.org/C164085508","wikidata":"https://www.wikidata.org/wiki/Q4811327","display_name":"Matthews correlation coefficient","level":3,"score":0.573227047920227},{"id":"https://openalex.org/C81363708","wikidata":"https://www.wikidata.org/wiki/Q17084460","display_name":"Convolutional neural network","level":2,"score":0.5014941692352295},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.49170905351638794},{"id":"https://openalex.org/C55105296","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interaction network","level":3,"score":0.45928099751472473},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.42741072177886963},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.14806079864501953},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.14003220200538635},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004338","descriptor_name":"Drug Combinations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/bib/bbab587","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbab587","pdf_url":"https://academic.oup.com/bib/article-pdf/23/2/bbab587/42806034/bbab587.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:35043159","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35043159","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:osti.gov:1841314","is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1841314","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:8921631","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8921631","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbab587","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbab587","pdf_url":"https://academic.oup.com/bib/article-pdf/23/2/bbab587/42806034/bbab587.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6800000071525574,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G2690504601","display_name":null,"funder_award_id":"2017YFC0908500","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G5701494014","display_name":null,"funder_award_id":"2016YFC1303205","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G6856097300","display_name":"\u57fa\u4e8e\u591a\u6e90\u751f\u7269\u6807\u5fd7\u7269\u878d\u5408\u5efa\u6a21\u7684\u80bf\u7624\u514d\u75ab\u68c0\u67e5\u70b9\u6291\u5236\u5242\u7597\u6548\u9884\u6d4b\u7814\u7a76","funder_award_id":"31970638","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7086079520","display_name":"\u57fa\u4e8e\u591a\u6e90\u6570\u636e\u878d\u5408\u53ca\u534f\u540c\u8fc7\u6ee4\u7684\u836f\u7269\u91cd\u5b9a\u4f4d\u7814\u7a76","funder_award_id":"61572361","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W1578932543","https://openalex.org/W1696775091","https://openalex.org/W1875287972","https://openalex.org/W1969763365","https://openalex.org/W1976526581","https://openalex.org/W1977863938","https://openalex.org/W1989053944","https://openalex.org/W2010457001","https://openalex.org/W2031441006","https://openalex.org/W2044834685","https://openalex.org/W2049224937","https://openalex.org/W2055498530","https://openalex.org/W2055722855","https://openalex.org/W2062533676","https://openalex.org/W2063076216","https://openalex.org/W2068258779","https://openalex.org/W2070163108","https://openalex.org/W2085493687","https://openalex.org/W2096439168","https://openalex.org/W2098809458","https://openalex.org/W2109991441","https://openalex.org/W2111264921","https://openalex.org/W2114621192","https://openalex.org/W2116566535","https://openalex.org/W2120682915","https://openalex.org/W2121604817","https://openalex.org/W2122825543","https://openalex.org/W2135001556","https://openalex.org/W2137226992","https://openalex.org/W2137724647","https://openalex.org/W2158323574","https://openalex.org/W2187089797","https://openalex.org/W2295598076","https://openalex.org/W2299417213","https://openalex.org/W2327195911","https://openalex.org/W2335854816","https://openalex.org/W2461427403","https://openalex.org/W2473258837","https://openalex.org/W2560405247","https://openalex.org/W2571957366","https://openalex.org/W2600452401","https://openalex.org/W2603868227","https://openalex.org/W2608863179","https://openalex.org/W2621361707","https://openalex.org/W2775061087","https://openalex.org/W2786016794","https://openalex.org/W2793608852","https://openalex.org/W2809953005","https://openalex.org/W2883248903","https://openalex.org/W2894305962","https://openalex.org/W2898789672","https://openalex.org/W2900569176","https://openalex.org/W2906092989","https://openalex.org/W2906625258","https://openalex.org/W2911964244","https://openalex.org/W2912083425","https://openalex.org/W2922229918","https://openalex.org/W2938206352","https://openalex.org/W2938214930","https://openalex.org/W2946834067","https://openalex.org/W2949524414","https://openalex.org/W2963046727","https://openalex.org/W2964015378","https://openalex.org/W2969085937","https://openalex.org/W2989977199","https://openalex.org/W2998807596","https://openalex.org/W3006386963","https://openalex.org/W3086347240","https://openalex.org/W3092034553","https://openalex.org/W3101756747","https://openalex.org/W3102269903","https://openalex.org/W3105523772","https://openalex.org/W3159462434","https://openalex.org/W3189189889","https://openalex.org/W4246105018","https://openalex.org/W6680532697","https://openalex.org/W6703221619","https://openalex.org/W6726873649","https://openalex.org/W6749447374","https://openalex.org/W6757534659"],"related_works":["https://openalex.org/W2953716828","https://openalex.org/W2904857019","https://openalex.org/W2944728705","https://openalex.org/W3011538607","https://openalex.org/W4226493464","https://openalex.org/W4312417841","https://openalex.org/W3193565141","https://openalex.org/W3133861977","https://openalex.org/W3167935049","https://openalex.org/W3029198973"],"abstract_inverted_index":{"Although":[0],"drug":[1,24,44,95,143],"combinations":[2,25,45],"in":[3,41],"cancer":[4],"treatment":[5],"appear":[6],"to":[7,15,20,27,60,113,133],"be":[8],"a":[9,84,124,198],"promising":[10],"therapeutic":[11],"strategy":[12],"with":[13,110,128],"respect":[14],"monotherapy,":[16],"it":[17],"is":[18,74],"arduous":[19],"discover":[21],"new":[22],"synergistic":[23,43,94],"due":[26],"the":[28,99,105,129,138,147,156,174,182,192,204,211,215,223,227,231],"combinatorial":[29],"explosion.":[30],"Deep":[31],"learning":[32,87,166,171],"technology":[33],"holds":[34],"immense":[35],"promise":[36],"for":[37,46,91,118],"better":[38],"prediction":[39,224],"of":[40,76,153,161,187,195,201],"vitro":[42],"certain":[47],"cell":[48,62,119,139],"lines.":[49,120],"In":[50,79,203],"methods":[51,167],"applying":[52],"such":[53],"technology,":[54],"omics":[55,111],"data":[56,68,112,213],"are":[57,69],"widely":[58],"adopted":[59],"construct":[61,114],"line":[63,140],"features.":[64,144],"However,":[65],"biological":[66],"network":[67,109,127],"rarely":[70],"considered":[71],"yet,":[72],"which":[73],"worthy":[75],"in-depth":[77],"study.":[78],"this":[80],"study,":[81,206],"we":[82,207],"propose":[83],"novel":[85],"deep":[86,125,165],"method,":[88],"termed":[89],"PRODeepSyn,":[90],"predicting":[92],"anticancer":[93],"combinations.":[96],"By":[97],"leveraging":[98],"Graph":[100],"Convolutional":[101],"Network,":[102],"PRODeepSyn":[103,121,145,177,234],"integrates":[104],"protein-protein":[106],"interaction":[107],"(PPI)":[108],"low-dimensional":[115],"dense":[116],"embeddings":[117,141],"then":[122],"builds":[123],"neural":[126],"Batch":[130],"Normalization":[131],"mechanism":[132],"predict":[134],"synergy":[135],"scores":[136],"using":[137,210],"and":[142,155,168,197,214,235],"achieves":[146,178],"lowest":[148],"root":[149],"mean":[150],"square":[151],"error":[152],"15.08":[154],"highest":[157],"Pearson":[158],"correlation":[159],"coefficient":[160],"0.75,":[162],"outperforming":[163],"two":[164],"four":[169],"machine":[170],"methods.":[172],"On":[173],"classification":[175],"task,":[176],"an":[179,189],"area":[180,190],"under":[181,191],"receiver":[183],"operator":[184],"characteristics":[185],"curve":[186,194],"0.90,":[188],"precision-recall":[193],"0.63":[196],"Cohen's":[199],"Kappa":[200],"0.53.":[202],"ablation":[205],"find":[208],"that":[209],"multi-omics":[212],"integrated":[216],"PPI":[217],"network's":[218],"information":[219],"both":[220],"can":[221],"improve":[222],"results.":[225],"Additionally,":[226],"case":[228],"study":[229],"demonstrates":[230],"consistency":[232],"between":[233],"previous":[236],"studies.":[237]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":30},{"year":2024,"cited_by_count":30},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":4}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}