{"id":"https://openalex.org/W4205126801","doi":"https://doi.org/10.1093/bib/bbab570","title":"A robust and scalable graph neural network for accurate single-cell classification","display_name":"A robust and scalable graph neural network for accurate single-cell classification","publication_year":2021,"publication_date":"2021-12-13","ids":{"openalex":"https://openalex.org/W4205126801","doi":"https://doi.org/10.1093/bib/bbab570","pmid":"https://pubmed.ncbi.nlm.nih.gov/35018408"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbab570","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbab570","pdf_url":"https://academic.oup.com/bib/article-pdf/23/2/bbab570/42805077/bbab570.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/23/2/bbab570/42805077/bbab570.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088056853","display_name":"Yuansong Zeng","orcid":"https://orcid.org/0000-0002-3145-430X"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuansong Zeng","raw_affiliation_strings":["School of Computer Science and Engineering, Sun Yat-sen University, Guangzhou 510000, China"],"raw_orcid":"https://orcid.org/0000-0002-3145-430X","affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Sun Yat-sen University, Guangzhou 510000, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016333384","display_name":"Zhuoyi Wei","orcid":null},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhuoyi Wei","raw_affiliation_strings":["School of Computer Science and Engineering, Sun Yat-sen University, Guangzhou 510000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Sun Yat-sen University, Guangzhou 510000, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005203378","display_name":"Zixiang Pan","orcid":"https://orcid.org/0000-0001-5128-6051"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zixiang Pan","raw_affiliation_strings":["School of Computer Science and Engineering, Sun Yat-sen University, Guangzhou 510000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Sun Yat-sen University, Guangzhou 510000, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101633465","display_name":"Yutong Lu","orcid":"https://orcid.org/0000-0001-5315-3375"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yutong Lu","raw_affiliation_strings":["School of Computer Science and Engineering, Sun Yat-sen University, Guangzhou 510000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Sun Yat-sen University, Guangzhou 510000, China","institution_ids":["https://openalex.org/I157773358"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023539493","display_name":"Yuedong Yang","orcid":"https://orcid.org/0000-0002-6782-2813"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210098034","display_name":"Key Laboratory of Guangdong Province","ror":"https://ror.org/00swtqp09","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210098034"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yuedong Yang","raw_affiliation_strings":["Key Laboratory of Machine Intelligence and Advanced Computing (MOE), Guangzhou 510000, China","School of Computer Science and Engineering, Sun Yat-sen University, Guangzhou 510000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Machine Intelligence and Advanced Computing (MOE), Guangzhou 510000, China","institution_ids":["https://openalex.org/I4210098034"]},{"raw_affiliation_string":"School of Computer Science and Engineering, Sun Yat-sen University, Guangzhou 510000, China","institution_ids":["https://openalex.org/I157773358"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5023539493","https://openalex.org/A5101633465"],"corresponding_institution_ids":["https://openalex.org/I157773358","https://openalex.org/I4210098034"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":1.9539,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.87142325,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"23","issue":"2","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9901000261306763,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12874","display_name":"Digital Imaging for Blood Diseases","score":0.9549999833106995,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7176955938339233},{"id":"https://openalex.org/keywords/scalability","display_name":"Scalability","score":0.679381251335144},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.5192599296569824},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4939458966255188},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.4569547176361084},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.32204335927963257},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.23537108302116394},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.10470789670944214}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7176955938339233},{"id":"https://openalex.org/C48044578","wikidata":"https://www.wikidata.org/wiki/Q727490","display_name":"Scalability","level":2,"score":0.679381251335144},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.5192599296569824},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4939458966255188},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.4569547176361084},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.32204335927963257},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.23537108302116394},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.10470789670944214}],"mesh":[{"descriptor_ui":"D000073359","descriptor_name":"Exome Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000073359","descriptor_name":"Exome Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000073359","descriptor_name":"Exome Sequencing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007858","descriptor_name":"Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbab570","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbab570","pdf_url":"https://academic.oup.com/bib/article-pdf/23/2/bbab570/42805077/bbab570.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:35018408","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35018408","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:research-repository.griffith.edu.au:10072/415963","is_oa":false,"landing_page_url":"http://hdl.handle.net/10072/415963","pdf_url":null,"source":{"id":"https://openalex.org/S4306402548","display_name":"Griffith Research Online (Griffith University, Queensland, Australia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I11701301","host_organization_name":"Griffith University","host_organization_lineage":["https://openalex.org/I11701301"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal article"}],"best_oa_location":{"id":"doi:10.1093/bib/bbab570","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbab570","pdf_url":"https://academic.oup.com/bib/article-pdf/23/2/bbab570/42805077/bbab570.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3931435871","display_name":null,"funder_award_id":"2020YFB0204803","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G5108781970","display_name":null,"funder_award_id":"61772566","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5178878423","display_name":null,"funder_award_id":"2020YFB0204803","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6346021793","display_name":null,"funder_award_id":"2019B020228001","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4205126801.pdf","grobid_xml":"https://content.openalex.org/works/W4205126801.grobid-xml"},"referenced_works_count":74,"referenced_works":["https://openalex.org/W1602702667","https://openalex.org/W1966701961","https://openalex.org/W2025828346","https://openalex.org/W2071010503","https://openalex.org/W2123273050","https://openalex.org/W2523620612","https://openalex.org/W2526262591","https://openalex.org/W2588569583","https://openalex.org/W2612519453","https://openalex.org/W2771542157","https://openalex.org/W2794083495","https://openalex.org/W2794480084","https://openalex.org/W2794521141","https://openalex.org/W2796170779","https://openalex.org/W2801527818","https://openalex.org/W2810097927","https://openalex.org/W2885927965","https://openalex.org/W2887910040","https://openalex.org/W2894687190","https://openalex.org/W2901677030","https://openalex.org/W2907514116","https://openalex.org/W2916020270","https://openalex.org/W2942380588","https://openalex.org/W2942880491","https://openalex.org/W2949086748","https://openalex.org/W2949237386","https://openalex.org/W2949275240","https://openalex.org/W2949685357","https://openalex.org/W2950684648","https://openalex.org/W2951187834","https://openalex.org/W2951914955","https://openalex.org/W2952644935","https://openalex.org/W2953251392","https://openalex.org/W2962073995","https://openalex.org/W2964015378","https://openalex.org/W2964159205","https://openalex.org/W2964643116","https://openalex.org/W2966569571","https://openalex.org/W2967177832","https://openalex.org/W2971398276","https://openalex.org/W2973034691","https://openalex.org/W2983354807","https://openalex.org/W2994976879","https://openalex.org/W2995410603","https://openalex.org/W3000145506","https://openalex.org/W3005127469","https://openalex.org/W3006566541","https://openalex.org/W3008278692","https://openalex.org/W3016020856","https://openalex.org/W3034168389","https://openalex.org/W3034749675","https://openalex.org/W3036137852","https://openalex.org/W3041515167","https://openalex.org/W3096200195","https://openalex.org/W3112976705","https://openalex.org/W3121168830","https://openalex.org/W3128961456","https://openalex.org/W3132715010","https://openalex.org/W3138479716","https://openalex.org/W3140605903","https://openalex.org/W3157103618","https://openalex.org/W3176693948","https://openalex.org/W3183323060","https://openalex.org/W3200266566","https://openalex.org/W4289389616","https://openalex.org/W6726873649","https://openalex.org/W6755863455","https://openalex.org/W6772235055","https://openalex.org/W6775999178","https://openalex.org/W6779659972","https://openalex.org/W6780358569","https://openalex.org/W6784856447","https://openalex.org/W6792121546","https://openalex.org/W6797866248"],"related_works":["https://openalex.org/W2389214306","https://openalex.org/W2965083567","https://openalex.org/W4235240664","https://openalex.org/W1838576100","https://openalex.org/W2095886385","https://openalex.org/W2889616422","https://openalex.org/W2089704382","https://openalex.org/W1983399550","https://openalex.org/W97075385","https://openalex.org/W2357523926"],"abstract_inverted_index":{"Single-cell":[0],"RNA":[1],"sequencing":[2],"(scRNA-seq)":[3],"techniques":[4],"provide":[5],"high-resolution":[6],"data":[7,20],"on":[8,189,207],"cellular":[9],"heterogeneity":[10],"in":[11],"diverse":[12],"tissues,":[13],"and":[14,32,43,60,121,140,143,193,205,210],"a":[15,119,202],"critical":[16],"step":[17],"for":[18,78,125,147,215],"the":[19,30,46,68,79,87,104,108,131,154,164,170],"analysis":[21],"is":[22,41,62,81,133,167],"cell":[23,35,84,179],"type":[24],"identification.":[25],"Traditional":[26],"methods":[27],"usually":[28],"cluster":[29],"cells":[31,56,101,138,218],"manually":[33],"identify":[34],"clusters":[36],"through":[37,86],"marker":[38],"genes,":[39],"which":[40],"time-consuming":[42],"subjective.":[44],"With":[45],"launch":[47],"of":[48,54,100,107,149,158],"several":[49],"large-scale":[50],"single-cell":[51,127],"projects,":[52],"millions":[53,99],"sequenced":[55],"have":[57,117],"been":[58],"annotated":[59,69],"it":[61],"promising":[63],"to":[64,71,82,97,103,135],"transfer":[65],"labels":[66],"from":[67],"datasets":[70,146],"newly":[72],"generated":[73],"datasets.":[74,196],"One":[75],"powerful":[76],"way":[77],"transferring":[80],"learn":[83],"relations":[85],"graph":[88,132],"neural":[89],"network":[90],"(GNN),":[91],"but":[92],"traditional":[93],"GNNs":[94],"are":[95],"difficult":[96],"process":[98],"due":[102],"expensive":[105],"costs":[106],"message-passing":[109],"procedure":[110],"at":[111,160],"each":[112,161],"training":[113,162],"epoch.":[114],"Here,":[115],"we":[116],"developed":[118],"robust":[120],"scalable":[122],"GNN-based":[123],"method":[124],"accurate":[126],"classification":[128],"(GraphCS),":[129],"where":[130],"constructed":[134],"connect":[136],"similar":[137],"within":[139,219],"between":[141],"labelled":[142],"unlabeled":[144],"scRNA-seq":[145,195],"propagation":[148,157],"shared":[150],"information.":[151],"To":[152],"overcome":[153],"slow":[155],"information":[156,166],"GNN":[159],"epoch,":[163],"diffused":[165],"pre-calculated":[168],"via":[169],"approximate":[171],"Generalized":[172],"PageRank":[173],"algorithm,":[174],"enabling":[175],"sublinear":[176],"complexity":[177],"over":[178],"numbers.":[180],"Compared":[181],"with":[182],"existing":[183],"methods,":[184],"GraphCS":[185],"demonstrates":[186],"better":[187],"performance":[188,214],"simulated,":[190],"cross-platform,":[191],"cross-species":[192],"cross-omics":[194],"More":[197],"importantly,":[198],"our":[199],"model":[200],"provides":[201],"high":[203],"speed":[204],"scalability":[206],"large":[208],"datasets,":[209],"can":[211],"achieve":[212],"superior":[213],"1":[216],"million":[217],"50":[220],"min.":[221]},"counts_by_year":[{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":6}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}