{"id":"https://openalex.org/W4205478771","doi":"https://doi.org/10.1093/bib/bbab526","title":"A deep learning method for repurposing antiviral drugs against new viruses via multi-view nonnegative matrix factorization and its application to SARS-CoV-2","display_name":"A deep learning method for repurposing antiviral drugs against new viruses via multi-view nonnegative matrix factorization and its application to SARS-CoV-2","publication_year":2021,"publication_date":"2021-11-15","ids":{"openalex":"https://openalex.org/W4205478771","doi":"https://doi.org/10.1093/bib/bbab526","pmid":"https://pubmed.ncbi.nlm.nih.gov/34965582"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbab526","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbab526","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045680312","display_name":"Xiaorui Su","orcid":"https://orcid.org/0000-0001-5468-6085"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106108","display_name":"Xinjiang Technical Institute of Physics & Chemistry","ror":"https://ror.org/00x44h034","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaorui Su","raw_affiliation_strings":["University of Chinese Academy of Sciences, Beijing, 100049, China","Xinjiang Laboratory of Minority Speech and Language Information Processing, Urumqi, 830011, China","Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing, 100049, China","institution_ids":["https://openalex.org/I4210165038"]},{"raw_affiliation_string":"Xinjiang Laboratory of Minority Speech and Language Information Processing, Urumqi, 830011, China","institution_ids":[]},{"raw_affiliation_string":"Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008221100","display_name":"Lun Hu","orcid":"https://orcid.org/0000-0002-1591-8549"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106108","display_name":"Xinjiang Technical Institute of Physics & Chemistry","ror":"https://ror.org/00x44h034","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lun Hu","raw_affiliation_strings":["University of Chinese Academy of Sciences, Beijing, 100049, China","Xinjiang Laboratory of Minority Speech and Language Information Processing, Urumqi, 830011, China","Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing, 100049, China","institution_ids":["https://openalex.org/I4210165038"]},{"raw_affiliation_string":"Xinjiang Laboratory of Minority Speech and Language Information Processing, Urumqi, 830011, China","institution_ids":[]},{"raw_affiliation_string":"Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019805735","display_name":"Zhu\u2010Hong You","orcid":"https://orcid.org/0000-0003-1266-2696"},"institutions":[{"id":"https://openalex.org/I17145004","display_name":"Northwestern Polytechnical University","ror":"https://ror.org/01y0j0j86","country_code":"CN","type":"education","lineage":["https://openalex.org/I17145004"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhuhong You","raw_affiliation_strings":["School of Computer Science, Northwestern Polytechnical University, Xi\u2019an, 710129, China","School of Computer Science, Northwestern Polytechnical University, Xi'an, 710129, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science, Northwestern Polytechnical University, Xi\u2019an, 710129, China","institution_ids":["https://openalex.org/I17145004"]},{"raw_affiliation_string":"School of Computer Science, Northwestern Polytechnical University, Xi'an, 710129, China","institution_ids":["https://openalex.org/I17145004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078808331","display_name":"Pengwei Hu","orcid":"https://orcid.org/0000-0001-5974-7932"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106108","display_name":"Xinjiang Technical Institute of Physics & Chemistry","ror":"https://ror.org/00x44h034","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengwei Hu","raw_affiliation_strings":["University of Chinese Academy of Sciences, Beijing, 100049, China","Xinjiang Laboratory of Minority Speech and Language Information Processing, Urumqi, 830011, China","Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing, 100049, China","institution_ids":["https://openalex.org/I4210165038"]},{"raw_affiliation_string":"Xinjiang Laboratory of Minority Speech and Language Information Processing, Urumqi, 830011, China","institution_ids":[]},{"raw_affiliation_string":"Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100436059","display_name":"Lei Wang","orcid":"https://orcid.org/0000-0003-0184-307X"},"institutions":[{"id":"https://openalex.org/I4210165264","display_name":"Guangxi Academy of Sciences","ror":"https://ror.org/054x1kd82","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210165264"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Wang","raw_affiliation_strings":["Big Data and Intelligent Computing Research Center, Guangxi Academy of Science, Nanning, 530007, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Big Data and Intelligent Computing Research Center, Guangxi Academy of Science, Nanning, 530007, China","institution_ids":["https://openalex.org/I4210165264"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5014724927","display_name":"Bo-Wei Zhao","orcid":"https://orcid.org/0000-0001-8200-6016"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210106108","display_name":"Xinjiang Technical Institute of Physics & Chemistry","ror":"https://ror.org/00x44h034","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bowei Zhao","raw_affiliation_strings":["University of Chinese Academy of Sciences, Beijing, 100049, China","Xinjiang Laboratory of Minority Speech and Language Information Processing, Urumqi, 830011, China","Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Chinese Academy of Sciences, Beijing, 100049, China","institution_ids":["https://openalex.org/I4210165038"]},{"raw_affiliation_string":"Xinjiang Laboratory of Minority Speech and Language Information Processing, Urumqi, 830011, China","institution_ids":[]},{"raw_affiliation_string":"Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106108"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5008221100"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210106108","https://openalex.org/I4210165038"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":9.7583,"has_fulltext":false,"cited_by_count":91,"citation_normalized_percentile":{"value":0.98505124,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"23","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9484999775886536,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6921678781509399},{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.6141253113746643},{"id":"https://openalex.org/keywords/repurposing","display_name":"Repurposing","score":0.5440115928649902},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.5406706929206848},{"id":"https://openalex.org/keywords/initialization","display_name":"Initialization","score":0.5390796661376953},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.533119261264801},{"id":"https://openalex.org/keywords/feature-learning","display_name":"Feature learning","score":0.4826996326446533},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4032515287399292},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3227813243865967},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.22471532225608826},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.13813436031341553}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6921678781509399},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.6141253113746643},{"id":"https://openalex.org/C519536355","wikidata":"https://www.wikidata.org/wiki/Q21021151","display_name":"Repurposing","level":2,"score":0.5440115928649902},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.5406706929206848},{"id":"https://openalex.org/C114466953","wikidata":"https://www.wikidata.org/wiki/Q6034165","display_name":"Initialization","level":2,"score":0.5390796661376953},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.533119261264801},{"id":"https://openalex.org/C59404180","wikidata":"https://www.wikidata.org/wiki/Q17013334","display_name":"Feature learning","level":2,"score":0.4826996326446533},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4032515287399292},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3227813243865967},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.22471532225608826},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13813436031341553},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbab526","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbab526","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34965582","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34965582","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8100000023841858}],"awards":[{"id":"https://openalex.org/G7911954467","display_name":null,"funder_award_id":"62172355","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":81,"referenced_works":["https://openalex.org/W378747138","https://openalex.org/W1482153588","https://openalex.org/W1966238900","https://openalex.org/W1969971113","https://openalex.org/W1975147762","https://openalex.org/W2008381136","https://openalex.org/W2044892160","https://openalex.org/W2081719521","https://openalex.org/W2086493164","https://openalex.org/W2104161734","https://openalex.org/W2105668062","https://openalex.org/W2112147913","https://openalex.org/W2113072832","https://openalex.org/W2116341502","https://openalex.org/W2124198028","https://openalex.org/W2130479394","https://openalex.org/W2149302140","https://openalex.org/W2151357092","https://openalex.org/W2151902743","https://openalex.org/W2154851992","https://openalex.org/W2157725602","https://openalex.org/W2160378127","https://openalex.org/W2169678694","https://openalex.org/W2187089797","https://openalex.org/W2346950316","https://openalex.org/W2767891136","https://openalex.org/W2790385355","https://openalex.org/W2943186426","https://openalex.org/W2945027804","https://openalex.org/W2960557205","https://openalex.org/W2962756421","https://openalex.org/W2963417420","https://openalex.org/W2964015378","https://openalex.org/W2971801381","https://openalex.org/W2980655992","https://openalex.org/W2985331920","https://openalex.org/W2987479113","https://openalex.org/W3001897055","https://openalex.org/W3003430844","https://openalex.org/W3005212621","https://openalex.org/W3008763357","https://openalex.org/W3008827533","https://openalex.org/W3009912996","https://openalex.org/W3010223921","https://openalex.org/W3012210633","https://openalex.org/W3013463737","https://openalex.org/W3018248252","https://openalex.org/W3046615517","https://openalex.org/W3087406311","https://openalex.org/W3093030756","https://openalex.org/W3093244828","https://openalex.org/W3096999989","https://openalex.org/W3104097132","https://openalex.org/W3111588371","https://openalex.org/W3114457750","https://openalex.org/W3125008742","https://openalex.org/W3127273912","https://openalex.org/W3127540890","https://openalex.org/W3127559895","https://openalex.org/W3131004003","https://openalex.org/W3136592363","https://openalex.org/W3158590963","https://openalex.org/W3177710193","https://openalex.org/W3192134500","https://openalex.org/W3193314306","https://openalex.org/W3193511962","https://openalex.org/W3196522895","https://openalex.org/W3198879735","https://openalex.org/W4206816857","https://openalex.org/W4236240719","https://openalex.org/W4239761798","https://openalex.org/W4245245123","https://openalex.org/W4247001379","https://openalex.org/W6612948155","https://openalex.org/W6726873649","https://openalex.org/W6757914502","https://openalex.org/W6769949199","https://openalex.org/W6773091853","https://openalex.org/W6775233596","https://openalex.org/W6785400279","https://openalex.org/W6800433328"],"related_works":["https://openalex.org/W2899096130","https://openalex.org/W3190782215","https://openalex.org/W2902729297","https://openalex.org/W3110500039","https://openalex.org/W4255531208","https://openalex.org/W4320009247","https://openalex.org/W4206422705","https://openalex.org/W3186872001","https://openalex.org/W3174741986","https://openalex.org/W4389861022"],"abstract_inverted_index":{"The":[0],"outbreak":[1],"of":[2,11,18,79,88,134,165,182,189,206,228],"COVID-19":[3],"caused":[4],"by":[5,60,74,238],"SARS-coronavirus":[6],"(CoV)-2":[7],"has":[8],"made":[9],"millions":[10],"deaths":[12],"since":[13],"2019.":[14],"Although":[15],"a":[16,34,63,104,116,146,169,187],"variety":[17],"computational":[19],"methods":[20],"have":[21,185,240],"been":[22],"proposed":[23],"to":[24,144,155,175,244],"repurpose":[25],"drugs":[26,89,124,135,236],"for":[27,37,122,196,223],"treating":[28],"SARS-CoV-2":[29,246],"infections,":[30],"it":[31],"is":[32,72,172],"still":[33],"challenging":[35],"task":[36],"new":[38,61,126,170,217],"viruses,":[39,62],"as":[40,225],"there":[41],"are":[42,101],"no":[43],"verified":[44],"virus-drug":[45],"associations":[46],"(VDAs)":[47],"between":[48],"them":[49],"and":[50,90,136,149],"existing":[51],"drugs.":[52],"To":[53,178],"efficiently":[54],"solve":[55],"the":[56,83,86,111,131,180,202,210,220,226,241],"cold-start":[57],"problem":[58],"posed":[59],"novel":[64],"constrained":[65],"multi-view":[66],"nonnegative":[67],"matrix":[68],"factorization":[69],"(CMNMF)":[70],"model":[71,212],"designed":[73],"jointly":[75],"utilizing":[76],"multiple":[77],"sources":[78],"biological":[80],"information.":[81],"With":[82],"CMNMF":[84,112,211],"model,":[85,113],"similarities":[87],"viruses":[91,137],"can":[92],"be":[93],"preserved":[94],"from":[95],"their":[96,139,157,176],"own":[97],"perspectives":[98],"when":[99],"they":[100],"projected":[102],"onto":[103],"unified":[105],"latent":[106,141],"feature":[107,142],"space.":[108],"Based":[109],"on":[110,191],"we":[114,184],"propose":[115],"deep":[117,214],"learning":[118,215],"method,":[119],"namely":[120],"VDA-DLCMNMF,":[121,183],"repurposing":[123,222],"against":[125],"viruses.":[127],"VDA-DLCMNMF":[128,239],"first":[129],"initializes":[130],"node":[132],"representations":[133],"with":[138,168],"corresponding":[140],"vectors":[143],"avoid":[145],"random":[147],"initialization":[148],"then":[150],"applies":[151],"graph":[152],"convolutional":[153],"network":[154],"optimize":[156],"representations.":[158,177],"Given":[159],"an":[160],"arbitrary":[161],"drug,":[162],"its":[163],"probability":[164],"being":[166],"associated":[167],"virus":[171],"computed":[173],"according":[174],"evaluate":[179],"performance":[181],"conducted":[186],"series":[188],"experiments":[190,231],"three":[192],"VDA":[193],"datasets":[194],"created":[195],"SARS-CoV-2.":[197],"Experimental":[198],"results":[199,227],"demonstrate":[200],"that":[201,233],"promising":[203],"prediction":[204],"accuracy":[205],"VDA-DLCMNMF.":[207],"Moreover,":[208],"incorporating":[209],"into":[213,219],"gains":[216],"insight":[218],"drug":[221],"SARS-CoV-2,":[224],"molecular":[229],"docking":[230],"reveal":[232],"four":[234],"antiviral":[235],"identified":[237],"potential":[242],"ability":[243],"treat":[245],"infections.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":24},{"year":2023,"cited_by_count":26},{"year":2022,"cited_by_count":24}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}