{"id":"https://openalex.org/W3215470628","doi":"https://doi.org/10.1093/bib/bbab473","title":"Deep learning-based advances and applications for single-cell RNA-sequencing data analysis","display_name":"Deep learning-based advances and applications for single-cell RNA-sequencing data analysis","publication_year":2021,"publication_date":"2021-10-18","ids":{"openalex":"https://openalex.org/W3215470628","doi":"https://doi.org/10.1093/bib/bbab473","mag":"3215470628","pmid":"https://pubmed.ncbi.nlm.nih.gov/34849562"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbab473","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbab473","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5003409838","display_name":"Siqi Bao","orcid":"https://orcid.org/0000-0003-3885-125X"},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210086973","display_name":"Affiliated Eye Hospital of Wenzhou Medical College","ror":"https://ror.org/000sxmx78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086973"]},{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siqi Bao","raw_affiliation_strings":["Hainan Institute of Real World Data, Haikou 570228, P. R. China","School of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou 325027, P. R. China","School of Information and Communication Engineering, Hainan University, Haikou 570228, P. R. China"],"affiliations":[{"raw_affiliation_string":"Hainan Institute of Real World Data, Haikou 570228, P. R. China","institution_ids":[]},{"raw_affiliation_string":"School of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou 325027, P. R. China","institution_ids":["https://openalex.org/I4210086973","https://openalex.org/I27781120"]},{"raw_affiliation_string":"School of Information and Communication Engineering, Hainan University, Haikou 570228, P. R. China","institution_ids":["https://openalex.org/I20942203"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100343478","display_name":"Ke Li","orcid":"https://orcid.org/0000-0002-1694-9742"},"institutions":[{"id":"https://openalex.org/I4210086973","display_name":"Affiliated Eye Hospital of Wenzhou Medical College","ror":"https://ror.org/000sxmx78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086973"]},{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ke Li","raw_affiliation_strings":["School of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou 325027, P. R. China"],"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou 325027, P. R. China","institution_ids":["https://openalex.org/I4210086973","https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074707446","display_name":"Congcong Yan","orcid":"https://orcid.org/0000-0002-3170-169X"},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210086973","display_name":"Affiliated Eye Hospital of Wenzhou Medical College","ror":"https://ror.org/000sxmx78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086973"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Congcong Yan","raw_affiliation_strings":["School of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou 325027, P. R. China"],"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou 325027, P. R. China","institution_ids":["https://openalex.org/I4210086973","https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101797193","display_name":"Zicheng Zhang","orcid":"https://orcid.org/0000-0002-9553-7358"},"institutions":[{"id":"https://openalex.org/I4210086973","display_name":"Affiliated Eye Hospital of Wenzhou Medical College","ror":"https://ror.org/000sxmx78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086973"]},{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zicheng Zhang","raw_affiliation_strings":["School of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou 325027, P. R. China"],"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou 325027, P. R. China","institution_ids":["https://openalex.org/I4210086973","https://openalex.org/I27781120"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115598119","display_name":"Jia Qu","orcid":"https://orcid.org/0000-0003-1678-966X"},"institutions":[{"id":"https://openalex.org/I4210086973","display_name":"Affiliated Eye Hospital of Wenzhou Medical College","ror":"https://ror.org/000sxmx78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086973"]},{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I20942203","display_name":"Hainan University","ror":"https://ror.org/03q648j11","country_code":"CN","type":"education","lineage":["https://openalex.org/I20942203"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jia Qu","raw_affiliation_strings":["Hainan Institute of Real World Data, Haikou 570228, P. R. China","School of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou 325027, P. R. China","School of Information and Communication Engineering, Hainan University, Haikou 570228, P. R. China"],"affiliations":[{"raw_affiliation_string":"Hainan Institute of Real World Data, Haikou 570228, P. R. China","institution_ids":[]},{"raw_affiliation_string":"School of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou 325027, P. R. China","institution_ids":["https://openalex.org/I4210086973","https://openalex.org/I27781120"]},{"raw_affiliation_string":"School of Information and Communication Engineering, Hainan University, Haikou 570228, P. R. China","institution_ids":["https://openalex.org/I20942203"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024023342","display_name":"Meng Zhou","orcid":"https://orcid.org/0000-0001-9987-9024"},"institutions":[{"id":"https://openalex.org/I27781120","display_name":"Wenzhou Medical University","ror":"https://ror.org/00rd5t069","country_code":"CN","type":"education","lineage":["https://openalex.org/I27781120"]},{"id":"https://openalex.org/I4210086973","display_name":"Affiliated Eye Hospital of Wenzhou Medical College","ror":"https://ror.org/000sxmx78","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210086973"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Meng Zhou","raw_affiliation_strings":["School of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou 325027, P. R. China"],"affiliations":[{"raw_affiliation_string":"School of Biomedical Engineering, School of Ophthalmology & Optometry and Eye Hospital, Wenzhou Medical University, Wenzhou 325027, P. R. China","institution_ids":["https://openalex.org/I4210086973","https://openalex.org/I27781120"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5024023342","https://openalex.org/A5115598119"],"corresponding_institution_ids":["https://openalex.org/I20942203","https://openalex.org/I27781120","https://openalex.org/I4210086973"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":2.2524,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.89280774,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"23","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9908999800682068,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9753999710083008,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.7305214405059814},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6776909232139587},{"id":"https://openalex.org/keywords/normalization","display_name":"Normalization (sociology)","score":0.5318127870559692},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5200462341308594},{"id":"https://openalex.org/keywords/rna-seq","display_name":"RNA-Seq","score":0.4563399851322174},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.45494934916496277},{"id":"https://openalex.org/keywords/deep-sequencing","display_name":"Deep sequencing","score":0.4185045063495636},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3206380605697632},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1421055793762207},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.12275466322898865},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.07175549864768982}],"concepts":[{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.7305214405059814},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6776909232139587},{"id":"https://openalex.org/C136886441","wikidata":"https://www.wikidata.org/wiki/Q926129","display_name":"Normalization (sociology)","level":2,"score":0.5318127870559692},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5200462341308594},{"id":"https://openalex.org/C107397762","wikidata":"https://www.wikidata.org/wiki/Q2542347","display_name":"RNA-Seq","level":5,"score":0.4563399851322174},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.45494934916496277},{"id":"https://openalex.org/C132917006","wikidata":"https://www.wikidata.org/wiki/Q5250436","display_name":"Deep sequencing","level":4,"score":0.4185045063495636},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3206380605697632},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1421055793762207},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12275466322898865},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.07175549864768982},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000078332","descriptor_name":"Data Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000078332","descriptor_name":"Data Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000078332","descriptor_name":"Data Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbab473","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbab473","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34849562","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34849562","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1869425275","display_name":null,"funder_award_id":"61973240","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5497275332","display_name":null,"funder_award_id":"62072341","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":79,"referenced_works":["https://openalex.org/W2069089843","https://openalex.org/W2123649031","https://openalex.org/W2158899491","https://openalex.org/W2160815625","https://openalex.org/W2555502666","https://openalex.org/W2598326928","https://openalex.org/W2606771561","https://openalex.org/W2618530766","https://openalex.org/W2739492614","https://openalex.org/W2741564801","https://openalex.org/W2751468300","https://openalex.org/W2783644856","https://openalex.org/W2792479311","https://openalex.org/W2792693509","https://openalex.org/W2794480084","https://openalex.org/W2794521141","https://openalex.org/W2805619986","https://openalex.org/W2805888371","https://openalex.org/W2808462996","https://openalex.org/W2885673883","https://openalex.org/W2889236955","https://openalex.org/W2898718502","https://openalex.org/W2900510132","https://openalex.org/W2901677030","https://openalex.org/W2924067995","https://openalex.org/W2926010705","https://openalex.org/W2937917790","https://openalex.org/W2949272108","https://openalex.org/W2951217100","https://openalex.org/W2951381561","https://openalex.org/W2951506174","https://openalex.org/W2951516098","https://openalex.org/W2951737297","https://openalex.org/W2952016241","https://openalex.org/W2952230511","https://openalex.org/W2953208595","https://openalex.org/W2954499361","https://openalex.org/W2964643116","https://openalex.org/W2965552103","https://openalex.org/W2968352143","https://openalex.org/W2970633838","https://openalex.org/W2971877487","https://openalex.org/W2978541146","https://openalex.org/W2979911343","https://openalex.org/W2980147288","https://openalex.org/W2980495984","https://openalex.org/W3001485171","https://openalex.org/W3011464861","https://openalex.org/W3013731060","https://openalex.org/W3016453687","https://openalex.org/W3019420398","https://openalex.org/W3021272327","https://openalex.org/W3024013192","https://openalex.org/W3029148360","https://openalex.org/W3037216933","https://openalex.org/W3041535345","https://openalex.org/W3042462196","https://openalex.org/W3047163763","https://openalex.org/W3047725782","https://openalex.org/W3092982430","https://openalex.org/W3095964485","https://openalex.org/W3100120689","https://openalex.org/W3102434595","https://openalex.org/W3113251307","https://openalex.org/W3113863876","https://openalex.org/W3119638436","https://openalex.org/W3120894151","https://openalex.org/W3121168830","https://openalex.org/W3124326131","https://openalex.org/W3129866267","https://openalex.org/W3131634425","https://openalex.org/W3132357920","https://openalex.org/W3138479716","https://openalex.org/W3140605903","https://openalex.org/W3164839005","https://openalex.org/W3164852867","https://openalex.org/W6683738474","https://openalex.org/W6785192039","https://openalex.org/W6792121546"],"related_works":["https://openalex.org/W2953716828","https://openalex.org/W2904857019","https://openalex.org/W2944728705","https://openalex.org/W4244387946","https://openalex.org/W4380075502","https://openalex.org/W2107018762","https://openalex.org/W2169001731","https://openalex.org/W2900469846","https://openalex.org/W3113577179","https://openalex.org/W4207033213"],"abstract_inverted_index":{"The":[0,15,91],"rapid":[1],"development":[2],"of":[3,17,46,57,77,86,102],"single-cell":[4],"RNA-sequencing":[5],"(scRNA-seq)":[6],"technology":[7],"has":[8],"raised":[9],"significant":[10],"computational":[11],"and":[12,27,37,39,43,55,75,84,106,110,116],"analytical":[13],"challenges.":[14],"application":[16,101],"deep":[18,58,103],"learning":[19],"to":[20,95],"scRNA-seq":[21,47,66,87],"data":[22,67,88],"analysis":[23,45,83],"is":[24],"rapidly":[25],"evolving":[26],"can":[28],"overcome":[29],"the":[30,50,72,81,99],"unique":[31],"challenges":[32,76],"in":[33,112],"upstream":[34],"(quality":[35],"control":[36],"normalization)":[38],"downstream":[40],"(cell-,":[41],"gene-":[42],"pathway-level)":[44],"data.":[48],"In":[49],"present":[51,92],"study,":[52],"recent":[53],"advances":[54],"applications":[56],"learning-based":[59,104],"methods,":[60],"together":[61],"with":[62],"specific":[63],"tools":[64,105],"for":[65],"analysis,":[68],"were":[69,89],"summarized.":[70],"Moreover,":[71],"future":[73],"perspectives":[74],"deep-learning":[78],"techniques":[79],"regarding":[80],"appropriate":[82],"interpretation":[85],"investigated.":[90],"study":[93],"aimed":[94],"provide":[96],"evidence":[97],"supporting":[98],"biomedical":[100],"may":[107],"aid":[108],"biologists":[109],"bioinformaticians":[111],"navigating":[113],"this":[114],"exciting":[115],"fast-moving":[117],"area.":[118]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
