{"id":"https://openalex.org/W3211554243","doi":"https://doi.org/10.1093/bib/bbab455","title":"Integrative COVID-19 biological network inference with probabilistic core decomposition","display_name":"Integrative COVID-19 biological network inference with probabilistic core decomposition","publication_year":2021,"publication_date":"2021-10-08","ids":{"openalex":"https://openalex.org/W3211554243","doi":"https://doi.org/10.1093/bib/bbab455","mag":"3211554243","pmid":"https://pubmed.ncbi.nlm.nih.gov/34791019"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbab455","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbab455","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8689992","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067965165","display_name":"Yang Guo","orcid":"https://orcid.org/0000-0003-0821-9755"},"institutions":[{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Yang Guo","raw_affiliation_strings":["Department of Mathematics and Statistics, University of Victoria, 3800 Finnerty Road, V8P 5C2, Victoria, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Statistics, University of Victoria, 3800 Finnerty Road, V8P 5C2, Victoria, BC, Canada","institution_ids":["https://openalex.org/I212119943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065315172","display_name":"Fatemeh Esfahani","orcid":"https://orcid.org/0000-0003-0697-0131"},"institutions":[{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Fatemeh Esfahani","raw_affiliation_strings":["Department of Computer Science, University of Victoria, 3800 Finnerty Road, V8P 5C2, Victoria, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Victoria, 3800 Finnerty Road, V8P 5C2, Victoria, BC, Canada","institution_ids":["https://openalex.org/I212119943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102222053","display_name":"Xiaojian Shao","orcid":null},"institutions":[{"id":"https://openalex.org/I4210159778","display_name":"National Research Council Canada","ror":"https://ror.org/04mte1k06","country_code":"CA","type":"government","lineage":["https://openalex.org/I4210159778"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Xiaojian Shao","raw_affiliation_strings":["Digital Technologies Research Centre, National Research Council Canada, 1200 Montreal Road, K1A 0R6, Ottawa, ON, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Digital Technologies Research Centre, National Research Council Canada, 1200 Montreal Road, K1A 0R6, Ottawa, ON, Canada","institution_ids":["https://openalex.org/I4210159778"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101961455","display_name":"Venkatesh Srinivasan","orcid":"https://orcid.org/0000-0003-3819-3998"},"institutions":[{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Venkatesh Srinivasan","raw_affiliation_strings":["Department of Computer Science, University of Victoria, 3800 Finnerty Road, V8P 5C2, Victoria, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Victoria, 3800 Finnerty Road, V8P 5C2, Victoria, BC, Canada","institution_ids":["https://openalex.org/I212119943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011013528","display_name":"Alex Thomo","orcid":"https://orcid.org/0000-0002-3020-2258"},"institutions":[{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Alex Thomo","raw_affiliation_strings":["Department of Computer Science, University of Victoria, 3800 Finnerty Road, V8P 5C2, Victoria, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science, University of Victoria, 3800 Finnerty Road, V8P 5C2, Victoria, BC, Canada","institution_ids":["https://openalex.org/I212119943"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103347049","display_name":"Li Xing","orcid":"https://orcid.org/0000-0002-4186-7909"},"institutions":[{"id":"https://openalex.org/I32625721","display_name":"University of Saskatchewan","ror":"https://ror.org/010x8gc63","country_code":"CA","type":"education","lineage":["https://openalex.org/I32625721"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Li Xing","raw_affiliation_strings":["Department of Mathematics and Statistics, University of Saskatchewan, 110 Science Place, S7N 5A2, Saskatoon, SK, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Statistics, University of Saskatchewan, 110 Science Place, S7N 5A2, Saskatoon, SK, Canada","institution_ids":["https://openalex.org/I32625721"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090281546","display_name":"Xuekui Zhang","orcid":"https://orcid.org/0000-0003-4728-2343"},"institutions":[{"id":"https://openalex.org/I212119943","display_name":"University of Victoria","ror":"https://ror.org/04s5mat29","country_code":"CA","type":"education","lineage":["https://openalex.org/I212119943"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Xuekui Zhang","raw_affiliation_strings":["Department of Mathematics and Statistics, University of Victoria, 3800 Finnerty Road, V8P 5C2, Victoria, BC, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Statistics, University of Victoria, 3800 Finnerty Road, V8P 5C2, Victoria, BC, Canada","institution_ids":["https://openalex.org/I212119943"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5090281546"],"corresponding_institution_ids":["https://openalex.org/I212119943"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":0.9131,"has_fulltext":false,"cited_by_count":11,"citation_normalized_percentile":{"value":0.79210968,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"23","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.9318000078201294,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6681011915206909},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5619828104972839},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.523108959197998},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.5005457401275635},{"id":"https://openalex.org/keywords/probabilistic-logic","display_name":"Probabilistic logic","score":0.4989757537841797},{"id":"https://openalex.org/keywords/pipeline","display_name":"Pipeline (software)","score":0.4638993740081787},{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.4520435929298401},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.37728455662727356},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.34044986963272095},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.28816890716552734},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.25564315915107727},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.15699893236160278}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6681011915206909},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5619828104972839},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.523108959197998},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.5005457401275635},{"id":"https://openalex.org/C49937458","wikidata":"https://www.wikidata.org/wiki/Q2599292","display_name":"Probabilistic logic","level":2,"score":0.4989757537841797},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.4638993740081787},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.4520435929298401},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.37728455662727356},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.34044986963272095},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.28816890716552734},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25564315915107727},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15699893236160278},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.0},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/bib/bbab455","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbab455","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34791019","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34791019","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:cisti-icist.nrc-cnrc.ca:cistinparc:c8ad0ee9-d76b-41bc-a519-bfd08da42ae2","is_oa":false,"landing_page_url":"https://nrc-publications.canada.ca/eng/view/object/?id=c8ad0ee9-d76b-41bc-a519-bfd08da42ae2","pdf_url":null,"source":{"id":"https://openalex.org/S7407055245","display_name":"NPARC","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8689992","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8689992","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8689992","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8689992","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7900000214576721}],"awards":[{"id":"https://openalex.org/G1408478613","display_name":null,"funder_award_id":"# 950-231363","funder_id":"https://openalex.org/F4320320994","funder_display_name":"Canada Research Chairs"},{"id":"https://openalex.org/G4342125878","display_name":null,"funder_award_id":"# RGPIN-2017-04039","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G6477913511","display_name":null,"funder_award_id":"# RGPIN-2016-04022","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G6659425776","display_name":null,"funder_award_id":"# RGPIN-2017-04722","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G7657501451","display_name":null,"funder_award_id":"# RGPIN-2021-03530","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"}],"funders":[{"id":"https://openalex.org/F4320320994","display_name":"Canada Research Chairs","ror":"https://ror.org/0517h6h17"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":107,"referenced_works":["https://openalex.org/W2018680580","https://openalex.org/W2035618305","https://openalex.org/W2110065044","https://openalex.org/W2113613985","https://openalex.org/W2116423958","https://openalex.org/W2133238553","https://openalex.org/W2133465414","https://openalex.org/W2148606255","https://openalex.org/W2158217645","https://openalex.org/W2166574880","https://openalex.org/W2291620117","https://openalex.org/W2928665623","https://openalex.org/W2955909511","https://openalex.org/W3001897055","https://openalex.org/W3003217347","https://openalex.org/W3005477589","https://openalex.org/W3009912996","https://openalex.org/W3010096538","https://openalex.org/W3012320055","https://openalex.org/W3012405893","https://openalex.org/W3012515447","https://openalex.org/W3013953493","https://openalex.org/W3014644244","https://openalex.org/W3015369767","https://openalex.org/W3015901070","https://openalex.org/W3016489853","https://openalex.org/W3016538246","https://openalex.org/W3019677453","https://openalex.org/W3020023582","https://openalex.org/W3021558098","https://openalex.org/W3022155659","https://openalex.org/W3022285953","https://openalex.org/W3022534749","https://openalex.org/W3023713343","https://openalex.org/W3023943690","https://openalex.org/W3025890551","https://openalex.org/W3025969587","https://openalex.org/W3026002191","https://openalex.org/W3027076786","https://openalex.org/W3029352185","https://openalex.org/W3029848232","https://openalex.org/W3030158388","https://openalex.org/W3033175577","https://openalex.org/W3033678288","https://openalex.org/W3034111647","https://openalex.org/W3035765027","https://openalex.org/W3036023138","https://openalex.org/W3036343558","https://openalex.org/W3036443347","https://openalex.org/W3037029628","https://openalex.org/W3037945517","https://openalex.org/W3038607673","https://openalex.org/W3039175241","https://openalex.org/W3041037591","https://openalex.org/W3043379468","https://openalex.org/W3043574076","https://openalex.org/W3043868614","https://openalex.org/W3045252049","https://openalex.org/W3046382549","https://openalex.org/W3046730374","https://openalex.org/W3046836256","https://openalex.org/W3047880178","https://openalex.org/W3048234386","https://openalex.org/W3048904234","https://openalex.org/W3049380005","https://openalex.org/W3049911747","https://openalex.org/W3082474050","https://openalex.org/W3084335073","https://openalex.org/W3085007997","https://openalex.org/W3087641332","https://openalex.org/W3089676968","https://openalex.org/W3090910519","https://openalex.org/W3093259931","https://openalex.org/W3094596347","https://openalex.org/W3094597057","https://openalex.org/W3097018328","https://openalex.org/W3098512766","https://openalex.org/W3099233807","https://openalex.org/W3100227868","https://openalex.org/W3102648521","https://openalex.org/W3104970765","https://openalex.org/W3108478838","https://openalex.org/W3110212045","https://openalex.org/W3110582391","https://openalex.org/W3110586950","https://openalex.org/W3110875071","https://openalex.org/W3116920768","https://openalex.org/W3120214263","https://openalex.org/W3136337343","https://openalex.org/W3154372950","https://openalex.org/W3154506654","https://openalex.org/W3157103823","https://openalex.org/W3158868742","https://openalex.org/W4211208250","https://openalex.org/W4213060373","https://openalex.org/W4239678514","https://openalex.org/W4313196085","https://openalex.org/W6676058677","https://openalex.org/W6774316164","https://openalex.org/W6775489320","https://openalex.org/W6775819616","https://openalex.org/W6776019886","https://openalex.org/W6776208904","https://openalex.org/W6777277859","https://openalex.org/W6778606649","https://openalex.org/W6779943961","https://openalex.org/W6784671015"],"related_works":["https://openalex.org/W3129816939","https://openalex.org/W2912862995","https://openalex.org/W2985427592","https://openalex.org/W2101501829","https://openalex.org/W2400569965","https://openalex.org/W2060263731","https://openalex.org/W2003194288","https://openalex.org/W4226161264","https://openalex.org/W3156186218","https://openalex.org/W2163814182"],"abstract_inverted_index":{"The":[0,169],"severe":[1],"acute":[2],"respiratory":[3],"syndrome":[4],"coronavirus":[5],"2":[6],"(SARS-CoV-2)":[7],"is":[8],"responsible":[9],"for":[10,142,161,234],"millions":[11],"of":[12,23,42,172,203],"deaths":[13],"around":[14],"the":[15,21,43,51,70,73,88,95,101,119,129,134,173,191,223],"world.":[16],"To":[17,81],"help":[18],"contribute":[19],"to":[20,27,33,167,190,210,232],"understanding":[22],"crucial":[24],"knowledge":[25,230],"and":[26,35,49,76,122,133,147,155,164,182,206],"further":[28,235],"generate":[29,62,82],"new":[30,108],"hypotheses":[31,136,175],"relevant":[32,231],"SARS-CoV-2":[34],"human":[36],"protein":[37],"interactions,":[38],"we":[39,85,105,183,198],"make":[40],"use":[41],"information":[44,68],"abundant":[45],"Biomine":[46,71],"probabilistic":[47],"database":[48],"extend":[50],"experimentally":[52,78,97,193],"identified":[53,130,162],"SARS-CoV-2-human":[54],"protein-protein":[55],"interaction":[56],"(PPI)":[57],"network":[58,65,75,121],"in":[59,100,137],"silico.":[60],"We":[61,126],"an":[63],"extended":[64,102,120],"by":[66,186],"integrating":[67],"from":[69],"database,":[72],"PPI":[74],"other":[77],"validated":[79,98,194],"results.":[80],"novel":[83,204,215,229],"hypotheses,":[84,225],"focus":[86],"on":[87,118,153,158],"high-connectivity":[89],"sub-communities":[90],"that":[91,112],"overlap":[92],"most":[93],"with":[94,178,222],"integrated":[96,192],"results":[99,227],"network.":[103],"Therefore,":[104],"propose":[106],"a":[107,200],"data":[109],"analysis":[110,152],"pipeline":[111],"can":[113],"efficiently":[114],"compute":[115],"core":[116],"decomposition":[117],"identify":[123],"dense":[124,131],"subgraphs.":[125],"then":[127],"evaluate":[128],"subgraph":[132],"generated":[135,174,224],"three":[138],"contexts:":[139],"literature":[140,156],"validation":[141],"uncovered":[143],"virus":[144],"targeting":[145],"genes":[146,181],"proteins,":[148],"gene":[149],"function":[150],"enrichment":[151],"subgraphs":[154],"support":[157],"drug":[159],"repurposing":[160],"tissues":[163],"diseases":[165,216],"related":[166,209],"COVID-19.":[168],"major":[170],"types":[171],"are":[176],"proteins":[177,207],"their":[179,188],"encoding":[180],"rank":[184],"them":[185],"sorting":[187],"connections":[189],"nodes.":[195],"In":[196],"addition,":[197],"compile":[199],"comprehensive":[201],"list":[202],"genes,":[205],"potentially":[208],"COVID-19,":[211],"as":[212,214],"well":[213],"which":[217],"might":[218],"be":[219],"comorbidities.":[220],"Together":[221],"our":[226],"provide":[228],"COVID-19":[233],"validation.":[236]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}