{"id":"https://openalex.org/W4220723470","doi":"https://doi.org/10.1093/bib/bbab410","title":"High dimensionality reduction by matrix factorization for systems pharmacology","display_name":"High dimensionality reduction by matrix factorization for systems pharmacology","publication_year":2021,"publication_date":"2021-09-08","ids":{"openalex":"https://openalex.org/W4220723470","doi":"https://doi.org/10.1093/bib/bbab410","pmid":"https://pubmed.ncbi.nlm.nih.gov/34891155"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbab410","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbab410","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8898012","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031408885","display_name":"Adel Mehrpooya","orcid":"https://orcid.org/0000-0002-5394-4262"},"institutions":[{"id":"https://openalex.org/I115566878","display_name":"Shahid Bahonar University of Kerman","ror":"https://ror.org/04zn42r77","country_code":"IR","type":"education","lineage":["https://openalex.org/I115566878"]},{"id":"https://openalex.org/I160993911","display_name":"Queensland University of Technology","ror":"https://ror.org/03pnv4752","country_code":"AU","type":"education","lineage":["https://openalex.org/I160993911"]}],"countries":["AU","IR"],"is_corresponding":false,"raw_author_name":"Adel Mehrpooya","raw_affiliation_strings":["Department of Computer Engineering, Faculty of Engineering, Shahid Bahonar University of Kerman, Kerman, Iran","School of Mathematical Sciences, Science and Engineering Faculty, Queensland University of Technology (QUT), Brisbane, Australia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Engineering, Faculty of Engineering, Shahid Bahonar University of Kerman, Kerman, Iran","institution_ids":["https://openalex.org/I115566878"]},{"raw_affiliation_string":"School of Mathematical Sciences, Science and Engineering Faculty, Queensland University of Technology (QUT), Brisbane, Australia","institution_ids":["https://openalex.org/I160993911"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053277804","display_name":"Farid Saberi-Movahed","orcid":"https://orcid.org/0000-0003-2718-229X"},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I183263030","display_name":"Graduate University of Advanced Technology","ror":"https://ror.org/0451xdy64","country_code":"IR","type":"education","lineage":["https://openalex.org/I183263030"]}],"countries":["IR","US"],"is_corresponding":true,"raw_author_name":"Farid Saberi-Movahed","raw_affiliation_strings":["College of Engineering, North Carolina State University, Raleigh, NC 22606, USA","Department of Applied Mathematics, Faculty of Sciences and Modern Technologies, Graduate University of Advanced Technology, Kerman, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Engineering, North Carolina State University, Raleigh, NC 22606, USA","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"Department of Applied Mathematics, Faculty of Sciences and Modern Technologies, Graduate University of Advanced Technology, Kerman, Iran","institution_ids":["https://openalex.org/I183263030"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053277804","display_name":"Farid Saberi-Movahed","orcid":"https://orcid.org/0000-0003-2718-229X"},"institutions":[{"id":"https://openalex.org/I115566878","display_name":"Shahid Bahonar University of Kerman","ror":"https://ror.org/04zn42r77","country_code":"IR","type":"education","lineage":["https://openalex.org/I115566878"]},{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I183263030","display_name":"Graduate University of Advanced Technology","ror":"https://ror.org/0451xdy64","country_code":"IR","type":"education","lineage":["https://openalex.org/I183263030"]}],"countries":["IR","US"],"is_corresponding":false,"raw_author_name":"Farid Saberi-Movahed","raw_affiliation_strings":["College of Engineering, North Carolina State University, Raleigh, NC 22606, USA","Department of Applied Mathematics, Faculty of Sciences and Modern Technologies, Graduate University of Advanced Technology, Kerman, Iran","Department of Applied Mathematics, Faculty of Mathematics and Computer, Shahid Bahonar University of Kerman, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Engineering, North Carolina State University, Raleigh, NC 22606, USA","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"Department of Applied Mathematics, Faculty of Sciences and Modern Technologies, Graduate University of Advanced Technology, Kerman, Iran","institution_ids":["https://openalex.org/I183263030"]},{"raw_affiliation_string":"Department of Applied Mathematics, Faculty of Mathematics and Computer, Shahid Bahonar University of Kerman, Iran","institution_ids":["https://openalex.org/I115566878"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083037168","display_name":"Najmeh Azizizadeh","orcid":null},"institutions":[{"id":"https://openalex.org/I115566878","display_name":"Shahid Bahonar University of Kerman","ror":"https://ror.org/04zn42r77","country_code":"IR","type":"education","lineage":["https://openalex.org/I115566878"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Najmeh Azizizadeh","raw_affiliation_strings":["Department of Applied Mathematics, Faculty of Mathematics and Computer, Shahid Bahonar University of Kerman, Iran","Department of Computer Engineering, Faculty of Engineering, Shahid Bahonar University of Kerman, Kerman, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Applied Mathematics, Faculty of Mathematics and Computer, Shahid Bahonar University of Kerman, Iran","institution_ids":["https://openalex.org/I115566878"]},{"raw_affiliation_string":"Department of Computer Engineering, Faculty of Engineering, Shahid Bahonar University of Kerman, Kerman, Iran","institution_ids":["https://openalex.org/I115566878"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034804299","display_name":"Mohammad Rezaei-Ravari","orcid":null},"institutions":[{"id":"https://openalex.org/I115566878","display_name":"Shahid Bahonar University of Kerman","ror":"https://ror.org/04zn42r77","country_code":"IR","type":"education","lineage":["https://openalex.org/I115566878"]},{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]}],"countries":["IR","US"],"is_corresponding":false,"raw_author_name":"Mohammad Rezaei-Ravari","raw_affiliation_strings":["Department of Computer Engineering, Faculty of Engineering, Shahid Bahonar University of Kerman, Kerman, Iran","College of Engineering, North Carolina State University, Raleigh, NC 22606, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Engineering, Faculty of Engineering, Shahid Bahonar University of Kerman, Kerman, Iran","institution_ids":["https://openalex.org/I115566878"]},{"raw_affiliation_string":"College of Engineering, North Carolina State University, Raleigh, NC 22606, USA","institution_ids":["https://openalex.org/I137902535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044369814","display_name":"Farshad Saberi-Movahed","orcid":"https://orcid.org/0000-0001-8556-4531"},"institutions":[{"id":"https://openalex.org/I115566878","display_name":"Shahid Bahonar University of Kerman","ror":"https://ror.org/04zn42r77","country_code":"IR","type":"education","lineage":["https://openalex.org/I115566878"]},{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I183263030","display_name":"Graduate University of Advanced Technology","ror":"https://ror.org/0451xdy64","country_code":"IR","type":"education","lineage":["https://openalex.org/I183263030"]}],"countries":["IR","US"],"is_corresponding":false,"raw_author_name":"Farshad Saberi-Movahed","raw_affiliation_strings":["College of Engineering, North Carolina State University, Raleigh, NC 22606, USA","Department of Applied Mathematics, Faculty of Sciences and Modern Technologies, Graduate University of Advanced Technology, Kerman, Iran","Department of Computer Engineering, Faculty of Engineering, Shahid Bahonar University of Kerman, Kerman, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Engineering, North Carolina State University, Raleigh, NC 22606, USA","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"Department of Applied Mathematics, Faculty of Sciences and Modern Technologies, Graduate University of Advanced Technology, Kerman, Iran","institution_ids":["https://openalex.org/I183263030"]},{"raw_affiliation_string":"Department of Computer Engineering, Faculty of Engineering, Shahid Bahonar University of Kerman, Kerman, Iran","institution_ids":["https://openalex.org/I115566878"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044369814","display_name":"Farshad Saberi-Movahed","orcid":"https://orcid.org/0000-0001-8556-4531"},"institutions":[{"id":"https://openalex.org/I137902535","display_name":"North Carolina State University","ror":"https://ror.org/04tj63d06","country_code":"US","type":"education","lineage":["https://openalex.org/I137902535"]},{"id":"https://openalex.org/I183263030","display_name":"Graduate University of Advanced Technology","ror":"https://ror.org/0451xdy64","country_code":"IR","type":"education","lineage":["https://openalex.org/I183263030"]},{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["IR","US"],"is_corresponding":true,"raw_author_name":"Farshad Saberi-Movahed","raw_affiliation_strings":["College of Engineering, North Carolina State University, Raleigh, NC 22606, USA","Department of Applied Mathematics, Faculty of Sciences and Modern Technologies, Graduate University of Advanced Technology, Kerman, Iran","Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY10029, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Engineering, North Carolina State University, Raleigh, NC 22606, USA","institution_ids":["https://openalex.org/I137902535"]},{"raw_affiliation_string":"Department of Applied Mathematics, Faculty of Sciences and Modern Technologies, Graduate University of Advanced Technology, Kerman, Iran","institution_ids":["https://openalex.org/I183263030"]},{"raw_affiliation_string":"Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY10029, USA","institution_ids":["https://openalex.org/I98704320"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048077935","display_name":"Mahdi Eftekhari","orcid":"https://orcid.org/0000-0002-0381-8225"},"institutions":[{"id":"https://openalex.org/I115566878","display_name":"Shahid Bahonar University of Kerman","ror":"https://ror.org/04zn42r77","country_code":"IR","type":"education","lineage":["https://openalex.org/I115566878"]}],"countries":["IR"],"is_corresponding":true,"raw_author_name":"Mahdi Eftekhari","raw_affiliation_strings":["Department of Computer Engineering, Faculty of Engineering, Shahid Bahonar University of Kerman, Kerman, Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Engineering, Faculty of Engineering, Shahid Bahonar University of Kerman, Kerman, Iran","institution_ids":["https://openalex.org/I115566878"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018700398","display_name":"Iman Tavassoly","orcid":"https://orcid.org/0000-0002-2258-1091"},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Iman Tavassoly","raw_affiliation_strings":["Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY10029, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY10029, USA","institution_ids":["https://openalex.org/I98704320"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5018700398","https://openalex.org/A5044369814","https://openalex.org/A5048077935","https://openalex.org/A5053277804"],"corresponding_institution_ids":["https://openalex.org/I115566878","https://openalex.org/I137902535","https://openalex.org/I183263030","https://openalex.org/I98704320"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":2.8141,"has_fulltext":false,"cited_by_count":41,"citation_normalized_percentile":{"value":0.92282189,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"23","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dimensionality-reduction","display_name":"Dimensionality reduction","score":0.7429888248443604},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5965795516967773},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.5771525502204895},{"id":"https://openalex.org/keywords/matrix-decomposition","display_name":"Matrix decomposition","score":0.562951922416687},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.42372068762779236},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4230392277240753},{"id":"https://openalex.org/keywords/curse-of-dimensionality","display_name":"Curse of dimensionality","score":0.4225490689277649},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.39244258403778076},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.33005309104919434},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3236294984817505},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.16188642382621765}],"concepts":[{"id":"https://openalex.org/C70518039","wikidata":"https://www.wikidata.org/wiki/Q16000077","display_name":"Dimensionality reduction","level":2,"score":0.7429888248443604},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5965795516967773},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.5771525502204895},{"id":"https://openalex.org/C42355184","wikidata":"https://www.wikidata.org/wiki/Q1361088","display_name":"Matrix decomposition","level":3,"score":0.562951922416687},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.42372068762779236},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4230392277240753},{"id":"https://openalex.org/C111030470","wikidata":"https://www.wikidata.org/wiki/Q1430460","display_name":"Curse of dimensionality","level":2,"score":0.4225490689277649},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.39244258403778076},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.33005309104919434},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3236294984817505},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16188642382621765},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C158693339","wikidata":"https://www.wikidata.org/wiki/Q190524","display_name":"Eigenvalues and eigenvectors","level":2,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000091484","descriptor_name":"Network Pharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000091484","descriptor_name":"Network Pharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000091484","descriptor_name":"Network Pharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000091484","descriptor_name":"Network Pharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000091484","descriptor_name":"Network Pharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000091484","descriptor_name":"Network Pharmacology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbab410","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbab410","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34891155","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34891155","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:8898012","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8898012","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8898012","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8898012","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"},"sustainable_development_goals":[{"score":0.6700000166893005,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1787582231","display_name":null,"funder_award_id":"R25 GM067110","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3101592849","display_name":null,"funder_award_id":"97021946","funder_id":"https://openalex.org/F4320322243","funder_display_name":"Iran National Science Foundation"},{"id":"https://openalex.org/G8754301648","display_name":null,"funder_award_id":"R25GM067110","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320322243","display_name":"Iran National Science Foundation","ror":"https://ror.org/03sr1ma14"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W753601896","https://openalex.org/W1493357981","https://openalex.org/W1580973103","https://openalex.org/W1594281588","https://openalex.org/W1902027874","https://openalex.org/W1922017469","https://openalex.org/W1935781822","https://openalex.org/W1964811177","https://openalex.org/W1970324691","https://openalex.org/W1971446946","https://openalex.org/W1983704480","https://openalex.org/W2015648984","https://openalex.org/W2015796769","https://openalex.org/W2035059302","https://openalex.org/W2038894244","https://openalex.org/W2043398720","https://openalex.org/W2056168656","https://openalex.org/W2069479716","https://openalex.org/W2075103606","https://openalex.org/W2085417547","https://openalex.org/W2087684630","https://openalex.org/W2088851040","https://openalex.org/W2111614606","https://openalex.org/W2119387367","https://openalex.org/W2120408219","https://openalex.org/W2132692097","https://openalex.org/W2132922290","https://openalex.org/W2136787567","https://openalex.org/W2137009853","https://openalex.org/W2141055671","https://openalex.org/W2142594886","https://openalex.org/W2143426320","https://openalex.org/W2147246240","https://openalex.org/W2149620660","https://openalex.org/W2162142051","https://openalex.org/W2241420790","https://openalex.org/W2344681634","https://openalex.org/W2344784208","https://openalex.org/W2479197897","https://openalex.org/W2480611454","https://openalex.org/W2520964758","https://openalex.org/W2593036017","https://openalex.org/W2753846453","https://openalex.org/W2773816511","https://openalex.org/W2790860521","https://openalex.org/W2791315675","https://openalex.org/W2791581894","https://openalex.org/W2884654161","https://openalex.org/W2890940470","https://openalex.org/W2895041039","https://openalex.org/W2899843038","https://openalex.org/W2900743027","https://openalex.org/W2911627187","https://openalex.org/W2928663587","https://openalex.org/W2946235261","https://openalex.org/W2946807672","https://openalex.org/W2949460307","https://openalex.org/W2955954653","https://openalex.org/W2974862798","https://openalex.org/W2995014960","https://openalex.org/W2997412521","https://openalex.org/W3006064283","https://openalex.org/W3011314731","https://openalex.org/W3013454794","https://openalex.org/W3044416185","https://openalex.org/W3099945807","https://openalex.org/W3124452137","https://openalex.org/W3132451580","https://openalex.org/W4205910419","https://openalex.org/W4289236186","https://openalex.org/W4292023222","https://openalex.org/W4299823361","https://openalex.org/W4301621763","https://openalex.org/W4388297464","https://openalex.org/W6629638915","https://openalex.org/W6634960711","https://openalex.org/W6673031265","https://openalex.org/W6681822384","https://openalex.org/W6768220193","https://openalex.org/W6773997658"],"related_works":["https://openalex.org/W1995622179","https://openalex.org/W1484111231","https://openalex.org/W4391160746","https://openalex.org/W1552543208","https://openalex.org/W2074396517","https://openalex.org/W2166963679","https://openalex.org/W2187269125","https://openalex.org/W1641615907","https://openalex.org/W20047544","https://openalex.org/W3089231081"],"abstract_inverted_index":{"The":[0,145],"extraction":[1],"of":[2,30,48,90,131,142,161],"predictive":[3,138,160],"features":[4,31,139],"from":[5],"the":[6,17,44,49,61,87,133,150,169],"complex":[7],"high-dimensional":[8,28],"multi-omic":[9],"data":[10,39],"is":[11,40],"necessary":[12],"for":[13,68,93,120],"decoding":[14],"and":[15,37,46,52,116,136,154],"overcoming":[16],"therapeutic":[18],"responses":[19,51],"in":[20,32,33,35,72,140,168],"systems":[21,73],"pharmacology.":[22,74],"Developing":[23],"computational":[24],"methods":[25,85,106,128,152],"to":[26,42,107,114],"reduce":[27],"space":[29],"vitro,":[34],"vivo":[36],"clinical":[38],"essential":[41],"discover":[43],"evolution":[45],"mechanisms":[47],"drug":[50,53],"resistance.":[54],"In":[55,75],"this":[56,76],"paper,":[57],"we":[58,78],"have":[59,79,96],"utilized":[60],"matrix":[62],"factorization":[63],"(MF)":[64],"as":[65,100,102],"a":[66,91,157,162],"modality":[67],"high":[69],"dimensionality":[70],"reduction":[71],"respect,":[77],"proposed":[80,147],"three":[81,103,146],"novel":[82],"feature":[83,121,134],"selection":[84],"using":[86],"mathematical":[88],"conception":[89],"basis":[92],"features.":[94],"We":[95],"applied":[97],"these":[98,127],"techniques":[99,148],"well":[101],"other":[104,151],"MF":[105],"analyze":[108],"eight":[109],"different":[110],"gene":[111],"expression":[112],"datasets":[113],"investigate":[115],"compare":[117],"their":[118],"performance":[119],"selection.":[122],"Our":[123],"results":[124],"show":[125],"that":[126],"are":[129],"capable":[130],"reducing":[132],"spaces":[135],"find":[137],"terms":[141],"phenotype":[143],"determination.":[144],"outperform":[149],"used":[153],"can":[155],"extract":[156],"2-gene":[158],"signature":[159],"tyrosine":[163],"kinase":[164],"inhibitor":[165],"treatment":[166],"response":[167],"Cancer":[170],"Cell":[171],"Line":[172],"Encyclopedia.":[173]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":17},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":1}],"updated_date":"2026-07-27T06:00:05.401030","created_date":"2025-10-10T00:00:00"}