{"id":"https://openalex.org/W3198742822","doi":"https://doi.org/10.1093/bib/bbab373","title":"Identification of potential therapeutic targets and mechanisms of COVID-19 through network analysis and screening of chemicals and herbal ingredients","display_name":"Identification of potential therapeutic targets and mechanisms of COVID-19 through network analysis and screening of chemicals and herbal ingredients","publication_year":2021,"publication_date":"2021-09-08","ids":{"openalex":"https://openalex.org/W3198742822","doi":"https://doi.org/10.1093/bib/bbab373","mag":"3198742822","pmid":"https://pubmed.ncbi.nlm.nih.gov/34505138"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbab373","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbab373","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8499921","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100369573","display_name":"Hong Wang","orcid":"https://orcid.org/0000-0001-5468-8400"},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hong Wang","raw_affiliation_strings":["Chongqing Engineering Research Center for Clinical Big-data and Drug Evaluation, Chongqing Medical University, Chongqing, 401331, China","Chongqing Key Research Laboratory for Drug Metabolism, College of Pharmacy, Chongqing Medical University, Chongqing, 400016, China","Medical Data Science Academy, Chongqing Medical University, Chongqing, 400016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Engineering Research Center for Clinical Big-data and Drug Evaluation, Chongqing Medical University, Chongqing, 401331, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"Chongqing Key Research Laboratory for Drug Metabolism, College of Pharmacy, Chongqing Medical University, Chongqing, 400016, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"Medical Data Science Academy, Chongqing Medical University, Chongqing, 400016, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046409585","display_name":"Jingqing Zhang","orcid":"https://orcid.org/0000-0002-3291-0995"},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingqing Zhang","raw_affiliation_strings":["Chongqing Key Research Laboratory for Drug Metabolism, College of Pharmacy, Chongqing Medical University, Chongqing, 400016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Key Research Laboratory for Drug Metabolism, College of Pharmacy, Chongqing Medical University, Chongqing, 400016, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071959801","display_name":"Zhigang Lu","orcid":"https://orcid.org/0000-0002-2880-7848"},"institutions":[{"id":"https://openalex.org/I4210090066","display_name":"First People\u2019s Hospital of Jingmen","ror":"https://ror.org/007x72212","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210090066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhigang Lu","raw_affiliation_strings":["Department of Neurology, The First People's Hospital of Jingmen affiliated to Hubei Minzu University, Jingmen, 448000, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, The First People's Hospital of Jingmen affiliated to Hubei Minzu University, Jingmen, 448000, China","institution_ids":["https://openalex.org/I4210090066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112579270","display_name":"Weina Dai","orcid":null},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weina Dai","raw_affiliation_strings":["Chongqing Key Research Laboratory for Drug Metabolism, College of Pharmacy, Chongqing Medical University, Chongqing, 400016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Key Research Laboratory for Drug Metabolism, College of Pharmacy, Chongqing Medical University, Chongqing, 400016, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100933589","display_name":"Chuanjiang Ma","orcid":null},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuanjiang Ma","raw_affiliation_strings":["Chongqing Key Research Laboratory for Drug Metabolism, College of Pharmacy, Chongqing Medical University, Chongqing, 400016, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chongqing Key Research Laboratory for Drug Metabolism, College of Pharmacy, Chongqing Medical University, Chongqing, 400016, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007650182","display_name":"Yun Xiang","orcid":"https://orcid.org/0000-0003-2982-425X"},"institutions":[{"id":"https://openalex.org/I4210105982","display_name":"Guangzhou Women and Children Medical Center","ror":"https://ror.org/01g53at17","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105982"]},{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yun Xiang","raw_affiliation_strings":["Gynaecology and Obstetrics, Guangzhou Women and Children's Medical Center, Guangzhou, 510623, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gynaecology and Obstetrics, Guangzhou Women and Children's Medical Center, Guangzhou, 510623, China","institution_ids":["https://openalex.org/I4210105982","https://openalex.org/I92039509"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100429043","display_name":"Yonghong Zhang","orcid":"https://orcid.org/0000-0001-8574-9288"},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yonghong Zhang","raw_affiliation_strings":["Chongqing Engineering Research Center for Clinical Big-data and Drug Evaluation, Chongqing Medical University, Chongqing, 401331, China","Chongqing Key Research Laboratory for Drug Metabolism, College of Pharmacy, Chongqing Medical University, Chongqing, 400016, China","Medical Data Science Academy, Chongqing Medical University, Chongqing, 400016, China"],"raw_orcid":"https://orcid.org/0000-0001-8574-9288","affiliations":[{"raw_affiliation_string":"Chongqing Engineering Research Center for Clinical Big-data and Drug Evaluation, Chongqing Medical University, Chongqing, 401331, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"Chongqing Key Research Laboratory for Drug Metabolism, College of Pharmacy, Chongqing Medical University, Chongqing, 400016, China","institution_ids":["https://openalex.org/I87780372"]},{"raw_affiliation_string":"Medical Data Science Academy, Chongqing Medical University, Chongqing, 400016, China","institution_ids":["https://openalex.org/I87780372"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100429043"],"corresponding_institution_ids":["https://openalex.org/I87780372"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":2.6374,"has_fulltext":false,"cited_by_count":23,"citation_normalized_percentile":{"value":0.90984162,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"23","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12023","display_name":"Cholinesterase and Neurodegenerative Diseases","score":0.9894999861717224,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12817","display_name":"Pharmacological Effects of Natural Compounds","score":0.968999981880188,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coronavirus-disease-2019","display_name":"Coronavirus disease 2019 (COVID-19)","score":0.8444693088531494},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.7654985189437866},{"id":"https://openalex.org/keywords/severe-acute-respiratory-syndrome-coronavirus-2","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","score":0.6315001845359802},{"id":"https://openalex.org/keywords/2019-20-coronavirus-outbreak","display_name":"2019-20 coronavirus outbreak","score":0.6262087821960449},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"Traditional medicine","score":0.3834066092967987},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3460855484008789},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.32767295837402344},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2907176613807678},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.23827898502349854},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15718737244606018},{"id":"https://openalex.org/keywords/infectious-disease","display_name":"Infectious disease (medical specialty)","score":0.06286680698394775},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.060536324977874756},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.058814793825149536}],"concepts":[{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.8444693088531494},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.7654985189437866},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.6315001845359802},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.6262087821960449},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.3834066092967987},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3460855484008789},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.32767295837402344},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2907176613807678},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.23827898502349854},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15718737244606018},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.06286680698394775},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.060536324977874756},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.058814793825149536},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004365","descriptor_name":"Drugs, Chinese Herbal","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058873","descriptor_name":"Pandemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D062105","descriptor_name":"Molecular Docking Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/bib/bbab373","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbab373","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34505138","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34505138","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:7393380","is_oa":false,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8499921","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8499921","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8499921","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8499921","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8499921","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8299999833106995,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1250556283","display_name":null,"funder_award_id":"22176020","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G2649659720","display_name":null,"funder_award_id":"32072262","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G8722323694","display_name":null,"funder_award_id":"cstc2020jcyj-msxmX0150","funder_id":"https://openalex.org/F4320323172","funder_display_name":"Natural Science Foundation of Chongqing"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320323172","display_name":"Natural Science Foundation of Chongqing","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":95,"referenced_works":["https://openalex.org/W1544009106","https://openalex.org/W1969541023","https://openalex.org/W1972264601","https://openalex.org/W2010903641","https://openalex.org/W2012307570","https://openalex.org/W2036385867","https://openalex.org/W2047926663","https://openalex.org/W2054465223","https://openalex.org/W2056782561","https://openalex.org/W2097805045","https://openalex.org/W2099499176","https://openalex.org/W2104571948","https://openalex.org/W2119111857","https://openalex.org/W2123971588","https://openalex.org/W2263739890","https://openalex.org/W2581754481","https://openalex.org/W2767680295","https://openalex.org/W2768471772","https://openalex.org/W2783523925","https://openalex.org/W2794373093","https://openalex.org/W2807892644","https://openalex.org/W2896002881","https://openalex.org/W2898210859","https://openalex.org/W2970872004","https://openalex.org/W2988915271","https://openalex.org/W2994900199","https://openalex.org/W3000413850","https://openalex.org/W3008394341","https://openalex.org/W3011072970","https://openalex.org/W3013198879","https://openalex.org/W3016247086","https://openalex.org/W3017271475","https://openalex.org/W3018023298","https://openalex.org/W3019096936","https://openalex.org/W3020404451","https://openalex.org/W3022120179","https://openalex.org/W3022722383","https://openalex.org/W3022970339","https://openalex.org/W3023606094","https://openalex.org/W3025962447","https://openalex.org/W3028659908","https://openalex.org/W3033514395","https://openalex.org/W3033671083","https://openalex.org/W3035802734","https://openalex.org/W3037867966","https://openalex.org/W3038910044","https://openalex.org/W3039476797","https://openalex.org/W3041403959","https://openalex.org/W3041960835","https://openalex.org/W3043379468","https://openalex.org/W3045719803","https://openalex.org/W3046419426","https://openalex.org/W3047753928","https://openalex.org/W3049237452","https://openalex.org/W3080090860","https://openalex.org/W3080247409","https://openalex.org/W3080418884","https://openalex.org/W3080720024","https://openalex.org/W3080981445","https://openalex.org/W3083806372","https://openalex.org/W3084335073","https://openalex.org/W3084804460","https://openalex.org/W3087234540","https://openalex.org/W3088219913","https://openalex.org/W3092122033","https://openalex.org/W3092207907","https://openalex.org/W3093367571","https://openalex.org/W3093686187","https://openalex.org/W3094971824","https://openalex.org/W3096177766","https://openalex.org/W3096261965","https://openalex.org/W3099959746","https://openalex.org/W3101403202","https://openalex.org/W3101432423","https://openalex.org/W3102648521","https://openalex.org/W3105815895","https://openalex.org/W3109034798","https://openalex.org/W3110466220","https://openalex.org/W3114925893","https://openalex.org/W3117730334","https://openalex.org/W3118874595","https://openalex.org/W3124827150","https://openalex.org/W3134906456","https://openalex.org/W3148337521","https://openalex.org/W3154642949","https://openalex.org/W3156430862","https://openalex.org/W3158868742","https://openalex.org/W3160788382","https://openalex.org/W3165237293","https://openalex.org/W3167140978","https://openalex.org/W3184618566","https://openalex.org/W4205093509","https://openalex.org/W6745990110","https://openalex.org/W6783242448","https://openalex.org/W6805312996"],"related_works":["https://openalex.org/W4206669628","https://openalex.org/W3036314732","https://openalex.org/W4205317059","https://openalex.org/W3009669391","https://openalex.org/W4382894326","https://openalex.org/W3198183218","https://openalex.org/W3081785542","https://openalex.org/W3171943759","https://openalex.org/W3176864053","https://openalex.org/W3084498529"],"abstract_inverted_index":{"After":[0],"experiencing":[1],"the":[2,37,50,55,74,84,100,133,139,144,158,169],"COVID-19":[3,80,90,145],"pandemic,":[4],"it":[5],"is":[6,15],"widely":[7],"acknowledged":[8],"that":[9,45,125],"a":[10],"rapid":[11],"drug":[12,22,77,162,165],"repurposing":[13,23,163],"method":[14,151],"highly":[16],"needed.":[17],"A":[18],"series":[19],"of":[20,54,93,103,135,143,161,171],"useful":[21],"tools":[24],"have":[25],"been":[26],"developed":[27],"based":[28],"on":[29,36],"data-driven":[30],"modeling":[31],"and":[32,52,79,88,97,110,118,123,138,141],"network":[33,67,87],"pharmacology.":[34],"Based":[35],"disease":[38,81],"module,":[39],"we":[40],"identified":[41],"several":[42],"hub":[43],"proteins":[44],"play":[46,129],"important":[47],"roles":[48,131],"in":[49,83,132,157,168],"onset":[51,140],"development":[53,142],"COVID-19,":[56],"which":[57],"are":[58],"potential":[59],"targets":[60,78,82],"for":[61],"repositioning":[62],"approved":[63],"drugs.":[64],"Moreover,":[65],"different":[66,126,130],"distance":[68],"metrics":[69],"were":[70,105],"applied":[71],"to":[72],"quantify":[73],"relationship":[75],"between":[76],"protein-protein-interaction":[85],"(PPI)":[86],"predict":[89],"therapeutic":[91],"effects":[92],"bioactive":[94],"herbal":[95,120,172],"ingredients":[96],"chemicals.":[98],"Furthermore,":[99],"tentative":[101],"mechanisms":[102],"candidates":[104,122],"illustrated":[106],"through":[107],"molecular":[108],"docking":[109],"gene":[111],"enrichment":[112],"analysis.":[113],"We":[114],"obtained":[115],"15":[116,119],"chemical":[117],"ingredient":[121],"found":[124],"drugs":[127],"may":[128],"process":[134],"virus":[136],"invasion":[137],"disease.":[146],"Given":[147],"pandemic":[148],"outbreaks,":[149],"our":[150],"has":[152],"an":[153],"undeniable":[154],"immense":[155],"advantage":[156],"feasibility":[159],"analysis":[160,170],"or":[164],"screening,":[166],"especially":[167],"ingredients.":[173]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":1}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}
