{"id":"https://openalex.org/W3189779471","doi":"https://doi.org/10.1093/bib/bbab307","title":"Data-driven identification of SARS-CoV-2 subpopulations using PhenoGraph and binary-coded genomic data","display_name":"Data-driven identification of SARS-CoV-2 subpopulations using PhenoGraph and binary-coded genomic data","publication_year":2021,"publication_date":"2021-07-19","ids":{"openalex":"https://openalex.org/W3189779471","doi":"https://doi.org/10.1093/bib/bbab307","mag":"3189779471","pmid":"https://pubmed.ncbi.nlm.nih.gov/34382087"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbab307","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbab307","pdf_url":"https://academic.oup.com/bib/article-pdf/22/6/bbab307/41090276/bbab307.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/22/6/bbab307/41090276/bbab307.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107220026","display_name":"Zhikai Yang","orcid":"https://orcid.org/0000-0001-6104-5083"},"institutions":[{"id":"https://openalex.org/I92039509","display_name":"Guangzhou Medical University","ror":"https://ror.org/00zat6v61","country_code":"CN","type":"education","lineage":["https://openalex.org/I92039509"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhi-Kai Yang","raw_affiliation_strings":["Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou 510700, China"],"raw_orcid":"https://orcid.org/0000-0001-6104-5083","affiliations":[{"raw_affiliation_string":"Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou 510700, China","institution_ids":["https://openalex.org/I92039509"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023778284","display_name":"Lingyu Pan","orcid":"https://orcid.org/0000-0002-4795-3744"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lingyu Pan","raw_affiliation_strings":["Guangzhou Nanxin Pharmaceutical Co., Ltd., Guangzhou 510700, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Guangzhou Nanxin Pharmaceutical Co., Ltd., Guangzhou 510700, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100604286","display_name":"Yanming Zhang","orcid":"https://orcid.org/0000-0002-1391-9572"},"institutions":[{"id":"https://openalex.org/I2801663168","display_name":"Chinese National Human Genome Center","ror":"https://ror.org/01wq93z70","country_code":"CN","type":"facility","lineage":["https://openalex.org/I2801663168"]},{"id":"https://openalex.org/I4210129994","display_name":"SinoGenoMax (China)","ror":"https://ror.org/02xfgyt86","country_code":"CN","type":"company","lineage":["https://openalex.org/I4210129994"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yanming Zhang","raw_affiliation_strings":["SinoGenoMax Co., Ltd./Chinese National Human Genome Center, Guangzhou 510700, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SinoGenoMax Co., Ltd./Chinese National Human Genome Center, Guangzhou 510700, China","institution_ids":["https://openalex.org/I2801663168","https://openalex.org/I4210129994"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009471000","display_name":"Hao Luo","orcid":"https://orcid.org/0000-0003-2714-8817"},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hao Luo","raw_affiliation_strings":["Department of Physics, School of Science, Tianjin University, Tianjin University, Tianjin 300072, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, School of Science, Tianjin University, Tianjin University, Tianjin 300072, China","institution_ids":["https://openalex.org/I162868743"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074242312","display_name":"Feng Gao","orcid":"https://orcid.org/0000-0002-9563-3841"},"institutions":[{"id":"https://openalex.org/I162868743","display_name":"Tianjin University","ror":"https://ror.org/012tb2g32","country_code":"CN","type":"education","lineage":["https://openalex.org/I162868743"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Feng Gao","raw_affiliation_strings":["Department of Physics, School of Science, and the Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin 300072, China"],"raw_orcid":"https://orcid.org/0000-0002-9563-3841","affiliations":[{"raw_affiliation_string":"Department of Physics, School of Science, and the Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin 300072, China","institution_ids":["https://openalex.org/I162868743"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5074242312","https://openalex.org/A5107220026"],"corresponding_institution_ids":["https://openalex.org/I162868743","https://openalex.org/I92039509"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":0.3865,"has_fulltext":true,"cited_by_count":9,"citation_normalized_percentile":{"value":0.63340221,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"22","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11754","display_name":"SARS-CoV-2 detection and testing","score":0.9898999929428101,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11775","display_name":"COVID-19 diagnosis using AI","score":0.9894999861717224,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/severe-acute-respiratory-syndrome-coronavirus-2","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","score":0.7544239163398743},{"id":"https://openalex.org/keywords/coronavirus-disease-2019","display_name":"Coronavirus disease 2019 (COVID-19)","score":0.7138022780418396},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.6218159198760986},{"id":"https://openalex.org/keywords/2019-20-coronavirus-outbreak","display_name":"2019-20 coronavirus outbreak","score":0.6211451292037964},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6017245054244995},{"id":"https://openalex.org/keywords/sars-virus","display_name":"Sars virus","score":0.4631611108779907},{"id":"https://openalex.org/keywords/binary-number","display_name":"Binary number","score":0.421505331993103},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.41622766852378845},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4062807559967041},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.3813212513923645},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3553256392478943},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.17697104811668396},{"id":"https://openalex.org/keywords/infectious-disease","display_name":"Infectious disease (medical specialty)","score":0.10776969790458679},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.092654287815094}],"concepts":[{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.7544239163398743},{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.7138022780418396},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6218159198760986},{"id":"https://openalex.org/C3006700255","wikidata":"https://www.wikidata.org/wiki/Q81068910","display_name":"2019-20 coronavirus outbreak","level":3,"score":0.6211451292037964},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6017245054244995},{"id":"https://openalex.org/C3020799909","wikidata":"https://www.wikidata.org/wiki/Q85438966","display_name":"Sars virus","level":5,"score":0.4631611108779907},{"id":"https://openalex.org/C48372109","wikidata":"https://www.wikidata.org/wiki/Q3913","display_name":"Binary number","level":2,"score":0.421505331993103},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41622766852378845},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4062807559967041},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.3813212513923645},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3553256392478943},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.17697104811668396},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.10776969790458679},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.092654287815094},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C94375191","wikidata":"https://www.wikidata.org/wiki/Q11205","display_name":"Arithmetic","level":1,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C116675565","wikidata":"https://www.wikidata.org/wiki/Q3241045","display_name":"Outbreak","level":2,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016679","descriptor_name":"Genome, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016679","descriptor_name":"Genome, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016679","descriptor_name":"Genome, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058872","descriptor_name":"Epidemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058872","descriptor_name":"Epidemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D058872","descriptor_name":"Epidemics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbab307","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbab307","pdf_url":"https://academic.oup.com/bib/article-pdf/22/6/bbab307/41090276/bbab307.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34382087","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34382087","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:8385964","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8385964","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbab307","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbab307","pdf_url":"https://academic.oup.com/bib/article-pdf/22/6/bbab307/41090276/bbab307.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8399999737739563,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1561421067","display_name":null,"funder_award_id":"21621004","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G518651691","display_name":null,"funder_award_id":"2018YFA0903700","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"},{"id":"https://openalex.org/G5865461599","display_name":null,"funder_award_id":"2018YFA0903700","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6762917330","display_name":null,"funder_award_id":"31801104","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7243257119","display_name":null,"funder_award_id":"21621004","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G999540423","display_name":null,"funder_award_id":"31571358","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3189779471.pdf","grobid_xml":"https://content.openalex.org/works/W3189779471.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W1631320694","https://openalex.org/W1989838792","https://openalex.org/W1993277203","https://openalex.org/W2026636502","https://openalex.org/W2078906786","https://openalex.org/W2087932775","https://openalex.org/W2096347191","https://openalex.org/W2096420865","https://openalex.org/W2105329815","https://openalex.org/W2123516016","https://openalex.org/W2142594090","https://openalex.org/W2142723641","https://openalex.org/W2145562754","https://openalex.org/W2187089797","https://openalex.org/W2292351551","https://openalex.org/W2332976672","https://openalex.org/W2522948376","https://openalex.org/W2605343262","https://openalex.org/W2751583588","https://openalex.org/W2761430568","https://openalex.org/W2773057694","https://openalex.org/W2915153321","https://openalex.org/W2927961455","https://openalex.org/W2951071106","https://openalex.org/W2952045272","https://openalex.org/W2958805699","https://openalex.org/W2997055652","https://openalex.org/W2998745401","https://openalex.org/W3003217347","https://openalex.org/W3003990157","https://openalex.org/W3003998076","https://openalex.org/W3004280078","https://openalex.org/W3004318991","https://openalex.org/W3006367816","https://openalex.org/W3008827533","https://openalex.org/W3010020071","https://openalex.org/W3015444032","https://openalex.org/W3015597138","https://openalex.org/W3022687324","https://openalex.org/W3026265675","https://openalex.org/W3031411888","https://openalex.org/W3035382254","https://openalex.org/W3040585768","https://openalex.org/W3041484742","https://openalex.org/W3042535264","https://openalex.org/W3043124965","https://openalex.org/W3047010983","https://openalex.org/W3047021267","https://openalex.org/W3092136311","https://openalex.org/W3105966753","https://openalex.org/W3112670826","https://openalex.org/W3119231619","https://openalex.org/W3128276018","https://openalex.org/W3129399011","https://openalex.org/W3129705281","https://openalex.org/W3130854832","https://openalex.org/W3132999071","https://openalex.org/W3133782701","https://openalex.org/W3133980772","https://openalex.org/W3134208712","https://openalex.org/W3137784605","https://openalex.org/W3138734145","https://openalex.org/W3143640227","https://openalex.org/W3162454605","https://openalex.org/W3164102793","https://openalex.org/W3164553962","https://openalex.org/W3169881791","https://openalex.org/W6702888862","https://openalex.org/W6736131465","https://openalex.org/W6775574005","https://openalex.org/W6785615831"],"related_works":["https://openalex.org/W4404084015","https://openalex.org/W3156916261","https://openalex.org/W3092656880","https://openalex.org/W3214333824","https://openalex.org/W4206249207","https://openalex.org/W3015777742","https://openalex.org/W4256095626","https://openalex.org/W3209591042","https://openalex.org/W3165952552","https://openalex.org/W3013867929"],"abstract_inverted_index":{"For":[0],"epidemic":[1],"prevention":[2],"and":[3,14,94,113,132,145,159,185,191,212,218],"control,":[4],"the":[5,25,42,56,65,75,79,95,101,107,136,148,162,169,182,189,193,210,215],"identification":[6,57],"of":[7,58,78,172,196,209,220],"SARS-CoV-2":[8,32,59,70,80,130,173,197],"subpopulations":[9,190],"sharing":[10],"similar":[11,34],"micro-epidemiological":[12],"patterns":[13,211],"evolutionary":[15,194],"histories":[16],"is":[17,53],"necessary":[18,54],"for":[19,55],"a":[20,199,206],"more":[21,143],"targeted":[22],"investigation":[23],"into":[24],"links":[26],"among":[27,188],"COVID-19":[28],"outbreaks":[29],"caused":[30],"by":[31],"with":[33],"genetic":[35,47],"backgrounds.":[36],"Genomic":[37],"sequencing":[38],"analysis":[39,52],"has":[40,175],"demonstrated":[41],"ability":[43],"to":[44,84,91,121,198],"uncover":[45],"viral":[46,92],"diversity.":[48],"However,":[49],"an":[50,115],"objective":[51],"subpopulations.":[60],"Herein,":[61],"we":[62,105,133,166],"detected":[63],"all":[64],"mutations":[66,109],"in":[67,100,110,214],"186":[68],"682":[69],"isolates.":[71],"We":[72,179],"found":[73,134,167],"that":[74,135,168],"GC":[76],"content":[77],"genome":[81],"had":[82],"evolved":[83],"be":[85,89],"lower,":[86],"which":[87],"may":[88],"conducive":[90],"spread,":[93],"frameshift":[96],"mutation":[97],"was":[98,139],"rare":[99],"global":[102],"population.":[103],"Next,":[104],"encoded":[106],"genomic":[108,216],"binary":[111],"form":[112],"used":[114],"unsupervised":[116],"learning":[117],"classifier,":[118],"namely":[119],"PhenoGraph,":[120],"classify":[122],"this":[123],"information.":[124],"Consequently,":[125],"PhenoGraph":[126,137],"successfully":[127],"identified":[128],"303":[129],"subpopulations,":[131],"classification":[138],"consistent":[140],"with,":[141],"but":[142],"detailed":[144],"precise":[146],"than":[147],"known":[149],"GISAID":[150],"clades":[151],"(S,":[152],"L,":[153],"V,":[154],"G,":[155],"GH,":[156],"GR,":[157],"GV":[158],"O).":[160],"By":[161],"change":[163],"trend":[164],"analysis,":[165],"growth":[170],"rate":[171],"diversity":[174],"slowed":[176],"down":[177],"significantly.":[178],"also":[180],"analyzed":[181],"temporal,":[183],"spatial":[184],"phylogenetic":[186],"relationships":[187],"revealed":[192],"trajectory":[195],"certain":[200],"extent.":[201],"Hence,":[202],"our":[203],"results":[204],"provide":[205],"better":[207],"understanding":[208],"trends":[213],"evolution":[217],"epidemiology":[219],"SARS-CoV-2.":[221]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}