{"id":"https://openalex.org/W3193129938","doi":"https://doi.org/10.1093/bib/bbab300","title":"Local ancestry inference in heterogeneous populations\u2014Are recent recombination events more relevant?","display_name":"Local ancestry inference in heterogeneous populations\u2014Are recent recombination events more relevant?","publication_year":2021,"publication_date":"2021-07-16","ids":{"openalex":"https://openalex.org/W3193129938","doi":"https://doi.org/10.1093/bib/bbab300","mag":"3193129938","pmid":"https://pubmed.ncbi.nlm.nih.gov/34343255"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbab300","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbab300","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060178381","display_name":"Gerald van Eeden","orcid":"https://orcid.org/0000-0002-8944-0162"},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Gerald van Eeden","raw_affiliation_strings":["Stellenbosch University, South Africa"],"raw_orcid":"https://orcid.org/0000-0002-8944-0162","affiliations":[{"raw_affiliation_string":"Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045743071","display_name":"Caitlin Uren","orcid":"https://orcid.org/0000-0003-2358-0135"},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Caitlin Uren","raw_affiliation_strings":["Stellenbosch University, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073585928","display_name":"Gian van der Spuy","orcid":"https://orcid.org/0000-0002-9067-5903"},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Gian van der Spuy","raw_affiliation_strings":["Department of Molecular Biology and Human Genetics, Stellenbosch University, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Human Genetics, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062230681","display_name":"Gerard Tromp","orcid":"https://orcid.org/0000-0002-7761-0806"},"institutions":[{"id":"https://openalex.org/I4210115889","display_name":"South African Tuberculosis Vaccine Initiative","ror":"https://ror.org/02jcef994","country_code":"ZA","type":"healthcare","lineage":["https://openalex.org/I4210115889"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Gerard Tromp","raw_affiliation_strings":["South African Tuberculosis Bioinformatics Initiative (SATBBI), South Africa"],"raw_orcid":"https://orcid.org/0000-0002-7761-0806","affiliations":[{"raw_affiliation_string":"South African Tuberculosis Bioinformatics Initiative (SATBBI), South Africa","institution_ids":["https://openalex.org/I4210115889"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5090236572","display_name":"Marlo M\u00f6ller","orcid":"https://orcid.org/0000-0002-0805-6741"},"institutions":[{"id":"https://openalex.org/I26092322","display_name":"Stellenbosch University","ror":"https://ror.org/05bk57929","country_code":"ZA","type":"education","lineage":["https://openalex.org/I26092322"]}],"countries":["ZA"],"is_corresponding":true,"raw_author_name":"Marlo M\u00f6ller","raw_affiliation_strings":["Department of Molecular Biology and Human Genetics, Stellenbosch University, South Africa"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biology and Human Genetics, Stellenbosch University, South Africa","institution_ids":["https://openalex.org/I26092322"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5090236572"],"corresponding_institution_ids":["https://openalex.org/I26092322"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":0.3306,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.66662434,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"22","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9861999750137329,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9861999750137329,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9207000136375427,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recombination","display_name":"Recombination","score":0.8633705973625183},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.7227118611335754},{"id":"https://openalex.org/keywords/recombination-rate","display_name":"Recombination rate","score":0.5493265986442566},{"id":"https://openalex.org/keywords/linkage-disequilibrium","display_name":"Linkage disequilibrium","score":0.46718931198120117},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4277181327342987},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.3798803687095642},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.35158711671829224},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.25687462091445923},{"id":"https://openalex.org/keywords/haplotype","display_name":"Haplotype","score":0.18786156177520752},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.12525469064712524},{"id":"https://openalex.org/keywords/allele","display_name":"Allele","score":0.06897598505020142}],"concepts":[{"id":"https://openalex.org/C156695909","wikidata":"https://www.wikidata.org/wiki/Q3373825","display_name":"Recombination","level":3,"score":0.8633705973625183},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.7227118611335754},{"id":"https://openalex.org/C2986401858","wikidata":"https://www.wikidata.org/wiki/Q843863","display_name":"Recombination rate","level":4,"score":0.5493265986442566},{"id":"https://openalex.org/C35605836","wikidata":"https://www.wikidata.org/wiki/Q2064311","display_name":"Linkage disequilibrium","level":5,"score":0.46718931198120117},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4277181327342987},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3798803687095642},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.35158711671829224},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.25687462091445923},{"id":"https://openalex.org/C197754878","wikidata":"https://www.wikidata.org/wiki/Q80711","display_name":"Haplotype","level":4,"score":0.18786156177520752},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.12525469064712524},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.06897598505020142},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D005828","descriptor_name":"Genetics, Population","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005828","descriptor_name":"Genetics, Population","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005828","descriptor_name":"Genetics, Population","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011995","descriptor_name":"Recombination, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbab300","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbab300","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34343255","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34343255","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320320672","display_name":"South African Medical Research Council","ror":"https://ror.org/05q60vz69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1588484659","https://openalex.org/W1982349920","https://openalex.org/W1987882116","https://openalex.org/W2008712670","https://openalex.org/W2027419388","https://openalex.org/W2029983700","https://openalex.org/W2061551371","https://openalex.org/W2061862213","https://openalex.org/W2098066250","https://openalex.org/W2119279196","https://openalex.org/W2125300654","https://openalex.org/W2128371599","https://openalex.org/W2129454675","https://openalex.org/W2314051380","https://openalex.org/W2340959325","https://openalex.org/W2343201819","https://openalex.org/W2883156642","https://openalex.org/W2951641704","https://openalex.org/W2952678685","https://openalex.org/W2961459138","https://openalex.org/W2981354404","https://openalex.org/W3014526310","https://openalex.org/W3031321880","https://openalex.org/W3034735081","https://openalex.org/W3037441421","https://openalex.org/W3107848492","https://openalex.org/W3119623178","https://openalex.org/W6704228718"],"related_works":["https://openalex.org/W2066259767","https://openalex.org/W2348666543","https://openalex.org/W3181392878","https://openalex.org/W2061551371","https://openalex.org/W2026743642","https://openalex.org/W2050343803","https://openalex.org/W2186355621","https://openalex.org/W2089437628","https://openalex.org/W2085054281","https://openalex.org/W1987674639"],"abstract_inverted_index":{"To":[0],"date,":[1],"numerous":[2],"software":[3,15],"tools":[4,16],"have":[5],"been":[6],"developed":[7,36],"to":[8,46,69],"infer":[9,17,27,70],"recombination":[10,19,28,44,49,67,72,92,100,110,113],"maps.":[11],"Many":[12],"of":[13,42,121],"these":[14,126],"the":[18,32,40,48,71,119],"rate":[20,73,114],"from":[21],"linkage":[22],"disequilibrium,":[23],"and":[24,56,102,108],"therefore":[25,84],"they":[26],"many":[29],"generations":[30],"into":[31],"past.":[33],"Other":[34],"recently":[35],"methods":[37,95],"rely":[38],"on":[39,129],"inference":[41,59],"recent":[43,66,99,107],"events":[45,68,101,111],"determine":[47],"rate,":[50],"such":[51],"as":[52],"identity":[53],"by":[54,125],"descent-":[55],"local":[57],"ancestry":[58],"(LAI)-based":[60],"tools.":[61],"Methods":[62],"that":[63,96,105],"mainly":[64,97],"use":[65,98],"might":[74],"be":[75],"more":[76],"relevant":[77],"for":[78,88,112],"certain":[79],"analyses":[80],"like":[81],"LAI.":[82],"We":[83],"describe":[85],"a":[86,103],"protocol":[87],"creating":[89],"high-resolution,":[90],"population-specific":[91],"maps":[93,123],"using":[94,122],"method":[104],"uses":[106],"distant":[109],"inference.":[115],"Subsequently,":[116],"we":[117],"compared":[118],"effect":[120],"inferred":[124],"two":[127],"paradigms":[128],"LAI":[130],"accuracy.":[131]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}