{"id":"https://openalex.org/W3180856665","doi":"https://doi.org/10.1093/bib/bbab274","title":"ADEIP: an integrated platform of age-dependent expression and immune profiles across human tissues","display_name":"ADEIP: an integrated platform of age-dependent expression and immune profiles across human tissues","publication_year":2021,"publication_date":"2021-06-26","ids":{"openalex":"https://openalex.org/W3180856665","doi":"https://doi.org/10.1093/bib/bbab274","mag":"3180856665","pmid":"https://pubmed.ncbi.nlm.nih.gov/34254996"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbab274","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbab274","pdf_url":"https://academic.oup.com/bib/article-pdf/22/6/bbab274/41088305/bbab274.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/22/6/bbab274/41088305/bbab274.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100362324","display_name":"Xuan Liu","orcid":"https://orcid.org/0000-0002-7356-7898"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuan Liu","raw_affiliation_strings":["College of Biomedicine and Health, Huazhong Agricultural University, Wuhan 430070, China","College of Informatics, Huazhong Agricultural University, Wuhan 430070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Biomedicine and Health, Huazhong Agricultural University, Wuhan 430070, China","institution_ids":["https://openalex.org/I204823248"]},{"raw_affiliation_string":"College of Informatics, Huazhong Agricultural University, Wuhan 430070, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100362710","display_name":"Wenbo Chen","orcid":"https://orcid.org/0000-0001-7220-7156"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenbo Chen","raw_affiliation_strings":["School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei 430071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei 430071, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101888160","display_name":"Yu Fang","orcid":"https://orcid.org/0000-0002-4851-5826"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yu Fang","raw_affiliation_strings":["College of Biomedicine and Health, Huazhong Agricultural University, Wuhan 430070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Biomedicine and Health, Huazhong Agricultural University, Wuhan 430070, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073518856","display_name":"Siqi Yang","orcid":"https://orcid.org/0000-0002-2785-6509"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Siqi Yang","raw_affiliation_strings":["School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei 430071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei 430071, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058544305","display_name":"Liuping Chang","orcid":null},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Liuping Chang","raw_affiliation_strings":["College of Biomedicine and Health, Huazhong Agricultural University, Wuhan 430070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Biomedicine and Health, Huazhong Agricultural University, Wuhan 430070, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100387350","display_name":"Xingyu Chen","orcid":"https://orcid.org/0000-0002-9284-4950"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingyu Chen","raw_affiliation_strings":["College of Biomedicine and Health, Huazhong Agricultural University, Wuhan 430070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Biomedicine and Health, Huazhong Agricultural University, Wuhan 430070, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043159616","display_name":"Haidong Ye","orcid":null},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haidong Ye","raw_affiliation_strings":["College of Biomedicine and Health, Huazhong Agricultural University, Wuhan 430070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Biomedicine and Health, Huazhong Agricultural University, Wuhan 430070, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090607267","display_name":"Xinyu Tang","orcid":"https://orcid.org/0000-0002-4567-4012"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyu Tang","raw_affiliation_strings":["School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei 430071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei 430071, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101731427","display_name":"Shan Zhong","orcid":"https://orcid.org/0009-0007-0802-0902"},"institutions":[{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shan Zhong","raw_affiliation_strings":["Hubei Province Key Laboratory of Allergy and Immunology, Wuhan, Hubei 430071, China","School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei 430071, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hubei Province Key Laboratory of Allergy and Immunology, Wuhan, Hubei 430071, China","institution_ids":[]},{"raw_affiliation_string":"School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei 430071, China","institution_ids":["https://openalex.org/I37461747"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100444425","display_name":"Wen Zhang","orcid":"https://orcid.org/0000-0003-3150-2751"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wen Zhang","raw_affiliation_strings":["College of Informatics, Huazhong Agricultural University, Wuhan 430070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Informatics, Huazhong Agricultural University, Wuhan 430070, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059737137","display_name":"Zhiqiang Dong","orcid":"https://orcid.org/0000-0001-6259-915X"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhiqiang Dong","raw_affiliation_strings":["College of Biomedicine and Health, Huazhong Agricultural University, Wuhan 430070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Biomedicine and Health, Huazhong Agricultural University, Wuhan 430070, China","institution_ids":["https://openalex.org/I204823248"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048715916","display_name":"Leng Han","orcid":"https://orcid.org/0000-0002-7380-2640"},"institutions":[{"id":"https://openalex.org/I2801753046","display_name":"Prevention Institute","ror":"https://ror.org/02xdygm42","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I2801753046"]},{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Leng Han","raw_affiliation_strings":["Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Epigenetics and Disease Prevention, Institute of Biosciences and Technology, Texas A&M University, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I2801753046","https://openalex.org/I91045830"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034357519","display_name":"Chunjiang He","orcid":"https://orcid.org/0000-0002-4868-331X"},"institutions":[{"id":"https://openalex.org/I204823248","display_name":"Huazhong Agricultural University","ror":"https://ror.org/023b72294","country_code":"CN","type":"education","lineage":["https://openalex.org/I204823248"]},{"id":"https://openalex.org/I37461747","display_name":"Wuhan University","ror":"https://ror.org/033vjfk17","country_code":"CN","type":"education","lineage":["https://openalex.org/I37461747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chunjiang He","raw_affiliation_strings":["College of Biomedicine and Health, Huazhong Agricultural University, Wuhan 430070, China","School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei 430071, China"],"raw_orcid":"https://orcid.org/0000-0002-4868-331X","affiliations":[{"raw_affiliation_string":"College of Biomedicine and Health, Huazhong Agricultural University, Wuhan 430070, China","institution_ids":["https://openalex.org/I204823248"]},{"raw_affiliation_string":"School of Basic Medical Sciences, Wuhan University, Wuhan, Hubei 430071, China","institution_ids":["https://openalex.org/I37461747"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":13,"corresponding_author_ids":["https://openalex.org/A5034357519","https://openalex.org/A5048715916","https://openalex.org/A5059737137"],"corresponding_institution_ids":["https://openalex.org/I204823248","https://openalex.org/I2801753046","https://openalex.org/I37461747","https://openalex.org/I91045830"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":0.8957,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.72807368,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"22","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9957000017166138,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.9914000034332275,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.8380391597747803},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7409582138061523},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6946476697921753},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.661347508430481},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.4672037959098816},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4451863169670105},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.43698850274086},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.394161581993103}],"concepts":[{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.8380391597747803},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7409582138061523},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6946476697921753},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.661347508430481},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4672037959098816},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4451863169670105},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.43698850274086},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.394161581993103}],"mesh":[{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009928","descriptor_name":"Organ Specificity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbab274","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbab274","pdf_url":"https://academic.oup.com/bib/article-pdf/22/6/bbab274/41088305/bbab274.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34254996","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34254996","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:8344678","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8344678","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbab274","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbab274","pdf_url":"https://academic.oup.com/bib/article-pdf/22/6/bbab274/41088305/bbab274.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5899999737739563}],"awards":[{"id":"https://openalex.org/G3986405684","display_name":"circ-AFF2\u8c03\u63a7PRC2\u590d\u5408\u7269\u4ecb\u5bfc\u7684AML\u53d1\u751f\u53d1\u5c55\u673a\u5236\u7814\u7a76","funder_award_id":"81870129","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W802300164","https://openalex.org/W1890667946","https://openalex.org/W1947944879","https://openalex.org/W1985987855","https://openalex.org/W2009288080","https://openalex.org/W2018838463","https://openalex.org/W2052685738","https://openalex.org/W2069389043","https://openalex.org/W2074963908","https://openalex.org/W2130410032","https://openalex.org/W2169456326","https://openalex.org/W2179438025","https://openalex.org/W2214074259","https://openalex.org/W2517897388","https://openalex.org/W2518307266","https://openalex.org/W2529494470","https://openalex.org/W2566825588","https://openalex.org/W2762514850","https://openalex.org/W2786355530","https://openalex.org/W2792468812","https://openalex.org/W2883803503","https://openalex.org/W2888254344","https://openalex.org/W2898081917","https://openalex.org/W2900044275","https://openalex.org/W3003257820","https://openalex.org/W3007498887","https://openalex.org/W3009788614","https://openalex.org/W3014357638","https://openalex.org/W3016489853","https://openalex.org/W3021923959","https://openalex.org/W3022285953","https://openalex.org/W3028729845","https://openalex.org/W3047880178","https://openalex.org/W3084033366","https://openalex.org/W3084331777","https://openalex.org/W3095186004","https://openalex.org/W3103145119","https://openalex.org/W3133859624","https://openalex.org/W6753567495","https://openalex.org/W6778315185"],"related_works":["https://openalex.org/W2052655934","https://openalex.org/W104645380","https://openalex.org/W2027213253","https://openalex.org/W2017047508","https://openalex.org/W2165201120","https://openalex.org/W2023641020","https://openalex.org/W2188530857","https://openalex.org/W2133040682","https://openalex.org/W2613929436","https://openalex.org/W1971081588"],"abstract_inverted_index":{"Gene":[0],"expression":[1,28,66,121,153],"and":[2,29,72,90,96,108,122,143,154,176],"immune":[3,30,87,91,123,155,172],"status":[4],"in":[5,34,53,160,174],"human":[6,144],"tissues":[7,33,52],"are":[8],"changed":[9],"with":[10,68],"aging.":[11],"There":[12],"is":[13,165],"a":[14,18,110,166],"need":[15],"to":[16,21,60],"develop":[17],"comprehensive":[19],"platform":[20,111,168],"explore":[22],"the":[23,106,118,129,152,161],"dynamics":[24,156],"of":[25,131,157],"age-related":[26,171],"gene":[27,65,73,120],"profiles":[31,124],"across":[32,125],"genome-wide":[35],"studies.":[36],"Here,":[37],"we":[38,103,133],"collected":[39],"RNA-Seq":[40],"datasets":[41],"from":[42,49,58,84],"GTEx":[43],"project,":[44],"containing":[45],"16":[46],"704":[47],"samples":[48],"30":[50],"major":[51],"six":[54],"age":[55,81,100],"groups":[56],"ranging":[57],"20":[59],"79":[61],"years":[62],"old.":[63],"Dynamic":[64],"along":[67],"aging":[69],"were":[70,94],"depicted":[71],"set":[74],"enrichment":[75],"analysis":[76],"was":[77],"performed":[78],"among":[79,98],"those":[80],"groups.":[82,101],"Genes":[83],"34":[85],"known":[86],"function":[88],"categories":[89],"cell":[92],"compositions":[93],"investigated":[95],"compared":[97],"different":[99],"Finally,":[102],"integrated":[104],"all":[105],"results":[107],"developed":[109],"named":[112],"ADEIP":[113,164],"(http://gb.whu.edu.cn/ADEIP":[114],"or":[115,179],"http://geneyun.net/ADEIP),":[116],"integrating":[117],"age-dependent":[119],"tissues.":[126],"To":[127],"demonstrate":[128],"usage":[130],"ADEIP,":[132],"applied":[134],"two":[135],"datasets:":[136],"severe":[137],"acute":[138],"respiratory":[139],"syndrome":[140],"coronavirus":[141],"2":[142],"mesenchymal":[145],"stem":[146],"cells-assoicated":[147],"genes.":[148],"We":[149],"also":[150],"included":[151],"these":[158],"genes":[159],"platform.":[162],"Collectively,":[163],"powerful":[167],"for":[169],"studying":[170],"regulation":[173],"organogenesis":[175],"other":[177],"infectious":[178],"genetic":[180],"diseases.":[181]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":2}],"updated_date":"2026-06-06T09:05:17.133730","created_date":"2025-10-10T00:00:00"}