{"id":"https://openalex.org/W3192627285","doi":"https://doi.org/10.1093/bib/bbab272","title":"Network-guided identification of cancer-selective combinatorial therapies in ovarian cancer","display_name":"Network-guided identification of cancer-selective combinatorial therapies in ovarian cancer","publication_year":2021,"publication_date":"2021-06-26","ids":{"openalex":"https://openalex.org/W3192627285","doi":"https://doi.org/10.1093/bib/bbab272","mag":"3192627285","pmid":"https://pubmed.ncbi.nlm.nih.gov/34343245"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbab272","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbab272","pdf_url":"https://academic.oup.com/bib/article-pdf/22/6/bbab272/41088658/bbab272.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bib/article-pdf/22/6/bbab272/41088658/bbab272.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073448938","display_name":"Liye He","orcid":"https://orcid.org/0000-0002-6632-2112"},"institutions":[{"id":"https://openalex.org/I4210133586","display_name":"Institute for Molecular Medicine Finland","ror":"https://ror.org/030sbze61","country_code":"FI","type":"facility","lineage":["https://openalex.org/I133731052","https://openalex.org/I4210133586"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Liye He","raw_affiliation_strings":["Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland"],"raw_orcid":"https://orcid.org/0000-0002-6632-2112","affiliations":[{"raw_affiliation_string":"Institute for Molecular Medicine Finland (FIMM), Helsinki, Finland","institution_ids":["https://openalex.org/I4210133586"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064674972","display_name":"Daria Bulanova","orcid":"https://orcid.org/0000-0002-5038-1724"},"institutions":[{"id":"https://openalex.org/I4210122519","display_name":"Biocenter Finland","ror":"https://ror.org/03aay6c48","country_code":"FI","type":"facility","lineage":["https://openalex.org/I4210122519"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Daria Bulanova","raw_affiliation_strings":["Biotech Research & Innovation Centre (BRIC) at the University of Copenhagen (UC), Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotech Research & Innovation Centre (BRIC) at the University of Copenhagen (UC), Helsinki, Finland","institution_ids":["https://openalex.org/I4210122519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075672043","display_name":"Jaana Oikkonen","orcid":"https://orcid.org/0000-0002-1063-2736"},"institutions":[{"id":"https://openalex.org/I4210162898","display_name":"Oncos Therapeutics (Finland)","ror":"https://ror.org/00b8bzq64","country_code":"FI","type":"company","lineage":["https://openalex.org/I4210162898"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Jaana Oikkonen","raw_affiliation_strings":["ONCOSYS Research Program in UH, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ONCOSYS Research Program in UH, Helsinki, Finland","institution_ids":["https://openalex.org/I4210162898"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033673376","display_name":"Antti H\u00e4kkinen","orcid":"https://orcid.org/0000-0002-8081-1588"},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Antti H\u00e4kkinen","raw_affiliation_strings":["University of Helsinki (UH), Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Helsinki (UH), Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022361893","display_name":"Kaiyang Zhang","orcid":"https://orcid.org/0000-0002-4256-0079"},"institutions":[{"id":"https://openalex.org/I4210162898","display_name":"Oncos Therapeutics (Finland)","ror":"https://ror.org/00b8bzq64","country_code":"FI","type":"company","lineage":["https://openalex.org/I4210162898"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Kaiyang Zhang","raw_affiliation_strings":["ONCOSYS Research Program in UH, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ONCOSYS Research Program in UH, Helsinki, Finland","institution_ids":["https://openalex.org/I4210162898"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025492532","display_name":"Shuyu Zheng","orcid":"https://orcid.org/0000-0003-0624-8077"},"institutions":[{"id":"https://openalex.org/I4210162898","display_name":"Oncos Therapeutics (Finland)","ror":"https://ror.org/00b8bzq64","country_code":"FI","type":"company","lineage":["https://openalex.org/I4210162898"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Shuyu Zheng","raw_affiliation_strings":["ONCOSYS Research Program in UH, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ONCOSYS Research Program in UH, Helsinki, Finland","institution_ids":["https://openalex.org/I4210162898"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100338161","display_name":"Wenyu Wang","orcid":"https://orcid.org/0000-0003-2816-9740"},"institutions":[{"id":"https://openalex.org/I4210162898","display_name":"Oncos Therapeutics (Finland)","ror":"https://ror.org/00b8bzq64","country_code":"FI","type":"company","lineage":["https://openalex.org/I4210162898"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Wenyu Wang","raw_affiliation_strings":["ONCOSYS Research Program in UH, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ONCOSYS Research Program in UH, Helsinki, Finland","institution_ids":["https://openalex.org/I4210162898"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066348743","display_name":"Erdo\u011fan Pekcan Erkan","orcid":"https://orcid.org/0000-0001-9287-4773"},"institutions":[{"id":"https://openalex.org/I4210162898","display_name":"Oncos Therapeutics (Finland)","ror":"https://ror.org/00b8bzq64","country_code":"FI","type":"company","lineage":["https://openalex.org/I4210162898"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Erdogan Pekcan Erkan","raw_affiliation_strings":["ONCOSYS Research Program in UH, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ONCOSYS Research Program in UH, Helsinki, Finland","institution_ids":["https://openalex.org/I4210162898"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030148031","display_name":"Olli Carp\u00e9n","orcid":"https://orcid.org/0000-0002-7847-5706"},"institutions":[{"id":"https://openalex.org/I4210162898","display_name":"Oncos Therapeutics (Finland)","ror":"https://ror.org/00b8bzq64","country_code":"FI","type":"company","lineage":["https://openalex.org/I4210162898"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Olli Carp\u00e9n","raw_affiliation_strings":["ONCOSYS Research Program in UH, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ONCOSYS Research Program in UH, Helsinki, Finland","institution_ids":["https://openalex.org/I4210162898"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091615132","display_name":"Titta Joutsiniemi","orcid":"https://orcid.org/0000-0003-2169-9933"},"institutions":[{"id":"https://openalex.org/I2801970007","display_name":"Turku University Hospital","ror":"https://ror.org/05dbzj528","country_code":"FI","type":"healthcare","lineage":["https://openalex.org/I2801970007","https://openalex.org/I4210127022"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Titta Joutsiniemi","raw_affiliation_strings":["Gynecologic oncology in Turku University Hospital, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gynecologic oncology in Turku University Hospital, Helsinki, Finland","institution_ids":["https://openalex.org/I2801970007"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081022486","display_name":"Sakari Hietanen","orcid":"https://orcid.org/0000-0003-4734-4743"},"institutions":[{"id":"https://openalex.org/I155660961","display_name":"University of Turku","ror":"https://ror.org/05vghhr25","country_code":"FI","type":"education","lineage":["https://openalex.org/I155660961"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Sakari Hietanen","raw_affiliation_strings":["ONCOSYS Research Program in UH and in University of Turku (UTU), Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ONCOSYS Research Program in UH and in University of Turku (UTU), Helsinki, Finland","institution_ids":["https://openalex.org/I155660961"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044104350","display_name":"Johanna Hynninen","orcid":"https://orcid.org/0000-0002-0854-7225"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Johanna Hynninen","raw_affiliation_strings":["ONCOSYS Research Programme in UH, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ONCOSYS Research Programme in UH, Helsinki, Finland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043341222","display_name":"Kaisa Huhtinen","orcid":"https://orcid.org/0000-0001-9685-5246"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Kaisa Huhtinen","raw_affiliation_strings":["ONCOSYS Research Programme in UH, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ONCOSYS Research Programme in UH, Helsinki, Finland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033102814","display_name":"Sampsa Hautaniemi","orcid":"https://orcid.org/0000-0002-7749-2694"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sampsa Hautaniemi","raw_affiliation_strings":["ONCOSYS Research Programme in UH, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ONCOSYS Research Programme in UH, Helsinki, Finland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076351886","display_name":"Anna V\u00e4h\u00e4rautio","orcid":"https://orcid.org/0000-0003-4721-3954"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna V\u00e4h\u00e4rautio","raw_affiliation_strings":["ONCOSYS Research Programme in UH, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"ONCOSYS Research Programme in UH, Helsinki, Finland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083397767","display_name":"Jing Tang","orcid":"https://orcid.org/0000-0001-7480-7710"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jing Tang","raw_affiliation_strings":["ONCOSYS Research Programme in UH, Helsinki, Finland"],"raw_orcid":"https://orcid.org/0000-0001-7480-7710","affiliations":[{"raw_affiliation_string":"ONCOSYS Research Programme in UH, Helsinki, Finland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067760174","display_name":"Krister Wennerberg","orcid":"https://orcid.org/0000-0002-1352-4220"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Krister Wennerberg","raw_affiliation_strings":["Biotech Research & Innovation Centre (BRIC), Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biotech Research & Innovation Centre (BRIC), Helsinki, Finland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016681267","display_name":"Tero Aittokallio","orcid":"https://orcid.org/0000-0002-0886-9769"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Tero Aittokallio","raw_affiliation_strings":["FIMM and OCBE/OUH, Helsinki, Finland"],"raw_orcid":"https://orcid.org/0000-0002-0886-9769","affiliations":[{"raw_affiliation_string":"FIMM and OCBE/OUH, Helsinki, Finland","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":18,"corresponding_author_ids":["https://openalex.org/A5016681267"],"corresponding_institution_ids":[],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":1.7913,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.85626308,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"22","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ovarian-cancer","display_name":"Ovarian cancer","score":0.6464883089065552},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5495555996894836},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.5335021018981934},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.517393946647644},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.46910199522972107},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4486423432826996},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.4232654869556427},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"Drug resistance","score":0.41709595918655396},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.4012031555175781},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.32470637559890747},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.26517409086227417},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.22350844740867615},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.16724666953086853},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.11219266057014465},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1053290069103241}],"concepts":[{"id":"https://openalex.org/C2780427987","wikidata":"https://www.wikidata.org/wiki/Q172341","display_name":"Ovarian cancer","level":3,"score":0.6464883089065552},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5495555996894836},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.5335021018981934},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.517393946647644},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.46910199522972107},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4486423432826996},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.4232654869556427},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.41709595918655396},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4012031555175781},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.32470637559890747},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26517409086227417},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22350844740867615},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.16724666953086853},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.11219266057014465},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1053290069103241},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D010051","descriptor_name":"Ovarian Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1093/bib/bbab272","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbab272","pdf_url":"https://academic.oup.com/bib/article-pdf/22/6/bbab272/41088658/bbab272.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34343245","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34343245","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pure.atira.dk:publications/be60aee2-e928-4b6a-942f-f301a6f1a4eb","is_oa":true,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/be60aee2-e928-4b6a-942f-f301a6f1a4eb","pdf_url":"https://curis.ku.dk/ws/files/289238842/bbab272.pdf","source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"He , L , Bulanova , D , Oikkonen , J , H\u00e4kkinen , A , Zhang , K , Zheng , S , Wang , W , Erkan , E P , Carp\u00e9n , O , Joutsiniemi , T , Hietanen , S , Hynninen , J , Huhtinen , K , Hautaniemi , S , V\u00e4h\u00e4rautio , A , Tang , J , Wennerberg , K & Aittokallio , T 2021 , ' Network-guided identification of cancer-selective combinatorial therapies in ovarian cancer ' , Briefings in Bioinformatics , vol. 22 , no. 6 . https://doi.org/10.1093/bib/bbab272","raw_type":"article"},{"id":"pmh:oai:europepmc.org:7467697","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8574973","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:helda.helsinki.fi:10138/337782","is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/337782","pdf_url":null,"source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8574973","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8574973","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbab272","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbab272","pdf_url":"https://academic.oup.com/bib/article-pdf/22/6/bbab272/41088658/bbab272.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.800000011920929,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1427963301","display_name":null,"funder_award_id":"317680","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G2193812721","display_name":null,"funder_award_id":"322927","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G2283403312","display_name":"Informatics approaches for the rational selection of personalized cancer drug combinations","funder_award_id":"716063","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G2496829247","display_name":null,"funder_award_id":"716063","funder_id":"https://openalex.org/F4320334678","funder_display_name":"European Research Council"},{"id":"https://openalex.org/G3634603146","display_name":null,"funder_award_id":"313267","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G3732400637","display_name":null,"funder_award_id":"326238","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G3756483984","display_name":null,"funder_award_id":"310507","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G5066627347","display_name":null,"funder_award_id":"344698","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G5283068966","display_name":null,"funder_award_id":"319243","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G62538357","display_name":null,"funder_award_id":"2020026","funder_id":"https://openalex.org/F4320335102","funder_display_name":"Helse S\u00f8r-\u00d8st RHF"},{"id":"https://openalex.org/G6602195238","display_name":"Comprehensive characterization and effective combinatorial targeting of high-grade serous ovarian cancer via single-cell analysis","funder_award_id":"667403","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G7044228676","display_name":null,"funder_award_id":"NNF17CC0027852","funder_id":"https://openalex.org/F4320322436","funder_display_name":"Novo Nordisk"},{"id":"https://openalex.org/G7701213674","display_name":"Tailoring the targeted treatment of chronic lymphocytic leukemia","funder_award_id":"344698","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"},{"id":"https://openalex.org/G8290519996","display_name":null,"funder_award_id":"289059","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321108","display_name":"Academy of Finland","ror":"https://ror.org/05k73zm37"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320323313","display_name":"Turun Yliopisto","ror":"https://ror.org/05vghhr25"},{"id":"https://openalex.org/F4320323760","display_name":"Sigrid Jus\u00e9liuksen S\u00e4\u00e4ti\u00f6","ror":"https://ror.org/00ckakm23"},{"id":"https://openalex.org/F4320324148","display_name":"Orionin Tutkimuss\u00e4\u00e4ti\u00f6","ror":"https://ror.org/0296s4x19"},{"id":"https://openalex.org/F4320326591","display_name":"Sy\u00f6p\u00e4s\u00e4\u00e4ti\u00f6","ror":null},{"id":"https://openalex.org/F4320327286","display_name":"Turun Yliopistollinen Keskussairaala","ror":"https://ror.org/05dbzj528"},{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"},{"id":"https://openalex.org/F4320335102","display_name":"Helse S\u00f8r-\u00d8st RHF","ror":"https://ror.org/02qx2s478"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":44,"referenced_works":["https://openalex.org/W1435191252","https://openalex.org/W1678356000","https://openalex.org/W1971875278","https://openalex.org/W2002783575","https://openalex.org/W2061061337","https://openalex.org/W2070493638","https://openalex.org/W2105800735","https://openalex.org/W2115517051","https://openalex.org/W2159675211","https://openalex.org/W2295598076","https://openalex.org/W2413012502","https://openalex.org/W2513777968","https://openalex.org/W2769605488","https://openalex.org/W2774112395","https://openalex.org/W2777884179","https://openalex.org/W2790982990","https://openalex.org/W2791147548","https://openalex.org/W2905452503","https://openalex.org/W2911964244","https://openalex.org/W2923655447","https://openalex.org/W2939543377","https://openalex.org/W2951449549","https://openalex.org/W2972783946","https://openalex.org/W2992010506","https://openalex.org/W3007934576","https://openalex.org/W3010256878","https://openalex.org/W3015554611","https://openalex.org/W3016665862","https://openalex.org/W3035604179","https://openalex.org/W3036531306","https://openalex.org/W3094540299","https://openalex.org/W3098913413","https://openalex.org/W3102476541","https://openalex.org/W3107514561","https://openalex.org/W3107626709","https://openalex.org/W3109819734","https://openalex.org/W3117536145","https://openalex.org/W3128618129","https://openalex.org/W3133479273","https://openalex.org/W3136028175","https://openalex.org/W3164680581","https://openalex.org/W4239421590","https://openalex.org/W6775627845","https://openalex.org/W6790306242"],"related_works":["https://openalex.org/W2399513595","https://openalex.org/W4388386498","https://openalex.org/W2028462563","https://openalex.org/W2982720988","https://openalex.org/W4388725868","https://openalex.org/W2104762330","https://openalex.org/W4379374180","https://openalex.org/W2523545060","https://openalex.org/W4229998356","https://openalex.org/W4392059188"],"abstract_inverted_index":{"Each":[0],"patient's":[1],"cancer":[2,34,82,132,175,246],"consists":[3],"of":[4,59,94,122,151,183,195],"multiple":[5,30],"cell":[6,35,202],"subpopulations":[7],"that":[8,37,62,100,159,238],"are":[9,38,230],"inherently":[10],"heterogeneous":[11],"and":[12,73,96,144,211,226],"may":[13],"develop":[14],"differing":[15],"phenotypes":[16],"such":[17],"as":[18],"drug":[19,124,137,189],"sensitivity":[20],"or":[21,43,105,214],"resistance.":[22],"A":[23],"personalized":[24],"treatment":[25,41,79],"regimen":[26],"should":[27],"therefore":[28],"target":[29],"oncoproteins":[31],"in":[32,46,108,164,173,244],"the":[33,40,71,118,170,180,193,227],"populations":[36],"driving":[39],"resistance":[42,106],"disease":[44],"progression":[45],"a":[47,87],"given":[48],"patient":[49],"to":[50,65,91,155,200,219,232],"provide":[51],"maximal":[52],"therapeutic":[53],"effect,":[54],"while":[55],"avoiding":[56],"severe":[57],"co-inhibition":[58],"non-malignant":[60],"cells":[61],"would":[63],"lead":[64,218],"toxic":[66],"side":[67],"effects.":[68],"To":[69],"address":[70],"intra-":[72],"inter-tumoral":[74],"heterogeneity":[75],"when":[76],"designing":[77],"combinatorial":[78,98],"regimens":[80],"for":[81,126,188,235],"patients,":[83,176],"we":[84,115,177],"have":[85],"implemented":[86],"machine":[88],"learning-based":[89],"platform":[90,119,148,225],"guide":[92],"identification":[93],"safe":[95],"effective":[97],"treatments":[99],"selectively":[101],"inhibit":[102],"cancer-related":[103],"dysfunctions":[104],"mechanisms":[107],"individual":[109],"patients.":[110],"In":[111],"this":[112],"case":[113,171],"study,":[114],"show":[116],"how":[117],"enables":[120],"prediction":[121],"cancer-selective":[123],"combinations":[125,158],"patients":[127],"with":[128,141],"high-grade":[129],"serous":[130],"ovarian":[131,174],"using":[133],"single-cell":[134,197],"imaging":[135],"cytometry":[136],"response":[138,190],"assay,":[139],"combined":[140],"genome-wide":[142],"transcriptomic":[143],"genetic":[145],"profiles.":[146],"The":[147,223],"makes":[149],"use":[150,194,239],"drug-target":[152],"interaction":[153],"networks":[154],"prioritize":[156],"those":[157],"warrant":[160],"further":[161],"preclinical":[162],"testing":[163],"scarce":[165],"patient-derived":[166],"primary":[167],"cells.":[168],"During":[169],"study":[172],"investigated":[178],"(i)":[179],"relative":[181],"performance":[182],"various":[184],"ensemble":[185],"learning":[186],"algorithms":[187],"prediction,":[191],"(ii)":[192],"matched":[196],"RNA-sequencing":[198],"data":[199],"deconvolute":[201],"population-specific":[203],"transcriptome":[204],"profiles":[205],"from":[206],"bulk":[207],"RNA-seq":[208],"data,":[209],"(iii)":[210],"whether":[212],"multi-patient":[213],"patient-specific":[215],"predictive":[216,221,241],"models":[217],"better":[220],"accuracy.":[222],"general":[224],"comparison":[228],"results":[229],"expected":[231],"become":[233],"useful":[234],"future":[236],"studies":[237],"similar":[240],"approaches":[242],"also":[243],"other":[245],"types.":[247]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":6}],"updated_date":"2026-06-22T08:00:12.763002","created_date":"2025-10-10T00:00:00"}
