{"id":"https://openalex.org/W3190577642","doi":"https://doi.org/10.1093/bib/bbab270","title":"Elucidation of dynamic microRNA regulations in cancer progression using integrative machine learning","display_name":"Elucidation of dynamic microRNA regulations in cancer progression using integrative machine learning","publication_year":2021,"publication_date":"2021-06-24","ids":{"openalex":"https://openalex.org/W3190577642","doi":"https://doi.org/10.1093/bib/bbab270","mag":"3190577642","pmid":"https://pubmed.ncbi.nlm.nih.gov/34373890"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbab270","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbab270","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8574978","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015511520","display_name":"Haluk Dogan","orcid":null},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haluk Dogan","raw_affiliation_strings":["Department of Computer Science and Engineering (CSE) at the University of Nebraska- Lincoln (UNL), Lincoln, NE 68588-0115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering (CSE) at the University of Nebraska- Lincoln (UNL), Lincoln, NE 68588-0115, USA","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029927409","display_name":"Zeynep Hakguder","orcid":null},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zeynep Hakguder","raw_affiliation_strings":["CSE department at UNL, Lincoln, NE 68588-0115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSE department at UNL, Lincoln, NE 68588-0115, USA","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042660753","display_name":"Roland Madadjim","orcid":"https://orcid.org/0009-0005-1849-6766"},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roland Madadjim","raw_affiliation_strings":["CSE department at UNL, Lincoln, NE 68588-0115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSE department at UNL, Lincoln, NE 68588-0115, USA","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002697978","display_name":"Stephen Scott","orcid":"https://orcid.org/0000-0001-5227-6875"},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephen Scott","raw_affiliation_strings":["CSE department at UNL, Lincoln, NE 68588-0115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSE department at UNL, Lincoln, NE 68588-0115, USA","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039872937","display_name":"Massimiliano Pierobon","orcid":"https://orcid.org/0000-0003-1074-6925"},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Massimiliano Pierobon","raw_affiliation_strings":["CSE department at UNL, Lincoln, NE 68588-0115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSE department at UNL, Lincoln, NE 68588-0115, USA","institution_ids":["https://openalex.org/I114395901"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029528457","display_name":"Juan Cui","orcid":"https://orcid.org/0000-0001-6581-6850"},"institutions":[{"id":"https://openalex.org/I114395901","display_name":"University of Nebraska\u2013Lincoln","ror":"https://ror.org/043mer456","country_code":"US","type":"education","lineage":["https://openalex.org/I114395901"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Juan Cui","raw_affiliation_strings":["CSE department at UNL, Lincoln, NE 68588-0115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CSE department at UNL, Lincoln, NE 68588-0115, USA","institution_ids":["https://openalex.org/I114395901"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5029528457"],"corresponding_institution_ids":["https://openalex.org/I114395901"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":0.2625,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.47610763,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"22","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.5532000064849854,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.5532000064849854,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.0843999981880188,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.04839999973773956,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.6642993688583374},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5717247724533081},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.568260669708252},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.5194584727287292},{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.46744999289512634},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4514819085597992},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4367053508758545},{"id":"https://openalex.org/keywords/interactome","display_name":"Interactome","score":0.43340831995010376},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.4320414066314697},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3277214765548706},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2377060353755951},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.16251951456069946},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.13731426000595093}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.6642993688583374},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5717247724533081},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.568260669708252},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.5194584727287292},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.46744999289512634},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4514819085597992},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4367053508758545},{"id":"https://openalex.org/C9760119","wikidata":"https://www.wikidata.org/wiki/Q841382","display_name":"Interactome","level":3,"score":0.43340831995010376},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4320414066314697},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3277214765548706},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2377060353755951},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.16251951456069946},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13731426000595093}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbab270","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbab270","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34373890","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34373890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:8574978","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8574978","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8574978","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8574978","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"},"sustainable_development_goals":[{"score":0.6499999761581421,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G3807647808","display_name":null,"funder_award_id":"P20 GM104320","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3914830383","display_name":null,"funder_award_id":"2016-67001-06314","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4282024772","display_name":null,"funder_award_id":"1R01 DK107264","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7151024487","display_name":null,"funder_award_id":"1P20GM104320","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W175049529","https://openalex.org/W1510646616","https://openalex.org/W1517993545","https://openalex.org/W1530964327","https://openalex.org/W1830719945","https://openalex.org/W1971623350","https://openalex.org/W1975062332","https://openalex.org/W1978697868","https://openalex.org/W2007368465","https://openalex.org/W2009777681","https://openalex.org/W2022725285","https://openalex.org/W2035618305","https://openalex.org/W2049633694","https://openalex.org/W2050869737","https://openalex.org/W2063645384","https://openalex.org/W2069898971","https://openalex.org/W2080327351","https://openalex.org/W2090554117","https://openalex.org/W2110687686","https://openalex.org/W2111840528","https://openalex.org/W2114104545","https://openalex.org/W2115260093","https://openalex.org/W2116445108","https://openalex.org/W2117977572","https://openalex.org/W2119106393","https://openalex.org/W2132555912","https://openalex.org/W2137526110","https://openalex.org/W2138019504","https://openalex.org/W2140099276","https://openalex.org/W2146512944","https://openalex.org/W2151128232","https://openalex.org/W2152890020","https://openalex.org/W2159092541","https://openalex.org/W2159482845","https://openalex.org/W2165009258","https://openalex.org/W2168175751","https://openalex.org/W2170112109","https://openalex.org/W2187089797","https://openalex.org/W2281419701","https://openalex.org/W2284915482","https://openalex.org/W2310584558","https://openalex.org/W2330192890","https://openalex.org/W2520632143","https://openalex.org/W2530423073","https://openalex.org/W2530515403","https://openalex.org/W2567675536","https://openalex.org/W2573268273","https://openalex.org/W2593459113","https://openalex.org/W2611370172","https://openalex.org/W2620621036","https://openalex.org/W2623329791","https://openalex.org/W2764036216","https://openalex.org/W2782571367","https://openalex.org/W2784007581","https://openalex.org/W2784313238","https://openalex.org/W2789952845","https://openalex.org/W2899288360","https://openalex.org/W2918193787","https://openalex.org/W2996140569","https://openalex.org/W3103967557","https://openalex.org/W4294216483","https://openalex.org/W4388323202","https://openalex.org/W6673567362","https://openalex.org/W6682227116","https://openalex.org/W6702436177","https://openalex.org/W6747345083"],"related_works":["https://openalex.org/W2009405916","https://openalex.org/W2063905494","https://openalex.org/W2156421048","https://openalex.org/W2135896045","https://openalex.org/W2010571965","https://openalex.org/W3128451840","https://openalex.org/W2884256268","https://openalex.org/W2002709996","https://openalex.org/W4387092964","https://openalex.org/W2171763327"],"abstract_inverted_index":{"MOTIVATION:":[0],"Empowered":[1],"by":[2],"advanced":[3],"genomics":[4],"discovery":[5,224],"tools,":[6],"recent":[7],"biomedical":[8],"research":[9,39],"has":[10,41,89,185],"produced":[11],"a":[12,105,120,138,156,220],"massive":[13],"amount":[14],"of":[15,69,81,95,159],"genomic":[16],"data":[17,59,83,132],"on":[18,57,84,123,180,205],"(post-)transcriptional":[19],"regulations":[20,116],"related":[21],"to":[22,128,145,226],"transcription":[23],"factors,":[24],"microRNAs,":[25],"long":[26],"non-coding":[27],"RNAs,":[28],"epigenetic":[29],"modifications":[30],"and":[31,77,98,134,199,222],"genetic":[32],"variations.":[33],"Computational":[34],"modeling,":[35],"as":[36,75,193,195],"an":[37],"essential":[38],"method,":[40],"generated":[42],"promising":[43],"testable":[44],"quantitative":[45],"models":[46],"that":[47,111],"represent":[48],"complex":[49,232],"interplay":[50],"among":[51],"different":[52,151],"gene":[53,115,167],"regulatory":[54,168,207,229],"mechanisms":[55],"based":[56],"these":[58],"in":[60,71,93,117,189,209,231],"many":[61],"biological":[62,233],"systems.":[63,234],"However,":[64],"given":[65],"the":[66,78],"dynamic":[67],"changes":[68,188],"interactome":[70],"chaotic":[72],"systems":[73],"such":[74,87],"cancers,":[76],"dramatic":[79],"growth":[80],"heterogeneous":[82],"this":[85,101,215],"topic,":[86],"promise":[88],"encountered":[90],"unprecedented":[91],"challenges":[92],"terms":[94],"model":[96,136,142,217],"complexity":[97],"scalability.":[99],"In":[100,126,155],"study,":[102],"we":[103,163],"introduce":[104],"new":[106,129],"integrative":[107,216],"machine":[108],"learning":[109,141],"approach":[110],"can":[112,218],"infer":[113],"multifaceted":[114],"cancers":[118],"with":[119,171],"particular":[121],"focus":[122],"microRNA":[124],"regulation.":[125],"addition":[127],"strategies":[130],"for":[131],"integration":[133],"graphical":[135],"fusion,":[137],"supervised":[139],"deep":[140],"was":[143],"integrated":[144],"identify":[146],"conditional":[147],"microRNA-mRNA":[148],"interactions":[149],"across":[150,183],"cancer":[152,191,211],"stages.":[153,174],"RESULTS:":[154],"case":[157],"study":[158],"human":[160],"breast":[161,210],"cancer,":[162],"have":[164],"identified":[165],"distinct":[166],"networks":[169],"associated":[170],"four":[172],"progressive":[173],"The":[175],"subsequent":[176],"functional":[177],"analysis":[178],"focusing":[179],"microRNA-mediated":[181],"dysregulation":[182],"stages":[184],"revealed":[186],"significant":[187],"major":[190],"hallmarks,":[192],"well":[194],"novel":[196],"pathological":[197],"signaling":[198],"metabolic":[200],"processes,":[201],"which":[202],"shed":[203],"light":[204],"microRNAs'":[206],"roles":[208],"progression.":[212],"We":[213],"believe":[214],"be":[219],"robust":[221],"effective":[223],"tool":[225],"understand":[227],"key":[228],"characteristics":[230],"AVAILABILITY:":[235],"http://sbbi-panda.unl.edu/pin/.":[236]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1}],"updated_date":"2026-06-18T08:10:14.011955","created_date":"2025-10-10T00:00:00"}