{"id":"https://openalex.org/W3179200440","doi":"https://doi.org/10.1093/bib/bbab257","title":"Performance evaluation of transcriptomics data normalization for survival risk prediction","display_name":"Performance evaluation of transcriptomics data normalization for survival risk prediction","publication_year":2021,"publication_date":"2021-06-25","ids":{"openalex":"https://openalex.org/W3179200440","doi":"https://doi.org/10.1093/bib/bbab257","mag":"3179200440","pmid":"https://pubmed.ncbi.nlm.nih.gov/34245143"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbab257","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbab257","pdf_url":"https://academic.oup.com/bib/article-pdf/22/6/bbab257/41089431/bbab257.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bib/article-pdf/22/6/bbab257/41089431/bbab257.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053498507","display_name":"Ai Ni","orcid":"https://orcid.org/0000-0003-3002-3556"},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ai Ni","raw_affiliation_strings":["Ohio State University, New York, NY 10017 USA"],"affiliations":[{"raw_affiliation_string":"Ohio State University, New York, NY 10017 USA","institution_ids":["https://openalex.org/I1327163397"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006374965","display_name":"Li\u2010Xuan Qin","orcid":"https://orcid.org/0000-0002-9367-3807"},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Li-Xuan Qin","raw_affiliation_strings":["Memorial Sloan Kettering Cancer Center, New York, NY 10017 USA"],"affiliations":[{"raw_affiliation_string":"Memorial Sloan Kettering Cancer Center, New York, NY 10017 USA","institution_ids":["https://openalex.org/I1334819555"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5006374965"],"corresponding_institution_ids":["https://openalex.org/I1334819555"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":0.6984,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.62849673,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"22","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/normalization","display_name":"Normalization (sociology)","score":0.9322488307952881},{"id":"https://openalex.org/keywords/benchmarking","display_name":"Benchmarking","score":0.7923660278320312},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6211413145065308},{"id":"https://openalex.org/keywords/database-normalization","display_name":"Database normalization","score":0.5368331670761108},{"id":"https://openalex.org/keywords/quantile","display_name":"Quantile","score":0.521946132183075},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.49945616722106934},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3747180700302124},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3307810425758362},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.26607394218444824},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.1955828070640564},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.13167035579681396}],"concepts":[{"id":"https://openalex.org/C136886441","wikidata":"https://www.wikidata.org/wiki/Q926129","display_name":"Normalization (sociology)","level":2,"score":0.9322488307952881},{"id":"https://openalex.org/C86251818","wikidata":"https://www.wikidata.org/wiki/Q816754","display_name":"Benchmarking","level":2,"score":0.7923660278320312},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6211413145065308},{"id":"https://openalex.org/C162984825","wikidata":"https://www.wikidata.org/wiki/Q339072","display_name":"Database normalization","level":3,"score":0.5368331670761108},{"id":"https://openalex.org/C118671147","wikidata":"https://www.wikidata.org/wiki/Q578714","display_name":"Quantile","level":2,"score":0.521946132183075},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.49945616722106934},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3747180700302124},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3307810425758362},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.26607394218444824},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.1955828070640564},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.13167035579681396},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C162853370","wikidata":"https://www.wikidata.org/wiki/Q39809","display_name":"Marketing","level":1,"score":0.0},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009026","descriptor_name":"Mortality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009026","descriptor_name":"Mortality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009026","descriptor_name":"Mortality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009026","descriptor_name":"Mortality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016016","descriptor_name":"Proportional Hazards Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1093/bib/bbab257","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbab257","pdf_url":"https://academic.oup.com/bib/article-pdf/22/6/bbab257/41089431/bbab257.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34245143","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34245143","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:7467711","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8575026","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8575026","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8575026","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbab257","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbab257","pdf_url":"https://academic.oup.com/bib/article-pdf/22/6/bbab257/41089431/bbab257.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/1","display_name":"No poverty","score":0.5}],"awards":[{"id":"https://openalex.org/G1336000981","display_name":null,"funder_award_id":"CA214845","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3179200440.pdf","grobid_xml":"https://content.openalex.org/works/W3179200440.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W144423133","https://openalex.org/W1255676896","https://openalex.org/W1900820545","https://openalex.org/W1966746701","https://openalex.org/W1982810690","https://openalex.org/W1989952819","https://openalex.org/W1998096683","https://openalex.org/W2010637767","https://openalex.org/W2012511861","https://openalex.org/W2014946489","https://openalex.org/W2018996580","https://openalex.org/W2020925091","https://openalex.org/W2050786374","https://openalex.org/W2060749612","https://openalex.org/W2064397275","https://openalex.org/W2092829295","https://openalex.org/W2093017030","https://openalex.org/W2093164161","https://openalex.org/W2096192437","https://openalex.org/W2107665951","https://openalex.org/W2113878188","https://openalex.org/W2115709314","https://openalex.org/W2118047185","https://openalex.org/W2120865735","https://openalex.org/W2122598723","https://openalex.org/W2124756133","https://openalex.org/W2129925362","https://openalex.org/W2135712768","https://openalex.org/W2135750592","https://openalex.org/W2149199519","https://openalex.org/W2154560360","https://openalex.org/W2156631105","https://openalex.org/W2157876843","https://openalex.org/W2163563958","https://openalex.org/W2165909549","https://openalex.org/W2409063347","https://openalex.org/W2510414099","https://openalex.org/W2583698053","https://openalex.org/W2618958001","https://openalex.org/W2761668583","https://openalex.org/W2797315825","https://openalex.org/W2797508167","https://openalex.org/W2804101972","https://openalex.org/W3002534707","https://openalex.org/W4302338619","https://openalex.org/W6677737529","https://openalex.org/W6680181915"],"related_works":["https://openalex.org/W4241705247","https://openalex.org/W2145362441","https://openalex.org/W2101622345","https://openalex.org/W3134304369","https://openalex.org/W2582603276","https://openalex.org/W2175373041","https://openalex.org/W4386281023","https://openalex.org/W4312138714","https://openalex.org/W2012771827","https://openalex.org/W2113286112"],"abstract_inverted_index":{"One":[0],"pivotal":[1],"feature":[2],"of":[3,30,36,53,71,77,108,187,194,202,206],"transcriptomics":[4,62],"data":[5,20,63],"is":[6],"the":[7,27,34,51,74,84,106,172,185,192,195,200,204],"unwanted":[8],"variations":[9],"caused":[10],"by":[11,209],"disparate":[12],"experimental":[13],"handling,":[14],"known":[15],"as":[16],"handling":[17,31,81,136],"effects.":[18],"Various":[19],"normalization":[21,111,115,161,189,225],"methods":[22,226],"were":[23],"developed":[24,88],"to":[25,46,104,158],"alleviate":[26],"adverse":[28],"impact":[29,142],"effects":[32,82,137],"in":[33,50,64,97,154,179,191,227],"setting":[35,52,198],"differential":[37],"expression":[38],"analysis.":[39],"However,":[40],"little":[41],"research":[42],"has":[43],"been":[44],"done":[45],"evaluate":[47,105],"their":[48],"performance":[49,107,178],"survival":[54,120,144,207],"outcome":[55],"prediction,":[56],"an":[57,95],"important":[58],"analysis":[59,197],"goal":[60],"for":[61,73,92,125,130,174,219],"biomedical":[65],"research.":[66],"Leveraging":[67],"a":[68,89,140,150,169],"unique":[69],"pair":[70],"datasets":[72],"same":[75],"set":[76],"tumor":[78],"samples-one":[79],"with":[80,168,229],"and":[83,116,128,146,162,199],"other":[85],"without,":[86],"we":[87],"benchmarking":[90,217],"tool":[91,103,218],"conducting":[93],"such":[94,221],"evaluation":[96,190,222],"microRNA":[98],"microarrays.":[99],"We":[100,133,166,213],"applied":[101],"this":[102,180],"three":[109],"popular":[110,152],"methods-quantile":[112],"normalization,":[113,149],"median":[114,160,211],"variance":[117,163],"stabilizing":[118,164],"normalization-in":[119],"prediction":[121,145,230],"using":[122],"various":[123],"approaches":[124],"model":[126],"building":[127],"designs":[129],"sample":[131],"assignment.":[132],"showed":[134],"that":[135,147],"can":[138],"have":[139],"strong":[141],"on":[143,223],"quantile":[148,175],"most":[151],"method":[153],"current":[155],"practice,":[156],"tends":[157],"underperform":[159],"normalization.":[165,212],"demonstrated":[167],"small":[170],"example":[171],"reason":[173],"normalization's":[176],"poor":[177],"setting.":[181],"Our":[182],"finding":[183],"highlights":[184],"importance":[186],"putting":[188],"context":[193],"downstream":[196],"potential":[201],"improving":[203],"development":[205],"predictors":[208],"applying":[210],"make":[214],"available":[215],"our":[216],"performing":[220],"additional":[224],"connection":[228],"modeling":[231],"approaches.":[232]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":1}],"updated_date":"2026-03-08T08:50:53.379069","created_date":"2025-10-10T00:00:00"}