{"id":"https://openalex.org/W3164168679","doi":"https://doi.org/10.1093/bib/bbab196","title":"HelPredictor models single-cell transcriptome to predict human embryo lineage allocation","display_name":"HelPredictor models single-cell transcriptome to predict human embryo lineage allocation","publication_year":2021,"publication_date":"2021-04-29","ids":{"openalex":"https://openalex.org/W3164168679","doi":"https://doi.org/10.1093/bib/bbab196","mag":"3164168679","pmid":"https://pubmed.ncbi.nlm.nih.gov/34037706"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbab196","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbab196","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101856804","display_name":"Pengfei Liang","orcid":"https://orcid.org/0000-0001-9541-9485"},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pengfei Liang","raw_affiliation_strings":["State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of life Sciences, Inner Mongolia University, Hohhot 010070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of life Sciences, Inner Mongolia University, Hohhot 010070, China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036796307","display_name":"Lei Zheng","orcid":"https://orcid.org/0000-0002-8531-6949"},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Zheng","raw_affiliation_strings":["State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010070, China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012243501","display_name":"Chunshen Long","orcid":"https://orcid.org/0000-0002-1942-5936"},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunshen Long","raw_affiliation_strings":["State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010070, China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102350468","display_name":"Wuritu Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wuritu Yang","raw_affiliation_strings":["State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010070, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010070, China","institution_ids":["https://openalex.org/I2722730"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057225835","display_name":"Lei Yang","orcid":"https://orcid.org/0000-0002-1133-9099"},"institutions":[{"id":"https://openalex.org/I156144747","display_name":"Harbin Medical University","ror":"https://ror.org/05jscf583","country_code":"CN","type":"education","lineage":["https://openalex.org/I156144747"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lei Yang","raw_affiliation_strings":["College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, China","institution_ids":["https://openalex.org/I156144747"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001300435","display_name":"Yongchun Zuo","orcid":"https://orcid.org/0000-0002-6065-7835"},"institutions":[{"id":"https://openalex.org/I2722730","display_name":"Inner Mongolia University","ror":"https://ror.org/0106qb496","country_code":"CN","type":"education","lineage":["https://openalex.org/I2722730"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yongchun Zuo","raw_affiliation_strings":["State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010070, China"],"raw_orcid":"https://orcid.org/0000-0002-6065-7835","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010070, China","institution_ids":["https://openalex.org/I2722730"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5001300435","https://openalex.org/A5057225835"],"corresponding_institution_ids":["https://openalex.org/I156144747","https://openalex.org/I2722730"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":1.3481,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.80404104,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"22","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9840999841690063,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.9781000018119812,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lineage","display_name":"Lineage (genetic)","score":0.7365915775299072},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6301740407943726},{"id":"https://openalex.org/keywords/feature-selection","display_name":"Feature selection","score":0.5741536617279053},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.5429641008377075},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.5330307483673096},{"id":"https://openalex.org/keywords/source-code","display_name":"Source code","score":0.4774775505065918},{"id":"https://openalex.org/keywords/task","display_name":"Task (project management)","score":0.4446844160556793},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4338662028312683},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4320889115333557},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4210895895957947},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.40167635679244995},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.19107958674430847},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.17932778596878052}],"concepts":[{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.7365915775299072},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6301740407943726},{"id":"https://openalex.org/C148483581","wikidata":"https://www.wikidata.org/wiki/Q446488","display_name":"Feature selection","level":2,"score":0.5741536617279053},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.5429641008377075},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.5330307483673096},{"id":"https://openalex.org/C43126263","wikidata":"https://www.wikidata.org/wiki/Q128751","display_name":"Source code","level":2,"score":0.4774775505065918},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.4446844160556793},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4338662028312683},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4320889115333557},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4210895895957947},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.40167635679244995},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19107958674430847},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.17932778596878052},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C187736073","wikidata":"https://www.wikidata.org/wiki/Q2920921","display_name":"Management","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018507","descriptor_name":"Gene Expression Regulation, Developmental","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047108","descriptor_name":"Embryonic Development","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D057188","descriptor_name":"Workflow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057188","descriptor_name":"Workflow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057188","descriptor_name":"Workflow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbab196","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbab196","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34037706","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34037706","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Partnerships for the goals","score":0.4099999964237213,"id":"https://metadata.un.org/sdg/17"}],"awards":[{"id":"https://openalex.org/G4172898863","display_name":"\u6574\u5408\u7f51\u7edc\u5206\u6790\u7b97\u6cd5\u9884\u6d4b\u7ec6\u80de\u7f16\u7a0b\u548c\u91cd\u7f16\u7a0b\u5148\u950b\u9a71\u52a8\u56e0\u5b50\u7684\u7814\u7a76","funder_award_id":"62061034","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7933117724","display_name":null,"funder_award_id":"61861036","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W91700548","https://openalex.org/W596558207","https://openalex.org/W836672374","https://openalex.org/W1817561967","https://openalex.org/W1967581724","https://openalex.org/W1986944049","https://openalex.org/W2003534444","https://openalex.org/W2010653277","https://openalex.org/W2012844246","https://openalex.org/W2025828346","https://openalex.org/W2045628618","https://openalex.org/W2045879558","https://openalex.org/W2058521801","https://openalex.org/W2062403136","https://openalex.org/W2072066100","https://openalex.org/W2075564676","https://openalex.org/W2094099211","https://openalex.org/W2108060388","https://openalex.org/W2110737932","https://openalex.org/W2120162279","https://openalex.org/W2123829995","https://openalex.org/W2151499551","https://openalex.org/W2155609574","https://openalex.org/W2163530926","https://openalex.org/W2165816035","https://openalex.org/W2236822143","https://openalex.org/W2316095770","https://openalex.org/W2510405398","https://openalex.org/W2571241168","https://openalex.org/W2576005654","https://openalex.org/W2618900678","https://openalex.org/W2619140115","https://openalex.org/W2800912249","https://openalex.org/W2873538059","https://openalex.org/W2911964244","https://openalex.org/W2919941598","https://openalex.org/W2923240451","https://openalex.org/W2964997533","https://openalex.org/W3005079056","https://openalex.org/W3005560263","https://openalex.org/W3011346188","https://openalex.org/W3033690697","https://openalex.org/W6684067349","https://openalex.org/W6732298114","https://openalex.org/W6778752808"],"related_works":["https://openalex.org/W2506149209","https://openalex.org/W2352153050","https://openalex.org/W2140071436","https://openalex.org/W2393965794","https://openalex.org/W2091678252","https://openalex.org/W4246442859","https://openalex.org/W4298086599","https://openalex.org/W4246926659","https://openalex.org/W4386564352","https://openalex.org/W2952668426"],"abstract_inverted_index":{"The":[0,160,202],"in-depth":[1],"understanding":[2],"of":[3,7,46,59,100,111,129,175],"cellular":[4],"fate":[5],"decision":[6],"human":[8,130],"preimplantation":[9],"embryos":[10],"has":[11],"prompted":[12],"investigations":[13],"on":[14],"how":[15,194],"changes":[16],"in":[17,167],"lineage":[18,49],"allocation,":[19],"which":[20],"is":[21,34,205],"far":[22],"from":[23],"trivial":[24],"and":[25,51,72,97,102,113,137,142,152,169,182,187,190],"remains":[26],"a":[27,38],"time-consuming":[28],"task":[29],"by":[30,118],"experimental":[31],"methods.":[32],"It":[33],"desirable":[35],"to":[36,43,63,125,199],"develop":[37],"novel":[39],"effective":[40],"bioinformatics":[41],"strategy":[42],"consider":[44],"transitions":[45,174],"coordinated":[47],"embryo":[48],"allocation":[50],"stage-specific":[52,188],"patterns.":[53],"There":[54],"are":[55],"rapidly":[56],"growing":[57],"applications":[58],"machine":[60,81,105],"learning":[61,82,106],"models":[62],"interpret":[64],"complex":[65],"datasets":[66],"for":[67,172],"identifying":[68],"candidate":[69,162],"development-related":[70],"factors":[71],"lineage-determining":[73],"molecular":[74],"events.":[75],"Here":[76],"we":[77],"developed":[78],"the":[79],"first":[80],"platform,":[83],"HelPredictor,":[84],"that":[85,108],"integrates":[86],"three":[87],"feature":[88,120],"selection":[89,121],"methods,":[90],"namely,":[91],"principal":[92],"components":[93],"analysis,":[94],"F-score":[95],"algorithm":[96],"squared":[98],"coefficient":[99],"variation,":[101],"four":[103],"classical":[104],"classifiers":[107,114],"different":[109,149],"combinations":[110],"methods":[112],"have":[115],"independent":[116,143],"outputs":[117],"increment":[119],"method.":[122],"With":[123],"application":[124],"single-cell":[126],"sequencing":[127],"data":[128],"embryo,":[131],"HelPredictor":[132],"not":[133],"only":[134],"achieved":[135],"94.9%":[136],"90.9%":[138],"respectively":[139],"with":[140],"cross-validation":[141],"test,":[144],"but":[145],"also":[146],"fast":[147,181],"classified":[148],"embryonic":[150,176],"lineages":[151],"their":[153],"development":[154,200],"trajectories":[155],"using":[156],"less":[157],"HelPredictor-predicted":[158],"factors.":[159],"above-mentioned":[161],"lineage-specific":[163,186],"genes":[164],"were":[165,170],"discussed":[166],"detail":[168],"clustered":[171],"exploring":[173],"heterogeneity.":[177],"Our":[178],"tool":[179],"can":[180],"efficiently":[183],"reveal":[184],"potential":[185],"biomarkers":[189],"provide":[191],"insights":[192],"into":[193],"advanced":[195],"computational":[196],"tools":[197],"contribute":[198],"research.":[201],"source":[203],"code":[204],"available":[206],"at":[207],"https://github.com/liameihao/HelPredictor.":[208]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}