{"id":"https://openalex.org/W3161051056","doi":"https://doi.org/10.1093/bib/bbab192","title":"Global characterization of B cell receptor repertoire in COVID-19 patients by single-cell V(D)J sequencing","display_name":"Global characterization of B cell receptor repertoire in COVID-19 patients by single-cell V(D)J sequencing","publication_year":2021,"publication_date":"2021-05-14","ids":{"openalex":"https://openalex.org/W3161051056","doi":"https://doi.org/10.1093/bib/bbab192","mag":"3161051056","pmid":"https://pubmed.ncbi.nlm.nih.gov/34015809"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbab192","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbab192","pdf_url":"https://academic.oup.com/bib/article-pdf/22/6/bbab192/41088987/bbab192.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/bib/article-pdf/22/6/bbab192/41088987/bbab192.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040655235","display_name":"Xiyun Jin","orcid":"https://orcid.org/0000-0003-2795-6451"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiyun Jin","raw_affiliation_strings":["School of Life Science and Technology at the Harbin Institute of Technology, China"],"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology at the Harbin Institute of Technology, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065919151","display_name":"Wenyang Zhou","orcid":"https://orcid.org/0000-0002-3676-0584"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenyang Zhou","raw_affiliation_strings":["School of Life Science and Technology at the Harbin Institute of Technology, China"],"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology at the Harbin Institute of Technology, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100634636","display_name":"Meng Luo","orcid":"https://orcid.org/0000-0003-0622-9060"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Meng Luo","raw_affiliation_strings":["School of Life Science and Technology at the Harbin Institute of Technology, China"],"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology at the Harbin Institute of Technology, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100754138","display_name":"Pingping Wang","orcid":"https://orcid.org/0000-0001-8888-8005"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pingping Wang","raw_affiliation_strings":["School of Life Science and Technology at the Harbin Institute of Technology, China"],"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology at the Harbin Institute of Technology, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018722475","display_name":"Zhaochun Xu","orcid":"https://orcid.org/0000-0003-1799-5529"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhaochun Xu","raw_affiliation_strings":["School of Life Science and Technology at the Harbin Institute of Technology, China"],"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology at the Harbin Institute of Technology, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101650067","display_name":"Kexin Ma","orcid":"https://orcid.org/0000-0002-9930-0104"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kexin Ma","raw_affiliation_strings":["School of Life Science and Technology at the Harbin Institute of Technology, China"],"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology at the Harbin Institute of Technology, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101600630","display_name":"Huimin Cao","orcid":"https://orcid.org/0000-0001-9083-7004"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huimin Cao","raw_affiliation_strings":["School of Life Science and Technology at the Harbin Institute of Technology, China"],"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology at the Harbin Institute of Technology, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110771712","display_name":"Chang Xu","orcid":"https://orcid.org/0000-0002-5659-6654"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chang Xu","raw_affiliation_strings":["School of Life Science and Technology at the Harbin Institute of Technology, China"],"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology at the Harbin Institute of Technology, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100722879","display_name":"Yan Huang","orcid":"https://orcid.org/0000-0002-2072-0190"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Huang","raw_affiliation_strings":["School of Life Science and Technology at the Harbin Institute of Technology, China"],"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology at the Harbin Institute of Technology, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080005655","display_name":"Rui Cheng","orcid":"https://orcid.org/0000-0002-9398-3514"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Cheng","raw_affiliation_strings":["Harbin Institute of Technology, China"],"affiliations":[{"raw_affiliation_string":"Harbin Institute of Technology, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007884260","display_name":"Lixing Xiao","orcid":"https://orcid.org/0000-0003-0929-0086"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lixing Xiao","raw_affiliation_strings":["School of Life Science and Technology at the Harbin Institute of Technology, China"],"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology at the Harbin Institute of Technology, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087031558","display_name":"Xiaoyu Lin","orcid":"https://orcid.org/0000-0001-7486-9452"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoyu Lin","raw_affiliation_strings":["Harbin Institute of Technology, China"],"affiliations":[{"raw_affiliation_string":"Harbin Institute of Technology, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028190287","display_name":"Fenglan Pang","orcid":"https://orcid.org/0000-0002-9889-3964"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fenglan Pang","raw_affiliation_strings":["Harbin Institute of Technology, China"],"affiliations":[{"raw_affiliation_string":"Harbin Institute of Technology, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100604268","display_name":"Yiqun Li","orcid":"https://orcid.org/0000-0001-7402-5081"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiqun Li","raw_affiliation_strings":["Harbin Institute of Technology, China"],"affiliations":[{"raw_affiliation_string":"Harbin Institute of Technology, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101821612","display_name":"Huan Nie","orcid":"https://orcid.org/0000-0001-9221-1283"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huan Nie","raw_affiliation_strings":["School of Life Science and Technology at the Harbin Institute of Technology, China"],"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology at the Harbin Institute of Technology, China","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038875139","display_name":"Qinghua Jiang","orcid":"https://orcid.org/0000-0002-1827-0389"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qinghua Jiang","raw_affiliation_strings":["School of Life Science and Technology at the Harbin Institute of Technology, China"],"affiliations":[{"raw_affiliation_string":"School of Life Science and Technology at the Harbin Institute of Technology, China","institution_ids":["https://openalex.org/I204983213"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":16,"corresponding_author_ids":["https://openalex.org/A5040655235"],"corresponding_institution_ids":["https://openalex.org/I204983213"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":3.3799,"has_fulltext":true,"cited_by_count":51,"citation_normalized_percentile":{"value":0.93968095,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"22","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11171","display_name":"Diabetes and associated disorders","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/somatic-hypermutation","display_name":"Somatic hypermutation","score":0.7868287563323975},{"id":"https://openalex.org/keywords/breakpoint-cluster-region","display_name":"breakpoint cluster region","score":0.7692902088165283},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6990239024162292},{"id":"https://openalex.org/keywords/b-cell-receptor","display_name":"B-cell receptor","score":0.67503821849823},{"id":"https://openalex.org/keywords/repertoire","display_name":"Repertoire","score":0.6214830279350281},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.555128812789917},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.5129966139793396},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.4794405996799469},{"id":"https://openalex.org/keywords/ighv","display_name":"IGHV@","score":0.4786294996738434},{"id":"https://openalex.org/keywords/antibody","display_name":"Antibody","score":0.42329341173171997},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.41948843002319336},{"id":"https://openalex.org/keywords/b-cell","display_name":"B cell","score":0.3890039920806885},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3559589982032776},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.26916465163230896},{"id":"https://openalex.org/keywords/chronic-lymphocytic-leukemia","display_name":"Chronic lymphocytic leukemia","score":0.1942092478275299},{"id":"https://openalex.org/keywords/leukemia","display_name":"Leukemia","score":0.08268702030181885}],"concepts":[{"id":"https://openalex.org/C128526571","wikidata":"https://www.wikidata.org/wiki/Q619302","display_name":"Somatic hypermutation","level":4,"score":0.7868287563323975},{"id":"https://openalex.org/C43907098","wikidata":"https://www.wikidata.org/wiki/Q903924","display_name":"breakpoint cluster region","level":3,"score":0.7692902088165283},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6990239024162292},{"id":"https://openalex.org/C157695867","wikidata":"https://www.wikidata.org/wiki/Q1100474","display_name":"B-cell receptor","level":4,"score":0.67503821849823},{"id":"https://openalex.org/C2778473898","wikidata":"https://www.wikidata.org/wiki/Q2145110","display_name":"Repertoire","level":2,"score":0.6214830279350281},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.555128812789917},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5129966139793396},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4794405996799469},{"id":"https://openalex.org/C2777609679","wikidata":"https://www.wikidata.org/wiki/Q5971015","display_name":"IGHV@","level":4,"score":0.4786294996738434},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.42329341173171997},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.41948843002319336},{"id":"https://openalex.org/C2778453870","wikidata":"https://www.wikidata.org/wiki/Q188930","display_name":"B cell","level":3,"score":0.3890039920806885},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3559589982032776},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26916465163230896},{"id":"https://openalex.org/C2777938653","wikidata":"https://www.wikidata.org/wiki/Q1088156","display_name":"Chronic lymphocytic leukemia","level":3,"score":0.1942092478275299},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.08268702030181885},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000472","qualifier_name":"pathogenicity","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007070","descriptor_name":"Immunoglobulin A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007070","descriptor_name":"Immunoglobulin A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007070","descriptor_name":"Immunoglobulin A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007070","descriptor_name":"Immunoglobulin A","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007070","descriptor_name":"Immunoglobulin A","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007070","descriptor_name":"Immunoglobulin A","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007074","descriptor_name":"Immunoglobulin G","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011947","descriptor_name":"Receptors, Antigen, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011947","descriptor_name":"Receptors, Antigen, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011947","descriptor_name":"Receptors, Antigen, B-Cell","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011947","descriptor_name":"Receptors, Antigen, B-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011947","descriptor_name":"Receptors, Antigen, B-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011947","descriptor_name":"Receptors, Antigen, B-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017421","descriptor_name":"Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017421","descriptor_name":"Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017421","descriptor_name":"Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050441","descriptor_name":"VDJ Exons","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050441","descriptor_name":"VDJ Exons","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050441","descriptor_name":"VDJ Exons","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050441","descriptor_name":"VDJ Exons","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050441","descriptor_name":"VDJ Exons","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050441","descriptor_name":"VDJ Exons","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbab192","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbab192","pdf_url":"https://academic.oup.com/bib/article-pdf/22/6/bbab192/41088987/bbab192.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34015809","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34015809","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:8194558","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8194558","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbab192","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbab192","pdf_url":"https://academic.oup.com/bib/article-pdf/22/6/bbab192/41088987/bbab192.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8700000047683716}],"awards":[{"id":"https://openalex.org/G2087396116","display_name":null,"funder_award_id":"China","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G3317480652","display_name":null,"funder_award_id":"Science","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4020255992","display_name":null,"funder_award_id":"Project","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4941696472","display_name":null,"funder_award_id":"61822108","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5537961059","display_name":null,"funder_award_id":"2020-001","funder_id":"https://openalex.org/F4320321940","funder_display_name":"Harbin Institute of Technology"},{"id":"https://openalex.org/G5939423041","display_name":null,"funder_award_id":"Technology","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5994120800","display_name":null,"funder_award_id":"Natural","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6256444366","display_name":null,"funder_award_id":"COVID-19","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6549098544","display_name":null,"funder_award_id":"62032007","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321940","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3161051056.pdf","grobid_xml":"https://content.openalex.org/works/W3161051056.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1586686032","https://openalex.org/W2018337150","https://openalex.org/W2020836294","https://openalex.org/W2042096299","https://openalex.org/W2046517086","https://openalex.org/W2091477384","https://openalex.org/W2113392525","https://openalex.org/W2129275039","https://openalex.org/W2139891717","https://openalex.org/W2290663115","https://openalex.org/W2327924953","https://openalex.org/W2342436442","https://openalex.org/W2419841684","https://openalex.org/W2518875783","https://openalex.org/W2556876931","https://openalex.org/W2737196618","https://openalex.org/W2789949322","https://openalex.org/W2808144819","https://openalex.org/W2811117758","https://openalex.org/W2887124376","https://openalex.org/W2900841241","https://openalex.org/W2911980279","https://openalex.org/W2978862345","https://openalex.org/W2993952845","https://openalex.org/W3001118548","https://openalex.org/W3001897055","https://openalex.org/W3003532529","https://openalex.org/W3003668884","https://openalex.org/W3005079553","https://openalex.org/W3008443627","https://openalex.org/W3009335299","https://openalex.org/W3009912996","https://openalex.org/W3011224398","https://openalex.org/W3013053784","https://openalex.org/W3013742505","https://openalex.org/W3016489853","https://openalex.org/W3021435052","https://openalex.org/W3021544284","https://openalex.org/W3022878099","https://openalex.org/W3024602798","https://openalex.org/W3025320502","https://openalex.org/W3025987322","https://openalex.org/W3029682964","https://openalex.org/W3034425032","https://openalex.org/W3035052349","https://openalex.org/W3036386821","https://openalex.org/W3040801404","https://openalex.org/W3042989521","https://openalex.org/W3082102108","https://openalex.org/W3095016916","https://openalex.org/W3107281945","https://openalex.org/W3165656738"],"related_works":["https://openalex.org/W1500486283","https://openalex.org/W4311367181","https://openalex.org/W2063199750","https://openalex.org/W4315796090","https://openalex.org/W4313240779","https://openalex.org/W2194452929","https://openalex.org/W2062581231","https://openalex.org/W4210535643","https://openalex.org/W2120929679","https://openalex.org/W4389235293"],"abstract_inverted_index":{"The":[0,107],"world":[1],"is":[2],"facing":[3],"a":[4,31,50,189],"pandemic":[5],"of":[6,34,53,110,192,204],"Corona":[7],"Virus":[8],"Disease":[9],"2019":[10],"(COVID-19)":[11],"caused":[12],"by":[13],"severe":[14],"acute":[15],"respiratory":[16],"syndrome":[17],"coronavirus":[18],"2":[19],"(SARS-CoV-2).":[20],"Adaptive":[21],"immune":[22,42,209],"responses":[23],"are":[24],"essential":[25],"for":[26,207],"SARS-CoV-2":[27,212],"virus":[28],"clearance.":[29],"Although":[30],"large":[32],"body":[33],"studies":[35],"have":[36],"been":[37],"conducted":[38],"to":[39,68,95,201,211],"investigate":[40],"the":[41,54,64,70,80,136,150,158,177,193,202,205,208],"mechanism":[43,206],"in":[44,57,86,102,113,116,123,135,196],"COVID-19":[45,75,103,197],"patients,":[46,198],"we":[47,62,128,166],"still":[48],"lack":[49],"comprehensive":[51,190],"understanding":[52,203],"BCR":[55,71,81,194],"repertoire":[56,72,195],"patients.":[58,76],"In":[59,126,143],"this":[60],"study,":[61],"used":[63],"single-cell":[65],"V(D)J":[66],"sequencing":[67],"characterize":[69],"across":[73],"convalescent":[74],"We":[77],"observed":[78],"that":[79,122,168],"diversity":[82],"was":[83],"significantly":[84],"reduced":[85],"disease":[87],"compared":[88],"with":[89],"healthy":[90,105,124],"controls.":[91,106,125],"And":[92],"BCRs":[93,115],"tend":[94],"skew":[96],"toward":[97],"different":[98,173],"V":[99],"gene":[100],"segments":[101],"and":[104,132,141,157,181],"CDR3":[108,182],"sequences":[109,183],"heavy":[111],"chain":[112],"clonal":[114,145,174],"patients":[117],"were":[118],"more":[119],"convergent":[120],"than":[121],"addition,":[127],"discovered":[129],"increased":[130],"IgG":[131,147],"IgA":[133],"isotypes":[134,148],"disease,":[137],"including":[138],"IgG1,":[139],"IgG3":[140,170],"IgA1.":[142],"all":[144],"BCRs,":[146],"had":[149,176],"most":[151],"frequent":[152],"class":[153],"switch":[154],"recombination":[155],"events":[156],"highest":[159],"somatic":[160],"hypermutation":[161],"rate,":[162],"especially":[163],"IgG3.":[164],"Moreover,":[165],"found":[167],"an":[169],"cluster":[171],"from":[172],"groups":[175],"same":[178],"IGHV,":[179],"IGHJ":[180],"(IGHV4-4-CARLANTNQFYDSSSYLNAMDVW-IGHJ6).":[184],"Overall,":[185],"our":[186],"study":[187],"provides":[188],"characterization":[191],"which":[199],"contributes":[200],"response":[210],"infection.":[213]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":20},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-04-18T07:56:08.524223","created_date":"2025-10-10T00:00:00"}