{"id":"https://openalex.org/W3161321660","doi":"https://doi.org/10.1093/bib/bbab187","title":"Identification of genetic variations associated with drug resistance in non-small cell lung cancer patients undergoing systemic treatment","display_name":"Identification of genetic variations associated with drug resistance in non-small cell lung cancer patients undergoing systemic treatment","publication_year":2021,"publication_date":"2021-04-23","ids":{"openalex":"https://openalex.org/W3161321660","doi":"https://doi.org/10.1093/bib/bbab187","mag":"3161321660","pmid":"https://pubmed.ncbi.nlm.nih.gov/34013324"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbab187","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbab187","pdf_url":"https://academic.oup.com/bib/article-pdf/22/6/bbab187/41088120/bbab187.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bib/article-pdf/22/6/bbab187/41088120/bbab187.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061423184","display_name":"Ruihan Luo","orcid":"https://orcid.org/0000-0001-5997-4051"},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruihan Luo","raw_affiliation_strings":["Department of Bioinformatics, The Basic Medical School of Chongqing Medical University, China"],"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, The Basic Medical School of Chongqing Medical University, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108902954","display_name":"Chuang Ge","orcid":null},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]},{"id":"https://openalex.org/I4210154480","display_name":"Chongqing Cancer Hospital","ror":"https://ror.org/047d8yx24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154480"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chuang Ge","raw_affiliation_strings":["Clinical Laboratory of Chongqing University Cancer Hospital, China"],"affiliations":[{"raw_affiliation_string":"Clinical Laboratory of Chongqing University Cancer Hospital, China","institution_ids":["https://openalex.org/I4210154480","https://openalex.org/I158842170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100451727","display_name":"Xiao Xiao","orcid":"https://orcid.org/0000-0002-4328-0634"},"institutions":[{"id":"https://openalex.org/I4210129459","display_name":"First Affiliated Hospital of Chongqing Medical University","ror":"https://ror.org/033vnzz93","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210129459"]},{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiao Xiao","raw_affiliation_strings":["Department of Surgery, The First Affiliated Hospital of Chongqing Medical University, China"],"affiliations":[{"raw_affiliation_string":"Department of Surgery, The First Affiliated Hospital of Chongqing Medical University, China","institution_ids":["https://openalex.org/I4210129459","https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002890531","display_name":"Jing Song","orcid":"https://orcid.org/0000-0003-1475-5263"},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Song","raw_affiliation_strings":["Molecular and Tumor Research Center, Chongqing Medical University, China"],"affiliations":[{"raw_affiliation_string":"Molecular and Tumor Research Center, Chongqing Medical University, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049163595","display_name":"Shiqi Miao","orcid":"https://orcid.org/0000-0002-5111-5161"},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shiqi Miao","raw_affiliation_strings":["Molecular and Tumor Research Center, Chongqing Medical University, China"],"affiliations":[{"raw_affiliation_string":"Molecular and Tumor Research Center, Chongqing Medical University, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033095261","display_name":"Yongyao Tang","orcid":null},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongyao Tang","raw_affiliation_strings":["Molecular and Tumor Research Center, Chongqing Medical University, China"],"affiliations":[{"raw_affiliation_string":"Molecular and Tumor Research Center, Chongqing Medical University, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112639897","display_name":"Jiayi Lai","orcid":null},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiayi Lai","raw_affiliation_strings":["Department of Bioinformatics, The Basic Medical School of Chongqing Medical University, China"],"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, The Basic Medical School of Chongqing Medical University, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002345896","display_name":"Weiqi Nian","orcid":"https://orcid.org/0000-0001-6596-9443"},"institutions":[{"id":"https://openalex.org/I158842170","display_name":"Chongqing University","ror":"https://ror.org/023rhb549","country_code":"CN","type":"education","lineage":["https://openalex.org/I158842170"]},{"id":"https://openalex.org/I4210154480","display_name":"Chongqing Cancer Hospital","ror":"https://ror.org/047d8yx24","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210154480"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Weiqi Nian","raw_affiliation_strings":["Phase 1 Clinical Trial Center of Chongqing University Cancer Hospital, China"],"affiliations":[{"raw_affiliation_string":"Phase 1 Clinical Trial Center of Chongqing University Cancer Hospital, China","institution_ids":["https://openalex.org/I4210154480","https://openalex.org/I158842170"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004676038","display_name":"Fangzhou Song","orcid":"https://orcid.org/0000-0002-4083-3889"},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fangzhou Song","raw_affiliation_strings":["Molecular and Tumor Research Center, Chongqing Medical University, China"],"affiliations":[{"raw_affiliation_string":"Molecular and Tumor Research Center, Chongqing Medical University, China","institution_ids":["https://openalex.org/I87780372"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110767001","display_name":"Longke Ran","orcid":null},"institutions":[{"id":"https://openalex.org/I87780372","display_name":"Chongqing Medical University","ror":"https://ror.org/017z00e58","country_code":"CN","type":"education","lineage":["https://openalex.org/I87780372"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Longke Ran","raw_affiliation_strings":["Department of Bioinformatics, The Basic Medical School of Chongqing Medical University, China"],"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, The Basic Medical School of Chongqing Medical University, China","institution_ids":["https://openalex.org/I87780372"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5110767001"],"corresponding_institution_ids":["https://openalex.org/I87780372"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":0.9558,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.70084097,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"22","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.9944999814033508,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.6016504764556885},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"Drug resistance","score":0.5835829973220825},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5322133302688599},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.5013470649719238},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.49028733372688293},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.48846808075904846},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.31597667932510376},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.2837889790534973},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.23535409569740295},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2057141363620758}],"concepts":[{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6016504764556885},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.5835829973220825},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5322133302688599},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.5013470649719238},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49028733372688293},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.48846808075904846},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.31597667932510376},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.2837889790534973},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.23535409569740295},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2057141363620758}],"mesh":[{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000971","descriptor_name":"Antineoplastic Combined Chemotherapy Protocols","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056915","descriptor_name":"DNA Copy Number Variations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058977","descriptor_name":"Molecular Sequence Annotation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bib/bbab187","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbab187","pdf_url":"https://academic.oup.com/bib/article-pdf/22/6/bbab187/41088120/bbab187.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34013324","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34013324","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:europepmc.org:7467694","is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC8574960","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:8574960","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8574960","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbab187","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbab187","pdf_url":"https://academic.oup.com/bib/article-pdf/22/6/bbab187/41088120/bbab187.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8700000047683716,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3161321660.pdf","grobid_xml":"https://content.openalex.org/works/W3161321660.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1491208893","https://openalex.org/W1546552389","https://openalex.org/W1919257374","https://openalex.org/W1969135135","https://openalex.org/W1972329707","https://openalex.org/W2009171847","https://openalex.org/W2035618305","https://openalex.org/W2049553585","https://openalex.org/W2055402151","https://openalex.org/W2065293650","https://openalex.org/W2097238709","https://openalex.org/W2103441770","https://openalex.org/W2104224322","https://openalex.org/W2104549677","https://openalex.org/W2108234281","https://openalex.org/W2135502243","https://openalex.org/W2135631135","https://openalex.org/W2138601221","https://openalex.org/W2157852151","https://openalex.org/W2161620765","https://openalex.org/W2180481128","https://openalex.org/W2195049434","https://openalex.org/W2206353098","https://openalex.org/W2225287204","https://openalex.org/W2256016639","https://openalex.org/W2294356527","https://openalex.org/W2416111151","https://openalex.org/W2490543344","https://openalex.org/W2508716485","https://openalex.org/W2560322684","https://openalex.org/W2560367415","https://openalex.org/W2593435710","https://openalex.org/W2606002996","https://openalex.org/W2608738563","https://openalex.org/W2612467560","https://openalex.org/W2741892140","https://openalex.org/W2765831845","https://openalex.org/W2795985841","https://openalex.org/W2805535338","https://openalex.org/W2901888695","https://openalex.org/W2952001873","https://openalex.org/W2972179964","https://openalex.org/W2972970991","https://openalex.org/W2973690026","https://openalex.org/W3011732303","https://openalex.org/W3021362363","https://openalex.org/W3120246130","https://openalex.org/W3121485073","https://openalex.org/W3211488171","https://openalex.org/W4247053599"],"related_works":["https://openalex.org/W2981696006","https://openalex.org/W2064573700","https://openalex.org/W2554284703","https://openalex.org/W2967366602","https://openalex.org/W2376385980","https://openalex.org/W1992227688","https://openalex.org/W2075817938","https://openalex.org/W1496498748","https://openalex.org/W1997032381","https://openalex.org/W2287922696"],"abstract_inverted_index":{"Non-small":[0],"cell":[1],"lung":[2],"cancer":[3],"(NSCLC)":[4],"is":[5],"characterized":[6],"by":[7,208],"relatively":[8,179],"rapid":[9],"response":[10,68,115],"to":[11,19,29,69,124,192,224],"systemic":[12,70,225],"treatments":[13,227],"yet":[14],"inevitable":[15],"resistance":[16,38,105,123,139,222],"and":[17,33,56,88,114,135,183,198,228],"predisposed":[18],"distant":[20],"metastasis.":[21],"We":[22,41,127],"thus":[23],"aimed":[24],"at":[25],"performing":[26],"sequencing":[27,44],"analysis":[28,163],"determine":[30],"genomic":[31],"events":[32,93],"underlying":[34],"mechanisms":[35,223],"concerning":[36],"drug":[37,104],"in":[39,80,95,122,132,152],"NSCLC.":[40],"performed":[42],"targeted":[43],"of":[45,59,73,90,100,149,173,201,235],"40":[46],"medication-relevant":[47],"genes":[48,150],"on":[49,62,137],"plasma":[50],"samples":[51,134],"from":[52,76],"98":[53],"NSCLC":[54,78,166,226],"patients":[55],"analyzed":[57],"impact":[58],"genetic":[60,98],"alterations":[61,188],"clinical":[63],"presentation":[64],"as":[65,67,156,158,210],"well":[66,157],"treatments.":[71],"Profiling":[72],"multi-omics":[74],"data":[75],"1024":[77],"tissues":[79],"public":[81],"datasets":[82],"was":[83,106,119],"carried":[84],"out":[85],"for":[86,215,232],"comparison":[87],"validation":[89],"identified":[91,107,207,220],"molecular":[92],"implicated":[94],"resistance.":[96],"A":[97],"association":[99],"CYP2D6":[101,145,168,216],"deletion":[102],"with":[103,167,195],"through":[108],"circulating":[109],"tumor":[110],"DNA":[111,186],"(ctDNA)":[112],"profiling":[113],"assessment.":[116],"FCGR3A":[117],"amplification":[118],"potentially":[120],"involved":[121,151],"EGFR":[125],"inhibitors.":[126],"further":[128],"verified":[129],"our":[130],"findings":[131],"tissue":[133],"focused":[136],"potential":[138],"mechanisms,":[140],"which":[141],"uncovered":[142],"that":[143,165],"depleted":[144],"affected":[146],"a":[147],"set":[148],"EMT,":[153],"oncogenic":[154],"signaling":[155],"inflammatory":[159],"pathways.":[160],"Tumor":[161],"microenvironment":[162],"revealed":[164],"loss":[169],"manifested":[170],"increased":[171],"levels":[172],"immunomodulatory":[174],"gene":[175],"expressions,":[176],"PD-L1":[177],"expression,":[178],"high":[180],"mutational":[181],"burden":[182],"lymphocyte":[184],"infiltration.":[185],"methylation":[187],"were":[189,206],"also":[190],"found":[191],"be":[193],"correlated":[194],"mRNA":[196],"expressions":[197],"copy":[199],"numbers":[200],"CYP2D6.":[202],"Finally,":[203],"MEK":[204],"inhibitors":[205],"CMap":[209],"the":[211,233],"prospective":[212],"therapeutic":[213],"drugs":[214],"deletion.":[217],"These":[218],"analyses":[219],"novel":[221],"had":[229],"significant":[230],"implications":[231],"development":[234],"new":[236],"treatment":[237],"strategies.":[238]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}