{"id":"https://openalex.org/W3152679112","doi":"https://doi.org/10.1093/bib/bbab091","title":"mi-IsoNet: systems-scale microRNA landscape reveals rampant isoform-mediated gain of target interaction diversity and signaling specificity","display_name":"mi-IsoNet: systems-scale microRNA landscape reveals rampant isoform-mediated gain of target interaction diversity and signaling specificity","publication_year":2021,"publication_date":"2021-03-03","ids":{"openalex":"https://openalex.org/W3152679112","doi":"https://doi.org/10.1093/bib/bbab091","mag":"3152679112","pmid":"https://pubmed.ncbi.nlm.nih.gov/33855356"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbab091","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbab091","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8579161","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071748997","display_name":"Li Guo","orcid":"https://orcid.org/0000-0001-5624-5259"},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Li Guo","raw_affiliation_strings":["Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100389127","display_name":"Yongsheng Li","orcid":"https://orcid.org/0000-0003-1914-0727"},"institutions":[{"id":"https://openalex.org/I1305023659","display_name":"Livestrong Foundation","ror":"https://ror.org/04ndvz759","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305023659"]},{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yongsheng Li","raw_affiliation_strings":["Department of Oncology, Livestrong Cancer Institutes, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Livestrong Cancer Institutes, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA","institution_ids":["https://openalex.org/I1305023659","https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014008600","display_name":"Kara M. Cirillo","orcid":"https://orcid.org/0000-0002-9040-0352"},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kara M Cirillo","raw_affiliation_strings":["Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008834307","display_name":"Robert A. Marick","orcid":null},"institutions":[{"id":"https://openalex.org/I1305023659","display_name":"Livestrong Foundation","ror":"https://ror.org/04ndvz759","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305023659"]},{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert A Marick","raw_affiliation_strings":["Department of Oncology, Livestrong Cancer Institutes, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Livestrong Cancer Institutes, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA","institution_ids":["https://openalex.org/I1305023659","https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085051340","display_name":"Zhe Su","orcid":"https://orcid.org/0000-0001-8683-5700"},"institutions":[{"id":"https://openalex.org/I1305023659","display_name":"Livestrong Foundation","ror":"https://ror.org/04ndvz759","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305023659"]},{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhe Su","raw_affiliation_strings":["Department of Oncology, Livestrong Cancer Institutes, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Livestrong Cancer Institutes, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA","institution_ids":["https://openalex.org/I1305023659","https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053598390","display_name":"Xing Yin","orcid":"https://orcid.org/0000-0003-3444-6687"},"institutions":[{"id":"https://openalex.org/I1305023659","display_name":"Livestrong Foundation","ror":"https://ror.org/04ndvz759","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305023659"]},{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xing Yin","raw_affiliation_strings":["Department of Oncology, Livestrong Cancer Institutes, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology, Livestrong Cancer Institutes, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA","institution_ids":["https://openalex.org/I1305023659","https://openalex.org/I86519309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083553317","display_name":"Xu Hua","orcid":"https://orcid.org/0000-0002-9775-4129"},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xu Hua","raw_affiliation_strings":["Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I1343551460"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005221518","display_name":"Gordon B. Mills","orcid":"https://orcid.org/0000-0002-0144-9614"},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]},{"id":"https://openalex.org/I4390039369","display_name":"OHSU Knight Cancer Institute","ror":"https://ror.org/002shna07","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I165690674","https://openalex.org/I4390039369"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gordon B Mills","raw_affiliation_strings":["Department of Cell, Developmental and Cancer Biology, School of Medicine, Oregon Health & Science University, Portland, OR 97201, USA","Precision Oncology, Knight Cancer Institute, Portland, OR 97201, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cell, Developmental and Cancer Biology, School of Medicine, Oregon Health & Science University, Portland, OR 97201, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"Precision Oncology, Knight Cancer Institute, Portland, OR 97201, USA","institution_ids":["https://openalex.org/I4390039369"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063425934","display_name":"Nidhi Sahni","orcid":"https://orcid.org/0000-0002-9155-5882"},"institutions":[{"id":"https://openalex.org/I1343551460","display_name":"The University of Texas MD Anderson Cancer Center","ror":"https://ror.org/04twxam07","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1343551460"]},{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nidhi Sahni","raw_affiliation_strings":["Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA","Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA","Program in Quantitative and Computational Biosciences (QCB), Baylor College of Medicine, Houston, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics and Computational Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Department of Epigenetics and Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center, Smithville, TX 78957, USA","institution_ids":["https://openalex.org/I1343551460"]},{"raw_affiliation_string":"Program in Quantitative and Computational Biosciences (QCB), Baylor College of Medicine, Houston, TX 77030, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063496035","display_name":"S. Stephen Yi","orcid":"https://orcid.org/0000-0003-0047-8103"},"institutions":[{"id":"https://openalex.org/I1305023659","display_name":"Livestrong Foundation","ror":"https://ror.org/04ndvz759","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1305023659"]},{"id":"https://openalex.org/I86519309","display_name":"The University of Texas at Austin","ror":"https://ror.org/00hj54h04","country_code":"US","type":"education","lineage":["https://openalex.org/I86519309"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"S Stephen Yi","raw_affiliation_strings":["Department of Biomedical Engineering, Cockrell School of Engineering, The University of Texas at Austin, Austin, TX 78712, USA","Department of Oncology, Livestrong Cancer Institutes, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA","Interdisciplinary Life Sciences Graduate Programs (ILSGP), College of Natural Sciences, The University of Texas at Austin, Austin, TX 78712, USA","Oden Institute for Computational Engineering and Sciences (ICES), The University of Texas at Austin, Austin, TX 78712, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Cockrell School of Engineering, The University of Texas at Austin, Austin, TX 78712, USA","institution_ids":["https://openalex.org/I86519309"]},{"raw_affiliation_string":"Department of Oncology, Livestrong Cancer Institutes, Dell Medical School, The University of Texas at Austin, Austin, TX 78712, USA","institution_ids":["https://openalex.org/I1305023659","https://openalex.org/I86519309"]},{"raw_affiliation_string":"Interdisciplinary Life Sciences Graduate Programs (ILSGP), College of Natural Sciences, The University of Texas at Austin, Austin, TX 78712, USA","institution_ids":["https://openalex.org/I86519309"]},{"raw_affiliation_string":"Oden Institute for Computational Engineering and Sciences (ICES), The University of Texas at Austin, Austin, TX 78712, USA","institution_ids":["https://openalex.org/I86519309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5063425934","https://openalex.org/A5063496035"],"corresponding_institution_ids":["https://openalex.org/I1305023659","https://openalex.org/I1343551460","https://openalex.org/I181547552","https://openalex.org/I86519309"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":0.9723,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.70490391,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"22","issue":"5","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.8523494601249695},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7338441014289856},{"id":"https://openalex.org/keywords/gene-isoform","display_name":"Gene isoform","score":0.7185423374176025},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6419974565505981},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5442533493041992},{"id":"https://openalex.org/keywords/small-rna","display_name":"Small RNA","score":0.4567490816116333},{"id":"https://openalex.org/keywords/locus","display_name":"Locus (genetics)","score":0.45483818650245667},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.4453132748603821},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.44168946146965027}],"concepts":[{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.8523494601249695},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7338441014289856},{"id":"https://openalex.org/C53345823","wikidata":"https://www.wikidata.org/wiki/Q5531554","display_name":"Gene isoform","level":3,"score":0.7185423374176025},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6419974565505981},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5442533493041992},{"id":"https://openalex.org/C2779341050","wikidata":"https://www.wikidata.org/wiki/Q24287527","display_name":"Small RNA","level":4,"score":0.4567490816116333},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.45483818650245667},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.4453132748603821},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.44168946146965027}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059014","descriptor_name":"High-Throughput Nucleotide Sequencing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D059368","descriptor_name":"RNA Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059368","descriptor_name":"RNA Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059368","descriptor_name":"RNA Isoforms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bib/bbab091","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbab091","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:33855356","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33855356","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:8579161","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8579161","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:8579161","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8579161","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G4711722764","display_name":null,"funder_award_id":"CCR19609287","funder_id":"https://openalex.org/F4320311413","funder_display_name":"Susan G. Komen"}],"funders":[{"id":"https://openalex.org/F4320306632","display_name":"Breast Cancer Alliance","ror":"https://ror.org/02n6dj587"},{"id":"https://openalex.org/F4320308400","display_name":"American Association for the Study of Liver Diseases","ror":"https://ror.org/005tjs461"},{"id":"https://openalex.org/F4320311413","display_name":"Susan G. Komen","ror":"https://ror.org/02nadbe75"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":60,"referenced_works":["https://openalex.org/W1648301895","https://openalex.org/W1934704664","https://openalex.org/W1991288564","https://openalex.org/W2002995168","https://openalex.org/W2004791359","https://openalex.org/W2017571136","https://openalex.org/W2028498643","https://openalex.org/W2031317360","https://openalex.org/W2059357290","https://openalex.org/W2078849828","https://openalex.org/W2089055162","https://openalex.org/W2098422994","https://openalex.org/W2102140136","https://openalex.org/W2116997575","https://openalex.org/W2129355962","https://openalex.org/W2130410032","https://openalex.org/W2133968430","https://openalex.org/W2134629862","https://openalex.org/W2154578855","https://openalex.org/W2158217645","https://openalex.org/W2158266834","https://openalex.org/W2159675211","https://openalex.org/W2166840595","https://openalex.org/W2168352935","https://openalex.org/W2174686320","https://openalex.org/W2174734928","https://openalex.org/W2179438025","https://openalex.org/W2180291937","https://openalex.org/W2230320310","https://openalex.org/W2253369415","https://openalex.org/W2470233900","https://openalex.org/W2564815597","https://openalex.org/W2583949540","https://openalex.org/W2588840062","https://openalex.org/W2589035382","https://openalex.org/W2597632520","https://openalex.org/W2614357436","https://openalex.org/W2652728872","https://openalex.org/W2737963069","https://openalex.org/W2749611213","https://openalex.org/W2768316161","https://openalex.org/W2781083957","https://openalex.org/W2781850233","https://openalex.org/W2789272752","https://openalex.org/W2789819037","https://openalex.org/W2790194360","https://openalex.org/W2794090160","https://openalex.org/W2794435764","https://openalex.org/W2897185013","https://openalex.org/W2905353241","https://openalex.org/W2933358772","https://openalex.org/W2950875202","https://openalex.org/W2979739847","https://openalex.org/W2986252381","https://openalex.org/W2999158618","https://openalex.org/W3000549569","https://openalex.org/W3014147366","https://openalex.org/W3034719013","https://openalex.org/W3163547524","https://openalex.org/W6731224346"],"related_works":["https://openalex.org/W1540936366","https://openalex.org/W2079625624","https://openalex.org/W2004254765","https://openalex.org/W2126407448","https://openalex.org/W2125691904","https://openalex.org/W2953122964","https://openalex.org/W2128583238","https://openalex.org/W2134405083","https://openalex.org/W2034500416","https://openalex.org/W2034377088"],"abstract_inverted_index":{"MicroRNA":[0],"(miRNA)":[1],"is":[2],"not":[3],"a":[4,8,164,199,249],"single":[5],"sequence,":[6,95],"but":[7],"series":[9],"of":[10,51,72,76,120,167,202],"multiple":[11,81,168],"variants":[12,229],"(also":[13],"termed":[14],"isomiRs)":[15],"with":[16,107,158,180,209],"sequence":[17],"and":[18,22,30,35,54,65,97,102,114,132,137,161,189,204,243,253],"expression":[19,50,78,96],"heterogeneity.":[20],"Whether":[21],"how":[23],"these":[24,121],"isoforms":[25],"contribute":[26,191],"to":[27,58,192,247],"functional":[28,60],"variation":[29,92],"complexity":[31],"at":[32],"the":[33,49,73,85,234],"systems":[34],"network":[36,194,223],"levels":[37],"remain":[38],"largely":[39],"unknown.":[40],"To":[41],"explore":[42],"this":[43,217],"question":[44],"systematically,":[45],"we":[46],"comprehensively":[47],"analyzed":[48],"small":[52,130,214,227],"RNAs":[53,131],"their":[55,66,94],"target":[56,187],"sites":[57],"interrogate":[59],"variations":[61,235],"between":[62,129],"novel":[63,108,118,186],"isomiRs":[64,82,106,123,153,157,169,179,237],"canonical":[67,213],"miRNA":[68,77,87,147,241],"sequences.":[69],"Our":[70,196],"analyses":[71,143],"pan-cancer":[74],"landscape":[75],"indicate":[79],"that":[80,124,145,154,178,238],"generated":[83],"from":[84],"same":[86],"locus":[88],"often":[89,155],"exhibit":[90],"remarkable":[91],"in":[93,170,212,236,256],"function.":[98],"We":[99],"interrogated":[100],"abundant":[101],"differentially":[103],"expressed":[104],"5'":[105,122],"seed":[109,112,182],"sequences":[110,183],"via":[111],"shifting":[113],"identified":[115],"many":[116],"potential":[117],"targets":[119],"would":[125],"expand":[126],"interaction":[127,206],"capabilities":[128],"mRNAs,":[133],"rewiring":[134],"regulatory":[135,193],"networks":[136,207],"increasing":[138],"signaling":[139],"circuit":[140],"complexity.":[141],"Further":[142],"revealed":[144],"some":[146],"loci":[148],"might":[149],"generate":[150],"diverse":[151],"dominant":[152],"involved":[156],"varied":[159],"seeds":[160],"arm-switching,":[162],"suggesting":[163],"selective":[165],"advantage":[166],"regulating":[171],"gene":[172,221,257],"expression.":[173],"Finally,":[174],"experimental":[175],"validation":[176],"indicated":[177],"shifted":[181],"could":[184],"regulate":[185],"mRNAs":[188],"therefore":[190],"rewiring.":[195],"analysis":[197],"uncovers":[198],"widespread":[200],"expansion":[201,218],"isomiR":[203],"mRNA":[205],"compared":[208],"those":[210],"seen":[211],"RNA":[215,228],"analysis;":[216],"suggests":[219],"global":[220],"regulation":[222,258],"perturbations":[224],"by":[225],"alternative":[226],"or":[230],"isoforms.":[231],"Taken":[232],"together,":[233],"occur":[239],"during":[240],"processing":[242],"maturation":[244],"are":[245],"likely":[246],"play":[248],"far":[250],"more":[251],"complex":[252],"plastic":[254],"role":[255],"than":[259],"previously":[260],"anticipated.":[261]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}
