{"id":"https://openalex.org/W3126541761","doi":"https://doi.org/10.1093/bib/bbaa417","title":"Integrated network analysis reveals new genes suggesting COVID-19 chronic effects and treatment","display_name":"Integrated network analysis reveals new genes suggesting COVID-19 chronic effects and treatment","publication_year":2020,"publication_date":"2020-12-21","ids":{"openalex":"https://openalex.org/W3126541761","doi":"https://doi.org/10.1093/bib/bbaa417","mag":"3126541761","pmid":"https://pubmed.ncbi.nlm.nih.gov/33569598"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbaa417","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaa417","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1093/bib/bbaa417","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032173283","display_name":"Alisa Pavel","orcid":"https://orcid.org/0000-0002-2983-0214"},"institutions":[{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Alisa Pavel","raw_affiliation_strings":["BioMediTech Institute, Tampere University, Tampere, Finland","Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioMediTech Institute, Tampere University, Tampere, Finland","institution_ids":["https://openalex.org/I166825849"]},{"raw_affiliation_string":"Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland","institution_ids":["https://openalex.org/I166825849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054987771","display_name":"Giusy del Giudice","orcid":"https://orcid.org/0000-0003-0999-4796"},"institutions":[{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Giusy del Giudice","raw_affiliation_strings":["BioMediTech Institute, Tampere University, Tampere, Finland","Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioMediTech Institute, Tampere University, Tampere, Finland","institution_ids":["https://openalex.org/I166825849"]},{"raw_affiliation_string":"Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland","institution_ids":["https://openalex.org/I166825849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101807666","display_name":"Antonio Federico","orcid":"https://orcid.org/0000-0003-2554-9879"},"institutions":[{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Antonio Federico","raw_affiliation_strings":["BioMediTech Institute, Tampere University, Tampere, Finland","Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioMediTech Institute, Tampere University, Tampere, Finland","institution_ids":["https://openalex.org/I166825849"]},{"raw_affiliation_string":"Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland","institution_ids":["https://openalex.org/I166825849"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045897474","display_name":"A. Di Lieto","orcid":"https://orcid.org/0000-0002-0265-7554"},"institutions":[{"id":"https://openalex.org/I204337017","display_name":"Aarhus University","ror":"https://ror.org/01aj84f44","country_code":"DK","type":"education","lineage":["https://openalex.org/I204337017"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Antonio Di Lieto","raw_affiliation_strings":["Department of Forensic Psychiatry, Aarhus University, Aarhus, Denmark"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Forensic Psychiatry, Aarhus University, Aarhus, Denmark","institution_ids":["https://openalex.org/I204337017"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057193559","display_name":"Pia Kinaret","orcid":"https://orcid.org/0000-0002-3312-5331"},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Pia A S Kinaret","raw_affiliation_strings":["Institute of Biotechnology, University of Helsinki, Helsinki, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biotechnology, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041632230","display_name":"Angela Serra","orcid":"https://orcid.org/0000-0002-3374-1492"},"institutions":[{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]}],"countries":["FI"],"is_corresponding":false,"raw_author_name":"Angela Serra","raw_affiliation_strings":["BioMediTech Institute, Tampere University, Tampere, Finland","Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BioMediTech Institute, Tampere University, Tampere, Finland","institution_ids":["https://openalex.org/I166825849"]},{"raw_affiliation_string":"Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland","institution_ids":["https://openalex.org/I166825849"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028682033","display_name":"Dario Greco","orcid":"https://orcid.org/0000-0001-9195-9003"},"institutions":[{"id":"https://openalex.org/I133731052","display_name":"University of Helsinki","ror":"https://ror.org/040af2s02","country_code":"FI","type":"education","lineage":["https://openalex.org/I133731052"]},{"id":"https://openalex.org/I166825849","display_name":"Tampere University","ror":"https://ror.org/033003e23","country_code":"FI","type":"education","lineage":["https://openalex.org/I166825849"]}],"countries":["FI"],"is_corresponding":true,"raw_author_name":"Dario Greco","raw_affiliation_strings":["BioMediTech Institute, Tampere University, Tampere, Finland","Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland","Institute of Biotechnology, University of Helsinki, Helsinki, Finland"],"raw_orcid":"https://orcid.org/0000-0001-9195-9003","affiliations":[{"raw_affiliation_string":"BioMediTech Institute, Tampere University, Tampere, Finland","institution_ids":["https://openalex.org/I166825849"]},{"raw_affiliation_string":"Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland","institution_ids":["https://openalex.org/I166825849"]},{"raw_affiliation_string":"Institute of Biotechnology, University of Helsinki, Helsinki, Finland","institution_ids":["https://openalex.org/I133731052"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5028682033"],"corresponding_institution_ids":["https://openalex.org/I133731052","https://openalex.org/I166825849"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":2.0876,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.88207114,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"22","issue":"2","first_page":"1430","last_page":"1441"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9966999888420105,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.9567999839782715,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coronavirus-disease-2019","display_name":"Coronavirus disease 2019 (COVID-19)","score":0.5570427775382996},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.538992702960968},{"id":"https://openalex.org/keywords/host-response","display_name":"Host response","score":0.5030321478843689},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5010268688201904},{"id":"https://openalex.org/keywords/severe-acute-respiratory-syndrome-coronavirus-2","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","score":0.47945037484169006},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.47070857882499695},{"id":"https://openalex.org/keywords/host","display_name":"Host (biology)","score":0.45963770151138306},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.42045944929122925},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.29910820722579956},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.2328568994998932},{"id":"https://openalex.org/keywords/infectious-disease","display_name":"Infectious disease (medical specialty)","score":0.185161292552948},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.17893093824386597},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1414002776145935},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.0652768611907959}],"concepts":[{"id":"https://openalex.org/C3008058167","wikidata":"https://www.wikidata.org/wiki/Q84263196","display_name":"Coronavirus disease 2019 (COVID-19)","level":4,"score":0.5570427775382996},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.538992702960968},{"id":"https://openalex.org/C2994443828","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Host response","level":3,"score":0.5030321478843689},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5010268688201904},{"id":"https://openalex.org/C3007834351","wikidata":"https://www.wikidata.org/wiki/Q82069695","display_name":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)","level":5,"score":0.47945037484169006},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47070857882499695},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.45963770151138306},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42045944929122925},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29910820722579956},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2328568994998932},{"id":"https://openalex.org/C524204448","wikidata":"https://www.wikidata.org/wiki/Q788926","display_name":"Infectious disease (medical specialty)","level":3,"score":0.185161292552948},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.17893093824386597},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1414002776145935},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0652768611907959}],"mesh":[{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000086382","descriptor_name":"COVID-19","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005814","descriptor_name":"Genes, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005814","descriptor_name":"Genes, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005814","descriptor_name":"Genes, Viral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1093/bib/bbaa417","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaa417","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:33569598","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33569598","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:helda.helsinki.fi:10138/332486","is_oa":true,"landing_page_url":"http://hdl.handle.net/10138/332486","pdf_url":"http://hdl.handle.net/10138/332486","source":{"id":"https://openalex.org/S4210213322","display_name":"Ty\u00f6v\u00e4entutkimus Vuosikirja","issn_l":"0784-1272","issn":["0784-1272","1459-7780"],"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7929418","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7929418","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"},{"id":"pmh:oai:trepo.tuni.fi:10024/219509","is_oa":true,"landing_page_url":"https://trepo.tuni.fi/handle/10024/219509","pdf_url":null,"source":{"id":"https://openalex.org/S4306401860","display_name":"Tampere University Institutional Repository (Tampere University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I150589677","host_organization_name":"Tampere University of Applied Sciences","host_organization_lineage":["https://openalex.org/I150589677"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"publishedVersion"}],"best_oa_location":{"id":"doi:10.1093/bib/bbaa417","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaa417","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.75}],"awards":[{"id":"https://openalex.org/G5445264010","display_name":null,"funder_award_id":"322761","funder_id":"https://openalex.org/F4320321108","funder_display_name":"Academy of Finland"}],"funders":[{"id":"https://openalex.org/F4320321108","display_name":"Academy of Finland","ror":"https://ror.org/05k73zm37"},{"id":"https://openalex.org/F4320322592","display_name":"Tampereen Yliopisto","ror":"https://ror.org/033003e23"},{"id":"https://openalex.org/F4320324148","display_name":"Orionin Tutkimuss\u00e4\u00e4ti\u00f6","ror":"https://ror.org/0296s4x19"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":102,"referenced_works":["https://openalex.org/W1529533208","https://openalex.org/W1564916293","https://openalex.org/W1695278265","https://openalex.org/W1948854550","https://openalex.org/W1963792980","https://openalex.org/W1970001436","https://openalex.org/W1971666606","https://openalex.org/W1972100164","https://openalex.org/W1984084871","https://openalex.org/W1987224493","https://openalex.org/W1995528370","https://openalex.org/W2000763979","https://openalex.org/W2007233425","https://openalex.org/W2022196194","https://openalex.org/W2039640602","https://openalex.org/W2070050178","https://openalex.org/W2075495945","https://openalex.org/W2081209272","https://openalex.org/W2083045667","https://openalex.org/W2085302266","https://openalex.org/W2087345723","https://openalex.org/W2098005762","https://openalex.org/W2108768020","https://openalex.org/W2110065044","https://openalex.org/W2117667168","https://openalex.org/W2127351311","https://openalex.org/W2130382073","https://openalex.org/W2133912767","https://openalex.org/W2136185148","https://openalex.org/W2143965359","https://openalex.org/W2145005920","https://openalex.org/W2147735312","https://openalex.org/W2161106528","https://openalex.org/W2169528473","https://openalex.org/W2170857331","https://openalex.org/W2179438025","https://openalex.org/W2277647142","https://openalex.org/W2296755350","https://openalex.org/W2320656788","https://openalex.org/W2345356016","https://openalex.org/W2347037915","https://openalex.org/W2464159408","https://openalex.org/W2534390616","https://openalex.org/W2550535012","https://openalex.org/W2557530941","https://openalex.org/W2559588208","https://openalex.org/W2606799292","https://openalex.org/W2724336500","https://openalex.org/W2735790845","https://openalex.org/W2737353457","https://openalex.org/W2743021819","https://openalex.org/W2754087526","https://openalex.org/W2756943716","https://openalex.org/W2757038198","https://openalex.org/W2767891136","https://openalex.org/W2781878364","https://openalex.org/W2899070097","https://openalex.org/W2900569176","https://openalex.org/W2902089463","https://openalex.org/W2911561283","https://openalex.org/W2918631818","https://openalex.org/W2946660717","https://openalex.org/W2951714618","https://openalex.org/W2953811685","https://openalex.org/W2966864197","https://openalex.org/W2970487695","https://openalex.org/W2998922495","https://openalex.org/W3001283638","https://openalex.org/W3003257820","https://openalex.org/W3008090866","https://openalex.org/W3009281473","https://openalex.org/W3014905182","https://openalex.org/W3015886046","https://openalex.org/W3016379496","https://openalex.org/W3016489853","https://openalex.org/W3017125154","https://openalex.org/W3018310975","https://openalex.org/W3020097680","https://openalex.org/W3021377320","https://openalex.org/W3022285953","https://openalex.org/W3022808144","https://openalex.org/W3022878099","https://openalex.org/W3024045279","https://openalex.org/W3025781472","https://openalex.org/W3026032531","https://openalex.org/W3027918021","https://openalex.org/W3029837668","https://openalex.org/W3030197534","https://openalex.org/W3032859583","https://openalex.org/W3033896008","https://openalex.org/W3036732116","https://openalex.org/W3036894637","https://openalex.org/W3037826211","https://openalex.org/W3042376507","https://openalex.org/W3047817970","https://openalex.org/W3103145119","https://openalex.org/W3103589660","https://openalex.org/W4241196708","https://openalex.org/W6640500082","https://openalex.org/W6679714033","https://openalex.org/W6741305852","https://openalex.org/W6766976422"],"related_works":["https://openalex.org/W4206669628","https://openalex.org/W4205317059","https://openalex.org/W3081785542","https://openalex.org/W3176864053","https://openalex.org/W3198183218","https://openalex.org/W4205810683","https://openalex.org/W4224279380","https://openalex.org/W4206548596","https://openalex.org/W4206651655","https://openalex.org/W4292098121"],"abstract_inverted_index":{"The":[0],"COVID-19":[1,59],"disease":[2],"led":[3],"to":[4,23,39,53,78,88,144],"an":[5],"unprecedented":[6],"health":[7],"emergency,":[8],"still":[9],"ongoing":[10],"worldwide.":[11],"Given":[12],"the":[13,25,44,58,117,141,145],"lack":[14],"of":[15,57,93,108,116,130,140],"a":[16,19,36,65,80,90,128],"vaccine":[17],"or":[18],"clear":[20],"therapeutic":[21],"strategy":[22],"counteract":[24],"infection":[26],"as":[27,29,120],"well":[28],"its":[30],"secondary":[31],"effects,":[32],"there":[33],"is":[34],"currently":[35],"pressing":[37],"need":[38],"generate":[40],"new":[41,55,91],"insights":[42],"into":[43],"SARS-CoV-2":[45,97],"induced":[46],"host":[47,98,142],"response.":[48],"Biomedical":[49],"data":[50,75],"can":[51],"help":[52],"investigate":[54],"aspects":[56],"pathogenesis,":[60],"but":[61],"source":[62],"heterogeneity":[63],"represents":[64],"major":[66],"drawback":[67],"and":[68,85,103,123],"limitation.":[69],"In":[70],"this":[71],"work,":[72],"we":[73,126],"applied":[74],"integration":[76],"methods":[77],"develop":[79],"Unified":[81],"Knowledge":[82],"Space":[83],"(UKS)":[84],"used":[86],"it":[87],"identify":[89],"set":[92,129],"genes":[94,110],"associated":[95],"with":[96],"response,":[99],"both":[100],"in":[101,104,137],"vitro":[102],"vivo.":[105],"Functional":[106],"analysis":[107],"these":[109],"reveals":[111],"possible":[112],"long-term":[113],"systemic":[114],"effects":[115],"infection,":[118],"such":[119],"vascular":[121],"remodelling":[122],"fibrosis.":[124],"Finally,":[125],"identified":[127],"potentially":[131],"relevant":[132],"drugs":[133],"targeting":[134],"proteins":[135],"involved":[136],"multiple":[138],"steps":[139],"response":[143],"virus.":[146]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":7}],"updated_date":"2026-08-04T08:18:43.703281","created_date":"2025-10-10T00:00:00"}