{"id":"https://openalex.org/W3107142041","doi":"https://doi.org/10.1093/bib/bbaa339","title":"FR-Match: robust matching of cell type clusters from single cell RNA sequencing data using the Friedman\u2013Rafsky non-parametric test","display_name":"FR-Match: robust matching of cell type clusters from single cell RNA sequencing data using the Friedman\u2013Rafsky non-parametric test","publication_year":2020,"publication_date":"2020-10-28","ids":{"openalex":"https://openalex.org/W3107142041","doi":"https://doi.org/10.1093/bib/bbaa339","mag":"3107142041","pmid":"https://pubmed.ncbi.nlm.nih.gov/33249453"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbaa339","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaa339","pdf_url":"https://academic.oup.com/bib/article-pdf/22/4/bbaa339/39136349/bbaa339.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bib/article-pdf/22/4/bbaa339/39136349/bbaa339.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070651801","display_name":"Yun Zhang","orcid":"https://orcid.org/0000-0003-2707-5881"},"institutions":[{"id":"https://openalex.org/I1301553790","display_name":"J. Craig Venter Institute","ror":"https://ror.org/049r1ts75","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1301553790"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yun Zhang","raw_affiliation_strings":["Staff Scientist and Biostatistician in the Informatics Department at the J. Craig Venter Institute"],"affiliations":[{"raw_affiliation_string":"Staff Scientist and Biostatistician in the Informatics Department at the J. Craig Venter Institute","institution_ids":["https://openalex.org/I1301553790"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055273184","display_name":"Brian D. Aevermann","orcid":"https://orcid.org/0000-0003-1346-1327"},"institutions":[{"id":"https://openalex.org/I1301553790","display_name":"J. Craig Venter Institute","ror":"https://ror.org/049r1ts75","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1301553790"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian D Aevermann","raw_affiliation_strings":["Senior Bioinformatics Analyst in the Informatics Department at the J. Craig Venter Institute"],"affiliations":[{"raw_affiliation_string":"Senior Bioinformatics Analyst in the Informatics Department at the J. Craig Venter Institute","institution_ids":["https://openalex.org/I1301553790"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014429025","display_name":"Trygve E. Bakken","orcid":"https://orcid.org/0000-0003-3373-7386"},"institutions":[{"id":"https://openalex.org/I1314596251","display_name":"Allen Institute for Brain Science","ror":"https://ror.org/00dcv1019","country_code":"US","type":"facility","lineage":["https://openalex.org/I1314596251","https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Trygve E Bakken","raw_affiliation_strings":["Allen Institute for Brain Science"],"affiliations":[{"raw_affiliation_string":"Allen Institute for Brain Science","institution_ids":["https://openalex.org/I4210140341","https://openalex.org/I1314596251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035033544","display_name":"Jeremy A. Miller","orcid":"https://orcid.org/0000-0003-4549-588X"},"institutions":[{"id":"https://openalex.org/I1314596251","display_name":"Allen Institute for Brain Science","ror":"https://ror.org/00dcv1019","country_code":"US","type":"facility","lineage":["https://openalex.org/I1314596251","https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeremy A Miller","raw_affiliation_strings":["Allen Institute for Brain Science"],"affiliations":[{"raw_affiliation_string":"Allen Institute for Brain Science","institution_ids":["https://openalex.org/I4210140341","https://openalex.org/I1314596251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017924092","display_name":"Rebecca D. Hodge","orcid":"https://orcid.org/0000-0002-5784-9668"},"institutions":[{"id":"https://openalex.org/I1314596251","display_name":"Allen Institute for Brain Science","ror":"https://ror.org/00dcv1019","country_code":"US","type":"facility","lineage":["https://openalex.org/I1314596251","https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca D Hodge","raw_affiliation_strings":["Allen Institute for Brain Science"],"affiliations":[{"raw_affiliation_string":"Allen Institute for Brain Science","institution_ids":["https://openalex.org/I4210140341","https://openalex.org/I1314596251"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085405013","display_name":"Ed S. Lein","orcid":"https://orcid.org/0000-0001-9012-6552"},"institutions":[{"id":"https://openalex.org/I1314596251","display_name":"Allen Institute for Brain Science","ror":"https://ror.org/00dcv1019","country_code":"US","type":"facility","lineage":["https://openalex.org/I1314596251","https://openalex.org/I4210140341"]},{"id":"https://openalex.org/I4210140341","display_name":"Allen Institute","ror":"https://ror.org/03cpe7c52","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210140341"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ed S Lein","raw_affiliation_strings":["Allen Institute for Brain Science"],"affiliations":[{"raw_affiliation_string":"Allen Institute for Brain Science","institution_ids":["https://openalex.org/I4210140341","https://openalex.org/I1314596251"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5034262562","display_name":"Richard H. Scheuermann","orcid":"https://orcid.org/0000-0003-1355-892X"},"institutions":[{"id":"https://openalex.org/I1301553790","display_name":"J. Craig Venter Institute","ror":"https://ror.org/049r1ts75","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1301553790"]},{"id":"https://openalex.org/I1311191458","display_name":"La Jolla Institute for Immunology","ror":"https://ror.org/05vkpd318","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1311191458"]},{"id":"https://openalex.org/I36258959","display_name":"University of California San Diego","ror":"https://ror.org/0168r3w48","country_code":"US","type":"education","lineage":["https://openalex.org/I36258959"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard H Scheuermann","raw_affiliation_strings":["J. Craig Venter Institute La Jolla Campus, an Adjunct Professor of Pathology at the University of California San Diego, and an Adjunct Professor at the La Jolla Institute for Immunology"],"affiliations":[{"raw_affiliation_string":"J. Craig Venter Institute La Jolla Campus, an Adjunct Professor of Pathology at the University of California San Diego, and an Adjunct Professor at the La Jolla Institute for Immunology","institution_ids":["https://openalex.org/I1311191458","https://openalex.org/I36258959","https://openalex.org/I1301553790"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5034262562"],"corresponding_institution_ids":["https://openalex.org/I1301553790","https://openalex.org/I1311191458","https://openalex.org/I36258959"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":1.0865,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.76932636,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"22","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9904000163078308,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.9695000052452087,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.646882951259613},{"id":"https://openalex.org/keywords/cell-type","display_name":"Cell type","score":0.6242865920066833},{"id":"https://openalex.org/keywords/cluster-analysis","display_name":"Cluster analysis","score":0.560349702835083},{"id":"https://openalex.org/keywords/matching","display_name":"Matching (statistics)","score":0.5133430361747742},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.5081567764282227},{"id":"https://openalex.org/keywords/dimensionality-reduction","display_name":"Dimensionality reduction","score":0.4831258952617645},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.48281726241111755},{"id":"https://openalex.org/keywords/hierarchical-clustering","display_name":"Hierarchical clustering","score":0.4791647493839264},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.45909222960472107},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.45350953936576843},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.42666077613830566},{"id":"https://openalex.org/keywords/feature","display_name":"Feature (linguistics)","score":0.42140114307403564},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.39496666193008423},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2267928123474121},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.11567386984825134},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.11081072688102722},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.10714617371559143}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.646882951259613},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.6242865920066833},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.560349702835083},{"id":"https://openalex.org/C165064840","wikidata":"https://www.wikidata.org/wiki/Q1321061","display_name":"Matching (statistics)","level":2,"score":0.5133430361747742},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.5081567764282227},{"id":"https://openalex.org/C70518039","wikidata":"https://www.wikidata.org/wiki/Q16000077","display_name":"Dimensionality reduction","level":2,"score":0.4831258952617645},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48281726241111755},{"id":"https://openalex.org/C92835128","wikidata":"https://www.wikidata.org/wiki/Q1277447","display_name":"Hierarchical clustering","level":3,"score":0.4791647493839264},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.45909222960472107},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.45350953936576843},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.42666077613830566},{"id":"https://openalex.org/C2776401178","wikidata":"https://www.wikidata.org/wiki/Q12050496","display_name":"Feature (linguistics)","level":2,"score":0.42140114307403564},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.39496666193008423},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2267928123474121},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11567386984825134},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.11081072688102722},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10714617371559143},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002540","descriptor_name":"Cerebral Cortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/bib/bbaa339","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaa339","pdf_url":"https://academic.oup.com/bib/article-pdf/22/4/bbaa339/39136349/bbaa339.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:33249453","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33249453","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:escholarship.org:ark:/13030/qt67n9b0vw","is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/67n9b0vw","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Briefings in Bioinformatics, vol 22, iss 4","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8294536","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8294536","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbaa339","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaa339","pdf_url":"https://academic.oup.com/bib/article-pdf/22/4/bbaa339/39136349/bbaa339.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1480823202","display_name":null,"funder_award_id":"2018-182730","funder_id":"https://openalex.org/F4320306192","funder_display_name":"Silicon Valley Community Foundation"},{"id":"https://openalex.org/G1677282903","display_name":null,"funder_award_id":"1RF1MH123220","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G2260602284","display_name":null,"funder_award_id":"2018\u2013182730","funder_id":"https://openalex.org/F4320306192","funder_display_name":"Silicon Valley Community Foundation"},{"id":"https://openalex.org/G8808247739","display_name":null,"funder_award_id":"RF1MH123220","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306192","display_name":"Silicon Valley Community Foundation","ror":"https://ror.org/001ader08"},{"id":"https://openalex.org/F4320306585","display_name":"ADA Foundation","ror":"https://ror.org/00cb9nn43"},{"id":"https://openalex.org/F4320309870","display_name":"Jiangsu Agricultural Science and Technology Innovation Fund","ror":"https://ror.org/0335n2618"},{"id":"https://openalex.org/F4320311557","display_name":"Brain Science Institute, Johns Hopkins University","ror":"https://ror.org/00za53h95"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3107142041.pdf","grobid_xml":"https://content.openalex.org/works/W3107142041.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W1596515083","https://openalex.org/W2004014148","https://openalex.org/W2027390033","https://openalex.org/W2068767807","https://openalex.org/W2103441770","https://openalex.org/W2104005232","https://openalex.org/W2128227827","https://openalex.org/W2131681506","https://openalex.org/W2134150137","https://openalex.org/W2169456326","https://openalex.org/W2279350325","https://openalex.org/W2286142055","https://openalex.org/W2343956310","https://openalex.org/W2520858613","https://openalex.org/W2533012945","https://openalex.org/W2553077886","https://openalex.org/W2598326928","https://openalex.org/W2605611918","https://openalex.org/W2612502013","https://openalex.org/W2612519453","https://openalex.org/W2767443671","https://openalex.org/W2780517934","https://openalex.org/W2794480084","https://openalex.org/W2794521141","https://openalex.org/W2795381779","https://openalex.org/W2796170779","https://openalex.org/W2800392236","https://openalex.org/W2906213364","https://openalex.org/W2942108345","https://openalex.org/W2942880491","https://openalex.org/W2948469692","https://openalex.org/W2949177718","https://openalex.org/W2950104637","https://openalex.org/W2951506174","https://openalex.org/W2964849163","https://openalex.org/W2967177832","https://openalex.org/W2967290233","https://openalex.org/W2969922972","https://openalex.org/W2969948459","https://openalex.org/W2981474097","https://openalex.org/W2984472267","https://openalex.org/W3002417351","https://openalex.org/W3049228855","https://openalex.org/W3088823130","https://openalex.org/W3099768174","https://openalex.org/W3165128404","https://openalex.org/W4213108508","https://openalex.org/W4232068952","https://openalex.org/W6704673101","https://openalex.org/W6729728365"],"related_works":["https://openalex.org/W2912862995","https://openalex.org/W3129816939","https://openalex.org/W2985427592","https://openalex.org/W2101501829","https://openalex.org/W2400569965","https://openalex.org/W2060263731","https://openalex.org/W2003194288","https://openalex.org/W391093122","https://openalex.org/W1521239975","https://openalex.org/W4361305867"],"abstract_inverted_index":{"Single":[0],"cell/nucleus":[1],"RNA":[2],"sequencing":[3],"(scRNAseq)":[4],"is":[5,87,142],"emerging":[6],"as":[7],"an":[8],"essential":[9],"tool":[10],"to":[11,34,37,71,107,126,150,163,222],"unravel":[12],"the":[13,32,79,123,139,143,197],"phenotypic":[14],"heterogeneity":[15],"of":[16,117,153,200],"cells":[17,70],"in":[18,131,185],"complex":[19],"biological":[20],"systems.":[21],"While":[22],"computational":[23],"methods":[24,97],"for":[25,62,220],"scRNAseq":[26,103,167,227],"cell":[27,42,54,75,94,119,129,158,182,202,228],"type":[28,55,76,95,203,229],"clustering":[29],"have":[30],"advanced,":[31],"ability":[33,125],"integrate":[35],"datasets":[36,168],"identify":[38,127],"common":[39],"and":[40,65,92,101,121,174,213,225],"novel":[41,128],"types":[43,183],"across":[44],"experiments":[45],"remains":[46],"a":[47,52,109],"challenge.":[48],"Here,":[49],"we":[50],"introduce":[51],"cluster-to-cluster":[53],"matching":[56,96],"method-FR-Match-that":[57],"utilizes":[58],"supervised":[59],"feature":[60],"selection":[61],"dimensionality":[63],"reduction":[64],"incorporates":[66],"shared":[67],"information":[68],"among":[69],"determine":[72],"whether":[73],"two":[74,164],"clusters":[77,230],"share":[78],"same":[80],"underlying":[81],"multivariate":[82],"gene":[83],"expression":[84],"distribution.":[85],"FR-Match":[86,105,160,194],"benchmarked":[88],"with":[89,231],"existing":[90],"cell-to-cell":[91],"cell-to-cluster":[93],"using":[98],"both":[99],"simulated":[100],"real":[102],"data.":[104],"proved":[106],"be":[108],"stringent":[110],"method":[111],"that":[112,138,147],"produced":[113],"fewer":[114],"erroneous":[115],"matches":[116],"distinct":[118,207],"subtypes":[120],"had":[122],"unique":[124],"phenotypes":[130],"new":[132],"datasets.":[133],"In":[134],"silico":[135],"validation":[136],"demonstrated":[137],"proposed":[140],"workflow":[141],"only":[144],"self-contained":[145],"algorithm":[146],"was":[148,161],"robust":[149],"increasing":[151],"numbers":[152],"true":[154],"negatives":[155],"(i.e.":[156],"non-represented":[157],"types).":[159],"applied":[162],"human":[165,191],"brain":[166,192],"sampled":[169],"from":[170,188],"cortical":[171],"layer":[172],"1":[173],"full":[175],"thickness":[176],"middle":[177],"temporal":[178],"gyrus.":[179],"When":[180],"mapping":[181],"identified":[184],"specimens":[186],"isolated":[187],"these":[189],"overlapping":[190],"regions,":[193],"precisely":[195],"recapitulated":[196],"laminar":[198],"characteristics":[199],"matched":[201],"clusters,":[204],"reflecting":[205],"their":[206],"neuroanatomical":[208],"distributions.":[209],"An":[210],"R":[211],"package":[212],"Shiny":[214],"application":[215],"are":[216],"provided":[217],"at":[218],"https://github.com/JCVenterInstitute/FRmatch":[219],"users":[221],"interactively":[223],"explore":[224],"match":[226],"complementary":[232],"visualization":[233],"tools.":[234]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":3}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}