{"id":"https://openalex.org/W3110693579","doi":"https://doi.org/10.1093/bib/bbaa314","title":"Goals and approaches for each processing step for single-cell RNA sequencing data","display_name":"Goals and approaches for each processing step for single-cell RNA sequencing data","publication_year":2020,"publication_date":"2020-12-12","ids":{"openalex":"https://openalex.org/W3110693579","doi":"https://doi.org/10.1093/bib/bbaa314","mag":"3110693579","pmid":"https://pubmed.ncbi.nlm.nih.gov/33316046"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbaa314","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbaa314","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100353028","display_name":"Zilong Zhang","orcid":"https://orcid.org/0000-0002-4934-1258"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zilong Zhang","raw_affiliation_strings":["University of Electronic Science and Technology of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Electronic Science and Technology of China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061028143","display_name":"Feifei Cui","orcid":"https://orcid.org/0000-0001-7055-3813"},"institutions":[{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Feifei Cui","raw_affiliation_strings":["University of Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Tokyo, Japan","institution_ids":["https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070849202","display_name":"Chunyu Wang","orcid":"https://orcid.org/0000-0002-2965-9920"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chunyu Wang","raw_affiliation_strings":["School of Computer Science and Technology, Harbin Institute of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Harbin Institute of Technology","institution_ids":["https://openalex.org/I204983213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012585076","display_name":"Lingling Zhao","orcid":"https://orcid.org/0000-0002-2808-3771"},"institutions":[{"id":"https://openalex.org/I204983213","display_name":"Harbin Institute of Technology","ror":"https://ror.org/01yqg2h08","country_code":"CN","type":"education","lineage":["https://openalex.org/I204983213"]},{"id":"https://openalex.org/I4210161462","display_name":"Heilongjiang Institute of Technology","ror":"https://ror.org/05x0m9n95","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210161462"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lingling Zhao","raw_affiliation_strings":["School of Computer Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang"],"raw_orcid":"https://orcid.org/0000-0002-2808-3771","affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang","institution_ids":["https://openalex.org/I204983213","https://openalex.org/I4210161462"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017426085","display_name":"Quan Zou","orcid":"https://orcid.org/0000-0001-6406-1142"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Quan Zou","raw_affiliation_strings":["Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China"],"raw_orcid":"https://orcid.org/0000-0001-6406-1142","affiliations":[{"raw_affiliation_string":"Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China","institution_ids":["https://openalex.org/I150229711"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5012585076","https://openalex.org/A5017426085"],"corresponding_institution_ids":["https://openalex.org/I150229711","https://openalex.org/I204983213","https://openalex.org/I4210161462"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":2.162,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.88676193,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"22","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9815999865531921,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.9646999835968018,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6708991527557373},{"id":"https://openalex.org/keywords/normalization","display_name":"Normalization (sociology)","score":0.6459421515464783},{"id":"https://openalex.org/keywords/imputation","display_name":"Imputation (statistics)","score":0.5928189754486084},{"id":"https://openalex.org/keywords/rna-seq","display_name":"RNA-Seq","score":0.5178514122962952},{"id":"https://openalex.org/keywords/pipeline","display_name":"Pipeline (software)","score":0.4971154034137726},{"id":"https://openalex.org/keywords/database-normalization","display_name":"Database normalization","score":0.4920894503593445},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4757230579853058},{"id":"https://openalex.org/keywords/dimensionality-reduction","display_name":"Dimensionality reduction","score":0.4339137673377991},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.417293518781662},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.27280521392822266},{"id":"https://openalex.org/keywords/missing-data","display_name":"Missing data","score":0.25616344809532166},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.23978734016418457},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2323031723499298},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.22333455085754395},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.2098122537136078},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19105634093284607},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.14587071537971497},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.11128473281860352}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6708991527557373},{"id":"https://openalex.org/C136886441","wikidata":"https://www.wikidata.org/wiki/Q926129","display_name":"Normalization (sociology)","level":2,"score":0.6459421515464783},{"id":"https://openalex.org/C58041806","wikidata":"https://www.wikidata.org/wiki/Q1660484","display_name":"Imputation (statistics)","level":3,"score":0.5928189754486084},{"id":"https://openalex.org/C107397762","wikidata":"https://www.wikidata.org/wiki/Q2542347","display_name":"RNA-Seq","level":5,"score":0.5178514122962952},{"id":"https://openalex.org/C43521106","wikidata":"https://www.wikidata.org/wiki/Q2165493","display_name":"Pipeline (software)","level":2,"score":0.4971154034137726},{"id":"https://openalex.org/C162984825","wikidata":"https://www.wikidata.org/wiki/Q339072","display_name":"Database normalization","level":3,"score":0.4920894503593445},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4757230579853058},{"id":"https://openalex.org/C70518039","wikidata":"https://www.wikidata.org/wiki/Q16000077","display_name":"Dimensionality reduction","level":2,"score":0.4339137673377991},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.417293518781662},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.27280521392822266},{"id":"https://openalex.org/C9357733","wikidata":"https://www.wikidata.org/wiki/Q6878417","display_name":"Missing data","level":2,"score":0.25616344809532166},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.23978734016418457},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2323031723499298},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.22333455085754395},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.2098122537136078},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19105634093284607},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.14587071537971497},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11128473281860352},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbaa314","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbaa314","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:33316046","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33316046","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4000000059604645,"display_name":"Industry, innovation and infrastructure","id":"https://metadata.un.org/sdg/9"}],"awards":[{"id":"https://openalex.org/G1587116901","display_name":null,"funder_award_id":"61771331","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G1674180717","display_name":null,"funder_award_id":"61922020","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G4071971942","display_name":null,"funder_award_id":"91935302","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6593862345","display_name":null,"funder_award_id":"2018YFC0910405","funder_id":"https://openalex.org/F4320335777","funder_display_name":"National Key Research and Development Program of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":107,"referenced_works":["https://openalex.org/W839653734","https://openalex.org/W1981509058","https://openalex.org/W1981641790","https://openalex.org/W1984883254","https://openalex.org/W1988391018","https://openalex.org/W2009458183","https://openalex.org/W2019552331","https://openalex.org/W2023887100","https://openalex.org/W2036897871","https://openalex.org/W2042789810","https://openalex.org/W2044010294","https://openalex.org/W2045317504","https://openalex.org/W2071010503","https://openalex.org/W2084942072","https://openalex.org/W2098454110","https://openalex.org/W2099500182","https://openalex.org/W2102212449","https://openalex.org/W2102278945","https://openalex.org/W2107564978","https://openalex.org/W2116699248","https://openalex.org/W2121690903","https://openalex.org/W2128227827","https://openalex.org/W2135937351","https://openalex.org/W2139838862","https://openalex.org/W2140729960","https://openalex.org/W2149573463","https://openalex.org/W2152239989","https://openalex.org/W2152692691","https://openalex.org/W2158948118","https://openalex.org/W2162955464","https://openalex.org/W2165909549","https://openalex.org/W2169456326","https://openalex.org/W2179438025","https://openalex.org/W2184331293","https://openalex.org/W2191679689","https://openalex.org/W2269040222","https://openalex.org/W2288153033","https://openalex.org/W2316095770","https://openalex.org/W2338756998","https://openalex.org/W2342016684","https://openalex.org/W2342688693","https://openalex.org/W2342807339","https://openalex.org/W2343956310","https://openalex.org/W2473258837","https://openalex.org/W2489812534","https://openalex.org/W2526262591","https://openalex.org/W2540833380","https://openalex.org/W2545155109","https://openalex.org/W2546514099","https://openalex.org/W2561508962","https://openalex.org/W2582033455","https://openalex.org/W2600453489","https://openalex.org/W2605611918","https://openalex.org/W2605810679","https://openalex.org/W2746479894","https://openalex.org/W2747545374","https://openalex.org/W2747841296","https://openalex.org/W2751468300","https://openalex.org/W2755506013","https://openalex.org/W2767792097","https://openalex.org/W2774761491","https://openalex.org/W2782146634","https://openalex.org/W2786672974","https://openalex.org/W2792479311","https://openalex.org/W2792693509","https://openalex.org/W2794480084","https://openalex.org/W2794891507","https://openalex.org/W2805619986","https://openalex.org/W2884197618","https://openalex.org/W2886347923","https://openalex.org/W2898718502","https://openalex.org/W2901677030","https://openalex.org/W2906625258","https://openalex.org/W2907783748","https://openalex.org/W2926010705","https://openalex.org/W2935703330","https://openalex.org/W2944073176","https://openalex.org/W2949237386","https://openalex.org/W2949800632","https://openalex.org/W2951065104","https://openalex.org/W2951217100","https://openalex.org/W2951381561","https://openalex.org/W2951506174","https://openalex.org/W2951764674","https://openalex.org/W2952109315","https://openalex.org/W2965118801","https://openalex.org/W2972926980","https://openalex.org/W2985644141","https://openalex.org/W2989807288","https://openalex.org/W2995108395","https://openalex.org/W2998065416","https://openalex.org/W3000145506","https://openalex.org/W3009302866","https://openalex.org/W3011204118","https://openalex.org/W3013022968","https://openalex.org/W3013135635","https://openalex.org/W3016251883","https://openalex.org/W3027637917","https://openalex.org/W3027765392","https://openalex.org/W4235276207","https://openalex.org/W4298082496","https://openalex.org/W6659577852","https://openalex.org/W6698064614","https://openalex.org/W6728888212","https://openalex.org/W6746336927","https://openalex.org/W6748816842","https://openalex.org/W6770127396"],"related_works":["https://openalex.org/W4244387946","https://openalex.org/W2107018762","https://openalex.org/W2145362441","https://openalex.org/W2582603276","https://openalex.org/W2000153057","https://openalex.org/W2175373041","https://openalex.org/W4386281023","https://openalex.org/W4312138714","https://openalex.org/W2113286112","https://openalex.org/W1910607297"],"abstract_inverted_index":{"Single-cell":[0],"RNA":[1],"sequencing":[2],"(scRNA-seq)":[3],"has":[4],"enabled":[5],"researchers":[6],"to":[7,17],"study":[8],"gene":[9,34],"expression":[10,35],"at":[11,36],"the":[12,18,86,105,114],"cellular":[13],"level.":[14],"However,":[15],"due":[16],"extremely":[19],"low":[20],"levels":[21],"of":[22,49,78,88,95,104,124],"transcripts":[23],"in":[24],"a":[25,37,53,64,75,92],"single":[26],"cell":[27],"and":[28,43,80,107,121],"technical":[29],"losses":[30],"during":[31],"reverse":[32],"transcription,":[33],"single-cell":[38,50],"resolution":[39],"is":[40,68],"usually":[41],"noisy":[42],"highly":[44],"dimensional;":[45],"thus,":[46],"statistical":[47],"analyses":[48],"data":[51,58],"are":[52,61],"challenge.":[54],"Although":[55],"many":[56],"scRNA-seq":[57,125],"analysis":[59,111],"tools":[60,90,112],"currently":[62],"available,":[63],"gold":[65],"standard":[66],"pipeline":[67],"not":[69],"available":[70],"for":[71,91,113],"all":[72],"datasets.":[73],"Therefore,":[74],"general":[76],"understanding":[77],"bioinformatics":[79],"associated":[81],"computational":[82,110],"issues":[83],"would":[84],"facilitate":[85],"selection":[87,120],"appropriate":[89],"given":[93],"set":[94],"data.":[96,126],"In":[97],"this":[98],"review,":[99],"we":[100],"provide":[101],"an":[102],"overview":[103],"goals":[106],"most":[108],"popular":[109],"quality":[115],"control,":[116],"normalization,":[117],"imputation,":[118],"feature":[119],"dimension":[122],"reduction":[123]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":5}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}