{"id":"https://openalex.org/W3101716656","doi":"https://doi.org/10.1093/bib/bbaa237","title":"Deep learning in systems medicine","display_name":"Deep learning in systems medicine","publication_year":2020,"publication_date":"2020-11-13","ids":{"openalex":"https://openalex.org/W3101716656","doi":"https://doi.org/10.1093/bib/bbaa237","mag":"3101716656","pmid":"https://pubmed.ncbi.nlm.nih.gov/33197934"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbaa237","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaa237","pdf_url":"https://academic.oup.com/bib/article-pdf/22/2/1543/39868206/bbaa237.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/bib/article-pdf/22/2/1543/39868206/bbaa237.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100379058","display_name":"Haiying Wang","orcid":"https://orcid.org/0000-0001-8358-9065"},"institutions":[{"id":"https://openalex.org/I138801177","display_name":"University of Ulster","ror":"https://ror.org/01yp9g959","country_code":"GB","type":"education","lineage":["https://openalex.org/I138801177"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Haiying Wang","raw_affiliation_strings":["computer science at Ulster University"],"affiliations":[{"raw_affiliation_string":"computer science at Ulster University","institution_ids":["https://openalex.org/I138801177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071949613","display_name":"Estelle Pujos\u2010Guillot","orcid":"https://orcid.org/0000-0002-4693-5712"},"institutions":[{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"funder","lineage":["https://openalex.org/I4210088668"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Estelle Pujos-Guillot","raw_affiliation_strings":["metabolomic platform dedicated to metabolism studies in nutrition and health in the French National Research Institute for Agriculture, Food and Environment"],"affiliations":[{"raw_affiliation_string":"metabolomic platform dedicated to metabolism studies in nutrition and health in the French National Research Institute for Agriculture, Food and Environment","institution_ids":["https://openalex.org/I4210088668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090984354","display_name":"Blandine Comte","orcid":"https://orcid.org/0000-0002-4662-6581"},"institutions":[{"id":"https://openalex.org/I4210088668","display_name":"Institut National de Recherche pour l'Agriculture, l'Alimentation et l'Environnement","ror":"https://ror.org/003vg9w96","country_code":"FR","type":"funder","lineage":["https://openalex.org/I4210088668"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Blandine Comte","raw_affiliation_strings":["French National Research Institute for Agriculture, Food and Environment"],"affiliations":[{"raw_affiliation_string":"French National Research Institute for Agriculture, Food and Environment","institution_ids":["https://openalex.org/I4210088668"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050831168","display_name":"Jo\u00e3o Lu\u00eds de Miranda","orcid":"https://orcid.org/0000-0003-1487-1758"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Joao Luis de Miranda","raw_affiliation_strings":["(ESTG/IPP) and a Researcher (CERENA/IST) in optimization methods and process systems engineering"],"affiliations":[{"raw_affiliation_string":"(ESTG/IPP) and a Researcher (CERENA/IST) in optimization methods and process systems engineering","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068377776","display_name":"Vojt\u011bch Spiwok","orcid":"https://orcid.org/0000-0001-8108-2033"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Vojtech Spiwok","raw_affiliation_strings":["Molecular Modelling Researcher applying machine learning to accelerate molecular simulations"],"affiliations":[{"raw_affiliation_string":"Molecular Modelling Researcher applying machine learning to accelerate molecular simulations","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003853785","display_name":"Ivan Chorbev","orcid":"https://orcid.org/0000-0002-9648-4438"},"institutions":[{"id":"https://openalex.org/I76245029","display_name":"Saints Cyril and Methodius University of Skopje","ror":"https://ror.org/02wk2vx54","country_code":"MK","type":"education","lineage":["https://openalex.org/I76245029"]}],"countries":["MK"],"is_corresponding":false,"raw_author_name":"Ivan Chorbev","raw_affiliation_strings":["Faculty for Computer Science and Engineering, University Ss Cyril and Methodius in Skopje, North Macedonia working in the area of eHealth and assistive technologies"],"affiliations":[{"raw_affiliation_string":"Faculty for Computer Science and Engineering, University Ss Cyril and Methodius in Skopje, North Macedonia working in the area of eHealth and assistive technologies","institution_ids":["https://openalex.org/I76245029"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010454141","display_name":"Filippo Castiglione","orcid":"https://orcid.org/0000-0002-1442-3552"},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"funder","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Filippo Castiglione","raw_affiliation_strings":["Computer Scientist working at the National Research Council of Italy"],"affiliations":[{"raw_affiliation_string":"Computer Scientist working at the National Research Council of Italy","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007136874","display_name":"Paolo Tieri","orcid":"https://orcid.org/0000-0002-3635-7664"},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"funder","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Paolo Tieri","raw_affiliation_strings":["National Research Council of Italy (CNR) and a lecturer at Sapienza University in Rome, working in the field of network medicine and computational biology"],"affiliations":[{"raw_affiliation_string":"National Research Council of Italy (CNR) and a lecturer at Sapienza University in Rome, working in the field of network medicine and computational biology","institution_ids":["https://openalex.org/I4210155236"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054484953","display_name":"Steven Watterson","orcid":"https://orcid.org/0000-0002-2750-6410"},"institutions":[{"id":"https://openalex.org/I138801177","display_name":"University of Ulster","ror":"https://ror.org/01yp9g959","country_code":"GB","type":"education","lineage":["https://openalex.org/I138801177"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Steven Watterson","raw_affiliation_strings":["computational biology at Ulster University"],"affiliations":[{"raw_affiliation_string":"computational biology at Ulster University","institution_ids":["https://openalex.org/I138801177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042299830","display_name":"Roisin McAllister","orcid":null},"institutions":[{"id":"https://openalex.org/I138801177","display_name":"University of Ulster","ror":"https://ror.org/01yp9g959","country_code":"GB","type":"education","lineage":["https://openalex.org/I138801177"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Roisin McAllister","raw_affiliation_strings":["Research Associate working in CTRIC, University of Ulster, Derry, and has worked in clinical and academic roles in the fields of molecular diagnostics and biomarker discovery"],"affiliations":[{"raw_affiliation_string":"Research Associate working in CTRIC, University of Ulster, Derry, and has worked in clinical and academic roles in the fields of molecular diagnostics and biomarker discovery","institution_ids":["https://openalex.org/I138801177"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074968875","display_name":"Tiago de Melo Malaquias","orcid":"https://orcid.org/0000-0002-5896-0448"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tiago de Melo Malaquias","raw_affiliation_strings":["Research Associate in CTIRC, Derry, UK"],"affiliations":[{"raw_affiliation_string":"Research Associate in CTIRC, Derry, UK","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031146559","display_name":"Massimiliano Zanin","orcid":"https://orcid.org/0000-0002-5839-0393"},"institutions":[{"id":"https://openalex.org/I4210095952","display_name":"Institute for Cross-Disciplinary Physics and Complex Systems","ror":"https://ror.org/00pfxsh56","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I4210095952","https://openalex.org/I50441567"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Massimiliano Zanin","raw_affiliation_strings":["Researcher working in the Institute for Cross-Disciplinary Physics and Complex Systems, Spain, with an interest on data analysis and integration using statistical physics techniques"],"affiliations":[{"raw_affiliation_string":"Researcher working in the Institute for Cross-Disciplinary Physics and Complex Systems, Spain, with an interest on data analysis and integration using statistical physics techniques","institution_ids":["https://openalex.org/I4210095952"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055005447","display_name":"Taranjit Singh","orcid":"https://orcid.org/0000-0002-7276-7492"},"institutions":[{"id":"https://openalex.org/I4210137574","display_name":"Cells Therapy (Poland)","ror":"https://ror.org/04wpnc326","country_code":"PL","type":"company","lineage":["https://openalex.org/I4210137574"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Taranjit Singh Rai","raw_affiliation_strings":["Lecturer in cellular ageing at the Centre for Stratified Medicine. Dr Rai\u2019s research interests are in cellular senescence, which is thought to promote cellular and tissue ageing in disease, and the development of senolytic compounds to restrict this process","Lecturer in cellular ageing at the Centre for Stratified Medicine. Dr Rai's research interests are in cellular senescence, which is thought to promote cellular and tissue ageing in disease, and the development of senolytic compounds to restrict this process"],"affiliations":[{"raw_affiliation_string":"Lecturer in cellular ageing at the Centre for Stratified Medicine. Dr Rai\u2019s research interests are in cellular senescence, which is thought to promote cellular and tissue ageing in disease, and the development of senolytic compounds to restrict this process","institution_ids":["https://openalex.org/I4210137574"]},{"raw_affiliation_string":"Lecturer in cellular ageing at the Centre for Stratified Medicine. Dr Rai's research interests are in cellular senescence, which is thought to promote cellular and tissue ageing in disease, and the development of senolytic compounds to restrict this process","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024401909","display_name":"Huiru Zheng","orcid":"https://orcid.org/0000-0001-7648-8709"},"institutions":[{"id":"https://openalex.org/I138801177","display_name":"University of Ulster","ror":"https://ror.org/01yp9g959","country_code":"GB","type":"education","lineage":["https://openalex.org/I138801177"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Huiru Zheng","raw_affiliation_strings":["Professor of computer sciences at Ulster University"],"affiliations":[{"raw_affiliation_string":"Professor of computer sciences at Ulster University","institution_ids":["https://openalex.org/I138801177"]}]}],"institutions":[],"countries_distinct_count":6,"institutions_distinct_count":14,"corresponding_author_ids":["https://openalex.org/A5024401909"],"corresponding_institution_ids":["https://openalex.org/I138801177"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":{"value":4011,"currency":"USD","value_usd":4011},"fwci":3.2621,"has_fulltext":true,"cited_by_count":48,"citation_normalized_percentile":{"value":0.93586409,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":99},"biblio":{"volume":"22","issue":"2","first_page":"1543","last_page":"1559"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.9884999990463257,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T13702","display_name":"Machine Learning in Healthcare","score":0.9884999990463257,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9718000292778015,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14393","display_name":"Health, Environment, Cognitive Aging","score":0.95660001039505,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interpretability","display_name":"Interpretability","score":0.9128804206848145},{"id":"https://openalex.org/keywords/relevance","display_name":"Relevance (law)","score":0.738540768623352},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6809749603271484},{"id":"https://openalex.org/keywords/task","display_name":"Task (project management)","score":0.5795145034790039},{"id":"https://openalex.org/keywords/key","display_name":"Key (lock)","score":0.5479623079299927},{"id":"https://openalex.org/keywords/set","display_name":"Set (abstract data type)","score":0.5473915338516235},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.5255172252655029},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.5177054405212402},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.49945688247680664},{"id":"https://openalex.org/keywords/precision-medicine","display_name":"Precision medicine","score":0.4781535565853119},{"id":"https://openalex.org/keywords/personalized-medicine","display_name":"Personalized medicine","score":0.4734853506088257},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3290814757347107},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.21461135149002075},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.13586142659187317},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.07631731033325195},{"id":"https://openalex.org/keywords/systems-engineering","display_name":"Systems engineering","score":0.06504467129707336}],"concepts":[{"id":"https://openalex.org/C2781067378","wikidata":"https://www.wikidata.org/wiki/Q17027399","display_name":"Interpretability","level":2,"score":0.9128804206848145},{"id":"https://openalex.org/C158154518","wikidata":"https://www.wikidata.org/wiki/Q7310970","display_name":"Relevance (law)","level":2,"score":0.738540768623352},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6809749603271484},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.5795145034790039},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.5479623079299927},{"id":"https://openalex.org/C177264268","wikidata":"https://www.wikidata.org/wiki/Q1514741","display_name":"Set (abstract data type)","level":2,"score":0.5473915338516235},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.5255172252655029},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.5177054405212402},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.49945688247680664},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.4781535565853119},{"id":"https://openalex.org/C32220436","wikidata":"https://www.wikidata.org/wiki/Q2072214","display_name":"Personalized medicine","level":2,"score":0.4734853506088257},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3290814757347107},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.21461135149002075},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.13586142659187317},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.07631731033325195},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.06504467129707336},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D004194","descriptor_name":"Disease","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013597","descriptor_name":"Systems Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013597","descriptor_name":"Systems Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013597","descriptor_name":"Systems Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040901","descriptor_name":"Proteomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055432","descriptor_name":"Metabolomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057285","descriptor_name":"Precision Medicine","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057286","descriptor_name":"Electronic Health Records","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059467","descriptor_name":"Transcriptome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1093/bib/bbaa237","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaa237","pdf_url":"https://academic.oup.com/bib/article-pdf/22/2/1543/39868206/bbaa237.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:33197934","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33197934","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null},{"id":"pmh:oai:pure.atira.dk:openaire/4e48a5ee-cd86-431e-ab71-1da0b54b0198","is_oa":true,"landing_page_url":"https://pure.ulster.ac.uk/en/publications/4e48a5ee-cd86-431e-ab71-1da0b54b0198","pdf_url":null,"source":{"id":"https://openalex.org/S4306402454","display_name":"Ulster University Research Portal (Ulster University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I138801177","host_organization_name":"University of Ulster","host_organization_lineage":["https://openalex.org/I138801177"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Wang, H HY, Pujos-Guillot, E, Comte, B, Luis de Miranda, J, Vojtech Spiwok, Chorbev, I, Castiglione, F, Tieri, P, Watterson, S, Mc Allister, R, De Melo Malaquias, T, Zanin, M, Rai, T S & Zheng, H 2021, 'Deep Learning in Systems Medicine', Briefings in Bioinformatics, vol. 22, no. 2, pp. 1543-1559. https://doi.org/10.1093/bib/bbaa237","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:HAL:hal-03049377v1","is_oa":true,"landing_page_url":"https://hal.inrae.fr/hal-03049377","pdf_url":null,"source":{"id":"https://openalex.org/S4406922466","display_name":"SPIRE - Sciences Po Institutional REpository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Briefings in Bioinformatics, 2020, 22 (2), pp.1543-1559. ⟨10.1093/bib/bbaa237⟩","raw_type":"Journal articles"},{"id":"pmh:oai:digital.csic.es:10261/229432","is_oa":true,"landing_page_url":"http://hdl.handle.net/10261/229432","pdf_url":null,"source":{"id":"https://openalex.org/S4306400616","display_name":"DIGITAL.CSIC (Spanish National Research Council (CSIC))","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I134820265","host_organization_name":"Consejo Superior de Investigaciones Cient\u00edficas","host_organization_lineage":["https://openalex.org/I134820265"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"art\u00edculo"},{"id":"pmh:oai:pubmedcentral.nih.gov:8382976","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8382976","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brief Bioinform","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1093/bib/bbaa237","is_oa":true,"landing_page_url":"https://doi.org/10.1093/bib/bbaa237","pdf_url":"https://academic.oup.com/bib/article-pdf/22/2/1543/39868206/bbaa237.pdf","source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1071130651","display_name":null,"funder_award_id":"UIDB/04028/2020","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G1159308595","display_name":null,"funder_award_id":"26121","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G1223316324","display_name":null,"funder_award_id":"MDM-2017-0711","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G2631452109","display_name":null,"funder_award_id":"(ERDF)","funder_id":"https://openalex.org/F4320335322","funder_display_name":"European Regional Development Fund"},{"id":"https://openalex.org/G2839616116","display_name":null,"funder_award_id":"851255","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3197824182","display_name":null,"funder_award_id":"UIDB/04028/2020","funder_id":"https://openalex.org/F4320335226","funder_display_name":"Instituto Superior T\u00e9cnico"},{"id":"https://openalex.org/G3272457656","display_name":null,"funder_award_id":"UIDB/","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G3514550006","display_name":null,"funder_award_id":"Centre","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G4303559637","display_name":null,"funder_award_id":"851255","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G4428648518","display_name":null,"funder_award_id":"FCT-UIDB/04028/2020","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G457914617","display_name":null,"funder_award_id":"UIDB/04028/2020","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"},{"id":"https://openalex.org/G5233838898","display_name":"Sensor Enabled Affective Computing for Enhancing Medical Care","funder_award_id":"690862","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5451116430","display_name":null,"funder_award_id":"826121","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6036776137","display_name":null,"funder_award_id":"MDM-2017-0711","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6274302846","display_name":null,"funder_award_id":"823978","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G6752267332","display_name":null,"funder_award_id":"MDM-2017-0711","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G675428038","display_name":null,"funder_award_id":"826121","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G6770288399","display_name":"STop Obesity Platform","funder_award_id":"823978","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G7158710198","display_name":"Development of an Easy-to-use Metagenomics Platform for Agricultural Science","funder_award_id":"690998","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G7945934622","display_name":null,"funder_award_id":"851255","funder_id":"https://openalex.org/F4320335598","funder_display_name":"Agencia Estatal de Investigaci\u00f3n"},{"id":"https://openalex.org/G7992351835","display_name":null,"funder_award_id":"UIDB/04028/2020","funder_id":"https://openalex.org/F4320316855","funder_display_name":"Centro de Recursos Naturais e Ambiente"},{"id":"https://openalex.org/G8318064016","display_name":null,"funder_award_id":"Horizon","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G8548662574","display_name":null,"funder_award_id":"FCT-UIDB/04028/2020","funder_id":"https://openalex.org/F4320316855","funder_display_name":"Centro de Recursos Naturais e Ambiente"},{"id":"https://openalex.org/G8831116050","display_name":null,"funder_award_id":"project","funder_id":"https://openalex.org/F4320332999","funder_display_name":"Horizon 2020 Framework Programme"},{"id":"https://openalex.org/G943999617","display_name":null,"funder_award_id":"Technology","funder_id":"https://openalex.org/F4320334779","funder_display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia"}],"funders":[{"id":"https://openalex.org/F4320316855","display_name":"Centro de Recursos Naturais e Ambiente","ror":null},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320320853","display_name":"Public Health Agency","ror":"https://ror.org/03ek62e72"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320334779","display_name":"Funda\u00e7\u00e3o para a Ci\u00eancia e a Tecnologia","ror":"https://ror.org/00snfqn58"},{"id":"https://openalex.org/F4320335226","display_name":"Instituto Superior T\u00e9cnico","ror":"https://ror.org/01c27hj86"},{"id":"https://openalex.org/F4320335322","display_name":"European Regional Development Fund","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320335598","display_name":"Agencia Estatal de Investigaci\u00f3n","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3101716656.pdf","grobid_xml":"https://content.openalex.org/works/W3101716656.grobid-xml"},"referenced_works_count":208,"referenced_works":["https://openalex.org/W31345105","https://openalex.org/W49996880","https://openalex.org/W62603772","https://openalex.org/W569478347","https://openalex.org/W995866566","https://openalex.org/W1019830208","https://openalex.org/W1531160357","https://openalex.org/W1561655718","https://openalex.org/W1710476689","https://openalex.org/W1909320841","https://openalex.org/W1992845341","https://openalex.org/W2001502878","https://openalex.org/W2020152108","https://openalex.org/W2026071514","https://openalex.org/W2032366341","https://openalex.org/W2033970420","https://openalex.org/W2035530476","https://openalex.org/W2038128936","https://openalex.org/W2060911968","https://openalex.org/W2069702585","https://openalex.org/W2074877635","https://openalex.org/W2082413834","https://openalex.org/W2083721046","https://openalex.org/W2088749788","https://openalex.org/W2089867412","https://openalex.org/W2095705004","https://openalex.org/W2097778810","https://openalex.org/W2097939227","https://openalex.org/W2099452979","https://openalex.org/W2100495367","https://openalex.org/W2107831053","https://openalex.org/W2111989898","https://openalex.org/W2112796928","https://openalex.org/W2121258779","https://openalex.org/W2122538988","https://openalex.org/W2124776405","https://openalex.org/W2125879914","https://openalex.org/W2127486628","https://openalex.org/W2127817386","https://openalex.org/W2130919803","https://openalex.org/W2135970444","https://openalex.org/W2136922672","https://openalex.org/W2141297584","https://openalex.org/W2141459724","https://openalex.org/W2145339207","https://openalex.org/W2145515423","https://openalex.org/W2148641246","https://openalex.org/W2149284026","https://openalex.org/W2154579312","https://openalex.org/W2155893237","https://openalex.org/W2164572080","https://openalex.org/W2164700406","https://openalex.org/W2165738847","https://openalex.org/W2165976376","https://openalex.org/W2166688610","https://openalex.org/W2213443318","https://openalex.org/W2248620004","https://openalex.org/W2271840356","https://openalex.org/W2311607323","https://openalex.org/W2404901863","https://openalex.org/W2490083709","https://openalex.org/W2510850936","https://openalex.org/W2519019522","https://openalex.org/W2529996553","https://openalex.org/W2531966375","https://openalex.org/W2533800772","https://openalex.org/W2552830104","https://openalex.org/W2557283755","https://openalex.org/W2558041282","https://openalex.org/W2558531213","https://openalex.org/W2561981131","https://openalex.org/W2569531558","https://openalex.org/W2579617530","https://openalex.org/W2579747565","https://openalex.org/W2588970299","https://openalex.org/W2592340788","https://openalex.org/W2616901848","https://openalex.org/W2618530766","https://openalex.org/W2620656322","https://openalex.org/W2620664872","https://openalex.org/W2625625371","https://openalex.org/W2736137960","https://openalex.org/W2736859409","https://openalex.org/W2738759181","https://openalex.org/W2747962007","https://openalex.org/W2748814859","https://openalex.org/W2750342792","https://openalex.org/W2752747624","https://openalex.org/W2754039296","https://openalex.org/W2754103191","https://openalex.org/W2761209172","https://openalex.org/W2765693785","https://openalex.org/W2766736793","https://openalex.org/W2767582147","https://openalex.org/W2769502140","https://openalex.org/W2770756135","https://openalex.org/W2772723798","https://openalex.org/W2781246871","https://openalex.org/W2781626870","https://openalex.org/W2782093256","https://openalex.org/W2784499877","https://openalex.org/W2787178869","https://openalex.org/W2788353510","https://openalex.org/W2788571670","https://openalex.org/W2789367970","https://openalex.org/W2789563975","https://openalex.org/W2790444357","https://openalex.org/W2790571740","https://openalex.org/W2790808809","https://openalex.org/W2793494524","https://openalex.org/W2794284562","https://openalex.org/W2800287564","https://openalex.org/W2802789529","https://openalex.org/W2805017040","https://openalex.org/W2810596708","https://openalex.org/W2810819381","https://openalex.org/W2885420314","https://openalex.org/W2886281300","https://openalex.org/W2887975519","https://openalex.org/W2888432608","https://openalex.org/W2888484772","https://openalex.org/W2889245000","https://openalex.org/W2891002136","https://openalex.org/W2897320536","https://openalex.org/W2899635607","https://openalex.org/W2900135733","https://openalex.org/W2904803701","https://openalex.org/W2909078770","https://openalex.org/W2910121883","https://openalex.org/W2910737182","https://openalex.org/W2911932738","https://openalex.org/W2913537096","https://openalex.org/W2919115771","https://openalex.org/W2921335007","https://openalex.org/W2921410104","https://openalex.org/W2921591500","https://openalex.org/W2922384037","https://openalex.org/W2922701384","https://openalex.org/W2931364255","https://openalex.org/W2933575979","https://openalex.org/W2938756926","https://openalex.org/W2938826237","https://openalex.org/W2945204225","https://openalex.org/W2946099214","https://openalex.org/W2947607756","https://openalex.org/W2951209146","https://openalex.org/W2951934944","https://openalex.org/W2954871450","https://openalex.org/W2955252073","https://openalex.org/W2955451033","https://openalex.org/W2962897886","https://openalex.org/W2962949934","https://openalex.org/W2963300950","https://openalex.org/W2963616173","https://openalex.org/W2964189045","https://openalex.org/W2964696298","https://openalex.org/W2964962196","https://openalex.org/W2968723626","https://openalex.org/W2969944904","https://openalex.org/W2971666515","https://openalex.org/W2977707586","https://openalex.org/W2978368159","https://openalex.org/W2982580298","https://openalex.org/W2982596783","https://openalex.org/W2985205784","https://openalex.org/W2987570851","https://openalex.org/W2988890139","https://openalex.org/W2993686854","https://openalex.org/W2994160326","https://openalex.org/W2994685918","https://openalex.org/W2994716258","https://openalex.org/W3000365770","https://openalex.org/W3003709606","https://openalex.org/W3006781240","https://openalex.org/W3008478462","https://openalex.org/W3013681994","https://openalex.org/W3014810983","https://openalex.org/W3017122739","https://openalex.org/W3081006013","https://openalex.org/W3098269892","https://openalex.org/W3098949126","https://openalex.org/W3100321043","https://openalex.org/W3101667008","https://openalex.org/W3104523752","https://openalex.org/W3207342693","https://openalex.org/W4210311545","https://openalex.org/W4232714830","https://openalex.org/W4288375227","https://openalex.org/W4295591957","https://openalex.org/W4300402905","https://openalex.org/W6633545359","https://openalex.org/W6639732818","https://openalex.org/W6659069647","https://openalex.org/W6674330103","https://openalex.org/W6694517276","https://openalex.org/W6698064614","https://openalex.org/W6733835587","https://openalex.org/W6738631160","https://openalex.org/W6747134593","https://openalex.org/W6747417605","https://openalex.org/W6748444998","https://openalex.org/W6754596162","https://openalex.org/W6758133621","https://openalex.org/W6760459497","https://openalex.org/W6761563905","https://openalex.org/W6770072504","https://openalex.org/W6773180216","https://openalex.org/W6774275331"],"related_works":["https://openalex.org/W3082935376","https://openalex.org/W3193951088","https://openalex.org/W4322484660","https://openalex.org/W2899657781","https://openalex.org/W4386960999","https://openalex.org/W2770866531","https://openalex.org/W4388011470","https://openalex.org/W4230423494","https://openalex.org/W4298001029","https://openalex.org/W4383105306"],"abstract_inverted_index":{"Systems":[0],"medicine":[1],"(SM)":[2],"has":[3],"emerged":[4],"as":[5],"a":[6,40,67,141],"powerful":[7],"tool":[8],"for":[9,39,143],"studying":[10],"the":[11,15,19,60,78,94,122,127,138,154],"human":[12],"body":[13],"at":[14],"systems":[16],"level":[17],"with":[18,90],"aim":[20],"of":[21,28,63,69,126,129,134,140],"improving":[22,113],"our":[23],"understanding,":[24],"prevention":[25],"and":[26,66,99,112,124,152,158],"treatment":[27],"complex":[29],"diseases.":[30],"Being":[31],"able":[32],"to":[33,88,96,120],"automatically":[34],"extract":[35],"relevant":[36],"features":[37],"needed":[38],"given":[41],"task":[42],"from":[43],"high-dimensional,":[44],"heterogeneous":[45],"data,":[46],"deep":[47],"learning":[48],"(DL)":[49],"holds":[50],"great":[51],"promise":[52],"in":[53,131,156],"this":[54],"endeavour.":[55],"This":[56],"review":[57,148],"paper":[58],"addresses":[59],"main":[61],"developments":[62],"DL":[64,73,84,130,157],"algorithms":[65],"set":[68],"general":[70],"topics":[71],"where":[72],"is":[74,136],"decisive,":[75],"namely,":[76],"within":[77],"SM":[79,89],"landscape.":[80],"It":[81],"discusses":[82],"how":[83],"can":[85],"be":[86],"applied":[87],"an":[91],"emphasis":[92],"on":[93],"applications":[95],"predictive,":[97],"preventive":[98],"precision":[100],"medicine.":[101],"Several":[102],"key":[103],"challenges":[104],"have":[105],"been":[106],"highlighted":[107],"including":[108],"delivering":[109],"clinical":[110],"impact":[111],"interpretability.":[114],"We":[115],"used":[116],"some":[117],"prototypical":[118],"examples":[119],"highlight":[121],"relevance":[123],"significance":[125],"adoption":[128],"SM,":[132],"one":[133],"them":[135],"involving":[137],"creation":[139],"model":[142],"personalized":[144],"Parkinson's":[145],"disease.":[146],"The":[147],"offers":[149],"valuable":[150],"insights":[151],"informs":[153],"research":[155],"SM.":[159]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":6}],"updated_date":"2026-04-13T07:58:08.660418","created_date":"2025-10-10T00:00:00"}