{"id":"https://openalex.org/W3090691469","doi":"https://doi.org/10.1093/bib/bbaa225","title":"Molecular characterization, biological function, tumor microenvironment association and clinical significance of m6A regulators in lung adenocarcinoma","display_name":"Molecular characterization, biological function, tumor microenvironment association and clinical significance of m6A regulators in lung adenocarcinoma","publication_year":2020,"publication_date":"2020-08-20","ids":{"openalex":"https://openalex.org/W3090691469","doi":"https://doi.org/10.1093/bib/bbaa225","mag":"3090691469","pmid":"https://pubmed.ncbi.nlm.nih.gov/33003204"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbaa225","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbaa225","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100451121","display_name":"Yin Li","orcid":"https://orcid.org/0000-0002-4754-2814"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yin Li","raw_affiliation_strings":["Department of Thoracic Surgery, Zhongshan Hospital, Fudan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Zhongshan Hospital, Fudan University","institution_ids":["https://openalex.org/I4210128921","https://openalex.org/I4210127074","https://openalex.org/I24943067","https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101661308","display_name":"Jie Gu","orcid":"https://orcid.org/0000-0001-6030-985X"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jie Gu","raw_affiliation_strings":["Department of Thoracic Surgery, Zhongshan Hospital, Fudan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Zhongshan Hospital, Fudan University","institution_ids":["https://openalex.org/I4210128921","https://openalex.org/I4210127074","https://openalex.org/I24943067","https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113494041","display_name":"Fengkai Xu","orcid":null},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fengkai Xu","raw_affiliation_strings":["Department of Thoracic Surgery, Zhongshan Hospital, Fudan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Zhongshan Hospital, Fudan University","institution_ids":["https://openalex.org/I4210128921","https://openalex.org/I4210127074","https://openalex.org/I24943067","https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102353806","display_name":"Qiaoliang Zhu","orcid":null},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qiaoliang Zhu","raw_affiliation_strings":["Department of Thoracic Surgery, Zhongshan Hospital, Fudan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Zhongshan Hospital, Fudan University","institution_ids":["https://openalex.org/I4210128921","https://openalex.org/I4210127074","https://openalex.org/I24943067","https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100432884","display_name":"Yiwei Chen","orcid":"https://orcid.org/0000-0003-3558-9954"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiwei Chen","raw_affiliation_strings":["Department of Thoracic Surgery, Zhongshan Hospital, Fudan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Zhongshan Hospital, Fudan University","institution_ids":["https://openalex.org/I4210128921","https://openalex.org/I4210127074","https://openalex.org/I24943067","https://openalex.org/I157773358"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001552260","display_name":"Di Ge","orcid":"https://orcid.org/0000-0001-5241-1766"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Di Ge","raw_affiliation_strings":["Department of Thoracic Surgery, Zhongshan Hospital, Fudan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Zhongshan Hospital, Fudan University","institution_ids":["https://openalex.org/I4210128921","https://openalex.org/I4210127074","https://openalex.org/I24943067","https://openalex.org/I157773358"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101407386","display_name":"Chunlai Lu","orcid":"https://orcid.org/0000-0003-4230-5120"},"institutions":[{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I24943067","display_name":"Fudan University","ror":"https://ror.org/013q1eq08","country_code":"CN","type":"education","lineage":["https://openalex.org/I24943067"]},{"id":"https://openalex.org/I4210127074","display_name":"Zhongshan Hospital","ror":"https://ror.org/032x22645","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210127074"]},{"id":"https://openalex.org/I4210128921","display_name":"The First Affiliated Hospital, Sun Yat-sen University","ror":"https://ror.org/037p24858","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210128921"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Chunlai Lu","raw_affiliation_strings":["Department of Thoracic Surgery, Zhongshan Hospital, Fudan University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Zhongshan Hospital, Fudan University","institution_ids":["https://openalex.org/I4210128921","https://openalex.org/I4210127074","https://openalex.org/I24943067","https://openalex.org/I157773358"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5101407386"],"corresponding_institution_ids":["https://openalex.org/I157773358","https://openalex.org/I24943067","https://openalex.org/I4210127074","https://openalex.org/I4210128921"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":9.3573,"has_fulltext":false,"cited_by_count":151,"citation_normalized_percentile":{"value":0.98821704,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"22","issue":"4","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13157","display_name":"Cancer-related gene regulation","score":0.9835000038146973,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9696999788284302,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"Tumor microenvironment","score":0.780431866645813},{"id":"https://openalex.org/keywords/adenocarcinoma","display_name":"Adenocarcinoma","score":0.5650601387023926},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5646836757659912},{"id":"https://openalex.org/keywords/regulator","display_name":"Regulator","score":0.4978055953979492},{"id":"https://openalex.org/keywords/immunotherapy","display_name":"Immunotherapy","score":0.49695447087287903},{"id":"https://openalex.org/keywords/cancer-research","display_name":"Cancer research","score":0.49507060647010803},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.4911770522594452},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.34413257241249084},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3230653405189514},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.29935115575790405},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.24852797389030457},{"id":"https://openalex.org/keywords/tumor-cells","display_name":"Tumor cells","score":0.2035869061946869},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1841433048248291}],"concepts":[{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.780431866645813},{"id":"https://openalex.org/C2781182431","wikidata":"https://www.wikidata.org/wiki/Q356033","display_name":"Adenocarcinoma","level":3,"score":0.5650601387023926},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5646836757659912},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.4978055953979492},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.49695447087287903},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.49507060647010803},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4911770522594452},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34413257241249084},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3230653405189514},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.29935115575790405},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.24852797389030457},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.2035869061946869},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1841433048248291}],"mesh":[{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000077192","descriptor_name":"Adenocarcinoma of Lung","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030561","descriptor_name":"Databases, Nucleic Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbaa225","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbaa225","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:33003204","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33003204","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5400000214576721}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":95,"referenced_works":["https://openalex.org/W1966107523","https://openalex.org/W1966327575","https://openalex.org/W1989683090","https://openalex.org/W2018663224","https://openalex.org/W2028335133","https://openalex.org/W2028426093","https://openalex.org/W2028433016","https://openalex.org/W2035618305","https://openalex.org/W2041328373","https://openalex.org/W2065847836","https://openalex.org/W2066671159","https://openalex.org/W2071930821","https://openalex.org/W2075294566","https://openalex.org/W2100239923","https://openalex.org/W2110678911","https://openalex.org/W2110687686","https://openalex.org/W2115462905","https://openalex.org/W2116634113","https://openalex.org/W2123879591","https://openalex.org/W2130430382","https://openalex.org/W2146512944","https://openalex.org/W2159707944","https://openalex.org/W2169353806","https://openalex.org/W2230320310","https://openalex.org/W2289712604","https://openalex.org/W2471029679","https://openalex.org/W2502908858","https://openalex.org/W2507880739","https://openalex.org/W2509465044","https://openalex.org/W2533508881","https://openalex.org/W2533922074","https://openalex.org/W2546967042","https://openalex.org/W2551911481","https://openalex.org/W2560624069","https://openalex.org/W2563912688","https://openalex.org/W2578528809","https://openalex.org/W2584920615","https://openalex.org/W2604320948","https://openalex.org/W2607211817","https://openalex.org/W2627064270","https://openalex.org/W2735132087","https://openalex.org/W2762830435","https://openalex.org/W2769807951","https://openalex.org/W2780430083","https://openalex.org/W2785803176","https://openalex.org/W2790543400","https://openalex.org/W2793785833","https://openalex.org/W2795989238","https://openalex.org/W2796207353","https://openalex.org/W2803154276","https://openalex.org/W2805703720","https://openalex.org/W2807777360","https://openalex.org/W2886806646","https://openalex.org/W2890106399","https://openalex.org/W2896872272","https://openalex.org/W2901016862","https://openalex.org/W2908862826","https://openalex.org/W2910561108","https://openalex.org/W2911349862","https://openalex.org/W2912369228","https://openalex.org/W2926636056","https://openalex.org/W2937818441","https://openalex.org/W2939559050","https://openalex.org/W2941121518","https://openalex.org/W2941172299","https://openalex.org/W2944063284","https://openalex.org/W2947674709","https://openalex.org/W2948797227","https://openalex.org/W2949273159","https://openalex.org/W2952001873","https://openalex.org/W2966546269","https://openalex.org/W2969704706","https://openalex.org/W2972174320","https://openalex.org/W2972917142","https://openalex.org/W2982058491","https://openalex.org/W2992289032","https://openalex.org/W2992466184","https://openalex.org/W2999417355","https://openalex.org/W3001336990","https://openalex.org/W3005737308","https://openalex.org/W3005827630","https://openalex.org/W3006273887","https://openalex.org/W3015190397","https://openalex.org/W3015377571","https://openalex.org/W3016402588","https://openalex.org/W3016849128","https://openalex.org/W3016947983","https://openalex.org/W3022968840","https://openalex.org/W3026033619","https://openalex.org/W3028187297","https://openalex.org/W3029516352","https://openalex.org/W3034120876","https://openalex.org/W3034923646","https://openalex.org/W3040385771","https://openalex.org/W6766555466"],"related_works":["https://openalex.org/W2354064740","https://openalex.org/W2389923937","https://openalex.org/W2380273283","https://openalex.org/W4200022043","https://openalex.org/W2079588331","https://openalex.org/W2112727616","https://openalex.org/W4296613612","https://openalex.org/W2884525857","https://openalex.org/W4322720888","https://openalex.org/W4366149851"],"abstract_inverted_index":{"N6-methyladenosine":[0],"(m6A)":[1],"modification":[2,15,29,99,202,221],"can":[3],"regulate":[4],"a":[5,138],"variety":[6],"of":[7,13,42,52,58,160,164,178,208,219,230],"biological":[8,104],"processes.":[9],"However,":[10],"the":[11,27,39,48,92,133,154,187,227],"implications":[12],"m6A":[14,28,44,53,69,98,112,201,220],"in":[16,31,74,205],"lung":[17],"adenocarcinoma":[18],"(LUAD)":[19],"remain":[20],"largely":[21],"unknown.":[22],"Here,":[23],"we":[24,136],"systematically":[25],"evaluated":[26],"features":[30,41,51,86],"more":[32,224,235],"than":[33],"2400":[34],"LUAD":[35,161,209,231],"samples":[36],"by":[37],"analyzing":[38],"multi-omics":[40],"23":[43],"regulators.":[45],"We":[46,120],"depicted":[47],"genetic":[49],"variation":[50],"regulators,":[54],"and":[55,60,81,114,150,158,168,194,210,232],"found":[56,121],"mutations":[57],"FTO":[59],"YTHDF3":[61],"were":[62,71],"linked":[63],"to":[64,212],"worse":[65],"overall":[66],"survival.":[67],"Many":[68],"regulators":[70,113],"aberrantly":[72],"expressed":[73],"tumors,":[75],"among":[76],"which":[77,143],"FTO,":[78],"IGF2BP3,":[79],"YTHDF1":[80],"RBM15":[82],"showed":[83],"consistent":[84],"alteration":[85],"across":[87],"11":[88],"independent":[89],"cohorts.":[90],"Besides,":[91],"regulator-pathway":[93],"interaction":[94],"network":[95],"demonstrated":[96,191],"that":[97,122,186,200],"was":[100,117,124,144,243],"associated":[101],"with":[102,127,147,246],"various":[103],"pathways,":[105],"including":[106],"immune-related":[107],"pathways.":[108],"The":[109],"correlation":[110],"between":[111,166],"tumor":[115,155,213],"microenvironment":[116,156,214],"also":[118],"assessed.":[119],"LRPPRC":[123],"negatively":[125],"correlated":[126,146],"most":[128],"tumor-infiltrating":[129],"immune":[130],"cells.":[131],"On":[132],"other":[134],"hand,":[135],"established":[137],"scoring":[139],"tool":[140],"named":[141],"m6Sig,":[142],"positively":[145],"PD-L1":[148],"expression":[149],"could":[151],"reflect":[152],"both":[153],"characterization":[157],"prognosis":[159],"patients.":[162],"Comparison":[163],"CNV":[165],"high":[167,188],"low":[169],"m6Sig":[170,179,189],"groups":[171],"revealed":[172],"differences":[173],"on":[174,180],"chromosome":[175],"7.":[176],"Application":[177],"an":[181],"anti-PD-L1":[182],"immunotherapy":[183],"cohort":[184],"confirmed":[185],"group":[190],"therapeutic":[192],"advantages":[193],"clinical":[195],"benefits.":[196],"Our":[197],"study":[198,248],"indicated":[199],"is":[203],"involved":[204],"many":[206],"aspects":[207],"contributes":[211],"formation.":[215],"A":[216,240],"better":[217],"understanding":[218],"will":[222],"provide":[223],"insights":[225],"into":[226],"molecular":[228],"mechanisms":[229],"facilitate":[233],"developing":[234],"effective":[236],"personalized":[237],"treatment":[238],"strategies.":[239],"web":[241],"application":[242],"built":[244],"along":[245],"this":[247],"(http://www.bioinfo-zs.com/luadexpress/).":[249]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":14},{"year":2023,"cited_by_count":38},{"year":2022,"cited_by_count":50},{"year":2021,"cited_by_count":27}],"updated_date":"2026-07-14T08:27:34.040176","created_date":"2025-10-10T00:00:00"}
