{"id":"https://openalex.org/W3080566245","doi":"https://doi.org/10.1093/bib/bbaa188","title":"Towards multi-omics characterization of tumor heterogeneity: a comprehensive review of statistical and machine learning approaches","display_name":"Towards multi-omics characterization of tumor heterogeneity: a comprehensive review of statistical and machine learning approaches","publication_year":2020,"publication_date":"2020-07-23","ids":{"openalex":"https://openalex.org/W3080566245","doi":"https://doi.org/10.1093/bib/bbaa188","mag":"3080566245","pmid":"https://pubmed.ncbi.nlm.nih.gov/34020548"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbaa188","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbaa188","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040041536","display_name":"Dohoon Lee","orcid":"https://orcid.org/0000-0003-2163-5489"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Dohoon Lee","raw_affiliation_strings":["Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul 08826, Korea"],"affiliations":[{"raw_affiliation_string":"Interdisciplinary Program in Bioinformatics, Seoul National University, Seoul 08826, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010225287","display_name":"Youngjun Park","orcid":"https://orcid.org/0000-0002-9963-7014"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Youngjune Park","raw_affiliation_strings":["Department of Computer Science and Engineering, Institute of Engineering Research, Seoul National University, Seoul 08826, Korea"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science and Engineering, Institute of Engineering Research, Seoul National University, Seoul 08826, Korea","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100460439","display_name":"\ufeffSun Kim","orcid":"https://orcid.org/0000-0001-5385-9546"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Sun Kim","raw_affiliation_strings":["Bioinformatics Institute, Seoul National University, Seoul 08826, Korea"],"affiliations":[{"raw_affiliation_string":"Bioinformatics Institute, Seoul National University, Seoul 08826, Korea","institution_ids":["https://openalex.org/I139264467"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100460439"],"corresponding_institution_ids":["https://openalex.org/I139264467"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":1.4185,"has_fulltext":false,"cited_by_count":34,"citation_normalized_percentile":{"value":0.81426702,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"22","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/omics","display_name":"Omics","score":0.7850848436355591},{"id":"https://openalex.org/keywords/epigenome","display_name":"Epigenome","score":0.6290298700332642},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6178321838378906},{"id":"https://openalex.org/keywords/tumor-heterogeneity","display_name":"Tumor heterogeneity","score":0.5616726875305176},{"id":"https://openalex.org/keywords/biomarker-discovery","display_name":"Biomarker discovery","score":0.5285025238990784},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5036546587944031},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.4106740951538086},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.3831288516521454},{"id":"https://openalex.org/keywords/proteomics","display_name":"Proteomics","score":0.35601648688316345},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.346166729927063},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3335553705692291},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.18367353081703186},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1411307454109192},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.07844528555870056}],"concepts":[{"id":"https://openalex.org/C157585117","wikidata":"https://www.wikidata.org/wiki/Q158666","display_name":"Omics","level":2,"score":0.7850848436355591},{"id":"https://openalex.org/C117717151","wikidata":"https://www.wikidata.org/wiki/Q3589155","display_name":"Epigenome","level":5,"score":0.6290298700332642},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6178321838378906},{"id":"https://openalex.org/C3018028425","wikidata":"https://www.wikidata.org/wiki/Q15917291","display_name":"Tumor heterogeneity","level":3,"score":0.5616726875305176},{"id":"https://openalex.org/C124535831","wikidata":"https://www.wikidata.org/wiki/Q4915074","display_name":"Biomarker discovery","level":4,"score":0.5285025238990784},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5036546587944031},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.4106740951538086},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3831288516521454},{"id":"https://openalex.org/C46111723","wikidata":"https://www.wikidata.org/wiki/Q471857","display_name":"Proteomics","level":3,"score":0.35601648688316345},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.346166729927063},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3335553705692291},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.18367353081703186},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1411307454109192},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.07844528555870056},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000069550","descriptor_name":"Machine Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018740","descriptor_name":"Genetic Heterogeneity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018740","descriptor_name":"Genetic Heterogeneity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018740","descriptor_name":"Genetic Heterogeneity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbaa188","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbaa188","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:34020548","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34020548","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1821041159","display_name":null,"funder_award_id":"HI15C3224","funder_id":"https://openalex.org/F4320310848","funder_display_name":"Ministry of Health and Welfare"},{"id":"https://openalex.org/G2770512274","display_name":null,"funder_award_id":"NRF-2014M3C9A3063541","funder_id":"https://openalex.org/F4320322347","funder_display_name":"Ministry of Science ICT and Future Planning"},{"id":"https://openalex.org/G5463853011","display_name":null,"funder_award_id":"NRF-2017M3C4A7065887","funder_id":"https://openalex.org/F4320322347","funder_display_name":"Ministry of Science ICT and Future Planning"}],"funders":[{"id":"https://openalex.org/F4320310848","display_name":"Ministry of Health and Welfare","ror":"https://ror.org/024w0ge69"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322107","display_name":"Korea Health Industry Development Institute","ror":"https://ror.org/00fdzyk40"},{"id":"https://openalex.org/F4320322347","display_name":"Ministry of Science ICT and Future Planning","ror":"https://ror.org/032e49973"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":192,"referenced_works":["https://openalex.org/W1482466249","https://openalex.org/W1492452294","https://openalex.org/W1504303645","https://openalex.org/W1554775680","https://openalex.org/W1556996865","https://openalex.org/W1598827266","https://openalex.org/W1658127082","https://openalex.org/W1878664294","https://openalex.org/W1903281529","https://openalex.org/W1934094702","https://openalex.org/W1964154017","https://openalex.org/W1967304777","https://openalex.org/W1967937330","https://openalex.org/W1974747095","https://openalex.org/W1975272871","https://openalex.org/W1976078521","https://openalex.org/W1979115864","https://openalex.org/W1983781571","https://openalex.org/W1983951224","https://openalex.org/W1984883254","https://openalex.org/W1985987855","https://openalex.org/W1986888627","https://openalex.org/W1990711772","https://openalex.org/W1993058562","https://openalex.org/W1993287310","https://openalex.org/W1994678797","https://openalex.org/W2002249792","https://openalex.org/W2006288875","https://openalex.org/W2006837755","https://openalex.org/W2009569945","https://openalex.org/W2015182193","https://openalex.org/W2016661249","https://openalex.org/W2019863483","https://openalex.org/W2023560061","https://openalex.org/W2024819383","https://openalex.org/W2030017878","https://openalex.org/W2030781210","https://openalex.org/W2032518018","https://openalex.org/W2034879676","https://openalex.org/W2040257851","https://openalex.org/W2042883111","https://openalex.org/W2044433401","https://openalex.org/W2046646392","https://openalex.org/W2048500586","https://openalex.org/W2049624178","https://openalex.org/W2054823635","https://openalex.org/W2055521874","https://openalex.org/W2056677678","https://openalex.org/W2056933088","https://openalex.org/W2059963348","https://openalex.org/W2062533676","https://openalex.org/W2067817997","https://openalex.org/W2071502814","https://openalex.org/W2090461073","https://openalex.org/W2096148096","https://openalex.org/W2096746187","https://openalex.org/W2097455931","https://openalex.org/W2103684001","https://openalex.org/W2109991075","https://openalex.org/W2110227850","https://openalex.org/W2111874706","https://openalex.org/W2112706474","https://openalex.org/W2114095872","https://openalex.org/W2115919763","https://openalex.org/W2117656191","https://openalex.org/W2119192314","https://openalex.org/W2122110341","https://openalex.org/W2122392334","https://openalex.org/W2123879591","https://openalex.org/W2126298009","https://openalex.org/W2128227526","https://openalex.org/W2130430382","https://openalex.org/W2130996300","https://openalex.org/W2132619562","https://openalex.org/W2134811927","https://openalex.org/W2137605677","https://openalex.org/W2144035153","https://openalex.org/W2144222696","https://openalex.org/W2144847592","https://openalex.org/W2146244933","https://openalex.org/W2148241659","https://openalex.org/W2149015703","https://openalex.org/W2149076862","https://openalex.org/W2150987201","https://openalex.org/W2151465627","https://openalex.org/W2152716163","https://openalex.org/W2154598603","https://openalex.org/W2155725346","https://openalex.org/W2161055995","https://openalex.org/W2161466790","https://openalex.org/W2163480486","https://openalex.org/W2164214190","https://openalex.org/W2164327622","https://openalex.org/W2164844813","https://openalex.org/W2165786425","https://openalex.org/W2166815431","https://openalex.org/W2169556367","https://openalex.org/W2170490448","https://openalex.org/W2171892226","https://openalex.org/W2185207072","https://openalex.org/W2267187060","https://openalex.org/W2274866051","https://openalex.org/W2291298003","https://openalex.org/W2332292689","https://openalex.org/W2338663666","https://openalex.org/W2340974016","https://openalex.org/W2346273585","https://openalex.org/W2358053195","https://openalex.org/W2405513305","https://openalex.org/W2426586472","https://openalex.org/W2468626607","https://openalex.org/W2482614962","https://openalex.org/W2507880739","https://openalex.org/W2515462796","https://openalex.org/W2523620612","https://openalex.org/W2524248040","https://openalex.org/W2533508881","https://openalex.org/W2537167162","https://openalex.org/W2553517216","https://openalex.org/W2553677484","https://openalex.org/W2556706815","https://openalex.org/W2579382924","https://openalex.org/W2586389371","https://openalex.org/W2586898076","https://openalex.org/W2592257068","https://openalex.org/W2593934358","https://openalex.org/W2600132724","https://openalex.org/W2600453489","https://openalex.org/W2600929284","https://openalex.org/W2602431927","https://openalex.org/W2606274694","https://openalex.org/W2747877289","https://openalex.org/W2754025713","https://openalex.org/W2756005140","https://openalex.org/W2760216793","https://openalex.org/W2765435739","https://openalex.org/W2766266723","https://openalex.org/W2767281692","https://openalex.org/W2782755171","https://openalex.org/W2788357641","https://openalex.org/W2789878273","https://openalex.org/W2796323824","https://openalex.org/W2805012568","https://openalex.org/W2861777839","https://openalex.org/W2885720383","https://openalex.org/W2888094747","https://openalex.org/W2895846631","https://openalex.org/W2896488942","https://openalex.org/W2899938658","https://openalex.org/W2900569176","https://openalex.org/W2901656544","https://openalex.org/W2903435154","https://openalex.org/W2907260934","https://openalex.org/W2912198494","https://openalex.org/W2913008832","https://openalex.org/W2917858269","https://openalex.org/W2942610007","https://openalex.org/W2947554843","https://openalex.org/W2949158283","https://openalex.org/W2949688529","https://openalex.org/W2951343553","https://openalex.org/W2951456889","https://openalex.org/W2951545629","https://openalex.org/W2952001873","https://openalex.org/W2952240309","https://openalex.org/W2952600302","https://openalex.org/W2953757801","https://openalex.org/W2957016002","https://openalex.org/W2962028921","https://openalex.org/W2962673659","https://openalex.org/W2967361057","https://openalex.org/W2972280747","https://openalex.org/W2978708928","https://openalex.org/W2980515223","https://openalex.org/W2980586637","https://openalex.org/W2981457875","https://openalex.org/W3001381700","https://openalex.org/W3004647847","https://openalex.org/W3006500278","https://openalex.org/W3006517346","https://openalex.org/W3012531418","https://openalex.org/W3019556496","https://openalex.org/W3029925672","https://openalex.org/W3100442728","https://openalex.org/W3103162178","https://openalex.org/W3122281318","https://openalex.org/W4210280122","https://openalex.org/W6629328033","https://openalex.org/W6633317617","https://openalex.org/W6636882156","https://openalex.org/W6684348521","https://openalex.org/W6759243761"],"related_works":["https://openalex.org/W1539981706","https://openalex.org/W1485011350","https://openalex.org/W4223912550","https://openalex.org/W2281038790","https://openalex.org/W4210973372","https://openalex.org/W2406946121","https://openalex.org/W2031369865","https://openalex.org/W1969295409","https://openalex.org/W2010715465","https://openalex.org/W2558197048"],"abstract_inverted_index":{"The":[0],"multi-omics":[1,63,134,164,200],"molecular":[2,103],"characterization":[3],"of":[4,13,26,94,105,114,128,149,156,171,199],"cancer":[5,14,82],"opened":[6],"a":[7,20,47,53,106,168,189],"new":[8],"horizon":[9],"for":[10,59,75,89,162,196],"our":[11],"understanding":[12],"biology":[15],"and":[16,40,55,186],"therapeutic":[17,90],"strategies.":[18],"However,":[19],"tumor":[21,37,107,176],"biopsy":[22],"comprises":[23],"diverse":[24,172],"types":[25],"cells":[27,33,39,129],"limited":[28],"not":[29],"only":[30,143],"to":[31,36,97,174],"cancerous":[32],"but":[34,112],"also":[35],"microenvironmental":[38],"adjacent":[41],"normal":[42],"cells.":[43,150],"This":[44],"heterogeneity":[45,67,100,127,177],"is":[46,130],"major":[48],"confounding":[49],"factor":[50],"that":[51,159],"hampers":[52],"robust":[54],"reproducible":[56],"bioinformatic":[57],"analysis":[58,198],"biomarker":[60],"identification":[61],"using":[62],"profiles.":[64],"Besides,":[65],"the":[66,73,118,126,146,157,197],"itself":[68],"has":[69],"been":[70,110],"recognized":[71],"over":[72],"years":[74],"its":[76],"significant":[77],"prognostic":[78],"values":[79],"in":[80],"some":[81],"types,":[83],"thus":[84],"offering":[85],"another":[86],"promising":[87],"avenue":[88],"intervention.":[91],"A":[92],"number":[93],"computational":[95],"approaches":[96,173],"unravel":[98],"such":[99],"from":[101,120],"high-throughput":[102],"profiles":[104,201],"sample":[108],"have":[109],"proposed,":[111],"most":[113],"them":[115],"rely":[116],"on":[117,138,179],"data":[119],"an":[121,139],"individual":[122,140],"omics":[123,182],"layer.":[124],"Since":[125],"widely":[131],"distributed":[132],"across":[133],"layers,":[135],"methods":[136],"based":[137,178],"layer":[141],"can":[142,193],"partially":[144],"characterize":[145,175],"heterogeneous":[147],"admixture":[148],"To":[151],"help":[152],"facilitate":[153],"further":[154],"development":[155],"methodologies":[158],"synchronously":[160],"account":[161],"several":[163],"profiles,":[165],"we":[166],"wrote":[167],"comprehensive":[169],"review":[170,192],"three":[180],"different":[181],"layers:":[183],"genome,":[184],"epigenome":[185],"transcriptome.":[187],"As":[188],"result,":[190],"this":[191],"be":[194],"useful":[195],"produced":[202],"by":[203],"many":[204],"large-scale":[205],"consortia.":[206],"Contact:sunkim.bioinfo@snu.ac.kr.":[207]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4}],"updated_date":"2026-03-31T07:56:22.981413","created_date":"2025-10-10T00:00:00"}
