{"id":"https://openalex.org/W3049439427","doi":"https://doi.org/10.1093/bib/bbaa171","title":"An <i>in silico</i> approach to identification, categorization and prediction of nucleic acid binding proteins","display_name":"An <i>in silico</i> approach to identification, categorization and prediction of nucleic acid binding proteins","publication_year":2020,"publication_date":"2020-07-06","ids":{"openalex":"https://openalex.org/W3049439427","doi":"https://doi.org/10.1093/bib/bbaa171","mag":"3049439427","pmid":"https://pubmed.ncbi.nlm.nih.gov/32793956"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbaa171","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbaa171","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100622723","display_name":"Lei Xu","orcid":"https://orcid.org/0000-0002-6440-6881"},"institutions":[{"id":"https://openalex.org/I182722699","display_name":"Shenzhen Polytechnic University","ror":"https://ror.org/00d2w9g53","country_code":"CN","type":"education","lineage":["https://openalex.org/I182722699"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lei Xu","raw_affiliation_strings":["School of Electronic and Communication Engineering, Shenzhen Polytechnic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Electronic and Communication Engineering, Shenzhen Polytechnic","institution_ids":["https://openalex.org/I182722699"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054556302","display_name":"Shanshan Jiang","orcid":"https://orcid.org/0000-0002-7841-9448"},"institutions":[{"id":"https://openalex.org/I20231570","display_name":"Peking University","ror":"https://ror.org/02v51f717","country_code":"CN","type":"education","lineage":["https://openalex.org/I20231570"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shanshan Jiang","raw_affiliation_strings":["Peking University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Peking University","institution_ids":["https://openalex.org/I20231570"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074898112","display_name":"Jin Wu","orcid":"https://orcid.org/0000-0001-9926-0993"},"institutions":[{"id":"https://openalex.org/I150229711","display_name":"University of Electronic Science and Technology of China","ror":"https://ror.org/04qr3zq92","country_code":"CN","type":"education","lineage":["https://openalex.org/I150229711"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jin Wu","raw_affiliation_strings":["Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Fundamental and Frontier Sciences, University of Electronic Science and Technology of China","institution_ids":["https://openalex.org/I150229711"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017426085","display_name":"Quan Zou","orcid":"https://orcid.org/0000-0001-6406-1142"},"institutions":[{"id":"https://openalex.org/I182722699","display_name":"Shenzhen Polytechnic University","ror":"https://ror.org/00d2w9g53","country_code":"CN","type":"education","lineage":["https://openalex.org/I182722699"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Quan Zou","raw_affiliation_strings":["School of Management, Shenzhen Polytechnic"],"raw_orcid":"https://orcid.org/0000-0001-6406-1142","affiliations":[{"raw_affiliation_string":"School of Management, Shenzhen Polytechnic","institution_ids":["https://openalex.org/I182722699"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5017426085","https://openalex.org/A5074898112"],"corresponding_institution_ids":["https://openalex.org/I150229711","https://openalex.org/I182722699"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":6.2652,"has_fulltext":false,"cited_by_count":95,"citation_normalized_percentile":{"value":0.97630482,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"22","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9976999759674072,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6809687614440918},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.640377402305603},{"id":"https://openalex.org/keywords/nucleic-acid","display_name":"Nucleic acid","score":0.6204217672348022},{"id":"https://openalex.org/keywords/protein-function-prediction","display_name":"Protein function prediction","score":0.5369470119476318},{"id":"https://openalex.org/keywords/protein\u2013protein-interaction","display_name":"Protein\u2013protein interaction","score":0.5342667698860168},{"id":"https://openalex.org/keywords/classifier","display_name":"Classifier (UML)","score":0.5255866646766663},{"id":"https://openalex.org/keywords/transcription","display_name":"Transcription (linguistics)","score":0.49381527304649353},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.4894605875015259},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4408491253852844},{"id":"https://openalex.org/keywords/categorization","display_name":"Categorization","score":0.4128248691558838},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4092678427696228},{"id":"https://openalex.org/keywords/protein-function","display_name":"Protein function","score":0.3705590069293976},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3629703223705292},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.28934383392333984},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2070271074771881},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.08191841840744019}],"concepts":[{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6809687614440918},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.640377402305603},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.6204217672348022},{"id":"https://openalex.org/C207060522","wikidata":"https://www.wikidata.org/wiki/Q7251473","display_name":"Protein function prediction","level":4,"score":0.5369470119476318},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.5342667698860168},{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.5255866646766663},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.49381527304649353},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4894605875015259},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4408491253852844},{"id":"https://openalex.org/C94124525","wikidata":"https://www.wikidata.org/wiki/Q912550","display_name":"Categorization","level":2,"score":0.4128248691558838},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4092678427696228},{"id":"https://openalex.org/C2986374874","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Protein function","level":3,"score":0.3705590069293976},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3629703223705292},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.28934383392333984},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2070271074771881},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08191841840744019},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009696","descriptor_name":"Nucleic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009696","descriptor_name":"Nucleic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009696","descriptor_name":"Nucleic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016601","descriptor_name":"RNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019985","descriptor_name":"Benchmarking","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060388","descriptor_name":"Support Vector Machine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbaa171","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbaa171","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:32793956","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32793956","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1587116901","display_name":null,"funder_award_id":"61771331","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5169269796","display_name":null,"funder_award_id":"61902259","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G5445134063","display_name":null,"funder_award_id":"2018A0303130084","funder_id":"https://openalex.org/F4320321921","funder_display_name":"Natural Science Foundation of Guangdong Province"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321921","display_name":"Natural Science Foundation of Guangdong Province","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":35,"referenced_works":["https://openalex.org/W1487894924","https://openalex.org/W1967580419","https://openalex.org/W1984794455","https://openalex.org/W2034070267","https://openalex.org/W2062296203","https://openalex.org/W2103017472","https://openalex.org/W2106612397","https://openalex.org/W2123525093","https://openalex.org/W2140047797","https://openalex.org/W2141205833","https://openalex.org/W2142068542","https://openalex.org/W2153187042","https://openalex.org/W2154139219","https://openalex.org/W2154189169","https://openalex.org/W2156125289","https://openalex.org/W2158714788","https://openalex.org/W2170463736","https://openalex.org/W2195950152","https://openalex.org/W2557496587","https://openalex.org/W2604808360","https://openalex.org/W2766737008","https://openalex.org/W2793278326","https://openalex.org/W2808487499","https://openalex.org/W2883977408","https://openalex.org/W2902565488","https://openalex.org/W2905281057","https://openalex.org/W2911617196","https://openalex.org/W2949685204","https://openalex.org/W2972223935","https://openalex.org/W2984633739","https://openalex.org/W2989500256","https://openalex.org/W6676201416","https://openalex.org/W6682473469","https://openalex.org/W6682719531","https://openalex.org/W6770019485"],"related_works":["https://openalex.org/W2094822546","https://openalex.org/W4388708026","https://openalex.org/W4255644844","https://openalex.org/W1969080446","https://openalex.org/W3108941781","https://openalex.org/W2181394498","https://openalex.org/W2287132924","https://openalex.org/W2131407941","https://openalex.org/W2125650596","https://openalex.org/W2586268529"],"abstract_inverted_index":{"The":[0,21,39,107,129,147,184],"interaction":[1,116],"between":[2],"proteins":[3,35,103,130],"and":[4,18,58,115,120,122,143,170],"nucleic":[5],"acid":[6,76],"plays":[7],"an":[8],"important":[9],"role":[10],"in":[11,36,48,104,131],"many":[12],"processes,":[13],"such":[14,69,85,138],"as":[15,86,139],"transcription,":[16,140],"translation":[17],"DNA":[19],"repair.":[20],"mechanisms":[22],"of":[23,34,41,60,81,102,149,174,190],"related":[24,82],"biological":[25,83],"events":[26],"can":[27,94],"be":[28,95],"understood":[29,97],"by":[30,98,192],"exploring":[31],"the":[32,52,56,79,100,163,172,181],"function":[33,59,101,114,148,173],"these":[37,105],"interactions.":[38,77,106],"number":[40],"known":[42],"protein":[43,61,151,176],"sequences":[44],"has":[45],"increased":[46],"rapidly":[47],"recent":[49],"years,":[50],"but":[51],"databases":[53,70],"for":[54,73,109],"describing":[55],"structure":[57],"have":[62],"unfortunately":[63],"grown":[64],"quite":[65],"slowly.":[66],"Thus,":[67],"improving":[68],"is":[71],"meaningful":[72],"predicting":[74],"protein-nucleic":[75],"Furthermore,":[78],"mechanism":[80],"events,":[84],"viral":[87],"infection":[88],"or":[89],"designing":[90],"novel":[91],"drug":[92],"targets,":[93],"further":[96],"understanding":[99],"information":[108],"each":[110,150],"sequence,":[111],"including":[112],"its":[113],"sites,":[117],"were":[118,133],"collected":[119],"identified,":[121],"a":[123,156,175,188],"database":[124],"called":[125],"PNIDB":[126,132],"was":[127,152,165,177],"built.":[128],"grouped":[134],"into":[135],"27":[136],"classes,":[137],"immune":[141],"system,":[142],"structural":[144],"protein,":[145],"etc.":[146],"then":[153,171],"predicted":[154,178],"using":[155],"machine":[157],"learning":[158],"method.":[159],"Using":[160],"our":[161],"method,":[162],"predictor":[164],"trained":[166,182],"on":[167,180],"labeled":[168],"sequences,":[169],"based":[179],"classifier.":[183],"prediction":[185],"accuracy":[186],"achieved":[187],"score":[189],"77.43%":[191],"10-fold":[193],"cross":[194],"validation.":[195]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":55},{"year":2020,"cited_by_count":3},{"year":2017,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2020-08-21T00:00:00"}