{"id":"https://openalex.org/W3037033301","doi":"https://doi.org/10.1093/bib/bbaa090","title":"A novel privacy-preserving federated genome-wide association study framework and its application in identifying potential risk variants in ankylosing spondylitis","display_name":"A novel privacy-preserving federated genome-wide association study framework and its application in identifying potential risk variants in ankylosing spondylitis","publication_year":2020,"publication_date":"2020-05-01","ids":{"openalex":"https://openalex.org/W3037033301","doi":"https://doi.org/10.1093/bib/bbaa090","mag":"3037033301","pmid":"https://pubmed.ncbi.nlm.nih.gov/32591779"},"language":"en","primary_location":{"id":"doi:10.1093/bib/bbaa090","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbaa090","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040587192","display_name":"Xin Wu","orcid":"https://orcid.org/0000-0002-3677-4660"},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xin Wu","raw_affiliation_strings":["Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0002-3677-4660","affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101552472","display_name":"Hao Zheng","orcid":"https://orcid.org/0000-0002-1678-9478"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hao Zheng","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-1678-9478","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057574564","display_name":"Zuochao Dou","orcid":"https://orcid.org/0000-0002-3880-5125"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zuochao Dou","raw_affiliation_strings":["Department of Bioinformatics, Hangzhou Nuowei Information Technology Co. Ltd, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Hangzhou Nuowei Information Technology Co. Ltd, Hangzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100352666","display_name":"Feng Chen","orcid":"https://orcid.org/0000-0001-6495-1030"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Feng Chen","raw_affiliation_strings":["Department of Bioinformatics, Hangzhou Nuowei Information Technology Co., Ltd, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Hangzhou Nuowei Information Technology Co., Ltd, Hangzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080327156","display_name":"Jieren Deng","orcid":"https://orcid.org/0000-0002-5738-0927"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jieren Deng","raw_affiliation_strings":["Department of Bioinformatics, Hangzhou Nuowei Information Technology Co., Ltd, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Hangzhou Nuowei Information Technology Co., Ltd, Hangzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100441958","display_name":"Xiang Chen","orcid":"https://orcid.org/0000-0003-3188-8332"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiang Chen","raw_affiliation_strings":["Department of Bioinformatics, Hangzhou Nuowei Information Technology Co., Ltd, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Hangzhou Nuowei Information Technology Co., Ltd, Hangzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002437368","display_name":"Shengqian Xu","orcid":"https://orcid.org/0000-0002-9559-1143"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shengqian Xu","raw_affiliation_strings":["Department of Rheumatology and Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Immunology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019886046","display_name":"Guanmin Gao","orcid":"https://orcid.org/0000-0001-7458-8378"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Guanmin Gao","raw_affiliation_strings":["Department of Rheumatology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100348216","display_name":"Mengmeng Li","orcid":"https://orcid.org/0000-0003-3967-8372"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mengmeng Li","raw_affiliation_strings":["Department of Rheumatology and Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Immunology","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100422422","display_name":"Zhen Wang","orcid":"https://orcid.org/0000-0003-3173-6961"},"institutions":[{"id":"https://openalex.org/I177933477","display_name":"Second Military Medical University","ror":"https://ror.org/04tavpn47","country_code":"CN","type":"education","lineage":["https://openalex.org/I177933477"]},{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhen Wang","raw_affiliation_strings":["Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Immunology, Shanghai Changzheng Hospital, Second Military Medical University, China","institution_ids":["https://openalex.org/I177933477","https://openalex.org/I4210099558"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102866472","display_name":"Yuhui Xiao","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuhui Xiao","raw_affiliation_strings":["Department of Bioinformatics, Hangzhou Nuowei Information Technology, Hangzhou, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, Hangzhou Nuowei Information Technology, Hangzhou, China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029754332","display_name":"Kang Xie","orcid":"https://orcid.org/0000-0002-8529-775X"},"institutions":[{"id":"https://openalex.org/I1302611135","display_name":"Ministry of Public Security of the People's Republic of China","ror":"https://ror.org/00bt9we26","country_code":"CN","type":"government","lineage":["https://openalex.org/I1302611135"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kang Xie","raw_affiliation_strings":["Key Lab of Information Network Security of the Ministry of Public Security"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Lab of Information Network Security of the Ministry of Public Security","institution_ids":["https://openalex.org/I1302611135"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100375557","display_name":"Shuang Wang","orcid":"https://orcid.org/0000-0001-6420-983X"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Shuang Wang","raw_affiliation_strings":["Hangzhou Nuowei Information Technology Co., Ltd, Hangzhou, China"],"raw_orcid":"https://orcid.org/0000-0001-6420-983X","affiliations":[{"raw_affiliation_string":"Hangzhou Nuowei Information Technology Co., Ltd, Hangzhou, China","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018788237","display_name":"Huji Xu","orcid":"https://orcid.org/0000-0002-8588-118X"},"institutions":[{"id":"https://openalex.org/I4210099558","display_name":"Shanghai Changzheng Hospital","ror":"https://ror.org/0103dxn66","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210099558"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huji Xu","raw_affiliation_strings":["Department of Rheumatology and Immunology, Shanghai Changzheng Hospital"],"raw_orcid":"https://orcid.org/0000-0002-8588-118X","affiliations":[{"raw_affiliation_string":"Department of Rheumatology and Immunology, Shanghai Changzheng Hospital","institution_ids":["https://openalex.org/I4210099558"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5018788237","https://openalex.org/A5100375557"],"corresponding_institution_ids":["https://openalex.org/I4210099558"],"apc_list":{"value":4011,"currency":"USD","value_usd":4011},"apc_paid":null,"fwci":2.3589,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.89151648,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"22","issue":"3","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10200","display_name":"Rheumatoid Arthritis Research and Therapies","score":0.9919000267982483,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.9855999946594238,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.6969828605651855},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6495751142501831},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5437702536582947},{"id":"https://openalex.org/keywords/data-sharing","display_name":"Data sharing","score":0.45411941409111023},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.44541552662849426},{"id":"https://openalex.org/keywords/information-privacy","display_name":"Information privacy","score":0.43875396251678467},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.42042112350463867},{"id":"https://openalex.org/keywords/data-science","display_name":"Data science","score":0.41715207695961},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4129691421985626},{"id":"https://openalex.org/keywords/internet-privacy","display_name":"Internet privacy","score":0.22153663635253906},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.15745198726654053},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.115296870470047},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.10560962557792664}],"concepts":[{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.6969828605651855},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6495751142501831},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5437702536582947},{"id":"https://openalex.org/C2779965156","wikidata":"https://www.wikidata.org/wiki/Q5227350","display_name":"Data sharing","level":3,"score":0.45411941409111023},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.44541552662849426},{"id":"https://openalex.org/C123201435","wikidata":"https://www.wikidata.org/wiki/Q456632","display_name":"Information privacy","level":2,"score":0.43875396251678467},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.42042112350463867},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.41715207695961},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4129691421985626},{"id":"https://openalex.org/C108827166","wikidata":"https://www.wikidata.org/wiki/Q175975","display_name":"Internet privacy","level":1,"score":0.22153663635253906},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.15745198726654053},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.115296870470047},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.10560962557792664},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013167","descriptor_name":"Spondylitis, Ankylosing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013167","descriptor_name":"Spondylitis, Ankylosing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013167","descriptor_name":"Spondylitis, Ankylosing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018907","descriptor_name":"Privacy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018907","descriptor_name":"Privacy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018907","descriptor_name":"Privacy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D055106","descriptor_name":"Genome-Wide Association Study","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1093/bib/bbaa090","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bib/bbaa090","pdf_url":null,"source":{"id":"https://openalex.org/S91767247","display_name":"Briefings in Bioinformatics","issn_l":"1467-5463","issn":["1467-5463","1477-4054"],"is_oa":false,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in Bioinformatics","raw_type":"journal-article"},{"id":"pmid:32591779","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32591779","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Briefings in bioinformatics","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/17","display_name":"Partnerships for the goals","score":0.5600000023841858}],"awards":[{"id":"https://openalex.org/G4417680553","display_name":null,"funder_award_id":"81430031","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7444632318","display_name":null,"funder_award_id":"31770988","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W18580977","https://openalex.org/W1563775131","https://openalex.org/W1583837637","https://openalex.org/W1838635991","https://openalex.org/W1847429134","https://openalex.org/W1923365686","https://openalex.org/W1946622722","https://openalex.org/W1966756689","https://openalex.org/W2002458933","https://openalex.org/W2030361273","https://openalex.org/W2040228409","https://openalex.org/W2043609703","https://openalex.org/W2051142108","https://openalex.org/W2051873544","https://openalex.org/W2080299747","https://openalex.org/W2083384763","https://openalex.org/W2095272373","https://openalex.org/W2101365565","https://openalex.org/W2118788747","https://openalex.org/W2124916392","https://openalex.org/W2132291180","https://openalex.org/W2141481372","https://openalex.org/W2142777830","https://openalex.org/W2146875405","https://openalex.org/W2157440718","https://openalex.org/W2158718916","https://openalex.org/W2160711416","https://openalex.org/W2166430366","https://openalex.org/W2168610667","https://openalex.org/W2211774783","https://openalex.org/W2249520589","https://openalex.org/W2482974298","https://openalex.org/W2499359132","https://openalex.org/W2568218703","https://openalex.org/W2573423285","https://openalex.org/W2605105376","https://openalex.org/W2608831233","https://openalex.org/W2617451774","https://openalex.org/W2766802942","https://openalex.org/W2774373932","https://openalex.org/W2806852271","https://openalex.org/W2883125028","https://openalex.org/W2905034922","https://openalex.org/W2927268014","https://openalex.org/W4205373044","https://openalex.org/W4211203343","https://openalex.org/W6670535726","https://openalex.org/W6679384156","https://openalex.org/W6736032805"],"related_works":["https://openalex.org/W4283582241","https://openalex.org/W2066467839","https://openalex.org/W2594299395","https://openalex.org/W2111842731","https://openalex.org/W2170506381","https://openalex.org/W2765794416","https://openalex.org/W2039666944","https://openalex.org/W1531630856","https://openalex.org/W2794350630","https://openalex.org/W2089097350"],"abstract_inverted_index":{"Genome-wide":[0],"association":[1],"studies":[2],"(GWAS)":[3],"have":[4],"been":[5],"widely":[6],"used":[7],"for":[8,159,208],"identifying":[9,160],"potential":[10,161,202],"risk":[11,162],"variants":[12,163],"in":[13,164,203],"various":[14],"diseases.":[15],"A":[16],"statistically":[17],"meaningful":[18],"GWAS":[19,111,126],"typically":[20],"requires":[21],"a":[22,34,40,63,107,156],"large":[23],"sample":[24,52],"size":[25,53],"to":[26,50,97,123],"detect":[27],"disease-associated":[28],"single":[29,35],"nucleotide":[30],"polymorphisms":[31],"(SNPs).":[32],"However,":[33,57],"institution":[36],"usually":[37],"only":[38],"possesses":[39],"limited":[41],"number":[42],"of":[43,74,78,149,176],"samples.":[44],"Therefore,":[45],"cross-institutional":[46,58],"partnerships":[47,59],"are":[48,86,137],"required":[49],"increase":[51],"and":[54,82,155],"statistical":[55],"power.":[56],"offer":[60],"significant":[61],"challenges,":[62],"major":[64],"one":[65],"being":[66],"data":[67,79,100,154,213],"privacy.":[68,214],"For":[69],"example,":[70],"the":[71,76,83,140,147,173,182],"privacy":[72,80],"awareness":[73],"people,":[75],"impact":[77],"leakages":[81],"privacy-related":[84],"risks":[85],"becoming":[87],"increasingly":[88],"important,":[89],"while":[90,211],"there":[91],"is":[92],"no":[93],"de-identification":[94],"standard":[95],"available":[96],"safeguard":[98],"genomic":[99,206],"sharing.":[101],"In":[102,143],"this":[103],"paper,":[104],"we":[105,145],"introduce":[106],"novel":[108],"privacy-preserving":[109,116],"federated":[110,117],"framework":[112,191],"(iPRIVATES).":[113],"Equipped":[114],"with":[115],"analysis,":[118],"iPRIVATES":[119,150,190],"enables":[120],"multiple":[121],"institutions":[122],"jointly":[124],"perform":[125],"analysis":[127],"without":[128],"leaking":[129],"patient-level":[130],"genotyping":[131],"data.":[132],"Only":[133],"aggregated":[134],"local":[135],"statistics":[136],"exchanged":[138],"within":[139],"study":[141],"network.":[142],"addition,":[144],"evaluate":[146],"performance":[148],"through":[151],"both":[152],"simulated":[153],"real-world":[157],"application":[158],"ankylosing":[165],"spondylitis":[166],"(AS).":[167],"The":[168,188],"experimental":[169],"results":[170,194],"showed":[171],"that":[172],"strongest":[174],"signal":[175],"AS-associated":[177],"SNPs":[178],"reside":[179],"mostly":[180],"around":[181],"human":[183],"leukocyte":[184],"antigen":[185],"(HLA)":[186],"regions.":[187],"proposed":[189],"achieved":[192],"equivalent":[193],"as":[195],"traditional":[196],"centralized":[197],"implementation,":[198],"demonstrating":[199],"its":[200],"great":[201],"driving":[204],"collaborative":[205],"research":[207],"different":[209],"diseases":[210],"preserving":[212]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":1}],"updated_date":"2026-05-21T06:26:12.895304","created_date":"2025-10-10T00:00:00"}