{"id":"https://openalex.org/W3160785216","doi":"https://doi.org/10.1089/brain.2020.0919","title":"Selective Effects of Healthy Cognitive Aging and Catechol- <i>O</i> -Methyl Transferase Polymorphism on Limbic White Matter Tracts","display_name":"Selective Effects of Healthy Cognitive Aging and Catechol- <i>O</i> -Methyl Transferase Polymorphism on Limbic White Matter Tracts","publication_year":2021,"publication_date":"2021-05-21","ids":{"openalex":"https://openalex.org/W3160785216","doi":"https://doi.org/10.1089/brain.2020.0919","mag":"3160785216","pmid":"https://pubmed.ncbi.nlm.nih.gov/34015958"},"language":"en","primary_location":{"id":"doi:10.1089/brain.2020.0919","is_oa":false,"landing_page_url":"https://doi.org/10.1089/brain.2020.0919","pdf_url":null,"source":{"id":"https://openalex.org/S2764941518","display_name":"Brain Connectivity","issn_l":"2158-0014","issn":["2158-0014","2158-0022"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443"],"host_organization_lineage_names":["Mary Ann Liebert, Inc."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Connectivity","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5016082334","display_name":"Arash Aghamohammadi\u2010Sereshki","orcid":"https://orcid.org/0000-0002-6753-0773"},"institutions":[{"id":"https://openalex.org/I168635309","display_name":"University of Calgary","ror":"https://ror.org/03yjb2x39","country_code":"CA","type":"education","lineage":["https://openalex.org/I168635309"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Arash Aghamohammadi-Sereshki","raw_affiliation_strings":["Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Radiology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada","institution_ids":["https://openalex.org/I168635309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042797086","display_name":"Fraser Olsen","orcid":null},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Fraser Olsen","raw_affiliation_strings":["Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008123542","display_name":"Peter Seres","orcid":"https://orcid.org/0000-0002-8812-2234"},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Peter Seres","raw_affiliation_strings":["Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Alberta, Edmonton, Alberta, Canada","institution_ids":["https://openalex.org/I154425047"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000967147","display_name":"Nikolai Malykhin","orcid":"https://orcid.org/0000-0002-7691-5050"},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]},{"id":"https://openalex.org/I4210131405","display_name":"Women and Children\u2019s Health Research Institute","ror":"https://ror.org/03e04kk51","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210131405"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Nikolai V. Malykhin","raw_affiliation_strings":["Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada","Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, University of Alberta, Edmonton, Alberta, Canada","institution_ids":["https://openalex.org/I154425047"]},{"raw_affiliation_string":"Neuroscience and Mental Health Institute, University of Alberta, Edmonton, Alberta, Canada","institution_ids":["https://openalex.org/I4210131405","https://openalex.org/I154425047"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5000967147"],"corresponding_institution_ids":["https://openalex.org/I154425047","https://openalex.org/I4210131405"],"apc_list":null,"apc_paid":null,"fwci":0.1386,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.46792241,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"12","issue":"2","first_page":"146","last_page":"163"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11097","display_name":"Cerebral Palsy and Movement Disorders","score":0.9890999794006348,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11538","display_name":"Ophthalmology and Eye Disorders","score":0.9466999769210815,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uncinate-fasciculus","display_name":"Uncinate fasciculus","score":0.9032262563705444},{"id":"https://openalex.org/keywords/cingulum","display_name":"Cingulum (brain)","score":0.8791452646255493},{"id":"https://openalex.org/keywords/white-matter","display_name":"White matter","score":0.7661523818969727},{"id":"https://openalex.org/keywords/fractional-anisotropy","display_name":"Fractional anisotropy","score":0.74053955078125},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.5989166498184204},{"id":"https://openalex.org/keywords/fasciculus","display_name":"Fasciculus","score":0.596636950969696},{"id":"https://openalex.org/keywords/diffusion-mri","display_name":"Diffusion MRI","score":0.4700298011302948},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.42457136511802673},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.2988196015357971},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2702450752258301},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.06626781821250916}],"concepts":[{"id":"https://openalex.org/C2779490353","wikidata":"https://www.wikidata.org/wiki/Q176007","display_name":"Uncinate fasciculus","level":5,"score":0.9032262563705444},{"id":"https://openalex.org/C2777193593","wikidata":"https://www.wikidata.org/wiki/Q15130814","display_name":"Cingulum (brain)","level":5,"score":0.8791452646255493},{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.7661523818969727},{"id":"https://openalex.org/C89916169","wikidata":"https://www.wikidata.org/wiki/Q17014600","display_name":"Fractional anisotropy","level":4,"score":0.74053955078125},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5989166498184204},{"id":"https://openalex.org/C2779497037","wikidata":"https://www.wikidata.org/wiki/Q1397368","display_name":"Fasciculus","level":5,"score":0.596636950969696},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.4700298011302948},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.42457136511802673},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.2988196015357971},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2702450752258301},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.06626781821250916}],"mesh":[{"descriptor_ui":"D000066492","descriptor_name":"Cognitive Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000066492","descriptor_name":"Cognitive Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000066492","descriptor_name":"Cognitive Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000073656","descriptor_name":"Healthy Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000073656","descriptor_name":"Healthy Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000073656","descriptor_name":"Healthy Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002394","descriptor_name":"Catechol O-Methyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002394","descriptor_name":"Catechol O-Methyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002394","descriptor_name":"Catechol O-Methyltransferase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002396","descriptor_name":"Catechols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002396","descriptor_name":"Catechols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002396","descriptor_name":"Catechols","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008715","descriptor_name":"Methionine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011110","descriptor_name":"Polymorphism, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014633","descriptor_name":"Valine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014633","descriptor_name":"Valine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014633","descriptor_name":"Valine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1089/brain.2020.0919","is_oa":false,"landing_page_url":"https://doi.org/10.1089/brain.2020.0919","pdf_url":null,"source":{"id":"https://openalex.org/S2764941518","display_name":"Brain Connectivity","issn_l":"2158-0014","issn":["2158-0014","2158-0022"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443"],"host_organization_lineage_names":["Mary Ann Liebert, Inc."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Connectivity","raw_type":"journal-article"},{"id":"pmid:34015958","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34015958","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain connectivity","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1969886036","https://openalex.org/W1971228815","https://openalex.org/W1971767575","https://openalex.org/W1977610079","https://openalex.org/W1978946251","https://openalex.org/W1983906797","https://openalex.org/W1990027430","https://openalex.org/W2002920339","https://openalex.org/W2012171192","https://openalex.org/W2023485038","https://openalex.org/W2045498423","https://openalex.org/W2047892647","https://openalex.org/W2054046969","https://openalex.org/W2059013849","https://openalex.org/W2069816444","https://openalex.org/W2074888367","https://openalex.org/W2076520446","https://openalex.org/W2079883356","https://openalex.org/W2083949193","https://openalex.org/W2087374707","https://openalex.org/W2102391253","https://openalex.org/W2105119061","https://openalex.org/W2106003398","https://openalex.org/W2109485534","https://openalex.org/W2111381386","https://openalex.org/W2118811112","https://openalex.org/W2119980272","https://openalex.org/W2126255160","https://openalex.org/W2137813387","https://openalex.org/W2140302517","https://openalex.org/W2140306145","https://openalex.org/W2147426453","https://openalex.org/W2154288487","https://openalex.org/W2162723250","https://openalex.org/W2166305102","https://openalex.org/W2168309258","https://openalex.org/W2178717736","https://openalex.org/W2561810854","https://openalex.org/W2895573662"],"related_works":["https://openalex.org/W3074439918","https://openalex.org/W2097232710","https://openalex.org/W1973926441","https://openalex.org/W2615051093","https://openalex.org/W2126588030","https://openalex.org/W2156508144","https://openalex.org/W2802368924","https://openalex.org/W2767644752","https://openalex.org/W2025187757","https://openalex.org/W2162936913"],"abstract_inverted_index":{"<b><i>Introduction:</i></b>":[0],"The":[1,19,57,102,142],"cingulum":[2,42,211],"bundle":[3,43],"and":[4,17,33,40,105,125,135,171,179,199,204,237],"uncinate":[5,38,111,181],"fasciculus":[6,39,182],"are":[7],"major":[8],"limbic":[9,228],"white":[10,78,247],"matter":[11,79,248],"tracts":[12,229],"involved":[13],"in":[14,50,207],"emotion,":[15],"memory,":[16],"cognition.":[18],"main":[20],"goal":[21,59],"of":[22,36,54,65,76,250],"the":[23,29,37,41,63,66,73,174,180,186,192,208,214,218,238,251],"present":[24],"study":[25,225],"was":[26,60,150,161],"to":[27,61],"investigate":[28],"relationship":[30],"between":[31],"age":[32,160],"structural":[34],"properties":[35,249],"using":[44,115,152],"diffusion":[45],"tensor":[46,138],"imaging":[47,100],"(DTI)":[48],"tractography":[49],"a":[51,96],"large":[52],"cohort":[53],"healthy":[55,85,235],"individuals.":[56],"second":[58],"determine":[62],"effects":[64],"catechol-<i>O</i>-methyl":[67],"transferase":[68],"(COMT)":[69],"gene":[70],"polymorphism":[71,144],"on":[72,95],"DTI":[74,90],"measurements":[75],"these":[77],"tracts.":[80],"<b><i>Methods:</i></b>":[81],"We":[82,157],"recruited":[83],"140":[84],"participants":[86],"(18-85":[87],"years":[88],"old).":[89],"data":[91],"sets":[92],"were":[93,113,140],"acquired":[94],"1.5T":[97],"magnetic":[98],"resonance":[99],"system.":[101],"rostral,":[103],"dorsal,":[104],"parahippocampal":[106,187],"cingulum,":[107,176,178],"as":[108,110],"well":[109],"fasciculus,":[112],"delineated":[114],"deterministic":[116],"tractography.":[117],"Fractional":[118],"anisotropy":[119],"(FA),":[120],"mean":[121],"(MD),":[122],"radial":[123],"(RD),":[124],"axial":[126],"(AD)":[127],"diffusivities,":[128],"tract":[129],"volume,":[130],"linear":[131],"(<i>C<sub>l</sub></i>),":[132],"planar":[133],"(<i>C<sub>p</sub></i>),":[134],"spherical":[136],"(<i>C<sub>s</sub></i>)":[137],"shapes":[139],"calculated.":[141],"COMT":[143,193],"(methionine":[145],"homozygous":[146,195,240],"vs.":[147],"valine":[148,215],"carriers)":[149],"determined":[151],"single":[153],"nucleotide":[154],"polymorphism.":[155],"<b><i>Results:</i></b>":[156],"found":[158],"that":[159,227],"negatively":[162],"associated":[163,168,244],"with":[164,169,191,213,245],"FA,":[165],"but":[166,183],"positively":[167],"MD":[170],"RD":[172],"for":[173,185],"rostral":[175,210,253],"dorsal":[177],"not":[184],"cingulum.":[188,254],"Furthermore,":[189],"individuals":[190],"methionine":[194,239],"had":[196],"higher":[197],"FA":[198],"lower":[200],"MD,":[201],"RD,":[202],"AD,":[203],"<i>C<sub>s</sub></i>":[205],"values":[206],"right":[209,252],"compared":[212],"carriers":[216],"across":[217],"entire":[219],"adult":[220],"life":[221],"span.":[222],"<b><i>Discussion:</i></b>":[223],"This":[224],"indicates":[226],"might":[230,242],"be":[231,243],"nonuniformly":[232],"affected":[233],"by":[234],"aging,":[236],"genotype":[241],"micro/macro":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":1}],"updated_date":"2026-03-10T16:38:18.471706","created_date":"2025-10-10T00:00:00"}
