{"id":"https://openalex.org/W2521565383","doi":"https://doi.org/10.1089/cmb.2016.0095","title":"EpiGeNet: A Graph Database of Interdependencies Between Genetic and Epigenetic Events in Colorectal Cancer","display_name":"EpiGeNet: A Graph Database of Interdependencies Between Genetic and Epigenetic Events in Colorectal Cancer","publication_year":2016,"publication_date":"2016-09-14","ids":{"openalex":"https://openalex.org/W2521565383","doi":"https://doi.org/10.1089/cmb.2016.0095","mag":"2521565383","pmid":"https://pubmed.ncbi.nlm.nih.gov/27627442"},"language":"en","primary_location":{"id":"doi:10.1089/cmb.2016.0095","is_oa":true,"landing_page_url":"https://doi.org/10.1089/cmb.2016.0095","pdf_url":"https://www.liebertpub.com/doi/pdf/10.1089/cmb.2016.0095","source":{"id":"https://openalex.org/S78571599","display_name":"Journal of Computational Biology","issn_l":"1066-5277","issn":["1066-5277","1557-8666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443"],"host_organization_lineage_names":["Mary Ann Liebert, Inc."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.liebertpub.com/doi/pdf/10.1089/cmb.2016.0095","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071459650","display_name":"Irina Balaur","orcid":"https://orcid.org/0000-0002-3671-895X"},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Irina Balaur","raw_affiliation_strings":["European Institute for Systems Biology and Medicine (EISBM), CIRI UMR CNRS 5308, CNRS-ENS-UCBL-INSERM, Universit\u00e9 Claude Bernard, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Institute for Systems Biology and Medicine (EISBM), CIRI UMR CNRS 5308, CNRS-ENS-UCBL-INSERM, Universit\u00e9 Claude Bernard, Lyon, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068307947","display_name":"Mansoor Saqi","orcid":"https://orcid.org/0000-0003-1222-475X"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mansoor Saqi","raw_affiliation_strings":["European Institute for Systems Biology and Medicine (EISBM), CIRI UMR CNRS 5308, CNRS-ENS-UCBL-INSERM, Universit\u00e9 Claude Bernard, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Institute for Systems Biology and Medicine (EISBM), CIRI UMR CNRS 5308, CNRS-ENS-UCBL-INSERM, Universit\u00e9 Claude Bernard, Lyon, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066565774","display_name":"Ana Barat","orcid":"https://orcid.org/0000-0001-7164-5322"},"institutions":[{"id":"https://openalex.org/I142762351","display_name":"Royal College of Surgeons in Ireland","ror":"https://ror.org/01hxy9878","country_code":"IE","type":"education","lineage":["https://openalex.org/I142762351"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Ana Barat","raw_affiliation_strings":["Department of Physiology and Medical Physics, Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology and Medical Physics, Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland","institution_ids":["https://openalex.org/I142762351"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068144584","display_name":"Artem Lysenko","orcid":"https://orcid.org/0000-0002-1441-0604"},"institutions":[{"id":"https://openalex.org/I2799553609","display_name":"Rothamsted Research","ror":"https://ror.org/0347fy350","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2799553609","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Artem Lysenko","raw_affiliation_strings":["Rothamsted Research, Hertfordshire, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rothamsted Research, Hertfordshire, United Kingdom","institution_ids":["https://openalex.org/I2799553609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044361124","display_name":"Alexander Mazein","orcid":"https://orcid.org/0000-0001-7137-4171"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander Mazein","raw_affiliation_strings":["European Institute for Systems Biology and Medicine (EISBM), CIRI UMR CNRS 5308, CNRS-ENS-UCBL-INSERM, Universit\u00e9 Claude Bernard, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Institute for Systems Biology and Medicine (EISBM), CIRI UMR CNRS 5308, CNRS-ENS-UCBL-INSERM, Universit\u00e9 Claude Bernard, Lyon, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038901466","display_name":"Chris Rawlings","orcid":"https://orcid.org/0000-0003-3702-1633"},"institutions":[{"id":"https://openalex.org/I2799553609","display_name":"Rothamsted Research","ror":"https://ror.org/0347fy350","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2799553609","https://openalex.org/I2799693246","https://openalex.org/I4210087105"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Christopher J. Rawlings","raw_affiliation_strings":["Rothamsted Research, Hertfordshire, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rothamsted Research, Hertfordshire, United Kingdom","institution_ids":["https://openalex.org/I2799553609"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022379752","display_name":"Heather J. Ruskin","orcid":"https://orcid.org/0000-0001-7101-2242"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Heather J. Ruskin","raw_affiliation_strings":["Centre for Scientific Computing and Complex Systems Modelling, School of Computing, Dublin City University, Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Scientific Computing and Complex Systems Modelling, School of Computing, Dublin City University, Dublin, Ireland","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5055008823","display_name":"Charles Auffray","orcid":"https://orcid.org/0000-0003-2226-7411"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles Auffray","raw_affiliation_strings":["European Institute for Systems Biology and Medicine (EISBM), CIRI UMR CNRS 5308, CNRS-ENS-UCBL-INSERM, Universit\u00e9 Claude Bernard, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"European Institute for Systems Biology and Medicine (EISBM), CIRI UMR CNRS 5308, CNRS-ENS-UCBL-INSERM, Universit\u00e9 Claude Bernard, Lyon, France","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5071459650"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0503,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.8710851,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"24","issue":"10","first_page":"969","last_page":"980"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9776999950408936,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12292","display_name":"Graph Theory and Algorithms","score":0.9772999882698059,"subfield":{"id":"https://openalex.org/subfields/1707","display_name":"Computer Vision and Pattern Recognition"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.7575901746749878},{"id":"https://openalex.org/keywords/graph-database","display_name":"Graph database","score":0.5450780987739563},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4968293011188507},{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"Colorectal cancer","score":0.43199461698532104},{"id":"https://openalex.org/keywords/carcinogenesis","display_name":"Carcinogenesis","score":0.41007208824157715},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3863089084625244},{"id":"https://openalex.org/keywords/database","display_name":"Database","score":0.3768625259399414},{"id":"https://openalex.org/keywords/graph","display_name":"Graph","score":0.35437285900115967},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3424811363220215},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.25299111008644104},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.21280595660209656},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.15378794074058533},{"id":"https://openalex.org/keywords/theoretical-computer-science","display_name":"Theoretical computer science","score":0.1526256799697876}],"concepts":[{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7575901746749878},{"id":"https://openalex.org/C176225458","wikidata":"https://www.wikidata.org/wiki/Q595971","display_name":"Graph database","level":3,"score":0.5450780987739563},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4968293011188507},{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.43199461698532104},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.41007208824157715},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3863089084625244},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.3768625259399414},{"id":"https://openalex.org/C132525143","wikidata":"https://www.wikidata.org/wiki/Q141488","display_name":"Graph","level":2,"score":0.35437285900115967},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3424811363220215},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.25299111008644104},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.21280595660209656},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15378794074058533},{"id":"https://openalex.org/C80444323","wikidata":"https://www.wikidata.org/wiki/Q2878974","display_name":"Theoretical computer science","level":1,"score":0.1526256799697876}],"mesh":[{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003196","descriptor_name":"Computer Graphics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015179","descriptor_name":"Colorectal Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1089/cmb.2016.0095","is_oa":true,"landing_page_url":"https://doi.org/10.1089/cmb.2016.0095","pdf_url":"https://www.liebertpub.com/doi/pdf/10.1089/cmb.2016.0095","source":{"id":"https://openalex.org/S78571599","display_name":"Journal of Computational Biology","issn_l":"1066-5277","issn":["1066-5277","1557-8666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443"],"host_organization_lineage_names":["Mary Ann Liebert, Inc."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computational Biology","raw_type":"journal-article"},{"id":"pmid:27627442","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27627442","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of computational biology : a journal of computational molecular cell biology","raw_type":null}],"best_oa_location":{"id":"doi:10.1089/cmb.2016.0095","is_oa":true,"landing_page_url":"https://doi.org/10.1089/cmb.2016.0095","pdf_url":"https://www.liebertpub.com/doi/pdf/10.1089/cmb.2016.0095","source":{"id":"https://openalex.org/S78571599","display_name":"Journal of Computational Biology","issn_l":"1066-5277","issn":["1066-5277","1557-8666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443"],"host_organization_lineage_names":["Mary Ann Liebert, Inc."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G2014059278","display_name":"From data to knowledge / the ONDEX System for integrating Life Sciences data sources","funder_award_id":"BB/F006039/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G2633328597","display_name":null,"funder_award_id":"BB/F006039/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G3829048491","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G3971285033","display_name":null,"funder_award_id":"115446","funder_id":"https://openalex.org/F4320326631","funder_display_name":"Innovative Medicines Initiative"},{"id":"https://openalex.org/G4697817625","display_name":"QTLNetMiner: Mining Candidate Gene Networks From Genetic Studies of Crops and Animals","funder_award_id":"BB/I023860/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G4839539168","display_name":"Delivering  European Translational Information & Knowledge Management Services","funder_award_id":"115446","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5199557389","display_name":null,"funder_award_id":"BB/I023860/1","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G5593277320","display_name":null,"funder_award_id":"2007-2013","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5702163051","display_name":null,"funder_award_id":"FP7/2007","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G6649312515","display_name":null,"funder_award_id":"CNRS/IN2P3","funder_id":"https://openalex.org/F4320335860","funder_display_name":"Institut National de Physique Nucl\u00e9aire et de Physique des Particules"},{"id":"https://openalex.org/G7195248210","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320326631","funder_display_name":"Innovative Medicines Initiative"},{"id":"https://openalex.org/G7364720146","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320314178","funder_display_name":"European Federation of Pharmaceutical Industries and Associations"},{"id":"https://openalex.org/G8290710666","display_name":null,"funder_award_id":"BBS/E/C/00004655","funder_id":"https://openalex.org/F4320334629","funder_display_name":"Biotechnology and Biological Sciences Research Council"},{"id":"https://openalex.org/G934046830","display_name":null,"funder_award_id":"CNRS/IN2P3","funder_id":"https://openalex.org/F4320322892","funder_display_name":"Centre National de la Recherche Scientifique"}],"funders":[{"id":"https://openalex.org/F4320314178","display_name":"European Federation of Pharmaceutical Industries and Associations","ror":"https://ror.org/00g1x4v36"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320322892","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73"},{"id":"https://openalex.org/F4320326631","display_name":"Innovative Medicines Initiative","ror":"https://ror.org/019af4n30"},{"id":"https://openalex.org/F4320334629","display_name":"Biotechnology and Biological Sciences Research Council","ror":"https://ror.org/00cwqg982"},{"id":"https://openalex.org/F4320335860","display_name":"Institut National de Physique Nucl\u00e9aire et de Physique des Particules","ror":"https://ror.org/03fd77x13"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2521565383.pdf","grobid_xml":"https://content.openalex.org/works/W2521565383.grobid-xml"},"referenced_works_count":29,"referenced_works":["https://openalex.org/W1835750525","https://openalex.org/W1975194044","https://openalex.org/W1976626368","https://openalex.org/W1997890656","https://openalex.org/W2000156285","https://openalex.org/W2004271888","https://openalex.org/W2009552880","https://openalex.org/W2016302314","https://openalex.org/W2017375853","https://openalex.org/W2023258833","https://openalex.org/W2033307063","https://openalex.org/W2041686632","https://openalex.org/W2042530916","https://openalex.org/W2082788171","https://openalex.org/W2100932663","https://openalex.org/W2118151336","https://openalex.org/W2123604001","https://openalex.org/W2134845483","https://openalex.org/W2137052779","https://openalex.org/W2140445011","https://openalex.org/W2142257318","https://openalex.org/W2156735784","https://openalex.org/W2158115943","https://openalex.org/W2158419964","https://openalex.org/W2166215505","https://openalex.org/W2301934630","https://openalex.org/W2412164231","https://openalex.org/W2496792076","https://openalex.org/W2739999456"],"related_works":["https://openalex.org/W4366603091","https://openalex.org/W2136708078","https://openalex.org/W2083798468","https://openalex.org/W2411374999","https://openalex.org/W4380318195","https://openalex.org/W2008978345","https://openalex.org/W2014135975","https://openalex.org/W3115442681","https://openalex.org/W2391000461","https://openalex.org/W4386112722"],"abstract_inverted_index":{"The":[0,174],"development":[1],"of":[2,15,73,107,120,128,132,184],"colorectal":[3,121,137],"cancer":[4,9],"(CRC)-the":[5],"third":[6],"most":[7,152],"common":[8],"type-has":[10],"been":[11],"associated":[12,172],"with":[13],"deregulations":[14],"cellular":[16],"mechanisms":[17],"stimulated":[18],"by":[19,81],"both":[20],"genetic":[21,38,155],"and":[22,30,39,42,93,105,113,156,162,171,182,193],"epigenetic":[23,40,157],"events.":[24,173],"StatEpigen":[25,49,92],"is":[26],"a":[27,51,83,100],"manually":[28],"curated":[29],"annotated":[31],"database,":[32],"containing":[33],"information":[34,57],"on":[35,186],"interdependencies":[36,158],"between":[37,63,110],"signals,":[41],"specialized":[43],"currently":[44],"for":[45,56,103,130,146,180],"CRC":[46,170,191],"research.":[47],"Although":[48],"provides":[50],"well-developed":[52],"graphical":[53],"user":[54],"interface":[55],"retrieval,":[58],"advanced":[59],"queries":[60,134],"involving":[61],"associations":[62],"multiple":[64],"concepts":[65],"can":[66,78],"benefit":[67],"from":[68,91],"more":[69],"detailed":[70],"graph":[71,84,101],"representation":[72],"the":[74,125,143],"integrated":[75],"data.":[76],"This":[77],"be":[79],"achieved":[80],"using":[82],"database":[85,102],"(NoSQL)":[86],"approach.":[87],"Data":[88],"were":[89],"extracted":[90],"imported":[94],"to":[95,136,190],"our":[96],"newly":[97],"developed":[98],"EpiGeNet,":[99],"storage":[104],"querying":[106],"conditional":[108],"relationships":[109],"molecular":[111,149,187],"(genetic":[112],"epigenetic)":[114],"events":[115,188],"observed":[116,154],"at":[117],"different":[118,133],"stages":[119],"oncogenesis.":[122],"We":[123],"illustrate":[124],"enhanced":[126],"capability":[127,179],"EpiGeNet":[129,175],"exploration":[131],"related":[135],"tumor":[138],"progression;":[139],"specifically,":[140],"we":[141],"demonstrate":[142],"query":[144],"process":[145],"(i)":[147],"stage-specific":[148],"events,":[150],"(ii)":[151],"frequently":[153],"in":[159,169],"colon":[160],"adenoma,":[161],"(iii)":[163],"paths":[164],"connecting":[165],"key":[166],"genes":[167],"reported":[168],"framework":[176],"offers":[177],"improved":[178],"management":[181],"visualization":[183],"data":[185],"specific":[189],"initiation":[192],"progression.":[194]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":1}],"updated_date":"2025-12-23T23:11:35.936235","created_date":"2025-10-10T00:00:00"}