{"id":"https://openalex.org/W2020019892","doi":"https://doi.org/10.1089/1066527041887366","title":"Comparing DNA Damage-Processing Pathways by Computer Analysis of Chromosome Painting Data","display_name":"Comparing DNA Damage-Processing Pathways by Computer Analysis of Chromosome Painting Data","publication_year":2004,"publication_date":"2004-07-01","ids":{"openalex":"https://openalex.org/W2020019892","doi":"https://doi.org/10.1089/1066527041887366","mag":"2020019892","pmid":"https://pubmed.ncbi.nlm.nih.gov/15579235"},"language":"en","primary_location":{"id":"doi:10.1089/1066527041887366","doi":"https://doi.org/10.1089/1066527041887366","is_oa":false,"landing_page_url":"https://doi.org/10.1089/1066527041887366","pdf_url":null,"source":{"id":"https://openalex.org/S78571599","display_name":"Journal of Computational Biology","issn_l":"1066-5277","issn":["1066-5277","1557-8666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computational Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Dan Levy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dan Levy","raw_affiliation_strings":["","Mathematics Department, University of California at Berkeley, Berkeley, CA 94720, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Mathematics Department, University of California at Berkeley, Berkeley, CA 94720, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087620774","display_name":"Mariel V\u00e1zquez","orcid":"https://orcid.org/0000-0001-8328-6806","observed_orcids":["https://orcid.org/0000-0001-8328-6806"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mariel Vazquez","raw_affiliation_strings":["","Mathematics Department, University of California at Berkeley, Berkeley, CA 94720"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Mathematics Department, University of California at Berkeley, Berkeley, CA 94720","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048752550","display_name":"Michael N. Cornforth","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Cornforth","raw_affiliation_strings":["","Department of Radiation Oncology, The University of Texas Medical Branch, Galveston, TX 77555"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Department of Radiation Oncology, The University of Texas Medical Branch, Galveston, TX 77555","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041963992","display_name":"Bradford D. Loucas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bradford Loucas","raw_affiliation_strings":["","Department of Radiation Oncology, The University of Texas Medical Branch, Galveston, TX 77555"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Department of Radiation Oncology, The University of Texas Medical Branch, Galveston, TX 77555","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105986180","display_name":"Rainer K. Sachs","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rainer K. Sachs","raw_affiliation_strings":["","Mathematics Department, University of California at Berkeley, Berkeley, CA 94720"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Mathematics Department, University of California at Berkeley, Berkeley, CA 94720","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077553966","display_name":"Javier Arsuaga","orcid":"https://orcid.org/0000-0002-4979-8215","observed_orcids":["https://orcid.org/0000-0002-4979-8215"]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Javier Arsuaga","raw_affiliation_strings":["","Mathematics Department, University of California at Berkeley, Berkeley, CA 94720","Molecular and Cell Biology Department, University of California at Berkeley, Berkeley, CA 94720"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Mathematics Department, University of California at Berkeley, Berkeley, CA 94720","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"Molecular and Cell Biology Department, University of California at Berkeley, Berkeley, CA 94720","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.984,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.71217184,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"11","issue":"4","first_page":"626","last_page":"641"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.7939000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10123","display_name":"DNA Repair Mechanisms","score":0.7939000129699707,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.04769999906420708,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13664","display_name":"Genome Rearrangement Algorithms","score":0.04600000008940697,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chromosomal-abnormalities","display_name":"chromosomal abnormalities","score":0.9670000076293945},{"id":"https://openalex.org/keywords/dna-damage-processing","display_name":"DNA damage processing","score":0.7879999876022339},{"id":"https://openalex.org/keywords/chromosome-painting","display_name":"chromosome painting","score":0.9449999928474426},{"id":"https://openalex.org/keywords/cycle-decomposition","display_name":"cycle decomposition","score":0.6370000243186951},{"id":"https://openalex.org/keywords/graph-theory","display_name":"graph theory","score":0.625},{"id":"https://openalex.org/keywords/computer-algorithms","display_name":"computational algorithms","score":0.3529999852180481}],"concepts":[{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6248637437820435},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5299604535102844},{"id":"https://openalex.org/C2781188995","wikidata":"https://www.wikidata.org/wiki/Q6934982","display_name":"Multiplex","level":2,"score":0.5076414346694946},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4774911105632782},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.47655966877937317},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4602765738964081},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.45401349663734436},{"id":"https://openalex.org/C2994296024","wikidata":"https://www.wikidata.org/wiki/Q744962","display_name":"Chromosome aberration","level":4,"score":0.414779394865036},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.33744317293167114},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.3221881091594696},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15002384781837463}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003627","descriptor_name":"Data Interpretation, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004249","descriptor_name":"DNA Damage","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008433","descriptor_name":"Mathematics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017404","descriptor_name":"In Situ Hybridization, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020223","descriptor_name":"Chromosome Painting","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020223","descriptor_name":"Chromosome Painting","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020223","descriptor_name":"Chromosome Painting","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1089/1066527041887366","doi":"https://doi.org/10.1089/1066527041887366","is_oa":false,"landing_page_url":"https://doi.org/10.1089/1066527041887366","pdf_url":null,"source":{"id":"https://openalex.org/S78571599","display_name":"Journal of Computational Biology","issn_l":"1066-5277","issn":["1066-5277","1557-8666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computational Biology","raw_type":"journal-article"},{"id":"doi:10.1089/cmb.2004.11.626","doi":"https://doi.org/10.1089/cmb.2004.11.626","is_oa":false,"landing_page_url":"https://doi.org/10.1089/cmb.2004.11.626","pdf_url":null,"source":{"id":"https://openalex.org/S78571599","display_name":"Journal of Computational Biology","issn_l":"1066-5277","issn":["1066-5277","1557-8666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443","https://openalex.org/P4310320017"],"host_organization_lineage_names":["Mary Ann Liebert, Inc.","SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computational Biology","raw_type":"journal-article"},{"id":"pmid:15579235","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15579235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of computational biology : a journal of computational molecular cell biology","raw_type":"Comparative Study"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.161.7145","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.161.7145","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://math.sfsu.edu/vazquez/Levy04.pdf","raw_type":"text"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1814569855","display_name":null,"funder_award_id":"GM 68423","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G2226748148","display_name":null,"funder_award_id":"CA76260","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G394606135","display_name":null,"funder_award_id":"P30-ES01896","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W1490430289","https://openalex.org/W1509538618","https://openalex.org/W1543325825","https://openalex.org/W1600463518","https://openalex.org/W1982417445","https://openalex.org/W2000311152","https://openalex.org/W2000836329","https://openalex.org/W2017081319","https://openalex.org/W2023508619","https://openalex.org/W2036885055","https://openalex.org/W2037479635","https://openalex.org/W2041397659","https://openalex.org/W2056129638","https://openalex.org/W2058800908","https://openalex.org/W2059481733","https://openalex.org/W2072294308","https://openalex.org/W2074427839","https://openalex.org/W2075206831","https://openalex.org/W2076328665","https://openalex.org/W2095006567","https://openalex.org/W2099923914","https://openalex.org/W2104354381","https://openalex.org/W2110324506","https://openalex.org/W2113741637","https://openalex.org/W2119855736","https://openalex.org/W2130871581","https://openalex.org/W2131745631","https://openalex.org/W2144160265","https://openalex.org/W2157622572","https://openalex.org/W2159479483","https://openalex.org/W2164080508","https://openalex.org/W2165720675","https://openalex.org/W2166687761","https://openalex.org/W2173010031","https://openalex.org/W2175518400","https://openalex.org/W2179101840","https://openalex.org/W2183103763","https://openalex.org/W2193477924","https://openalex.org/W2333763533","https://openalex.org/W4240950604"],"related_works":["https://openalex.org/W2263663981","https://openalex.org/W2368952999","https://openalex.org/W2086343121","https://openalex.org/W1600379936","https://openalex.org/W2004058902","https://openalex.org/W2379458154","https://openalex.org/W2050171995","https://openalex.org/W2314761016","https://openalex.org/W2415182150","https://openalex.org/W2048622055"],"abstract_inverted_index":{"Chromosome":[0],"aberrations":[1],"are":[2,10,51,63,71],"large-scale":[3],"illegitimate":[4],"rearrangements":[5],"of":[6,12,48,80,93,159],"the":[7,27,81,99,156],"genome.":[8],"They":[9],"indicative":[11],"DNA":[13],"damage":[14,18],"and":[15,50,68],"informative":[16],"about":[17],"processing":[19],"pathways.":[20],"Despite":[21],"extensive":[22],"investigations":[23],"over":[24],"many":[25],"years,":[26],"mechanisms":[28,152],"underlying":[29],"aberration":[30,55,61,131,143],"formation":[31,56,144],"remain":[32],"controversial.":[33],"New":[34],"experimental":[35],"assays":[36],"such":[37],"as":[38],"multiplex":[39],"fluorescent":[40],"in":[41,112,166],"situ":[42],"hybridyzation":[43],"(mFISH)":[44],"allow":[45],"combinatorial":[46],"\"painting\"":[47],"chromosomes":[49],"promising":[52],"for":[53,73,121],"elucidating":[54],"mechanisms.":[57,145],"Recently":[58],"observed":[59,127,165],"mFISH":[60,130],"patterns":[62],"so":[64],"complex":[65,160],"that":[66,106,135,150],"computer":[67],"graph-theoretical":[69],"methods":[70],"needed":[72],"their":[74],"full":[75],"analysis.":[76],"An":[77],"important":[78],"part":[79,111],"analysis":[82],"is":[83],"decomposing":[84],"a":[85,113],"chromosome":[86],"rearrangement":[87],"process":[88],"into":[89],"\"cycles.\"":[90],"A":[91],"cycle":[92,123],"order":[94],"n,":[95],"characterized":[96],"formally":[97],"by":[98],"cyclic":[100],"graph":[101],"with":[102],"2n":[103],"vertices,":[104],"indicates":[105],"n":[107],"chromatin":[108],"breaks":[109],"take":[110],"single":[114],"irreducible":[115],"reaction.":[116],"We":[117,133],"here":[118],"describe":[119],"algorithms":[120],"computing":[122],"structures":[124],"from":[125],"experimentally":[126],"or":[128],"computer-simulated":[129],"patterns.":[132],"show":[134,149],"analyzing":[136],"cycles":[137],"quantitatively":[138],"can":[139],"distinguish":[140],"between":[141],"different":[142],"In":[146],"particular,":[147],"we":[148],"homology-based":[151],"do":[153],"not":[154],"generate":[155],"large":[157],"number":[158],"aberrations,":[161],"involving":[162],"higher-order":[163],"cycles,":[164],"irradiated":[167],"human":[168],"lymphocytes.":[169]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2025-10-10T00:00:00"}