{"id":"https://openalex.org/W2088515634","doi":"https://doi.org/10.1089/brain.2014.0236","title":"Network Dysfunction in Alzheimer's Disease: Refining the Disconnection Hypothesis","display_name":"Network Dysfunction in Alzheimer's Disease: Refining the Disconnection Hypothesis","publication_year":2014,"publication_date":"2014-05-05","ids":{"openalex":"https://openalex.org/W2088515634","doi":"https://doi.org/10.1089/brain.2014.0236","mag":"2088515634","pmid":"https://pubmed.ncbi.nlm.nih.gov/24796856"},"language":"en","primary_location":{"id":"doi:10.1089/brain.2014.0236","is_oa":false,"landing_page_url":"https://doi.org/10.1089/brain.2014.0236","pdf_url":null,"source":{"id":"https://openalex.org/S2764941518","display_name":"Brain Connectivity","issn_l":"2158-0014","issn":["2158-0014","2158-0022"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443"],"host_organization_lineage_names":["Mary Ann Liebert, Inc."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Connectivity","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://digitalcommons.wustl.edu/open_access_pubs/4695","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026771730","display_name":"Matthew R. Brier","orcid":"https://orcid.org/0000-0001-5987-8705"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Matthew R. Brier","raw_affiliation_strings":["Department of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri","Program in Neuroscience, Division of Biological and Biomedical Science, School of Medicine, Washington University in St. Louis, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri","institution_ids":[]},{"raw_affiliation_string":"Program in Neuroscience, Division of Biological and Biomedical Science, School of Medicine, Washington University in St. Louis, St. Louis, Missouri","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110030233","display_name":"Jewell B. Thomas","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jewell B. Thomas","raw_affiliation_strings":["Department of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076073942","display_name":"Beau M. Ances","orcid":"https://orcid.org/0000-0003-3862-7397"},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]},{"id":"https://openalex.org/I4210123851","display_name":"Hope Center for Neurological Disorders","ror":"https://ror.org/035nzyk88","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210123851"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Beau M. Ances","raw_affiliation_strings":["Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri","Department of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri","Department of Radiology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri","Hope Center for Neurological Disorders, Washington University in St. Louis, St. Louis, Missouri","Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, Missouri"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Neurology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri","institution_ids":[]},{"raw_affiliation_string":"Department of Radiology, School of Medicine, Washington University in St. Louis, St. Louis, Missouri","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Hope Center for Neurological Disorders, Washington University in St. Louis, St. Louis, Missouri","institution_ids":["https://openalex.org/I4210123851","https://openalex.org/I204465549"]},{"raw_affiliation_string":"Knight Alzheimer's Disease Research Center, Washington University in St. Louis, St. Louis, Missouri","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5076073942"],"corresponding_institution_ids":["https://openalex.org/I204465549","https://openalex.org/I4210123851"],"apc_list":null,"apc_paid":null,"fwci":5.844,"has_fulltext":true,"cited_by_count":206,"citation_normalized_percentile":{"value":0.96848446,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"4","issue":"5","first_page":"299","last_page":"311"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9889000058174133,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.984499990940094,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/functional-connectivity","display_name":"Functional connectivity","score":0.8180639743804932},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.6761345267295837},{"id":"https://openalex.org/keywords/disconnection","display_name":"Disconnection","score":0.6641679406166077},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.6377196311950684},{"id":"https://openalex.org/keywords/resting-state-fmri","display_name":"Resting state fMRI","score":0.5564596056938171},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.4504205286502838},{"id":"https://openalex.org/keywords/functional-impairment","display_name":"Functional impairment","score":0.4478882849216461},{"id":"https://openalex.org/keywords/default-mode-network","display_name":"Default mode network","score":0.4320133328437805},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.42451170086860657},{"id":"https://openalex.org/keywords/cognitive-science","display_name":"Cognitive science","score":0.33118459582328796},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2628268599510193},{"id":"https://openalex.org/keywords/psychiatry","display_name":"Psychiatry","score":0.14055931568145752},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1389111876487732},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.07056224346160889}],"concepts":[{"id":"https://openalex.org/C3018011982","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Functional connectivity","level":2,"score":0.8180639743804932},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6761345267295837},{"id":"https://openalex.org/C2780371621","wikidata":"https://www.wikidata.org/wiki/Q3709910","display_name":"Disconnection","level":2,"score":0.6641679406166077},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.6377196311950684},{"id":"https://openalex.org/C66324658","wikidata":"https://www.wikidata.org/wiki/Q7316120","display_name":"Resting state fMRI","level":2,"score":0.5564596056938171},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.4504205286502838},{"id":"https://openalex.org/C2993918154","wikidata":"https://www.wikidata.org/wiki/Q12131","display_name":"Functional impairment","level":2,"score":0.4478882849216461},{"id":"https://openalex.org/C141516989","wikidata":"https://www.wikidata.org/wiki/Q1182555","display_name":"Default mode network","level":3,"score":0.4320133328437805},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.42451170086860657},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.33118459582328796},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2628268599510193},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.14055931568145752},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1389111876487732},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.07056224346160889},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D009434","descriptor_name":"Neural Pathways","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1089/brain.2014.0236","is_oa":false,"landing_page_url":"https://doi.org/10.1089/brain.2014.0236","pdf_url":null,"source":{"id":"https://openalex.org/S2764941518","display_name":"Brain Connectivity","issn_l":"2158-0014","issn":["2158-0014","2158-0022"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443"],"host_organization_lineage_names":["Mary Ann Liebert, Inc."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Connectivity","raw_type":"journal-article"},{"id":"pmid:24796856","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24796856","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain connectivity","raw_type":null},{"id":"pmh:oai:digitalcommons.wustl.edu:open_access_pubs-5709","is_oa":true,"landing_page_url":"https://digitalcommons.wustl.edu/open_access_pubs/4695","pdf_url":"https://digitalcommons.wustl.edu/open_access_pubs/4695","source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications","raw_type":"text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4064730","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4064730","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Brain Connect","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:digitalcommons.wustl.edu:open_access_pubs-5709","is_oa":true,"landing_page_url":"https://digitalcommons.wustl.edu/open_access_pubs/4695","pdf_url":"https://digitalcommons.wustl.edu/open_access_pubs/4695","source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications","raw_type":"text"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G194882960","display_name":null,"funder_award_id":"R21MH099979","funder_id":"https://openalex.org/F4320337346","funder_display_name":"National Institute of Mental Health"},{"id":"https://openalex.org/G2384317924","display_name":null,"funder_award_id":"R01NR012657","funder_id":"https://openalex.org/F4320337353","funder_display_name":"National Institute of Nursing Research"},{"id":"https://openalex.org/G4254044632","display_name":null,"funder_award_id":"R01 NR012907","funder_id":"https://openalex.org/F4320337353","funder_display_name":"National Institute of Nursing Research"},{"id":"https://openalex.org/G4261530155","display_name":null,"funder_award_id":"R01NR012907","funder_id":"https://openalex.org/F4320337353","funder_display_name":"National Institute of Nursing Research"},{"id":"https://openalex.org/G4449353164","display_name":null,"funder_award_id":"R01NR012907","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4922028077","display_name":null,"funder_award_id":"R01NR014449","funder_id":"https://openalex.org/F4320337353","funder_display_name":"National Institute of Nursing Research"},{"id":"https://openalex.org/G724744001","display_name":null,"funder_award_id":"R01NR012657","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8395381081","display_name":null,"funder_award_id":"R01NR014449","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8460935875","display_name":null,"funder_award_id":"R01 NR012657","funder_id":"https://openalex.org/F4320337353","funder_display_name":"National Institute of Nursing Research"}],"funders":[{"id":"https://openalex.org/F4320306219","display_name":"Alzheimer's Association","ror":"https://ror.org/0375f4d26"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337346","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08"},{"id":"https://openalex.org/F4320337353","display_name":"National Institute of Nursing Research","ror":"https://ror.org/01y3zfr79"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2088515634.pdf","grobid_xml":"https://content.openalex.org/works/W2088515634.grobid-xml"},"referenced_works_count":123,"referenced_works":["https://openalex.org/W39879652","https://openalex.org/W1486416255","https://openalex.org/W1760829075","https://openalex.org/W1806186915","https://openalex.org/W1967823816","https://openalex.org/W1970695058","https://openalex.org/W1971136065","https://openalex.org/W1971824641","https://openalex.org/W1973272857","https://openalex.org/W1973776237","https://openalex.org/W1974528285","https://openalex.org/W1974594322","https://openalex.org/W1976968567","https://openalex.org/W1979631864","https://openalex.org/W1983306600","https://openalex.org/W1983493842","https://openalex.org/W1985327120","https://openalex.org/W1985747467","https://openalex.org/W1989208474","https://openalex.org/W1990134753","https://openalex.org/W1991952617","https://openalex.org/W1993023011","https://openalex.org/W1993571512","https://openalex.org/W1999605218","https://openalex.org/W1999653836","https://openalex.org/W2000363330","https://openalex.org/W2002610924","https://openalex.org/W2002923643","https://openalex.org/W2007386823","https://openalex.org/W2007572953","https://openalex.org/W2009494091","https://openalex.org/W2009870816","https://openalex.org/W2011502145","https://openalex.org/W2011541551","https://openalex.org/W2016654175","https://openalex.org/W2018197567","https://openalex.org/W2022040401","https://openalex.org/W2033105539","https://openalex.org/W2035339855","https://openalex.org/W2035466596","https://openalex.org/W2035509566","https://openalex.org/W2038003980","https://openalex.org/W2041325253","https://openalex.org/W2042557239","https://openalex.org/W2049649543","https://openalex.org/W2050716103","https://openalex.org/W2051489981","https://openalex.org/W2051670319","https://openalex.org/W2052742260","https://openalex.org/W2054423686","https://openalex.org/W2058248579","https://openalex.org/W2059143861","https://openalex.org/W2064066094","https://openalex.org/W2066904587","https://openalex.org/W2067456724","https://openalex.org/W2067462624","https://openalex.org/W2068375947","https://openalex.org/W2070854761","https://openalex.org/W2073391538","https://openalex.org/W2074829442","https://openalex.org/W2080816290","https://openalex.org/W2082714165","https://openalex.org/W2084479203","https://openalex.org/W2087924155","https://openalex.org/W2087938247","https://openalex.org/W2088774650","https://openalex.org/W2089729956","https://openalex.org/W2093972428","https://openalex.org/W2094698071","https://openalex.org/W2095963715","https://openalex.org/W2100442068","https://openalex.org/W2100634972","https://openalex.org/W2101334128","https://openalex.org/W2103717170","https://openalex.org/W2107018300","https://openalex.org/W2109862162","https://openalex.org/W2112090702","https://openalex.org/W2113586298","https://openalex.org/W2114222094","https://openalex.org/W2114302768","https://openalex.org/W2115017507","https://openalex.org/W2115738813","https://openalex.org/W2118323338","https://openalex.org/W2124141514","https://openalex.org/W2124443688","https://openalex.org/W2126650951","https://openalex.org/W2128155135","https://openalex.org/W2129267808","https://openalex.org/W2129478224","https://openalex.org/W2129497119","https://openalex.org/W2130010412","https://openalex.org/W2131001963","https://openalex.org/W2132175842","https://openalex.org/W2132627224","https://openalex.org/W2135475851","https://openalex.org/W2136435696","https://openalex.org/W2137526583","https://openalex.org/W2138092999","https://openalex.org/W2138962340","https://openalex.org/W2138991775","https://openalex.org/W2143285014","https://openalex.org/W2143433106","https://openalex.org/W2149862198","https://openalex.org/W2155369114","https://openalex.org/W2155525875","https://openalex.org/W2156997013","https://openalex.org/W2158592797","https://openalex.org/W2160282855","https://openalex.org/W2162010696","https://openalex.org/W2163057869","https://openalex.org/W2165942026","https://openalex.org/W2167160506","https://openalex.org/W2167720733","https://openalex.org/W2167840686","https://openalex.org/W2168801837","https://openalex.org/W2169787465","https://openalex.org/W2171250577","https://openalex.org/W2171630967","https://openalex.org/W2575359420","https://openalex.org/W2582524520","https://openalex.org/W4211156109","https://openalex.org/W4235092975","https://openalex.org/W4295750005"],"related_works":["https://openalex.org/W2143570064","https://openalex.org/W2075991736","https://openalex.org/W3205149984","https://openalex.org/W2038307665","https://openalex.org/W2948361065","https://openalex.org/W2793605638","https://openalex.org/W1520477417","https://openalex.org/W1585336261","https://openalex.org/W3150454329","https://openalex.org/W4253292488"],"abstract_inverted_index":{"Much":[0],"effort":[1,19],"in":[2,22,36,142],"recent":[3],"years":[4],"has":[5,20,45],"focused":[6,59],"on":[7,15,60],"understanding":[8,100],"the":[9,32,61,86,107,123,133],"effects":[10],"of":[11,26,31,64,83,88,101,122,137],"Alzheimer's":[12],"disease":[13,71,73],"(AD)":[14],"neural":[16],"function.":[17],"This":[18],"resulted":[21],"an":[23],"enormous":[24],"number":[25],"papers":[27],"describing":[28],"different":[29],"facets":[30],"functional":[33,48,55,65,95,113,138],"derangement":[34],"seen":[35,141],"AD.":[37,143],"A":[38],"particularly":[39],"important":[40],"tool":[41],"for":[42,70],"these":[43,78],"investigations":[44],"been":[46],"resting-state":[47,54],"connectivity.":[49],"Attempts":[50],"to":[51,92],"comprehensively":[52],"synthesize":[53],"connectivity":[56,66,96,114,139],"results":[57],"have":[58],"potential":[62],"utility":[63],"as":[67],"a":[68,119,130],"biomarker":[69],"risk,":[72],"staging,":[74],"or":[75],"prognosis.":[76],"While":[77],"are":[79],"all":[80],"appropriate":[81],"uses":[82],"this":[84,89],"technique,":[85],"purpose":[87],"review":[90,121],"is":[91],"examine":[93,106],"how":[94],"disruptions":[97],"inform":[98],"our":[99],"AD":[102],"pathophysiology.":[103],"Here,":[104],"we":[105,128],"rationale":[108],"and":[109,116,135],"methodological":[110],"considerations":[111],"behind":[112],"studies":[115],"then":[117],"provide":[118],"critical":[120],"existing":[124],"literature.":[125],"In":[126],"conclusion,":[127],"propose":[129],"hypothesis":[131],"regarding":[132],"development":[134],"spread":[136],"deficits":[140]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":22},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":21},{"year":2022,"cited_by_count":33},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":23},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":15},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":13}],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-10-10T00:00:00"}