{"id":"https://openalex.org/W2094378111","doi":"https://doi.org/10.1089/10665270252935449","title":"Rapid Significance Estimation in Local Sequence Alignment with Gaps","display_name":"Rapid Significance Estimation in Local Sequence Alignment with Gaps","publication_year":2002,"publication_date":"2002-04-01","ids":{"openalex":"https://openalex.org/W2094378111","doi":"https://doi.org/10.1089/10665270252935449","mag":"2094378111","pmid":"https://pubmed.ncbi.nlm.nih.gov/12015880"},"language":"en","primary_location":{"id":"doi:10.1089/10665270252935449","is_oa":false,"landing_page_url":"https://doi.org/10.1089/10665270252935449","pdf_url":null,"source":{"id":"https://openalex.org/S78571599","display_name":"Journal of Computational Biology","issn_l":"1066-5277","issn":["1066-5277","1557-8666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443"],"host_organization_lineage_names":["Mary Ann Liebert, Inc."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044969846","display_name":"Ralf Bundschuh","orcid":"https://orcid.org/0000-0002-6699-8614"},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ralf Bundschuh","raw_affiliation_strings":["Department of Physics, Ohio State University, Columbus, OH 43210","Department of Physics, Ohio State University, Columbus, OH 43210,#N#USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physics, Ohio State University, Columbus, OH 43210","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Department of Physics, Ohio State University, Columbus, OH 43210,#N#USA","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5044969846"],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":null,"apc_paid":null,"fwci":1.0306,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.75334051,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"9","issue":"2","first_page":"243","last_page":"260"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11269","display_name":"Algorithms and Data Compression","score":0.9939000010490417,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9778000116348267,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gumbel-distribution","display_name":"Gumbel distribution","score":0.9593168497085571},{"id":"https://openalex.org/keywords/sequence","display_name":"Sequence (biology)","score":0.6929227113723755},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5854793787002563},{"id":"https://openalex.org/keywords/task","display_name":"Task (project management)","score":0.5616536736488342},{"id":"https://openalex.org/keywords/estimation","display_name":"Estimation","score":0.5401801466941833},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.5244182348251343},{"id":"https://openalex.org/keywords/distribution","display_name":"Distribution (mathematics)","score":0.466171532869339},{"id":"https://openalex.org/keywords/empirical-distribution-function","display_name":"Empirical distribution function","score":0.4513208568096161},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3402091860771179},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.3336677551269531},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.23868149518966675},{"id":"https://openalex.org/keywords/extreme-value-theory","display_name":"Extreme value theory","score":0.16360539197921753},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.09456866979598999},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.08078202605247498}],"concepts":[{"id":"https://openalex.org/C137610916","wikidata":"https://www.wikidata.org/wiki/Q1096862","display_name":"Gumbel distribution","level":3,"score":0.9593168497085571},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.6929227113723755},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5854793787002563},{"id":"https://openalex.org/C2780451532","wikidata":"https://www.wikidata.org/wiki/Q759676","display_name":"Task (project management)","level":2,"score":0.5616536736488342},{"id":"https://openalex.org/C96250715","wikidata":"https://www.wikidata.org/wiki/Q965330","display_name":"Estimation","level":2,"score":0.5401801466941833},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.5244182348251343},{"id":"https://openalex.org/C110121322","wikidata":"https://www.wikidata.org/wiki/Q865811","display_name":"Distribution (mathematics)","level":2,"score":0.466171532869339},{"id":"https://openalex.org/C98385598","wikidata":"https://www.wikidata.org/wiki/Q1339385","display_name":"Empirical distribution function","level":2,"score":0.4513208568096161},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3402091860771179},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.3336677551269531},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.23868149518966675},{"id":"https://openalex.org/C147581598","wikidata":"https://www.wikidata.org/wiki/Q729429","display_name":"Extreme value theory","level":2,"score":0.16360539197921753},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.09456866979598999},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.08078202605247498},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/10665270252935449","is_oa":false,"landing_page_url":"https://doi.org/10.1089/10665270252935449","pdf_url":null,"source":{"id":"https://openalex.org/S78571599","display_name":"Journal of Computational Biology","issn_l":"1066-5277","issn":["1066-5277","1557-8666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443"],"host_organization_lineage_names":["Mary Ann Liebert, Inc."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computational Biology","raw_type":"journal-article"},{"id":"pmid:12015880","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12015880","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of computational biology : a journal of computational molecular cell biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":28,"referenced_works":["https://openalex.org/W1659313070","https://openalex.org/W1965998064","https://openalex.org/W1988670311","https://openalex.org/W2015292449","https://openalex.org/W2015315215","https://openalex.org/W2026257220","https://openalex.org/W2026586467","https://openalex.org/W2032295681","https://openalex.org/W2034123395","https://openalex.org/W2041976742","https://openalex.org/W2045067706","https://openalex.org/W2048102092","https://openalex.org/W2054698853","https://openalex.org/W2054849588","https://openalex.org/W2055043387","https://openalex.org/W2057177664","https://openalex.org/W2064640453","https://openalex.org/W2070220641","https://openalex.org/W2072340282","https://openalex.org/W2074231493","https://openalex.org/W2089499735","https://openalex.org/W2091913260","https://openalex.org/W2094519647","https://openalex.org/W2102479256","https://openalex.org/W2133312664","https://openalex.org/W2139621307","https://openalex.org/W2143210482","https://openalex.org/W2158714788"],"related_works":["https://openalex.org/W3102632868","https://openalex.org/W2081647779","https://openalex.org/W1998707102","https://openalex.org/W2032649343","https://openalex.org/W1558704946","https://openalex.org/W4237750775","https://openalex.org/W3128051602","https://openalex.org/W3103393851","https://openalex.org/W2319091001","https://openalex.org/W1979053898"],"abstract_inverted_index":{"In":[0],"order":[1],"to":[2,12],"assess":[3],"the":[4,14,33,40,44,47,68,72,81,105],"significance":[5,102],"of":[6,16,19,21,35,39,46,49,67,71,86,107],"sequence":[7],"alignments,":[8],"it":[9,28],"is":[10,29,38,52],"crucial":[11],"know":[13],"distribution":[15,37,51],"alignment":[17],"scores":[18],"pairs":[20],"random":[22],"sequences.":[23],"For":[24],"gapped":[25],"local":[26],"alignment,":[27],"empirically":[30],"known":[31],"that":[32],"shape":[34],"this":[36,50],"Gumbel":[41,73],"form.":[42],"However,":[43],"determination":[45],"parameters":[48,74],"a":[53,60,92,95,99],"computationally":[54],"very":[55],"expensive":[56],"task.":[57],"We":[58],"present":[59],"new":[61],"algorithmic":[62],"approach":[63],"which":[64],"allows":[65],"estimation":[66,103],"more":[69],"important":[70],"at":[75],"least":[76],"five":[77],"times":[78],"faster":[79],"than":[80,91],"traditional":[82],"methods.":[83],"Actual":[84],"runtimes":[85],"our":[87],"algorithm":[88],"between":[89],"less":[90],"second":[93],"and":[94],"few":[96],"minutes":[97],"on":[98],"workstation":[100],"bring":[101],"into":[104],"realm":[106],"interactive":[108],"applications.":[109]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":3}],"updated_date":"2025-12-23T23:11:35.936235","created_date":"2025-10-10T00:00:00"}
