{"id":"https://openalex.org/W2611370172","doi":"https://doi.org/10.1089/106652700750050961","title":"Using Bayesian Networks to Analyze Expression Data","display_name":"Using Bayesian Networks to Analyze Expression Data","publication_year":2000,"publication_date":"2000-08-01","ids":{"openalex":"https://openalex.org/W2611370172","doi":"https://doi.org/10.1089/106652700750050961","mag":"2611370172","pmid":"https://pubmed.ncbi.nlm.nih.gov/11108481"},"language":"en","primary_location":{"id":"doi:10.1089/106652700750050961","is_oa":false,"landing_page_url":"https://doi.org/10.1089/106652700750050961","pdf_url":null,"source":{"id":"https://openalex.org/S78571599","display_name":"Journal of Computational Biology","issn_l":"1066-5277","issn":["1066-5277","1557-8666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443"],"host_organization_lineage_names":["Mary Ann Liebert, Inc."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5076999649","display_name":"Nir Friedman","orcid":"https://orcid.org/0000-0002-9678-3550"},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Nir Friedman","raw_affiliation_strings":["School of Computer Science and Engineering, Hebrew University, Jerusalem, 91904, Israel"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Hebrew University, Jerusalem, 91904, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085924022","display_name":"Michal Linial","orcid":"https://orcid.org/0000-0002-9357-4526"},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Michal Linial","raw_affiliation_strings":["Institute of Life Sciences, Hebrew University, Jerusalem, 91904, Israel"],"affiliations":[{"raw_affiliation_string":"Institute of Life Sciences, Hebrew University, Jerusalem, 91904, Israel","institution_ids":["https://openalex.org/I197251160"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010737438","display_name":"Iftach Nachman","orcid":"https://orcid.org/0000-0002-4667-0398"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Iftach Nachman","raw_affiliation_strings":["Center for Neural Computation and School of Computer Science and Engineering, Hebrew University, Jerusalem, 91904, Israel"],"affiliations":[{"raw_affiliation_string":"Center for Neural Computation and School of Computer Science and Engineering, Hebrew University, Jerusalem, 91904, Israel","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5074451448","display_name":"Dana Pe\u2019er","orcid":"https://orcid.org/0000-0002-9259-8817"},"institutions":[{"id":"https://openalex.org/I197251160","display_name":"Hebrew University of Jerusalem","ror":"https://ror.org/03qxff017","country_code":"IL","type":"education","lineage":["https://openalex.org/I197251160"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Dana Pe'er","raw_affiliation_strings":["School of Computer Science and Engineering, Hebrew University, Jerusalem, 91904, Israel"],"affiliations":[{"raw_affiliation_string":"School of Computer Science and Engineering, Hebrew University, Jerusalem, 91904, Israel","institution_ids":["https://openalex.org/I197251160"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5076999649"],"corresponding_institution_ids":["https://openalex.org/I197251160"],"apc_list":null,"apc_paid":null,"fwci":22.4399,"has_fulltext":false,"cited_by_count":3317,"citation_normalized_percentile":{"value":0.99790968,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"7","issue":"3-4","first_page":"601","last_page":"620"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11303","display_name":"Bayesian Modeling and Causal Inference","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/1702","display_name":"Artificial Intelligence"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bayesian-network","display_name":"Bayesian network","score":0.6807219386100769},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6539526581764221},{"id":"https://openalex.org/keywords/conditional-independence","display_name":"Conditional independence","score":0.6008614301681519},{"id":"https://openalex.org/keywords/snapshot","display_name":"Snapshot (computer storage)","score":0.5481588244438171},{"id":"https://openalex.org/keywords/bayesian-probability","display_name":"Bayesian probability","score":0.5457838773727417},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.5397423505783081},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4810360074043274},{"id":"https://openalex.org/keywords/variable-order-bayesian-network","display_name":"Variable-order Bayesian network","score":0.4798809587955475},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.44930368661880493},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.4409494996070862},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4215676486492157},{"id":"https://openalex.org/keywords/dynamic-bayesian-network","display_name":"Dynamic Bayesian network","score":0.4100644588470459},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3499309718608856},{"id":"https://openalex.org/keywords/bayesian-inference","display_name":"Bayesian inference","score":0.30964556336402893},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2648681402206421},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.239872545003891},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19174352288246155},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.11270120739936829}],"concepts":[{"id":"https://openalex.org/C33724603","wikidata":"https://www.wikidata.org/wiki/Q812540","display_name":"Bayesian network","level":2,"score":0.6807219386100769},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6539526581764221},{"id":"https://openalex.org/C79772020","wikidata":"https://www.wikidata.org/wiki/Q5159264","display_name":"Conditional independence","level":2,"score":0.6008614301681519},{"id":"https://openalex.org/C55282118","wikidata":"https://www.wikidata.org/wiki/Q252683","display_name":"Snapshot (computer storage)","level":2,"score":0.5481588244438171},{"id":"https://openalex.org/C107673813","wikidata":"https://www.wikidata.org/wiki/Q812534","display_name":"Bayesian probability","level":2,"score":0.5457838773727417},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5397423505783081},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4810360074043274},{"id":"https://openalex.org/C71983512","wikidata":"https://www.wikidata.org/wiki/Q7915687","display_name":"Variable-order Bayesian network","level":4,"score":0.4798809587955475},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.44930368661880493},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.4409494996070862},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4215676486492157},{"id":"https://openalex.org/C82142266","wikidata":"https://www.wikidata.org/wiki/Q3456604","display_name":"Dynamic Bayesian network","level":3,"score":0.4100644588470459},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3499309718608856},{"id":"https://openalex.org/C160234255","wikidata":"https://www.wikidata.org/wiki/Q812535","display_name":"Bayesian inference","level":3,"score":0.30964556336402893},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2648681402206421},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.239872545003891},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19174352288246155},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.11270120739936829},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1089/106652700750050961","is_oa":false,"landing_page_url":"https://doi.org/10.1089/106652700750050961","pdf_url":null,"source":{"id":"https://openalex.org/S78571599","display_name":"Journal of Computational Biology","issn_l":"1066-5277","issn":["1066-5277","1557-8666"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320443","host_organization_name":"Mary Ann Liebert, Inc.","host_organization_lineage":["https://openalex.org/P4310320443"],"host_organization_lineage_names":["Mary Ann Liebert, Inc."],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Computational Biology","raw_type":"journal-article"},{"id":"pmid:11108481","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11108481","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of computational biology : a journal of computational molecular cell biology","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322252","display_name":"Israel Science Foundation","ror":"https://ror.org/04sazxf24"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":61,"referenced_works":["https://openalex.org/W5684683","https://openalex.org/W1517993545","https://openalex.org/W1521206682","https://openalex.org/W1524326598","https://openalex.org/W1530964327","https://openalex.org/W1570594552","https://openalex.org/W1575323954","https://openalex.org/W1590398161","https://openalex.org/W1601274137","https://openalex.org/W1615454278","https://openalex.org/W1626295059","https://openalex.org/W1645969895","https://openalex.org/W1769824028","https://openalex.org/W1813877927","https://openalex.org/W1815331012","https://openalex.org/W1817561967","https://openalex.org/W1896341954","https://openalex.org/W1941358455","https://openalex.org/W1963648581","https://openalex.org/W1964465385","https://openalex.org/W1971141362","https://openalex.org/W1984783785","https://openalex.org/W1995945562","https://openalex.org/W2005762860","https://openalex.org/W2008906462","https://openalex.org/W2013007269","https://openalex.org/W2038374320","https://openalex.org/W2041862730","https://openalex.org/W2044837620","https://openalex.org/W2046543735","https://openalex.org/W2081793676","https://openalex.org/W2087684630","https://openalex.org/W2095734615","https://openalex.org/W2103453943","https://openalex.org/W2105130030","https://openalex.org/W2109970232","https://openalex.org/W2111051773","https://openalex.org/W2119245063","https://openalex.org/W2124871329","https://openalex.org/W2126986674","https://openalex.org/W2130494035","https://openalex.org/W2131820435","https://openalex.org/W2133241531","https://openalex.org/W2135951244","https://openalex.org/W2142634942","https://openalex.org/W2149337551","https://openalex.org/W2150926065","https://openalex.org/W2157815868","https://openalex.org/W2158714788","https://openalex.org/W2165011536","https://openalex.org/W2170112109","https://openalex.org/W2171265988","https://openalex.org/W2330192890","https://openalex.org/W2605522404","https://openalex.org/W2611831635","https://openalex.org/W2974701791","https://openalex.org/W3133236490","https://openalex.org/W4236354166","https://openalex.org/W4247420482","https://openalex.org/W4253305902","https://openalex.org/W4285719527"],"related_works":["https://openalex.org/W2963184928","https://openalex.org/W1964038743","https://openalex.org/W2305973433","https://openalex.org/W4294537149","https://openalex.org/W4241942934","https://openalex.org/W2204775314","https://openalex.org/W1604786655","https://openalex.org/W2361364127","https://openalex.org/W2167178068","https://openalex.org/W2295783658"],"abstract_inverted_index":{"DNA":[0],"hybridization":[1],"arrays":[2],"simultaneously":[3],"measure":[4],"the":[5,21,66,155],"expression":[6,60],"level":[7],"for":[8,52,71,99,114,136,145],"thousands":[9],"of":[10,17,41,68,82,90,160],"genes.":[11,130],"These":[12],"measurements":[13,159],"provide":[14,110],"a":[15,49,79,111,134],"\"snapshot\"":[16],"transcription":[18],"levels":[19],"within":[20],"cell.":[22],"A":[23,75],"major":[24],"challenge":[25],"in":[26],"computational":[27],"biology":[28],"is":[29,78],"to":[30,102],"uncover,":[31],"from":[32,116,140],"such":[33],"measurements,":[34],"gene/protein":[35],"interactions":[36,54,128,139],"and":[37,107],"key":[38],"biological":[39],"features":[40],"cellular":[42],"systems.":[43],"In":[44],"this":[45,152],"paper,":[46],"we":[47,150],"propose":[48],"new":[50],"framework":[51,63],"discovering":[53],"between":[55,93,129],"genes":[56],"based":[57],"on":[58,65,154],"multiple":[59],"measurements.":[61],"This":[62],"builds":[64],"use":[67],"Bayesian":[69,76,124,147],"networks":[70,125],"representing":[72],"statistical":[73],"dependencies.":[74],"network":[77],"graph-based":[80],"model":[81],"joint":[83],"multivariate":[84],"probability":[85],"distributions":[86],"that":[87],"captures":[88],"properties":[89],"conditional":[91],"independence":[92],"variables.":[94],"Such":[95],"models":[96],"are":[97],"attractive":[98],"their":[100],"ability":[101],"describe":[103,127,133],"complex":[104],"stochastic":[105],"processes":[106],"because":[108],"they":[109],"clear":[112],"methodology":[113],"learning":[115,146],"(noisy)":[117],"observations.":[118],"We":[119,131],"start":[120],"by":[121],"showing":[122],"how":[123],"can":[126],"then":[132],"method":[135,153],"recovering":[137],"gene":[138],"microarray":[141],"data":[142],"using":[143],"tools":[144],"networks.":[148],"Finally,":[149],"demonstrate":[151],"S.":[156],"cerevisiae":[157],"cell-cycle":[158],"Spellman":[161],"et":[162],"al.":[163],"(1998).":[164]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":30},{"year":2024,"cited_by_count":29},{"year":2023,"cited_by_count":65},{"year":2022,"cited_by_count":68},{"year":2021,"cited_by_count":87},{"year":2020,"cited_by_count":134},{"year":2019,"cited_by_count":105},{"year":2018,"cited_by_count":129},{"year":2017,"cited_by_count":112},{"year":2016,"cited_by_count":130},{"year":2015,"cited_by_count":172},{"year":2014,"cited_by_count":180},{"year":2013,"cited_by_count":201},{"year":2012,"cited_by_count":197}],"updated_date":"2026-04-05T17:49:38.594831","created_date":"2025-10-10T00:00:00"}
