{"id":"https://openalex.org/W4323308276","doi":"https://doi.org/10.1088/2632-2153/acc1c0","title":"Machine learning to predict the antimicrobial activity of cold atmospheric plasma-activated liquids","display_name":"Machine learning to predict the antimicrobial activity of cold atmospheric plasma-activated liquids","publication_year":2023,"publication_date":"2023-03-01","ids":{"openalex":"https://openalex.org/W4323308276","doi":"https://doi.org/10.1088/2632-2153/acc1c0"},"language":"en","primary_location":{"id":"doi:10.1088/2632-2153/acc1c0","is_oa":true,"landing_page_url":"https://doi.org/10.1088/2632-2153/acc1c0","pdf_url":null,"source":{"id":"https://openalex.org/S4210200687","display_name":"Machine Learning Science and Technology","issn_l":"2632-2153","issn":["2632-2153"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Machine Learning: Science and Technology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1088/2632-2153/acc1c0","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5088292562","display_name":"Mehmet Akif \u00d6zdemir","orcid":"https://orcid.org/0000-0002-8758-113X"},"institutions":[{"id":"https://openalex.org/I250383648","display_name":"Izmir K\u00e2tip \u00c7elebi University","ror":"https://ror.org/024nx4843","country_code":"TR","type":"education","lineage":["https://openalex.org/I250383648"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mehmet Akif \u00d6zdemir","raw_affiliation_strings":["Department of Biomedical Engineering, Izmir Katip Celebi University, Cigli 35620, Izmir, Turkey","Department of Biomedical Technologies, Graduate School of Natural and Applied Sciences, Izmir Katip Celebi University, Cigli 35620, Izmir, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-8758-113X","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Izmir Katip Celebi University, Cigli 35620, Izmir, Turkey","institution_ids":["https://openalex.org/I250383648"]},{"raw_affiliation_string":"Department of Biomedical Technologies, Graduate School of Natural and Applied Sciences, Izmir Katip Celebi University, Cigli 35620, Izmir, Turkey","institution_ids":["https://openalex.org/I250383648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049249226","display_name":"Gizem Dilara \u00d6zdemir","orcid":"https://orcid.org/0000-0002-3682-3733"},"institutions":[{"id":"https://openalex.org/I250383648","display_name":"Izmir K\u00e2tip \u00c7elebi University","ror":"https://ror.org/024nx4843","country_code":"TR","type":"education","lineage":["https://openalex.org/I250383648"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Gizem Dilara \u00d6zdemir","raw_affiliation_strings":["Department of Biomedical Engineering, Izmir Katip Celebi University, Cigli 35620, Izmir, Turkey","Department of Biomedical Technologies, Graduate School of Natural and Applied Sciences, Izmir Katip Celebi University, Cigli 35620, Izmir, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-3682-3733","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Izmir Katip Celebi University, Cigli 35620, Izmir, Turkey","institution_ids":["https://openalex.org/I250383648"]},{"raw_affiliation_string":"Department of Biomedical Technologies, Graduate School of Natural and Applied Sciences, Izmir Katip Celebi University, Cigli 35620, Izmir, Turkey","institution_ids":["https://openalex.org/I250383648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066231475","display_name":"Merve G\u00fcl","orcid":"https://orcid.org/0000-0003-4277-9174"},"institutions":[{"id":"https://openalex.org/I250383648","display_name":"Izmir K\u00e2tip \u00c7elebi University","ror":"https://ror.org/024nx4843","country_code":"TR","type":"education","lineage":["https://openalex.org/I250383648"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Merve G\u00fcl","raw_affiliation_strings":["Department of Biomedical Technologies, Graduate School of Natural and Applied Sciences, Izmir Katip Celebi University, Cigli 35620, Izmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Technologies, Graduate School of Natural and Applied Sciences, Izmir Katip Celebi University, Cigli 35620, Izmir, Turkey","institution_ids":["https://openalex.org/I250383648"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076242672","display_name":"Onan G\u00fcren","orcid":"https://orcid.org/0000-0001-5808-3767"},"institutions":[{"id":"https://openalex.org/I250383648","display_name":"Izmir K\u00e2tip \u00c7elebi University","ror":"https://ror.org/024nx4843","country_code":"TR","type":"education","lineage":["https://openalex.org/I250383648"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Onan G\u00fcren","raw_affiliation_strings":["Department of Biomedical Engineering, Izmir Katip Celebi University, Cigli 35620, Izmir, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Izmir Katip Celebi University, Cigli 35620, Izmir, Turkey","institution_ids":["https://openalex.org/I250383648"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088458570","display_name":"Utku K\u00fcr\u015fat Ercan","orcid":"https://orcid.org/0000-0002-9762-2265"},"institutions":[{"id":"https://openalex.org/I250383648","display_name":"Izmir K\u00e2tip \u00c7elebi University","ror":"https://ror.org/024nx4843","country_code":"TR","type":"education","lineage":["https://openalex.org/I250383648"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Utku K\u00fcr\u015fat Ercan","raw_affiliation_strings":["Department of Biomedical Engineering, Izmir Katip Celebi University, Cigli 35620, Izmir, Turkey"],"raw_orcid":"https://orcid.org/0000-0002-9762-2265","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Izmir Katip Celebi University, Cigli 35620, Izmir, Turkey","institution_ids":["https://openalex.org/I250383648"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088458570"],"corresponding_institution_ids":["https://openalex.org/I250383648"],"apc_list":{"value":3000,"currency":"USD","value_usd":3000},"apc_paid":{"value":3000,"currency":"USD","value_usd":3000},"fwci":6.2695,"has_fulltext":false,"cited_by_count":35,"citation_normalized_percentile":{"value":0.97413705,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"4","issue":"1","first_page":"015030","last_page":"015030"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13324","display_name":"Scientific and Engineering Research Topics","score":0.9853000044822693,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13324","display_name":"Scientific and Engineering Research Topics","score":0.9853000044822693,"subfield":{"id":"https://openalex.org/subfields/3506","display_name":"Periodontics"},"field":{"id":"https://openalex.org/fields/35","display_name":"Dentistry"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antimicrobial","display_name":"Antimicrobial","score":0.6927264332771301},{"id":"https://openalex.org/keywords/normalization","display_name":"Normalization (sociology)","score":0.5956131219863892},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5412371754646301},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5332987308502197},{"id":"https://openalex.org/keywords/cross-validation","display_name":"Cross-validation","score":0.5067153573036194},{"id":"https://openalex.org/keywords/regression","display_name":"Regression","score":0.48082268238067627},{"id":"https://openalex.org/keywords/resampling","display_name":"Resampling","score":0.46200037002563477},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.40293803811073303},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3464413285255432},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.2966049313545227},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.19527900218963623},{"id":"https://openalex.org/keywords/microbiology","display_name":"Microbiology","score":0.09921294450759888}],"concepts":[{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.6927264332771301},{"id":"https://openalex.org/C136886441","wikidata":"https://www.wikidata.org/wiki/Q926129","display_name":"Normalization (sociology)","level":2,"score":0.5956131219863892},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5412371754646301},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5332987308502197},{"id":"https://openalex.org/C27181475","wikidata":"https://www.wikidata.org/wiki/Q541014","display_name":"Cross-validation","level":2,"score":0.5067153573036194},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.48082268238067627},{"id":"https://openalex.org/C150921843","wikidata":"https://www.wikidata.org/wiki/Q1170431","display_name":"Resampling","level":2,"score":0.46200037002563477},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.40293803811073303},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3464413285255432},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2966049313545227},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.19527900218963623},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.09921294450759888},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1088/2632-2153/acc1c0","is_oa":true,"landing_page_url":"https://doi.org/10.1088/2632-2153/acc1c0","pdf_url":null,"source":{"id":"https://openalex.org/S4210200687","display_name":"Machine Learning Science and Technology","issn_l":"2632-2153","issn":["2632-2153"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Machine Learning: Science and Technology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:49f8f0e3331b43aeba21bf13bdc2a9c1","is_oa":true,"landing_page_url":"https://doaj.org/article/49f8f0e3331b43aeba21bf13bdc2a9c1","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Machine Learning: Science and Technology, Vol 4, Iss 1, p 015030 (2023)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1088/2632-2153/acc1c0","is_oa":true,"landing_page_url":"https://doi.org/10.1088/2632-2153/acc1c0","pdf_url":null,"source":{"id":"https://openalex.org/S4210200687","display_name":"Machine Learning Science and Technology","issn_l":"2632-2153","issn":["2632-2153"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320083","host_organization_name":"IOP Publishing","host_organization_lineage":["https://openalex.org/P4310320083","https://openalex.org/P4310311669"],"host_organization_lineage_names":["IOP Publishing","Institute of Physics"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Machine Learning: Science and Technology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4399999976158142,"display_name":"Life in Land","id":"https://metadata.un.org/sdg/15"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":96,"referenced_works":["https://openalex.org/W1985142359","https://openalex.org/W1996866249","https://openalex.org/W1999635750","https://openalex.org/W2028746240","https://openalex.org/W2052684427","https://openalex.org/W2053634812","https://openalex.org/W2065588344","https://openalex.org/W2086546209","https://openalex.org/W2091223416","https://openalex.org/W2095804773","https://openalex.org/W2097137621","https://openalex.org/W2102636708","https://openalex.org/W2106608568","https://openalex.org/W2116719896","https://openalex.org/W2126585173","https://openalex.org/W2140104693","https://openalex.org/W2148143831","https://openalex.org/W2161581583","https://openalex.org/W2283530457","https://openalex.org/W2288281651","https://openalex.org/W2327037637","https://openalex.org/W2338065342","https://openalex.org/W2549976854","https://openalex.org/W2550576290","https://openalex.org/W2600371898","https://openalex.org/W2738681903","https://openalex.org/W2739905084","https://openalex.org/W2759590411","https://openalex.org/W2763731921","https://openalex.org/W2768055745","https://openalex.org/W2772032254","https://openalex.org/W2785331471","https://openalex.org/W2789348411","https://openalex.org/W2792178709","https://openalex.org/W2793997912","https://openalex.org/W2794916302","https://openalex.org/W2805771669","https://openalex.org/W2806587241","https://openalex.org/W2884091561","https://openalex.org/W2893924712","https://openalex.org/W2896797685","https://openalex.org/W2904290041","https://openalex.org/W2909240409","https://openalex.org/W2909729347","https://openalex.org/W2913997948","https://openalex.org/W2934399013","https://openalex.org/W2942635952","https://openalex.org/W2944819716","https://openalex.org/W2946924560","https://openalex.org/W2947709821","https://openalex.org/W2947750276","https://openalex.org/W2953550695","https://openalex.org/W2953760448","https://openalex.org/W2981111316","https://openalex.org/W2992764683","https://openalex.org/W2999315714","https://openalex.org/W2999347613","https://openalex.org/W2999758875","https://openalex.org/W3003799045","https://openalex.org/W3005455537","https://openalex.org/W3008175761","https://openalex.org/W3011746839","https://openalex.org/W3012008782","https://openalex.org/W3021505856","https://openalex.org/W3027778245","https://openalex.org/W3036139765","https://openalex.org/W3043938810","https://openalex.org/W3080459878","https://openalex.org/W3082059448","https://openalex.org/W3082801777","https://openalex.org/W3106668323","https://openalex.org/W3126645943","https://openalex.org/W3127253295","https://openalex.org/W3137136880","https://openalex.org/W3143098515","https://openalex.org/W3148181069","https://openalex.org/W3158116207","https://openalex.org/W3164746735","https://openalex.org/W3165670202","https://openalex.org/W3180281962","https://openalex.org/W3181005754","https://openalex.org/W3181609980","https://openalex.org/W3183252304","https://openalex.org/W3185256938","https://openalex.org/W3212295688","https://openalex.org/W3217065659","https://openalex.org/W4200445723","https://openalex.org/W4220896049","https://openalex.org/W4226311503","https://openalex.org/W4229082061","https://openalex.org/W4237916292","https://openalex.org/W4281787428","https://openalex.org/W6703810579","https://openalex.org/W6746224901","https://openalex.org/W6768457005","https://openalex.org/W6810800508"],"related_works":["https://openalex.org/W2052515325","https://openalex.org/W2050948537","https://openalex.org/W2767646790","https://openalex.org/W2352041579","https://openalex.org/W2138381686","https://openalex.org/W1998176685","https://openalex.org/W2141585124","https://openalex.org/W1903837062","https://openalex.org/W1800458610","https://openalex.org/W2384527366"],"abstract_inverted_index":{"Abstract":[0],"Plasma":[1],"is":[2,34,76,193,202,347],"defined":[3],"as":[4,87,204],"the":[5,50,57,62,73,82,102,127,157,163,182,218,235,249,260,283,297,302,314,320,328,334,341,348,353,378,388,395],"fourth":[6],"state":[7],"of":[8,30,41,52,68,84,104,132,160,251,287,294,307,316,331,343,356,369,390],"matter,":[9],"and":[10,26,55,140,168,177,198,211,230,242,266,280,291],"non-thermal":[11],"plasma":[12,85,370,392],"can":[13,325],"be":[14],"produced":[15],"at":[16],"atmospheric":[17],"pressure":[18],"under":[19],"a":[20,96,205,366,374,391],"high":[21],"electrical":[22],"field.":[23],"The":[24,38,65,256],"strong":[25],"broad-spectrum":[27],"antimicrobial":[28,39,63,109,130,158,329,354,380],"effect":[29,250],"plasma-activated":[31],"liquids":[32],"(PALs)":[33],"now":[35],"well":[36],"known.":[37],"effects":[40],"PALs":[42,93,317,332,357],"depend":[43],"on":[44,92,107,254],"many":[45],"different":[46,53,209,222,252],"variables,":[47],"which":[48],"complicates":[49],"comparison":[51],"studies":[54],"determining":[56],"most":[58,304],"dominant":[59,375],"parameters":[60,106,371],"for":[61,78,199,228,278,289,296,336],"effect.":[64,381],"proven":[66],"applicability":[67],"machine":[69],"learning":[70],"(ML)":[71],"in":[72,81,128,195,311,319,377,394],"medical":[74],"field":[75,83],"encouraging":[77],"its":[79],"application":[80],"medicine":[86],"well.":[88],"Thus,":[89],"ML":[90,116,173,323,361],"applications":[91],"could":[94,363],"present":[95],"new":[97],"perspective":[98],"to":[99,125,145,154,181,184,216,233,275,365,387],"better":[100,367],"understand":[101],"influences":[103],"various":[105],"their":[108],"effects.":[110],"In":[111],"this":[112,346],"paper,":[113],"comparative":[114],"supervised":[115,172],"models":[117,232,277,309],"are":[118,179,214,226,299,310],"presented":[119],"by":[120],"using":[121],"previously":[122],"obtained":[123],"data":[124,183],"predict":[126,156,217,327],"vitro":[129],"activity":[131,159,330],"PALs.":[133,161],"A":[134],"comprehensive":[135],"literature":[136],"search":[137],"was":[138],"performed,":[139],"12":[141],"distinct":[142],"features":[143,253,306],"related":[144],"PAL-microorganism":[146],"interactions":[147],"were":[148],"collected":[149],"from":[150],"33":[151],"relevant":[152],"articles":[153],"automatically":[155],"After":[162],"required":[164],"normalization,":[165],"feature":[166],"encoding,":[167],"resampling":[169],"steps,":[170],"two":[171],"methods,":[174],"namely":[175],"classification":[176,229,279],"regression,":[178,200],"applied":[180],"obtain":[185],"microbial":[186],"inactivation":[187],"(MI)":[188],"predictions.":[189],"For":[190],"classification,":[191],"MI":[192,201,219],"labeled":[194],"four":[196],"categories,":[197],"used":[203],"continuous":[206],"variable.":[207],"Sixteen":[208],"classifiers":[210],"14":[212],"regressors":[213],"implemented":[215],"value.":[220],"Two":[221],"robust":[223],"cross-validation":[224,241],"strategies":[225],"conducted":[227],"regression":[231],"evaluate":[234],"proposed":[236],"method:":[237],"repeated":[238],"stratified":[239],"k-fold":[240,243],"cross-validation,":[244],"respectively.":[245],"We":[246],"also":[247],"investigate":[248],"models.":[255],"results":[257],"demonstrated":[258],"that":[259,351,372],"hyperparameter-optimized":[261],"Random":[262,267],"Forest":[263,268],"Classifier":[264],"(oRFC)":[265],"Regressor":[269],"(oRFR)":[270],"provided":[271],"superior":[272],"performance":[273],"compared":[274],"other":[276],"regression.":[281],"Finally,":[282],"best":[284,342],"test":[285],"accuracy":[286],"82.68%":[288],"oRFC":[290],"R":[292],"2":[293],"0.75":[295],"oRFR":[298],"obtained.":[300],"Furthermore,":[301,360],"determined":[303],"important":[305],"predictive":[308],"line":[312],"with":[313,358],"outcomes":[315],"reported":[318],"literature.":[321],"An":[322],"framework":[324],"accurately":[326],"without":[333],"need":[335],"any":[337],"experimental":[338],"studies.":[339],"To":[340],"our":[344],"knowledge,":[345],"first":[349],"study":[350],"investigates":[352],"efficacy":[355],"ML.":[359],"techniques":[362],"contribute":[364,386],"understanding":[368],"have":[373],"role":[376],"desired":[379],"Moreover,":[382],"such":[383],"findings":[384],"may":[385],"definition":[389],"dose":[393],"future.":[396]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":21},{"year":2023,"cited_by_count":5}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2025-10-10T00:00:00"}
