{"id":"https://openalex.org/W3046060136","doi":"https://doi.org/10.1080/24725854.2020.1856982","title":"A calibration-free method for biosensing in cell manufacturing","display_name":"A calibration-free method for biosensing in cell manufacturing","publication_year":2020,"publication_date":"2020-11-30","ids":{"openalex":"https://openalex.org/W3046060136","doi":"https://doi.org/10.1080/24725854.2020.1856982","mag":"3046060136"},"language":"en","primary_location":{"id":"doi:10.1080/24725854.2020.1856982","is_oa":false,"landing_page_url":"https://doi.org/10.1080/24725854.2020.1856982","pdf_url":null,"source":{"id":"https://openalex.org/S4210225672","display_name":"IISE Transactions","issn_l":"2472-5854","issn":["2472-5854","2472-5862"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547"],"host_organization_lineage_names":["Taylor & Francis"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IISE Transactions","raw_type":"journal-article"},"type":"article","indexed_in":["arxiv","crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://arxiv.org/pdf/2007.14391","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Jialei Chen","orcid":"https://orcid.org/0000-0002-6053-9302"},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I4210104624","display_name":"Manufacturing Institute","ror":"https://ror.org/027wewa02","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210104624"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jialei Chen","raw_affiliation_strings":["Georgia Tech Manufacturing Institute, Georgia Institute of Technology, Atlanta, GA, USA","H. Milton Stewart School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, GA, USA"],"raw_orcid":"https://orcid.org/0000-0002-6053-9302","affiliations":[{"raw_affiliation_string":"Georgia Tech Manufacturing Institute, Georgia Institute of Technology, Atlanta, GA, USA","institution_ids":["https://openalex.org/I130701444","https://openalex.org/I4210104624"]},{"raw_affiliation_string":"H. Milton Stewart School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, GA, USA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Zhaonan Liu","orcid":null},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I4210104624","display_name":"Manufacturing Institute","ror":"https://ror.org/027wewa02","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210104624"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhaonan Liu","raw_affiliation_strings":["Georgia Tech Manufacturing Institute, Georgia Institute of Technology, Atlanta, GA, USA","School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgia Tech Manufacturing Institute, Georgia Institute of Technology, Atlanta, GA, USA","institution_ids":["https://openalex.org/I130701444","https://openalex.org/I4210104624"]},{"raw_affiliation_string":"School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA, USA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kan Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I4210104624","display_name":"Manufacturing Institute","ror":"https://ror.org/027wewa02","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210104624"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kan Wang","raw_affiliation_strings":["Georgia Tech Manufacturing Institute, Georgia Institute of Technology, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgia Tech Manufacturing Institute, Georgia Institute of Technology, Atlanta, GA, USA","institution_ids":["https://openalex.org/I130701444","https://openalex.org/I4210104624"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chen Jiang","orcid":null},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I4210104624","display_name":"Manufacturing Institute","ror":"https://ror.org/027wewa02","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210104624"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chen Jiang","raw_affiliation_strings":["Georgia Tech Manufacturing Institute, Georgia Institute of Technology, Atlanta, GA, USA","School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgia Tech Manufacturing Institute, Georgia Institute of Technology, Atlanta, GA, USA","institution_ids":["https://openalex.org/I130701444","https://openalex.org/I4210104624"]},{"raw_affiliation_string":"School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA, USA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Chuck Zhang","orcid":null},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I4210104624","display_name":"Manufacturing Institute","ror":"https://ror.org/027wewa02","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210104624"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chuck Zhang","raw_affiliation_strings":["Georgia Tech Manufacturing Institute, Georgia Institute of Technology, Atlanta, GA, USA","H. Milton Stewart School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgia Tech Manufacturing Institute, Georgia Institute of Technology, Atlanta, GA, USA","institution_ids":["https://openalex.org/I130701444","https://openalex.org/I4210104624"]},{"raw_affiliation_string":"H. Milton Stewart School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, GA, USA","institution_ids":["https://openalex.org/I130701444"]}]},{"author_position":"last","author":{"id":null,"display_name":"Ben Wang","orcid":null},"institutions":[{"id":"https://openalex.org/I130701444","display_name":"Georgia Institute of Technology","ror":"https://ror.org/01zkghx44","country_code":"US","type":"education","lineage":["https://openalex.org/I130701444"]},{"id":"https://openalex.org/I4210104624","display_name":"Manufacturing Institute","ror":"https://ror.org/027wewa02","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210104624"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ben Wang","raw_affiliation_strings":["Georgia Tech Manufacturing Institute, Georgia Institute of Technology, Atlanta, GA, USA","H. Milton Stewart School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, GA, USA","School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Georgia Tech Manufacturing Institute, Georgia Institute of Technology, Atlanta, GA, USA","institution_ids":["https://openalex.org/I130701444","https://openalex.org/I4210104624"]},{"raw_affiliation_string":"H. Milton Stewart School of Industrial and Systems Engineering, Georgia Institute of Technology, Atlanta, GA, USA","institution_ids":["https://openalex.org/I130701444"]},{"raw_affiliation_string":"School of Materials Science and Engineering, Georgia Institute of Technology, Atlanta, GA, USA","institution_ids":["https://openalex.org/I130701444"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I130701444","https://openalex.org/I4210104624"],"apc_list":null,"apc_paid":null,"fwci":0.0838,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.45107323,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"39"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.732200026512146,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.732200026512146,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.02500000037252903,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.021199999377131462,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/calibration","display_name":"Calibration","score":0.7289000153541565},{"id":"https://openalex.org/keywords/quality","display_name":"Quality (philosophy)","score":0.42590001225471497},{"id":"https://openalex.org/keywords/biosensor","display_name":"Biosensor","score":0.42329999804496765},{"id":"https://openalex.org/keywords/construct","display_name":"Construct (python library)","score":0.3935999870300293},{"id":"https://openalex.org/keywords/statistic","display_name":"Statistic","score":0.34060001373291016},{"id":"https://openalex.org/keywords/work","display_name":"Work (physics)","score":0.33880001306533813}],"concepts":[{"id":"https://openalex.org/C165838908","wikidata":"https://www.wikidata.org/wiki/Q736777","display_name":"Calibration","level":2,"score":0.7289000153541565},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5834000110626221},{"id":"https://openalex.org/C2779530757","wikidata":"https://www.wikidata.org/wiki/Q1207505","display_name":"Quality (philosophy)","level":2,"score":0.42590001225471497},{"id":"https://openalex.org/C160756335","wikidata":"https://www.wikidata.org/wiki/Q669391","display_name":"Biosensor","level":2,"score":0.42329999804496765},{"id":"https://openalex.org/C2780801425","wikidata":"https://www.wikidata.org/wiki/Q5164392","display_name":"Construct (python library)","level":2,"score":0.3935999870300293},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3749000132083893},{"id":"https://openalex.org/C89128539","wikidata":"https://www.wikidata.org/wiki/Q1949963","display_name":"Statistic","level":2,"score":0.34060001373291016},{"id":"https://openalex.org/C18762648","wikidata":"https://www.wikidata.org/wiki/Q42213","display_name":"Work (physics)","level":2,"score":0.33880001306533813},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.3386000096797943},{"id":"https://openalex.org/C2780449318","wikidata":"https://www.wikidata.org/wiki/Q18344773","display_name":"Critical quality attributes","level":3,"score":0.32100000977516174},{"id":"https://openalex.org/C34559072","wikidata":"https://www.wikidata.org/wiki/Q2334061","display_name":"Design of experiments","level":2,"score":0.31790000200271606},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.27480000257492065},{"id":"https://openalex.org/C12725497","wikidata":"https://www.wikidata.org/wiki/Q810247","display_name":"Baseline (sea)","level":2,"score":0.26809999346733093},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.2671999931335449},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.2671999931335449},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.25679999589920044}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1080/24725854.2020.1856982","is_oa":false,"landing_page_url":"https://doi.org/10.1080/24725854.2020.1856982","pdf_url":null,"source":{"id":"https://openalex.org/S4210225672","display_name":"IISE Transactions","issn_l":"2472-5854","issn":["2472-5854","2472-5862"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547"],"host_organization_lineage_names":["Taylor & Francis"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"IISE Transactions","raw_type":"journal-article"},{"id":"pmh:oai:arXiv.org:2007.14391","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2007.14391","pdf_url":"https://arxiv.org/pdf/2007.14391","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},{"id":"pmh:oai:RePEc:taf:uiiexx:v:54:y:2021:i:1:p:29-39","is_oa":false,"landing_page_url":"http://hdl.handle.net/10.1080/24725854.2020.1856982","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"}],"best_oa_location":{"id":"pmh:oai:arXiv.org:2007.14391","is_oa":true,"landing_page_url":"http://arxiv.org/abs/2007.14391","pdf_url":"https://arxiv.org/pdf/2007.14391","source":{"id":"https://openalex.org/S4306400194","display_name":"arXiv (Cornell University)","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"text"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W16794263","https://openalex.org/W34339474","https://openalex.org/W129305155","https://openalex.org/W1540764732","https://openalex.org/W1973333099","https://openalex.org/W2019164609","https://openalex.org/W2039144238","https://openalex.org/W2050834445","https://openalex.org/W2051434435","https://openalex.org/W2073523882","https://openalex.org/W2082137964","https://openalex.org/W2084583747","https://openalex.org/W2135046866","https://openalex.org/W2166771618","https://openalex.org/W2335984750","https://openalex.org/W2336392079","https://openalex.org/W2497245202","https://openalex.org/W2510654329","https://openalex.org/W2553829801","https://openalex.org/W2755155569","https://openalex.org/W2761202053","https://openalex.org/W2792588868","https://openalex.org/W2890191583","https://openalex.org/W2901761063","https://openalex.org/W2912278137","https://openalex.org/W2919653404","https://openalex.org/W2963045461","https://openalex.org/W2971847850","https://openalex.org/W2972947493","https://openalex.org/W4250589301","https://openalex.org/W4300008344"],"related_works":[],"abstract_inverted_index":{"Chimeric":[0],"antigen":[1],"receptor":[2],"T-cell":[3],"therapy":[4],"has":[5],"demonstrated":[6],"innovative":[7],"therapeutic":[8],"effectiveness":[9],"in":[10,24,29,123],"fighting":[11],"cancers;":[12],"however,":[13],"it":[14],"is":[15],"extremely":[16],"expensive,":[17],"due":[18],"to":[19,37,63,87],"the":[20,44,70,73,89,94,98,104,112,119,128,149],"intrinsic":[21],"patient-to-patient":[22,45],"variability":[23,51],"cell":[25,129,140,150],"manufacturing.":[26],"We":[27,115],"propose":[28],"this":[30,50],"work":[31],"a":[32,53,65],"novel":[33],"calibration-free":[34,121],"statistical":[35],"framework":[36,84],"effectively":[38,137],"deduce":[39,103],"critical":[40,105],"quality":[41,106],"attributes":[42],"under":[43],"variability.":[46],"Specifically,":[47],"we":[48,101],"model":[49,95],"via":[52],"patient-specific":[54],"calibration":[55,74,113],"parameter,":[56],"and":[57,81,93],"use":[58],"readings":[59],"from":[60,111],"multiple":[61],"biosensors":[62],"construct":[64],"patient-invariance":[66,91,99],"statistic,":[67,100],"thereby":[68],"alleviating":[69],"effect":[71],"of":[72,108,118],"parameter.":[75,114],"A":[76],"carefully":[77],"formulated":[78],"optimization":[79],"problem":[80],"an":[82],"algorithmic":[83],"are":[85],"presented":[86],"find":[88],"best":[90],"statistic":[92],"parameters.":[96],"Using":[97],"can":[102],"attribute":[107],"interest,":[109],"free":[110],"demonstrate":[116],"improvements":[117],"proposed":[120],"method":[122,134],"different":[124],"simulation":[125],"experiments.":[126],"In":[127],"manufacturing":[130,151],"case":[131],"study,":[132],"our":[133],"not":[135],"only":[136],"deduces":[138],"viable":[139],"concentration":[141],"for":[142,148],"monitoring,":[143],"but":[144],"also":[145],"reveals":[146],"insights":[147],"process.":[152]},"counts_by_year":[{"year":2021,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2020-08-03T00:00:00"}