{"id":"https://openalex.org/W2118778037","doi":"https://doi.org/10.1080/17486700903535922","title":"Multiscale Estimation of Cell Kinetics","display_name":"Multiscale Estimation of Cell Kinetics","publication_year":2009,"publication_date":"2009-12-04","ids":{"openalex":"https://openalex.org/W2118778037","doi":"https://doi.org/10.1080/17486700903535922","mag":"2118778037","pmid":"https://pubmed.ncbi.nlm.nih.gov/20582763"},"language":"en","primary_location":{"id":"doi:10.1080/17486700903535922","is_oa":true,"landing_page_url":"https://doi.org/10.1080/17486700903535922","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2010/219156.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://downloads.hindawi.com/journals/cmmm/2010/219156.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5050121906","display_name":"Larry W. Jean","orcid":null},"institutions":[{"id":"https://openalex.org/I4210138199","display_name":"University of Washington Applied Physics Laboratory","ror":"https://ror.org/03d17d270","country_code":"US","type":"facility","lineage":["https://openalex.org/I201448701","https://openalex.org/I4210138199"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larry W. Jean","raw_affiliation_strings":["Program in Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA","Department of Applied Mathematics, University of Washington, Seattle, WA 98195-2420, USA"],"affiliations":[{"raw_affiliation_string":"Program in Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA","institution_ids":["https://openalex.org/I4210089486"]},{"raw_affiliation_string":"Department of Applied Mathematics, University of Washington, Seattle, WA 98195-2420, USA","institution_ids":["https://openalex.org/I4210138199"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066068798","display_name":"Martin T. Suchorolski","orcid":null},"institutions":[{"id":"https://openalex.org/I201448701","display_name":"University of Washington","ror":"https://ror.org/00cvxb145","country_code":"US","type":"education","lineage":["https://openalex.org/I201448701"]},{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin T. Suchorolski","raw_affiliation_strings":["Department of Molecular and Cell Biology, University of Washington, Seattle, WA 98195-7275, USA","Program in Human Biology, Fred Hutchinson Cancer Research Center, M2-B500, Seattle, WA 98109, USA"],"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cell Biology, University of Washington, Seattle, WA 98195-7275, USA","institution_ids":["https://openalex.org/I201448701"]},{"raw_affiliation_string":"Program in Human Biology, Fred Hutchinson Cancer Research Center, M2-B500, Seattle, WA 98109, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054540962","display_name":"Jihyoun Jeon","orcid":"https://orcid.org/0000-0001-7003-3412"},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jihyoun Jeon","raw_affiliation_strings":["Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA"],"affiliations":[{"raw_affiliation_string":"Program in Biostatistics and Biomathematics, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA","institution_ids":["https://openalex.org/I4210089486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5070588649","display_name":"E. Georg Luebeck","orcid":"https://orcid.org/0000-0002-4378-2829"},"institutions":[{"id":"https://openalex.org/I4210089486","display_name":"Fred Hutch Cancer Center","ror":"https://ror.org/007ps6h72","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210089486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"E. Georg Luebeck","raw_affiliation_strings":["Program in Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA"],"affiliations":[{"raw_affiliation_string":"Program in Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA","institution_ids":["https://openalex.org/I4210089486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5070588649"],"corresponding_institution_ids":["https://openalex.org/I4210089486"],"apc_list":{"value":2100,"currency":"USD","value_usd":2100},"apc_paid":{"value":2100,"currency":"USD","value_usd":2100},"fwci":0.7675,"has_fulltext":true,"cited_by_count":3,"citation_normalized_percentile":{"value":0.82478514,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"11","issue":"3","first_page":"239","last_page":"254"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12859","display_name":"Cell Image Analysis Techniques","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9919000267982483,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9847999811172485,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kinetics","display_name":"Kinetics","score":0.5978346467018127},{"id":"https://openalex.org/keywords/estimation","display_name":"Estimation","score":0.5371765494346619},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.478061705827713},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4515388309955597},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.270679771900177},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.16128358244895935},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.1611323058605194},{"id":"https://openalex.org/keywords/systems-engineering","display_name":"Systems engineering","score":0.0893215537071228}],"concepts":[{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.5978346467018127},{"id":"https://openalex.org/C96250715","wikidata":"https://www.wikidata.org/wiki/Q965330","display_name":"Estimation","level":2,"score":0.5371765494346619},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.478061705827713},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4515388309955597},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.270679771900177},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.16128358244895935},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.1611323058605194},{"id":"https://openalex.org/C201995342","wikidata":"https://www.wikidata.org/wiki/Q682496","display_name":"Systems engineering","level":1,"score":0.0893215537071228},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015982","descriptor_name":"Bias","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015982","descriptor_name":"Bias","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015982","descriptor_name":"Bias","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1080/17486700903535922","is_oa":true,"landing_page_url":"https://doi.org/10.1080/17486700903535922","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2010/219156.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},{"id":"pmid:20582763","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20582763","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and mathematical methods in medicine","raw_type":null},{"id":"pmh:oai:doaj.org/article:874de7821674446096c7c4b22abb12f1","is_oa":true,"landing_page_url":"https://doaj.org/article/874de7821674446096c7c4b22abb12f1","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Computational and Mathematical Methods in Medicine, Vol 11, Iss 3, Pp 239-254 (2010)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4395034","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4395034","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Comput Math Methods Med","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1080/17486700903535922","is_oa":true,"landing_page_url":"https://doi.org/10.1080/17486700903535922","pdf_url":"https://downloads.hindawi.com/journals/cmmm/2010/219156.pdf","source":{"id":"https://openalex.org/S36980176","display_name":"Computational and Mathematical Methods in Medicine","issn_l":"1748-670X","issn":["1748-670X","1748-6718"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869"],"host_organization_lineage_names":["Hindawi Publishing Corporation"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and Mathematical Methods in Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G6192972131","display_name":null,"funder_award_id":"RO1 CA107028","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8901101912","display_name":null,"funder_award_id":"RO1 CA119224","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2118778037.pdf","grobid_xml":"https://content.openalex.org/works/W2118778037.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W118005394","https://openalex.org/W1490412158","https://openalex.org/W1533199841","https://openalex.org/W1966001093","https://openalex.org/W1967304777","https://openalex.org/W1973220852","https://openalex.org/W1985173348","https://openalex.org/W1990072281","https://openalex.org/W1990198869","https://openalex.org/W1997208245","https://openalex.org/W2010871781","https://openalex.org/W2013735712","https://openalex.org/W2014268112","https://openalex.org/W2029996517","https://openalex.org/W2031468048","https://openalex.org/W2045848160","https://openalex.org/W2047396583","https://openalex.org/W2050818040","https://openalex.org/W2076432328","https://openalex.org/W2079491906","https://openalex.org/W2082470200","https://openalex.org/W2105813828","https://openalex.org/W2117814314","https://openalex.org/W2123558100","https://openalex.org/W2135532205","https://openalex.org/W2138825607","https://openalex.org/W2155507496","https://openalex.org/W2170343590","https://openalex.org/W2412550760","https://openalex.org/W2623408274","https://openalex.org/W2774788831","https://openalex.org/W2905349247","https://openalex.org/W4256571893","https://openalex.org/W6600236328","https://openalex.org/W6607950872","https://openalex.org/W6608756034","https://openalex.org/W6777256359","https://openalex.org/W6811378387","https://openalex.org/W6831536258"],"related_works":["https://openalex.org/W4391375266","https://openalex.org/W2899084033","https://openalex.org/W2748952813","https://openalex.org/W2390279801","https://openalex.org/W1980203814","https://openalex.org/W4391913857","https://openalex.org/W2358668433","https://openalex.org/W4396701345","https://openalex.org/W2376932109","https://openalex.org/W2001405890"],"abstract_inverted_index":{"We":[0,40,84,111],"introduce":[1],"a":[2,42,103],"methodology":[3,145],"based":[4,45],"on":[5,46,76],"the":[6,12,26,31,35,51,55,69,79,92,95,114,117,121,132],"Luria-Delbruck":[7],"fluctuation":[8],"model":[9],"for":[10,148],"estimating":[11],"cell":[13,28,82],"kinetics":[14],"of":[15,25,54,59,71,81,94,128,138],"clonally":[16],"expanding":[17],"populations.":[18],"In":[19],"particular,":[20],"this":[21,144],"approach":[22,44],"allows":[23],"estimation":[24,122],"net":[27],"proliferation":[29],"rate,":[30],"extinction":[32],"coefficient":[33],"and":[34,57,78,97,108,120],"initial":[36],"(viable)":[37],"population":[38,134],"size.":[39],"present":[41],"systematic":[43],"spatial":[47],"partitioning,":[48],"which":[49,73],"captures":[50],"local":[52],"fluctuations":[53],"number":[56,70],"sizes":[58],"individual":[60,139],"clones.":[61],"However,":[62],"partitioning":[63],"introduces":[64],"measurement":[65,118],"error":[66,119],"by":[67],"inflating":[68],"clones,":[72,140],"is":[74,146],"dependent":[75],"time":[77],"degree":[80],"migration.":[83],"perform":[85],"various":[86],"in":[87,152],"silico":[88],"experiments":[89],"to":[90,136],"explore":[91,113],"properties":[93],"estimators":[96],"we":[98,141],"show":[99,142],"that":[100,143],"there":[101],"exists":[102],"direct":[104],"relationship":[105],"between":[106,116],"precision":[107],"observation":[109],"time.":[110],"also":[112],"trade-off":[115],"accuracy.":[123],"By":[124],"exploring":[125],"different":[126],"scales":[127],"cellular":[129],"fluctuations,":[130],"from":[131],"entire":[133],"down":[135],"those":[137],"useful":[147],"inferring":[149],"important":[150],"parameters":[151],"neoplastic":[153],"progression.":[154]},"counts_by_year":[{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
