{"id":"https://openalex.org/W20461597","doi":"https://doi.org/10.1080/17486700903170712","title":"Towards prediction of HCV therapy efficiency.","display_name":"Towards prediction of HCV therapy efficiency.","publication_year":2010,"publication_date":"2010-06-01","ids":{"openalex":"https://openalex.org/W20461597","doi":"https://doi.org/10.1080/17486700903170712","mag":"20461597","pmid":"https://pubmed.ncbi.nlm.nih.gov/20461597"},"language":"en","primary_location":{"id":"pmid:20461597","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20461597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and mathematical methods in medicine","raw_type":null},"type":"dissertation","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/2433/151498","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084740986","display_name":"\u4eae \u5c71\u68ee","orcid":null},"institutions":[{"id":"https://openalex.org/I46597724","display_name":"Pozna\u0144 University of Technology","ror":"https://ror.org/00p7p3302","country_code":"PL","type":"education","lineage":["https://openalex.org/I46597724"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Szymon Wasik","raw_affiliation_strings":["Institute of Computing Science, Poznan University of Technology, Piotrowo 2, 60-965 Poznan, Poland. szymon.wasik@cs.put.poznan.pl"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Computing Science, Poznan University of Technology, Piotrowo 2, 60-965 Poznan, Poland. szymon.wasik@cs.put.poznan.pl","institution_ids":["https://openalex.org/I46597724"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Paulina Jackowiak","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paulina Jackowiak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Jacek B Krawczyk","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jacek B Krawczyk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Pawe\u0142 Kedziora","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Pawe\u0142 Kedziora","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Piotr Formanowicz","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Piotr Formanowicz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":null,"display_name":"Marek Figlerowicz","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marek Figlerowicz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":null,"display_name":"Jacek B\u0142azewicz","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jacek B\u0142azewicz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5084740986"],"corresponding_institution_ids":["https://openalex.org/I46597724"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.00329939,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"2","first_page":"185","last_page":"99"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14423","display_name":"Military Technology and Strategies","score":0.018400000408291817,"subfield":{"id":"https://openalex.org/subfields/2202","display_name":"Aerospace Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T14423","display_name":"Military Technology and Strategies","score":0.018400000408291817,"subfield":{"id":"https://openalex.org/subfields/2202","display_name":"Aerospace Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13154","display_name":"Legal and Regulatory Analysis","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/3313","display_name":"Transportation"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T14235","display_name":"Linguistic, Cultural, and Literary Studies","score":0.00860000029206276,"subfield":{"id":"https://openalex.org/subfields/3312","display_name":"Sociology and Political Science"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/environmental-science","display_name":"Environmental science","score":0.27534013986587524}],"concepts":[{"id":"https://openalex.org/C39432304","wikidata":"https://www.wikidata.org/wiki/Q188847","display_name":"Environmental science","level":0,"score":0.27534013986587524}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006526","descriptor_name":"Hepatitis C","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016174","descriptor_name":"Hepacivirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"pmid:20461597","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20461597","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational and mathematical methods in medicine","raw_type":null},{"id":"pmh:oai:repository.kulib.kyoto-u.ac.jp:2433/151498","is_oa":true,"landing_page_url":"http://hdl.handle.net/2433/151498","pdf_url":"http://hdl.handle.net/2433/151498","source":{"id":"https://openalex.org/S4306401454","display_name":"Kyoto University Research Information Repository (Kyoto University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I22299242","host_organization_name":"Kyoto University","host_organization_lineage":["https://openalex.org/I22299242"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"DAM"},{"id":"mag:20461597","is_oa":false,"landing_page_url":"https://repository.kulib.kyoto-u.ac.jp/dspace/bitstream/2433/151498/1/ykeik00098.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":null,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:repository.kulib.kyoto-u.ac.jp:2433/151498","is_oa":true,"landing_page_url":"http://hdl.handle.net/2433/151498","pdf_url":"http://hdl.handle.net/2433/151498","source":{"id":"https://openalex.org/S4306401454","display_name":"Kyoto University Research Information Repository (Kyoto University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I22299242","host_organization_name":"Kyoto University","host_organization_lineage":["https://openalex.org/I22299242"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"DAM"},"sustainable_development_goals":[{"display_name":"Decent work and economic growth","id":"https://metadata.un.org/sdg/8","score":0.4099999964237213}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W20461597.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"We":[0,41,68,94],"investigate":[1],"a":[2,45,55,64,84],"correlation":[3,73],"between":[4,31],"genetic":[5,51],"diversity":[6,23,61],"of":[7,15,34,78,88,90],"hepatitis":[8],"C":[9],"virus":[10,35],"population":[11],"and":[12],"the":[13,27,39,71,76,79],"level":[14,82],"viral":[16,80,104],"RNA":[17,36,57,66,81,105],"accumulation":[18],"in":[19],"patient":[20,98],"blood.":[21],"Genetic":[22],"is":[24],"defined":[25],"as":[26,83],"mean":[28],"Hamming":[29,47],"distance":[30,48],"all":[32],"pairs":[33],"sequences":[37],"representing":[38],"population.":[40],"have":[42],"found":[43],"that":[44,70,97],"low":[46,50,65],"(i.e.":[49],"diversity)":[52],"correlates":[53],"with":[54],"high":[56,60],"level;":[58],"symmetrically,":[59],"corresponds":[62],"to":[63],"level.":[67],"contend":[69],"obtained":[72],"strength":[74],"justifies":[75],"use":[77],"measure":[85],"enabling":[86],"prediction":[87],"efficiency":[89],"an":[91],"established":[92],"therapy.":[93],"also":[95],"propose":[96],"qualification":[99],"for":[100],"therapy,":[101],"based":[102],"on":[103],"level,":[106],"improves":[107],"its":[108],"efficiency.":[109]},"counts_by_year":[],"updated_date":"2026-06-20T20:08:15.867695","created_date":"2025-10-10T00:00:00"}