{"id":"https://openalex.org/W4283266034","doi":"https://doi.org/10.1080/09540091.2022.2086217","title":"Predicting algorithm of attC site based on combination optimization strategy","display_name":"Predicting algorithm of attC site based on combination optimization strategy","publication_year":2022,"publication_date":"2022-06-21","ids":{"openalex":"https://openalex.org/W4283266034","doi":"https://doi.org/10.1080/09540091.2022.2086217"},"language":"en","primary_location":{"id":"doi:10.1080/09540091.2022.2086217","is_oa":true,"landing_page_url":"https://doi.org/10.1080/09540091.2022.2086217","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/09540091.2022.2086217?needAccess=true","source":{"id":"https://openalex.org/S4210188800","display_name":"Connection Science","issn_l":"0954-0091","issn":["0954-0091","1360-0494"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547"],"host_organization_lineage_names":["Taylor & Francis"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Connection Science","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.tandfonline.com/doi/pdf/10.1080/09540091.2022.2086217?needAccess=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5102002957","display_name":"Zhendong Liu","orcid":"https://orcid.org/0000-0002-4131-313X"},"institutions":[{"id":"https://openalex.org/I44445938","display_name":"Shandong Jianzhu University","ror":"https://ror.org/01gbfax37","country_code":"CN","type":"education","lineage":["https://openalex.org/I44445938"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhendong Liu","raw_affiliation_strings":["School of Computer Science and Technology, Shandong Jianzhu University, Jinan, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Shandong Jianzhu University, Jinan, People\u2019s Republic of China","institution_ids":["https://openalex.org/I44445938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100329945","display_name":"Xi Chen","orcid":"https://orcid.org/0000-0002-4151-4820"},"institutions":[{"id":"https://openalex.org/I44445938","display_name":"Shandong Jianzhu University","ror":"https://ror.org/01gbfax37","country_code":"CN","type":"education","lineage":["https://openalex.org/I44445938"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Chen","raw_affiliation_strings":["School of Computer Science and Technology, Shandong Jianzhu University, Jinan, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Shandong Jianzhu University, Jinan, People\u2019s Republic of China","institution_ids":["https://openalex.org/I44445938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100601018","display_name":"Dongyan Li","orcid":"https://orcid.org/0000-0003-2337-4163"},"institutions":[{"id":"https://openalex.org/I44445938","display_name":"Shandong Jianzhu University","ror":"https://ror.org/01gbfax37","country_code":"CN","type":"education","lineage":["https://openalex.org/I44445938"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Dongyan Li","raw_affiliation_strings":["School of Computer Science and Technology, Shandong Jianzhu University, Jinan, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Shandong Jianzhu University, Jinan, People\u2019s Republic of China","institution_ids":["https://openalex.org/I44445938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063560993","display_name":"Xinrong Lv","orcid":"https://orcid.org/0000-0002-6448-7511"},"institutions":[{"id":"https://openalex.org/I44445938","display_name":"Shandong Jianzhu University","ror":"https://ror.org/01gbfax37","country_code":"CN","type":"education","lineage":["https://openalex.org/I44445938"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinrong Lv","raw_affiliation_strings":["School of Computer Science and Technology, Shandong Jianzhu University, Jinan, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Shandong Jianzhu University, Jinan, People\u2019s Republic of China","institution_ids":["https://openalex.org/I44445938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059686117","display_name":"Mengying Qin","orcid":null},"institutions":[{"id":"https://openalex.org/I44445938","display_name":"Shandong Jianzhu University","ror":"https://ror.org/01gbfax37","country_code":"CN","type":"education","lineage":["https://openalex.org/I44445938"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mengying Qin","raw_affiliation_strings":["School of Computer Science and Technology, Shandong Jianzhu University, Jinan, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Shandong Jianzhu University, Jinan, People\u2019s Republic of China","institution_ids":["https://openalex.org/I44445938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036667044","display_name":"Ke Bai","orcid":null},"institutions":[{"id":"https://openalex.org/I44445938","display_name":"Shandong Jianzhu University","ror":"https://ror.org/01gbfax37","country_code":"CN","type":"education","lineage":["https://openalex.org/I44445938"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ke Bai","raw_affiliation_strings":["School of Computer Science and Technology, Shandong Jianzhu University, Jinan, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Shandong Jianzhu University, Jinan, People\u2019s Republic of China","institution_ids":["https://openalex.org/I44445938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087269274","display_name":"Zhiqiang He","orcid":null},"institutions":[{"id":"https://openalex.org/I44445938","display_name":"Shandong Jianzhu University","ror":"https://ror.org/01gbfax37","country_code":"CN","type":"education","lineage":["https://openalex.org/I44445938"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiqiang He","raw_affiliation_strings":["School of Computer Science and Technology, Shandong Jianzhu University, Jinan, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Shandong Jianzhu University, Jinan, People\u2019s Republic of China","institution_ids":["https://openalex.org/I44445938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101015709","display_name":"Yurong Yang","orcid":null},"institutions":[{"id":"https://openalex.org/I44445938","display_name":"Shandong Jianzhu University","ror":"https://ror.org/01gbfax37","country_code":"CN","type":"education","lineage":["https://openalex.org/I44445938"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yurong Yang","raw_affiliation_strings":["School of Computer Science and Technology, Shandong Jianzhu University, Jinan, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Shandong Jianzhu University, Jinan, People\u2019s Republic of China","institution_ids":["https://openalex.org/I44445938"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100347687","display_name":"Xiaofeng Li","orcid":"https://orcid.org/0000-0002-3946-5791"},"institutions":[{"id":"https://openalex.org/I44445938","display_name":"Shandong Jianzhu University","ror":"https://ror.org/01gbfax37","country_code":"CN","type":"education","lineage":["https://openalex.org/I44445938"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaofeng Li","raw_affiliation_strings":["School of Computer Science and Technology, Shandong Jianzhu University, Jinan, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Computer Science and Technology, Shandong Jianzhu University, Jinan, People\u2019s Republic of China","institution_ids":["https://openalex.org/I44445938"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080722708","display_name":"Qionghai Dai","orcid":"https://orcid.org/0000-0001-7043-3061"},"institutions":[{"id":"https://openalex.org/I99065089","display_name":"Tsinghua University","ror":"https://ror.org/03cve4549","country_code":"CN","type":"education","lineage":["https://openalex.org/I99065089"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qionghai Dai","raw_affiliation_strings":["Department of Automation, Tsinghua University, Beijing, People\u2019s Republic of China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Automation, Tsinghua University, Beijing, People\u2019s Republic of China","institution_ids":["https://openalex.org/I99065089"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5102002957"],"corresponding_institution_ids":["https://openalex.org/I44445938"],"apc_list":{"value":1270,"currency":"USD","value_usd":1270},"apc_paid":{"value":1270,"currency":"USD","value_usd":1270},"fwci":0.0866,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.41921889,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"34","issue":"1","first_page":"1895","last_page":"1912"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10878","display_name":"CRISPR and Genetic Engineering","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12856","display_name":"Transgenic Plants and Applications","score":0.9921000003814697,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/recombination","display_name":"Recombination","score":0.6306995749473572},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5981118679046631},{"id":"https://openalex.org/keywords/algorithm","display_name":"Algorithm","score":0.5731992721557617},{"id":"https://openalex.org/keywords/software-portability","display_name":"Software portability","score":0.5581164956092834},{"id":"https://openalex.org/keywords/mean-squared-error","display_name":"Mean squared error","score":0.5046204328536987},{"id":"https://openalex.org/keywords/genetic-algorithm","display_name":"Genetic algorithm","score":0.4602877199649811},{"id":"https://openalex.org/keywords/correlation-coefficient","display_name":"Correlation coefficient","score":0.43901559710502625},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.3275798559188843},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.2619761824607849},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2566291093826294},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.12001371383666992}],"concepts":[{"id":"https://openalex.org/C156695909","wikidata":"https://www.wikidata.org/wiki/Q3373825","display_name":"Recombination","level":3,"score":0.6306995749473572},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5981118679046631},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.5731992721557617},{"id":"https://openalex.org/C63000827","wikidata":"https://www.wikidata.org/wiki/Q3080428","display_name":"Software portability","level":2,"score":0.5581164956092834},{"id":"https://openalex.org/C139945424","wikidata":"https://www.wikidata.org/wiki/Q1940696","display_name":"Mean squared error","level":2,"score":0.5046204328536987},{"id":"https://openalex.org/C8880873","wikidata":"https://www.wikidata.org/wiki/Q187787","display_name":"Genetic algorithm","level":2,"score":0.4602877199649811},{"id":"https://openalex.org/C2780092901","wikidata":"https://www.wikidata.org/wiki/Q3433612","display_name":"Correlation coefficient","level":2,"score":0.43901559710502625},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.3275798559188843},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.2619761824607849},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2566291093826294},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12001371383666992},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1080/09540091.2022.2086217","is_oa":true,"landing_page_url":"https://doi.org/10.1080/09540091.2022.2086217","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/09540091.2022.2086217?needAccess=true","source":{"id":"https://openalex.org/S4210188800","display_name":"Connection Science","issn_l":"0954-0091","issn":["0954-0091","1360-0494"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547"],"host_organization_lineage_names":["Taylor & Francis"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Connection Science","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:7a05d7e419a248e3885efdcd17203edd","is_oa":false,"landing_page_url":"https://doaj.org/article/7a05d7e419a248e3885efdcd17203edd","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Connection Science, Vol 34, Iss 1, Pp 1895-1912 (2022)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1080/09540091.2022.2086217","is_oa":true,"landing_page_url":"https://doi.org/10.1080/09540091.2022.2086217","pdf_url":"https://www.tandfonline.com/doi/pdf/10.1080/09540091.2022.2086217?needAccess=true","source":{"id":"https://openalex.org/S4210188800","display_name":"Connection Science","issn_l":"0954-0091","issn":["0954-0091","1360-0494"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547"],"host_organization_lineage_names":["Taylor & Francis"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Connection Science","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/9","score":0.5,"display_name":"Industry, innovation and infrastructure"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4283266034.pdf"},"referenced_works_count":48,"referenced_works":["https://openalex.org/W1505191356","https://openalex.org/W1977687525","https://openalex.org/W2024663436","https://openalex.org/W2026967058","https://openalex.org/W2064983847","https://openalex.org/W2097633719","https://openalex.org/W2098305228","https://openalex.org/W2140746184","https://openalex.org/W2145063082","https://openalex.org/W2146521959","https://openalex.org/W2295598076","https://openalex.org/W2321915572","https://openalex.org/W2339374701","https://openalex.org/W2342484850","https://openalex.org/W2497897406","https://openalex.org/W2501009553","https://openalex.org/W2592627654","https://openalex.org/W2604897194","https://openalex.org/W2741615951","https://openalex.org/W2790756470","https://openalex.org/W2905254503","https://openalex.org/W2941951094","https://openalex.org/W2949701613","https://openalex.org/W2965932947","https://openalex.org/W2977617597","https://openalex.org/W3006116138","https://openalex.org/W3044079631","https://openalex.org/W3049002444","https://openalex.org/W3105982350","https://openalex.org/W3123012027","https://openalex.org/W3133549211","https://openalex.org/W3138409927","https://openalex.org/W3158757007","https://openalex.org/W3160244726","https://openalex.org/W3173096650","https://openalex.org/W3175300744","https://openalex.org/W3188014327","https://openalex.org/W3191844924","https://openalex.org/W3196564748","https://openalex.org/W3217452736","https://openalex.org/W4205118596","https://openalex.org/W4210469624","https://openalex.org/W4220805888","https://openalex.org/W4234173777","https://openalex.org/W4234482043","https://openalex.org/W4238473618","https://openalex.org/W4241825398","https://openalex.org/W4246392581"],"related_works":["https://openalex.org/W2784803070","https://openalex.org/W2077030552","https://openalex.org/W110609005","https://openalex.org/W2377544373","https://openalex.org/W2211967836","https://openalex.org/W2120994104","https://openalex.org/W1517479908","https://openalex.org/W2127814643","https://openalex.org/W3017119374","https://openalex.org/W3039465437"],"abstract_inverted_index":{"Site-specific":[0],"recombination":[1,13,28,39,96,177],"systems":[2,178],"are":[3,116],"widely":[4],"used":[5],"as":[6],"bioengineering":[7],"tools.":[8],"However,":[9],"the":[10,20,43,47,58,81,87,91,95,101,104,120,137,143,173],"traditional":[11],"site-specific":[12,38],"system":[14],"requires":[15],"a":[16,53,75,111,182],"consensus":[17],"sequence":[18],"for":[19,118,172,185],"specific":[21],"site.":[22],"Such":[23],"sequence-level":[24],"constraints":[25],"limit":[26],"effective":[27,117],"between":[29,98],"sites.":[30,125],"Therefore,":[31],"in":[32,113],"order":[33],"to":[34,56,63],"develop":[35],"an":[36,68],"efficient":[37,176],"system,":[40],"we":[41,66],"investigated":[42],"attC":[44,69,85,124],"site":[45,70],"of":[46,84,94,103,123,175],"bacterial":[48],"integration":[49],"subsystem":[50],"and":[51,100,131,160],"built":[52],"predictive":[54],"model":[55],"infer":[57],"important":[59,107],"features":[60,83,108],"that":[61,109],"contribute":[62],"recombination.":[64],"Here,":[65],"design":[67,121],"prediction":[71,88,93,133],"algorithm":[72,89,127],"based":[73],"on":[74,80],"combination":[76],"optimisation":[77],"strategy.":[78],"Based":[79],"structural":[82],"sites,":[86],"realises":[90],"high-precision":[92],"frequencies":[97],"sites":[99],"screening":[102],"top":[105],"20":[106],"play":[110],"role":[112],"recombination,":[114],"which":[115,142],"improving":[119],"method":[122],"The":[126],"has":[128],"better":[129],"portability":[130],"higher":[132],"accuracy":[134],"compared":[135],"with":[136],"existing":[138],"advanced":[139],"algorithms,":[140],"among":[141],"Pearson":[144],"correlation":[145],"coefficient":[146],"is":[147,152,158,164],"0.87,":[148],"explained":[149],"variance":[150],"score":[151],"0.73,":[153],"root":[154],"mean":[155,161],"square":[156],"error":[157,163],"0.006":[159],"absolute":[162],"0.041.":[165],"This":[166],"can":[167],"not":[168],"only":[169],"provide":[170,181],"ideas":[171],"research":[174],"but":[179],"also":[180],"theoretical":[183],"basis":[184],"developing":[186],"genetic":[187],"engineering":[188],"further.":[189]},"counts_by_year":[{"year":2022,"cited_by_count":1}],"updated_date":"2026-05-22T06:13:13.366637","created_date":"2025-10-10T00:00:00"}