{"id":"https://openalex.org/W2906757809","doi":"https://doi.org/10.1080/0952813x.2018.1552319","title":"A multivariate regression approach for identification of SNPs importance in prostate cancer","display_name":"A multivariate regression approach for identification of SNPs importance in prostate cancer","publication_year":2018,"publication_date":"2018-12-31","ids":{"openalex":"https://openalex.org/W2906757809","doi":"https://doi.org/10.1080/0952813x.2018.1552319","mag":"2906757809"},"language":"en","primary_location":{"id":"doi:10.1080/0952813x.2018.1552319","is_oa":false,"landing_page_url":"https://doi.org/10.1080/0952813x.2018.1552319","pdf_url":null,"source":{"id":"https://openalex.org/S153467142","display_name":"Journal of Experimental & Theoretical Artificial Intelligence","issn_l":"0952-813X","issn":["0952-813X","1362-3079"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547"],"host_organization_lineage_names":["Taylor & Francis"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental & Theoretical Artificial Intelligence","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10651/52033","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5020547625","display_name":"Juan Enrique S\u00e1nchez Lasheras","orcid":null},"institutions":[{"id":"https://openalex.org/I4210101311","display_name":"Hospital Carmen y Severo Ochoa","ror":"https://ror.org/01azs0t89","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2800212897","https://openalex.org/I4210101311"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Juan Enrique S\u00e1nchez Lasheras","raw_affiliation_strings":["Anesthesiology and Resuscitation Service, Hospital Carmen y Severo Ochoa, Cangas del Narcea, Spain"],"affiliations":[{"raw_affiliation_string":"Anesthesiology and Resuscitation Service, Hospital Carmen y Severo Ochoa, Cangas del Narcea, Spain","institution_ids":["https://openalex.org/I4210101311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058965809","display_name":"Sergio Luis Su\u00e1rez G\u00f3mez","orcid":"https://orcid.org/0000-0003-4970-0502"},"institutions":[{"id":"https://openalex.org/I165339363","display_name":"Universidad de Oviedo","ror":"https://ror.org/006gksa02","country_code":"ES","type":"education","lineage":["https://openalex.org/I165339363"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Sergio Luis Su\u00e1rez G\u00f3mez","raw_affiliation_strings":["Department of Physics, University of Oviedo, Gij\u00f3n, Spain"],"affiliations":[{"raw_affiliation_string":"Department of Physics, University of Oviedo, Gij\u00f3n, Spain","institution_ids":["https://openalex.org/I165339363"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Jes\u00fas Daniel Santos","orcid":null},"institutions":[{"id":"https://openalex.org/I165339363","display_name":"Universidad de Oviedo","ror":"https://ror.org/006gksa02","country_code":"ES","type":"education","lineage":["https://openalex.org/I165339363"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jes\u00fas Daniel Santos","raw_affiliation_strings":["Department of Physics, University of Oviedo, Gij\u00f3n, Spain"],"affiliations":[{"raw_affiliation_string":"Department of Physics, University of Oviedo, Gij\u00f3n, Spain","institution_ids":["https://openalex.org/I165339363"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079784857","display_name":"Gemma Casta\u00f1o\u2010Vinyals","orcid":"https://orcid.org/0000-0003-4468-1816"},"institutions":[{"id":"https://openalex.org/I4210092159","display_name":"Center for Research in Environmental Epidemiology","ror":"https://ror.org/00ftv8552","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210092159"]},{"id":"https://openalex.org/I4210148332","display_name":"Barcelona Institute for Global Health","ror":"https://ror.org/03hjgt059","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210148332","https://openalex.org/I4387153040"]},{"id":"https://openalex.org/I4210154894","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica","ror":"https://ror.org/050q0kv47","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4210154894","https://openalex.org/I4387152914"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Gemma Casta\u00f1o-Vinyals","raw_affiliation_strings":["ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain","Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain","institution_ids":["https://openalex.org/I4210092159","https://openalex.org/I4210148332"]},{"raw_affiliation_string":"Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain","institution_ids":["https://openalex.org/I4210154894"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056934110","display_name":"Beatriz P\u00e9rez\u2010G\u00f3mez","orcid":"https://orcid.org/0000-0002-4299-8214"},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"funder","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210154894","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica","ror":"https://ror.org/050q0kv47","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4210154894","https://openalex.org/I4387152914"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Beatriz P\u00e9rez-G\u00f3mez","raw_affiliation_strings":["Cancer and Environmental Epidemiology Unit, Carlos III Institute of Health, National Center for Epidemiology, Madrid, Spain","Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain"],"affiliations":[{"raw_affiliation_string":"Cancer and Environmental Epidemiology Unit, Carlos III Institute of Health, National Center for Epidemiology, Madrid, Spain","institution_ids":["https://openalex.org/I2801357902"]},{"raw_affiliation_string":"Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain","institution_ids":["https://openalex.org/I4210154894"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002857362","display_name":"Adonina Tard\u00f3n","orcid":"https://orcid.org/0000-0001-5150-1209"},"institutions":[{"id":"https://openalex.org/I165339363","display_name":"Universidad de Oviedo","ror":"https://ror.org/006gksa02","country_code":"ES","type":"education","lineage":["https://openalex.org/I165339363"]},{"id":"https://openalex.org/I4210154894","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Epidemiolog\u00eda y Salud P\u00fablica","ror":"https://ror.org/050q0kv47","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4210115082","https://openalex.org/I4210154894","https://openalex.org/I4387152914"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Adonina Tard\u00f3n","raw_affiliation_strings":["Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain","Universitary Institute of Oncology of Asturias (IUOPA), University of Oviedo, Oviedo, Spain"],"affiliations":[{"raw_affiliation_string":"Spanish Consortium for Research on Epidemiology and Public Health (CIBERESP), Madrid, Spain","institution_ids":["https://openalex.org/I4210154894"]},{"raw_affiliation_string":"Universitary Institute of Oncology of Asturias (IUOPA), University of Oviedo, Oviedo, Spain","institution_ids":["https://openalex.org/I165339363"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5058965809"],"corresponding_institution_ids":["https://openalex.org/I165339363"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.15770729,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":96},"biblio":{"volume":"31","issue":"6","first_page":"817","last_page":"828"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.983299970626831,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11970","display_name":"Molecular Biology Techniques and Applications","score":0.977400004863739,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.7736341953277588},{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.7197971343994141},{"id":"https://openalex.org/keywords/receiver-operating-characteristic","display_name":"Receiver operating characteristic","score":0.6718817353248596},{"id":"https://openalex.org/keywords/multivariate-adaptive-regression-splines","display_name":"Multivariate adaptive regression splines","score":0.6026013493537903},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.593734622001648},{"id":"https://openalex.org/keywords/snp","display_name":"SNP","score":0.572807252407074},{"id":"https://openalex.org/keywords/principal-component-analysis","display_name":"Principal component analysis","score":0.5367634892463684},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.5267536044120789},{"id":"https://openalex.org/keywords/regression","display_name":"Regression","score":0.5202604532241821},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.45467835664749146},{"id":"https://openalex.org/keywords/data-mining","display_name":"Data mining","score":0.4423680603504181},{"id":"https://openalex.org/keywords/regression-analysis","display_name":"Regression analysis","score":0.3523310422897339},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3147601783275604},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.2990916073322296},{"id":"https://openalex.org/keywords/bayesian-multivariate-linear-regression","display_name":"Bayesian multivariate linear regression","score":0.16092848777770996},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.13438761234283447},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.13193035125732422},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.08294332027435303},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.07877534627914429}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7736341953277588},{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.7197971343994141},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.6718817353248596},{"id":"https://openalex.org/C44882253","wikidata":"https://www.wikidata.org/wiki/Q3455882","display_name":"Multivariate adaptive regression splines","level":4,"score":0.6026013493537903},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.593734622001648},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.572807252407074},{"id":"https://openalex.org/C27438332","wikidata":"https://www.wikidata.org/wiki/Q2873","display_name":"Principal component analysis","level":2,"score":0.5367634892463684},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.5267536044120789},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.5202604532241821},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.45467835664749146},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4423680603504181},{"id":"https://openalex.org/C152877465","wikidata":"https://www.wikidata.org/wiki/Q208042","display_name":"Regression analysis","level":2,"score":0.3523310422897339},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3147601783275604},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.2990916073322296},{"id":"https://openalex.org/C64946054","wikidata":"https://www.wikidata.org/wiki/Q4874476","display_name":"Bayesian multivariate linear regression","level":3,"score":0.16092848777770996},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13438761234283447},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.13193035125732422},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08294332027435303},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.07877534627914429},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1080/0952813x.2018.1552319","is_oa":false,"landing_page_url":"https://doi.org/10.1080/0952813x.2018.1552319","pdf_url":null,"source":{"id":"https://openalex.org/S153467142","display_name":"Journal of Experimental & Theoretical Artificial Intelligence","issn_l":"0952-813X","issn":["0952-813X","1362-3079"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547"],"host_organization_lineage_names":["Taylor & Francis"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental & Theoretical Artificial Intelligence","raw_type":"journal-article"},{"id":"pmh:oai:digibuo.uniovi.es:10651/52033","is_oa":true,"landing_page_url":"http://hdl.handle.net/10651/52033","pdf_url":null,"source":{"id":"https://openalex.org/S4306402334","display_name":"Consultation of the Doctoral Thesis Database (TESEO) (Ministerio de Educaci\u00f3n, Cultura y Deporte)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801976130","host_organization_name":"Ministerio de Educaci\u00f3n Cultura y Deporte","host_organization_lineage":["https://openalex.org/I2801976130"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:digibuo.uniovi.es:10651/52033","is_oa":true,"landing_page_url":"http://hdl.handle.net/10651/52033","pdf_url":null,"source":{"id":"https://openalex.org/S4306402334","display_name":"Consultation of the Doctoral Thesis Database (TESEO) (Ministerio de Educaci\u00f3n, Cultura y Deporte)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2801976130","host_organization_name":"Ministerio de Educaci\u00f3n Cultura y Deporte","host_organization_lineage":["https://openalex.org/I2801976130"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Scopus","raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.699999988079071,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1480376833","https://openalex.org/W1491002046","https://openalex.org/W1757407923","https://openalex.org/W1907267245","https://openalex.org/W2001485777","https://openalex.org/W2011481463","https://openalex.org/W2012255354","https://openalex.org/W2019275873","https://openalex.org/W2023160088","https://openalex.org/W2034654759","https://openalex.org/W2036845311","https://openalex.org/W2041552396","https://openalex.org/W2049654793","https://openalex.org/W2052938830","https://openalex.org/W2071108289","https://openalex.org/W2080063818","https://openalex.org/W2085129489","https://openalex.org/W2087345933","https://openalex.org/W2088531552","https://openalex.org/W2089415609","https://openalex.org/W2093729382","https://openalex.org/W2094549173","https://openalex.org/W2128220262","https://openalex.org/W2131323911","https://openalex.org/W2328838746","https://openalex.org/W2509157981","https://openalex.org/W2604474890","https://openalex.org/W2609553042","https://openalex.org/W2749072641","https://openalex.org/W2758486852","https://openalex.org/W2787894218","https://openalex.org/W2789020168","https://openalex.org/W4249984073"],"related_works":["https://openalex.org/W10576317","https://openalex.org/W1481829876","https://openalex.org/W4256152544","https://openalex.org/W2055800560","https://openalex.org/W2519969434","https://openalex.org/W1991715599","https://openalex.org/W2969801794","https://openalex.org/W2033531685","https://openalex.org/W3148095850","https://openalex.org/W2148211789"],"abstract_inverted_index":{"Nowadays,":[0],"it":[1],"is":[2,28,46,124],"well-known":[3],"that":[4,10,101,149],"there":[5],"are":[6,77,102,119,165],"several":[7],"genetic":[8,15,152],"alterations":[9],"can":[11],"be":[12,105],"employed":[13],"as":[14,60,86,180],"markers":[16],"of":[17,23,30,35,42,51,57,68,74,107,128,134,159,170,175,184],"prostate":[18],"cancer":[19,38],"(PCa).":[20],"The":[21,40],"use":[22],"single":[24],"nucleotide":[25],"polymorphism":[26],"(SNP)":[27],"one":[29],"the":[31,43,49,52,55,66,72,99,111,129,135,160,163,168,181,185,189],"most":[32,182],"promising":[33],"areas":[34],"research":[36,45],"in":[37,126],"investigation.":[39],"aim":[41],"present":[44],"to":[47,64,96,104],"study":[48],"influence":[50],"pathways":[53],"with":[54,110,144,151],"help":[56],"models":[58,118,164],"such":[59],"recursive":[61],"partitioning":[62,91],"method,":[63],"detect":[65],"SNP":[67],"relevance,":[69],"and":[70,84,121,157],"consequently":[71],"detection":[73],"PCa.":[75],"Data":[76],"retrieved":[78],"from":[79],"MCC-Spain":[80],"database,":[81],"selecting":[82],"cases":[83],"controls":[85],"a":[87,142,154,173],"heterogeneous":[88],"group.":[89],"Recursive":[90],"method":[92],"decision":[93],"trees":[94],"allow":[95],"prune":[97],"off":[98],"splits":[100],"supposed":[103],"not":[106],"interest.":[108],"Then,":[109],"selected":[112],"pathways,":[113],"multivariate":[114],"adaptive":[115],"regression":[116],"spline":[117],"trained,":[120],"its":[122],"performance":[123,145],"assessed":[125],"terms":[127],"Area":[130],"Under":[131],"Curve":[132],"(AUC)":[133],"Receiver":[136],"Operating":[137],"Characteristics":[138],"(ROC)":[139],"curve.":[140],"As":[141],"result,":[143],"tests":[146],"for":[147,162,188],"researchers":[148],"work":[150],"datasets,":[153],"dimensional":[155],"reduction":[156],"tuning":[158],"parameters":[161],"determined.":[166],"In":[167],"case":[169],"our":[171],"research,":[172],"total":[174],"12":[176],"SNPs":[177],"were":[178],"found":[179],"relevant":[183],"above-mentioned":[186],"database":[187],"PCa":[190],"detection.":[191]},"counts_by_year":[{"year":2022,"cited_by_count":2}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}