{"id":"https://openalex.org/W2571438772","doi":"https://doi.org/10.1080/03610918.2016.1275690","title":"Properties of adaptive clinical trial signature design in the presence of gene and gene-treatment interaction","display_name":"Properties of adaptive clinical trial signature design in the presence of gene and gene-treatment interaction","publication_year":2017,"publication_date":"2017-01-05","ids":{"openalex":"https://openalex.org/W2571438772","doi":"https://doi.org/10.1080/03610918.2016.1275690","mag":"2571438772"},"language":"en","primary_location":{"id":"doi:10.1080/03610918.2016.1275690","is_oa":false,"landing_page_url":"https://doi.org/10.1080/03610918.2016.1275690","pdf_url":null,"source":{"id":"https://openalex.org/S153329750","display_name":"Communications in Statistics - Simulation and Computation","issn_l":"0361-0918","issn":["0361-0918","1532-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547"],"host_organization_lineage_names":["Taylor & Francis"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications in Statistics - Simulation and Computation","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059600423","display_name":"A. Cambon","orcid":"https://orcid.org/0000-0002-8025-7898"},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. C. Cambon","raw_affiliation_strings":["Biostatistics Shared Facility, James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA","Department of Bioinformatics and Biostatistics, University of Louisville, Louisville, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics Shared Facility, James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Department of Bioinformatics and Biostatistics, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085805379","display_name":"Kathy B. Baumgartner","orcid":"https://orcid.org/0000-0002-5274-9756"},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"K. B. Baumgartner","raw_affiliation_strings":["Department of Epidemiology and Population Health, University of Louisville, Louisville, KY, USA"],"raw_orcid":"https://orcid.org/0000-0002-5274-9756","affiliations":[{"raw_affiliation_string":"Department of Epidemiology and Population Health, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035224040","display_name":"Guy Brock","orcid":"https://orcid.org/0000-0001-5317-079X"},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G. N. Brock","raw_affiliation_strings":["Department of Bioinformatics and Biostatistics, University of Louisville, Louisville, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics and Biostatistics, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101840051","display_name":"Nigel G. F. Cooper","orcid":"https://orcid.org/0000-0001-6598-5136"},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. G. F. Cooper","raw_affiliation_strings":["Department of Anatomical Sciences & Neurobiology, University of Louisville, Louisville, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomical Sciences & Neurobiology, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075747858","display_name":"David Wu","orcid":"https://orcid.org/0000-0002-9030-3667"},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Wu","raw_affiliation_strings":["Department of Bioinformatics and Biostatistics, University of Louisville, Louisville, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics and Biostatistics, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112958544","display_name":"S. N.","orcid":null},"institutions":[{"id":"https://openalex.org/I142740786","display_name":"University of Louisville","ror":"https://ror.org/01ckdn478","country_code":"US","type":"education","lineage":["https://openalex.org/I142740786"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"S. N. Rai","raw_affiliation_strings":["Biostatistics Shared Facility, James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA","Department of Bioinformatics and Biostatistics, University of Louisville, Louisville, KY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biostatistics Shared Facility, James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]},{"raw_affiliation_string":"Department of Bioinformatics and Biostatistics, University of Louisville, Louisville, KY, USA","institution_ids":["https://openalex.org/I142740786"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5112958544"],"corresponding_institution_ids":["https://openalex.org/I142740786"],"apc_list":null,"apc_paid":null,"fwci":0.243,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.55882353,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"46","issue":"10","first_page":"8233","last_page":"8250"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9958999752998352,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/signature","display_name":"Signature (topology)","score":0.7457975745201111},{"id":"https://openalex.org/keywords/adaptive-design","display_name":"Adaptive design","score":0.5677554607391357},{"id":"https://openalex.org/keywords/gene-signature","display_name":"Gene signature","score":0.5075668096542358},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.4596215784549713},{"id":"https://openalex.org/keywords/clinical-trial","display_name":"Clinical trial","score":0.4321284592151642},{"id":"https://openalex.org/keywords/treatment-effect","display_name":"Treatment effect","score":0.41069281101226807},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.37848061323165894},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.36865341663360596},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.3600468337535858},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.35388293862342834},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3435325026512146},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.34011590480804443},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2679387331008911},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.22724220156669617},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.13962572813034058},{"id":"https://openalex.org/keywords/traditional-medicine","display_name":"Traditional medicine","score":0.09910711646080017}],"concepts":[{"id":"https://openalex.org/C2779696439","wikidata":"https://www.wikidata.org/wiki/Q7512811","display_name":"Signature (topology)","level":2,"score":0.7457975745201111},{"id":"https://openalex.org/C2982777018","wikidata":"https://www.wikidata.org/wiki/Q99268086","display_name":"Adaptive design","level":3,"score":0.5677554607391357},{"id":"https://openalex.org/C2779733811","wikidata":"https://www.wikidata.org/wiki/Q5531562","display_name":"Gene signature","level":4,"score":0.5075668096542358},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4596215784549713},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.4321284592151642},{"id":"https://openalex.org/C2987370644","wikidata":"https://www.wikidata.org/wiki/Q7836903","display_name":"Treatment effect","level":2,"score":0.41069281101226807},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.37848061323165894},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.36865341663360596},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.3600468337535858},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.35388293862342834},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3435325026512146},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34011590480804443},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2679387331008911},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.22724220156669617},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13962572813034058},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.09910711646080017},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1080/03610918.2016.1275690","is_oa":false,"landing_page_url":"https://doi.org/10.1080/03610918.2016.1275690","pdf_url":null,"source":{"id":"https://openalex.org/S153329750","display_name":"Communications in Statistics - Simulation and Computation","issn_l":"0361-0918","issn":["0361-0918","1532-4141"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547"],"host_organization_lineage_names":["Taylor & Francis"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Communications in Statistics - Simulation and Computation","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7799999713897705}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W646952906","https://openalex.org/W1480376833","https://openalex.org/W1489950266","https://openalex.org/W1513618424","https://openalex.org/W1532109533","https://openalex.org/W1663973292","https://openalex.org/W2003073513","https://openalex.org/W2019607817","https://openalex.org/W2036197503","https://openalex.org/W2036796028","https://openalex.org/W2048576932","https://openalex.org/W2049633694","https://openalex.org/W2083466846","https://openalex.org/W2105400786","https://openalex.org/W2106298710","https://openalex.org/W2110065044","https://openalex.org/W2114850871","https://openalex.org/W2118250684","https://openalex.org/W2131104444","https://openalex.org/W2133105825","https://openalex.org/W2135046866","https://openalex.org/W2135647278","https://openalex.org/W2136371968"],"related_works":["https://openalex.org/W1671124163","https://openalex.org/W2168674042","https://openalex.org/W2535275505","https://openalex.org/W3030774134","https://openalex.org/W2104499293","https://openalex.org/W2102771100","https://openalex.org/W2088568753","https://openalex.org/W2593264985","https://openalex.org/W1484781150","https://openalex.org/W2029992136"],"abstract_inverted_index":{"Traditional":[0],"phase":[1],"III":[2],"clinical":[3],"trials":[4],"are":[5,22,62,73],"powered":[6],"to":[7,38,47],"detect":[8],"an":[9],"overall":[10,51],"treatment":[11,52,56],"effect.":[12],"However,":[13],"it":[14],"has":[15],"increasingly":[16],"been":[17],"shown":[18],"that":[19,80],"many":[20],"treatments":[21],"effective":[23],"only":[24],"for":[25,50,55],"a":[26,29,41],"subset":[27,42,61],"of":[28,43,68],"population.":[30],"The":[31],"adaptive":[32,70],"signature":[33,71],"design":[34,72],"uses":[35],"genomic/proteomic":[36],"information":[37],"prospectively":[39],"predict":[40],"patients":[44],"more":[45],"sensitive":[46],"treatment.":[48],"Tests":[49],"effect":[53,57,86],"and":[54],"in":[58],"the":[59,69],"predicted":[60],"conducted.":[63],"In":[64],"this":[65],"work":[66],"properties":[67],"investigated":[74],"through":[75],"simulation.":[76],"It":[77],"was":[78],"found":[79],"models":[81,93],"which":[82,94],"excluded":[83],"expression":[84],"main":[85],"terms":[87],"had":[88],"higher":[89],"empirical":[90],"power":[91],"than":[92],"included":[95],"them.":[96]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}